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At least 595 records · Page 33Linked to original sources
PubMed2004

Ticking fast or ticking slow, through Shc must you go?

Circumstantial evidence places the p66 isoform of the adapter protein Shc in a position to mediate the accelerated aging phenotype displayed by mice expressing shortened forms of the tumor suppressor protein p53. We present a model in which p66(shc) may be responsible for integrating signals from the p53 pathway with signals from the insulin-like growth factor-1/Daf pathway in mammals. A full understanding of how interactions between p53 and p66(shc) affect longevity will require the production of animals with mutations in the genes encoding both proteins.

Adaptor Proteins, Signal Transducing↗
PubMed2004

[Preparations for serodiagnosis of diseases due to causative agents of ixode tick-borne Borreliosis (Lyme disease). Communication 2. Comparative study of recombinant enzyme immunoassay test-systems (rELISA) for serological diagnosis of ixode tick-borne Borreliosis].

One foreign and two Russian recombinant enzyme immunoassay test-systems were comparatively investigated under conditions of an encoded experiment. Sensitivity in the experiment with the Russian test-systems Borreliosis-ELISA-IgG and Lyme Best was 63.8 and 68.8% respectively. As for the test-system Borrelia IgG Recombinant, it was 47.5%. All the test-systems were highly specific (94.4 to 99.5%). The test-systems Lyme Best and Borrelia IgG Recombinant revealed partial cross reactions with sera from patients with systemic lupus erythematosus and leptospirosis.

Antibodies, Bacterial↗
PubMed2006

Potential risk of pathogen transmission by acaricide-poisoned ticks.

Many aspects of tick poisoning with acaricides have yet to be elucidated. One of them is the influence of acaricide poisoning on tick infectivity to their hosts. To clarify this problem, we should know how tick poisoning develops after acaricide application. Data obtained during more than three decades of work with ticks of various species and with acaricides of different groups are presented in the paper. The first important phenomenon found was the gradual and progressive development of toxic symptoms after acaricide application, with death of the treated ticks delayed for days or even weeks ('slow-death syndrome'). The development of symptoms was much faster after the application of fenthion, an organophosphorous acaricide, when compared to DDT, a chlorinated hydrocarbon. The larger the adult ticks of a particular species, the more refractory they were to acaricide action. The duration of the development of toxic symptoms directly correlates with the degree of species-specific refractoriness. A special index T(LD(50)) (T(LC(50)) was introduced for comparing the duration of the poisoning development between different tick species, populations etc. The index determines the time when the final mortality is reached after using the LD(50) of a particular acaricide. Another index , T(LD(90)), was used for practical purposes. The values of these indices decreased with increasing age of tick populations. The prolonged duration of poisoning was also observed in nymphal ticks of species with a prolonged life-span and the ability to over-winter (Ixodes, Haemaphysalis) but not in ticks characterized by a short life-span (Dermacentor). During the entire period of poisoning, from acaricide application until tick death, the individual tick passes through six stages defined by its locomotor capabilities. The stages are the same for nymphs and adults of both hard and soft ticks after treatment with various acaricides. When ticks are at the initial stages of poisoning (1st to 3rd stage for DDT or 1st to 2nd for fenthion), they can attach to hosts and imbibe blood. The average body weight of such ticks after repletion corresponded to that of control ticks. Engorged nymphal ticks normally molted to adults, engorged females normally oviposited, and their progeny did not differ from the progeny of control females. This second important phenomenon, called 'overcoming the poisoning', was observed in all studied species of ticks from several genera. Thus, the slow development of tick poisoning creates a potential for ticks to attach to hosts and to gorge blood, and for infected ticks to transmit pathogens to those hosts, while the ability to overcome the poisoning allows the ticks to survive and makes possible the subsequent trans-stadial and transovarial passage of pathogens. These data can be considered as strong circumstantial evidence of the risk that ticks can present to humans and animals at the initial stages of poisoning after acaricide treatment.

Aging↗