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PubMed1992

The development of functional and equivalence classes in high-functioning autistic children: the role of naming.

The development of functional and equivalence classes was studied in four high-functioning, preschool-aged autistic children. Initially, all subjects failed to demonstrate match-to-sample relations indicative of stimulus equivalence among two three-member classes of visual stimuli. Then, 2 subjects showed emergence of those relations after they were taught to assign the same name to all members in each class. Next, subjects were taught names for new stimuli outside the match-to-sample format. On subsequent match-to-sample tests, 2 subjects demonstrated untrained conditional relations among the stimuli given a common name. New, unnamed stimuli were then related via match-to-sample training to stimuli from sets of named stimuli. Tests for emergent conditional relations between the new unnamed stimuli and the named stimuli yielded positive results for 1 subject and somewhat mixed results for 3 subjects. Finally, without naming, 2 subjects developed stimulus equivalence among two new three-member classes of visual stimuli. These data suggest that naming may remediate failures to develop untrained conditional relations, some of which are indicative of stimulus equivalence.

Association Learning↗
PubMed1999

[Anatomical names of fossae and foveae in skeleton].

Latin anatomical names of Fossae and Foveae in the skeleton were analyzed and compared with Japanese anatomical names for better understanding of the structures of the human body and for possible revision in the future. The conclusions were as follows: 1. In general, round excavations were called Foveae (singular : Fovea), and nonround excavations were called Fossae (singular : Fossa). Some shallow excavations for articulation and some shallow excavations with the names which indicate their contents were called Foveae even though they were not round. 2. Each name of Fossae contained the word which indicates form, location or content of Fossa, the bone (or osseous structure) which articulates with Fossa, or the muscle which is attached to Fossa. 3. Each name of Foveae contained the word which indicates location, content or articulation of Fovea, the bone (or osseous structure) which articulates with Fovea, or the muscle (or muscular trochlea) which is attached to Fovea. 4. The Japanese name which corresponds to Fossa canina should be changed from Kenshi (canine tooth) = ka (fossa) to Kenshikin (canine muscle) = ka or Koukakukyokin (levator anguli oris muscle) = ka. 5. The Japanese name which corresponds to Fossa pterygopalatina should be changed from Yoku (wing) = kougai (palate) = ka (fossa) to Yokutotsu (pterygoid process) = kougaikotsu (palatine bone) = ka.

Bone and Bones↗
PubMedDate not supplied

Musical instrument naming impairments: the crucial exception to the living/nonliving dichotomy in category-specific agnosia.

In category-specific agnosia (CSA) patients typically have more trouble naming animals, fruits, and vegetables than tools, furniture, and articles of clothing. A crucial exception to this living vs nonliving rule involves the category of musical instruments. Patients with problems naming living objects often repeatedly fail to name musical instruments. In CSA it is crucial to equate living and nonliving object lists on object name frequency, complexity, and familiarity. The present study shows, however, that even the most rigorously controlled object lists can lead to erroneous conclusions if nonliving stimuli contain an overrepresentation of musical instruments. Naming capabilities of a herpes encephalitis patient were assessed using matched lists of living and nonliving objects and showed no indication of category-specific deficits. When exemplars were separated into biological objects, musical instruments and man-made artifacts, strong category-specificity emerged: artifact naming was flawless whereas musical instrument and biological object naming were both severely impaired. It is concluded that CSA is a veridical phenomenon but that our understanding of CSA is limited by adhering to the spurious living/nonliving distinction.

Agnosia↗
PubMedDate not supplied

Category-specific naming and modality-specific imagery.

Some attempts to explain category-specific disorders have stressed how different modality knowledge bases (i.e., visual knowledge vs motoric/functional knowledge) may underlie the distinction between living and nonliving things. This study examined 60 normal subjects for the relationship between picture naming in four subcategories (animals, fruit/vegetables, praxic and nonpraxic objects) and imagery vividness in seven modalities. Participants made more nonliving than living errors; and females made more nonliving errors than males. There was a significant correlation between naming of animals and fruits/vegetables and visual imagery vividness; however, this association was also significant for praxic and nonpraxic object naming. There was no evidence of associations between kinesthetic imagery and praxic object naming or gustatory/olfactory imagery and fruit/vegetable naming. These findings accord with the notion of a general association between visual imagery and picture naming, but provide no support for more specific links between modality-specific imagery vividness and naming in different categories.

