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Reimplantation of freeze-treated bone in immediate reconstruction of the mandible.

Surgical defects encountered with corrective surgery of the mandibular complex have been repaired most successfully with autogenous composite bone grafts. Their use belies inherent consequences associated with distant donor sites. Presented here are the experiences and results in two patients whose reconstructions consisted of immediate replacement of the resected mandibular segment after its devitalization with cryogenic freezing treatments. Such treated, autologous bone provides an ideal anatomic graft, nondistinct antigenicity, and immediate restoration of form and function. Monitoring of neoosteogenesis was performed with sequential panographic, nuclear, and histologic studies that documented clinical and histologic repair.

Aged↗

Retinal projection to a rotated tectal reimplant following long-term tectal denervation in adult goldfish.

Following optic nerve crush, the precise termination sites of regenerating goldfish optic axons may be influenced by the presence or absence of degenerating axonal debris from the previous projection. We investigated wheter tectal polarity reversal can be induced in the absence of axonal debris. The right optic tectum was denervated by contralateral eye removal. One year later, when no debris was present, a piece of the right tectum was rotated and innervation by the right eye was induced by removal of the left tectum. The new ipsilateral projection to the rotated region was correspondingly rotated. It is concluded that retention of tectal polarity is not dependent upon degenerating axonal debris.

Animals↗