Adolescent↗
PubMed2002

Inhibition of beta-1 receptor but not vagotomy can abolish the L-NAME evoked bradycardia in anesthetized rat.

We reported previously that the nitric oxide synthesis inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME) decreases cardiac output. Several studies have shown that inhibition of nitric oxide synthesis decreases the heart rate. In the present study, we investigated the effect of a single bolus administration of L-NAME on blood pressure and heart rate monitored for one hour in anesthetized rats and the influence of vagotomy and beta1-receptor blocker metoprolol on the L-NAME induced bradycardia. After L-NAME treatment, the blood pressure rose immediately after the injection of the drug (peak response in the third minute: +24%, p<0.001) and fell to the control level in the 20th minute. The heart rate decreased immediately after L-NAME administration, the lowest value being reached in the 10th minute (-14%, p<0.001). However, bradycardia was sustained even after the blood pressure had returned to the control level. Bilateral vagotomy failed to influence the negative chronotropic effect of L-NAME, but bradycardia was completely abolished by metoprolol pretreatment. We concluded that the bradycardia evoked by L-NAME is mainly due to the withdrawal of sympathetic tone upon the heart rate. However, the cause of sustained bradycardia after normalization of blood pressure cannot be elucidated.

Adrenergic beta-1 Receptor Antagonists↗
PubMed2005

[Name-day parties--social factor shaping patterns of ethanol poisonings].

Name-day party is a feature of the Polish culture. During these parties alcoholic drinks are served very often. In this paper it is shown that there is a positive correlation between the popularity of a name-day and the number of ethanol poisonings. Another finding of this paper is that the popularity of a name-day is also associated with the average age of ethanol-poisoned patients. This association is mediated by gender and a day of the week. On days of popular names the average age of poisoned woman is lower comparing to days of unpopular names. In case of males the pattern is more complicated. If a name-day of common names occurs on a week day then the male patients tend to be older, but if such a day occurs at the weekend then average age of male patients is higher.

Adolescent↗
PubMed2005

Are brand-name and generic warfarin interchangeable? A survey of Ontario patients and physicians.

BACKGROUND: The issue of therapeutic equivalence has been a source of controversy in Canada since the approval of generic warfarin products in 2000. OBJECTIVES: We surveyed Ontario patients and physicians on perceptions of generic warfarin and brand substitution. METHODS: Self-administered questionnaires employed 7.0-point Likert scales of agreement. Patient participants were drawn from a thromboembolism clinic in Hamilton, Ontario. Physician participants were from a random sample of 375 Ontario family physicians, internists, cardiologists and hematologists. RESULTS: Eighty-one patients responded: 52% female, mean age 63.4 years and 63% brand-name warfarin users. Overall, 33% of respondents agreed or strongly agreed that they would feel comfortable taking generic warfarin. However, seventeen percent agreed or strongly agreed that generic warfarin was neither as safe nor as effective as brand-name warfarin, with this view more common amongst patients taking brand-name than those taking generic warfarin. One hundred and ten (29.3%) physicians returned the survey--29% females, mean age 45.3 years, 22% family physicians. Forty-four percent agreed or strongly agreed that they would rather prescribe brand-name than generic warfarin for patients starting warfarin therapy, while 40.7% agreed or strongly agreed that they would not feel comfortable switching from brand-name to generic warfarin. However, only 19.4% of physicians who had switched patients from brand-name to generic warfarin actually reported difficulties in managing the switch. CONCLUSION: While most patients and physicians appear to have accepted the principle of therapeutic equivalence of generic and brand-name warfarin, a sizable minority has concerns that could influence prescribing and compliance.

Anticoagulants↗
PubMed1998

[Functional difference between the left supplementary motor area and the left premotor area in a task of confrontation naming and word fluency].

We assessed the faculty of confrontation naming and word fluency of the 11 patients afflicted with frontal lobe infarction or hemorrhage. All the patients were right-handed and manifested transcortical motor aphasia due to cerebrovascular diseases. We carried out the Western Aphasia Battery, and we adopted V-A; the naming task involved confrontation naming of 20 objects, and V-B; the word fluency task involved the naming as many animals as possible in a one minute period. Six patients who have lesions in the left medial frontal lobe performed excellency in the confrontation naming task but exhibited poor word fluency, and 5 patients who have lesions in the left dorso-lateral frontal lobe performed poorly in both tasks. This results suggests that the left dorso-lateral frontal lobe is important in confrontation naming, while the left medial frontal lobe is important in word fluency. Mushiake et al. (1991) showed that the premotor area was involved in visually guided sequential movements, and the supplementary motor area was involved internally determined sequential movements in primates. Regarding language function as analogous to movement, confrontation naming is analogous to visually guided movements and word fluency is analogous to internally determined movements. Thus, our results suggest that the functional difference between the left medial frontal lobe, which includes the supplementary motor area, and the left dorso-lateral frontal lobe, which includes the premotor area, which was demonstrated in primates for movement is also true of language function in humans.

Aphasia, Broca↗
PubMed1998

Reduction of corneal edema in endotoxin-induced uveitis after application of L-NAME as nitric oxide synthase inhibitor in rats by iontophoresis.

PURPOSE: To investigate the involvement of the cornea during endotoxin-induced uveitis (EIU) in the rat and the effect of Ngamma-nitro-L-arginine methyl ester (L-NAME) as nitric oxide synthase (NOS) inhibitor, administered by iontophoresis. METHODS: EIU was induced in Lewis rats that were killed at 8 and 16 hours after lipopolysaccharide (LPS) injection. The severity of uveitis was evaluated clinically at 16 hours, and nitrite levels were evaluated in the aqueous humor at 8 hours. Corneal thickness was measured, 16 hours after LPS injection, on histologic sections using an image analyzer. Transmission electron microscopy (TEM) was used for fine analysis of the cornea. Transcorneoscleral iontophoresis of L-NAME (100 mM) was performed either at LPS injection or at 1 and 2 hours after LPS injection. RESULTS: At 16 hours after LPS injection, mean corneal thickness was 153.7+/-5.58 microm in the group of rats injected with LPS (n=8) compared with 126.89+/-11.11 microm in the saline-injected rats (n=8) (P < 0.01). TEM showed stromal edema and signs of damage in the endothelial and epithelial layers. In the group of rats treated by three successive iontophoreses of L-NAME (n=8), corneal thickness was 125.24+/-10.36 microm compared with 146.76+/-7.52 microm in the group of rats treated with iontophoresis of saline (n=8), (P=0.015). TEM observation showed a reduction of stromal edema and a normal endothelium. Nitrite levels in the aqueous humor were significantly reduced at 8 hours by L-NAME treatment (P=0.03). No effect on corneal edema was observed after a single iontophoresis of L-NAME at LPS injection (P=0.19). Iontophoresis of saline by itself induced no change in corneal thickness nor in TEM structure analysis compared with normal rats. CONCLUSIONS: Corneal edema is observed during EIU. This edema is significantly reduced by three successive iontophoreses of L-NAME, which partially inhibited the inflammation. A role of nitric oxide in the corneal endothelium functions may explain the antiedematous effect of L-NAME.

Animals↗
PubMed2006

Effect of transcranial magnetic stimulation on action naming in patients with Alzheimer disease.

OBJECTIVE: To assess the effect of repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) on picture naming in patients with Alzheimer disease (AD). DESIGN: Experimental study. Patients with AD underwent rTMS in real and control conditions during picture-naming tasks. SETTING: San Giovanni di Dio Fatebenefratelli Scientific Institute in Brescia, Italy. Patients Fifteen patients with probable AD. Intervention High-frequency rTMS was applied to the left and right DLPFC during object and action naming. MAIN OUTCOME MEASURES: Language ability was assessed by accuracy of verbal response during online rTMS. RESULTS: Stimulation to the left and right DLPFC improved accuracy in action naming. CONCLUSIONS: These findings indicate that rTMS to the DLPFC, which speeds up action naming in normal controls, improves performance in patients with AD. While the mechanisms of rTMS-induced naming facilitation in these patients are unknown, the procedure may be worth testing as a novel approach to the treatment of language dysfunction.

Alzheimer Disease↗
PubMed2004

Use of morphological analysis in protein name recognition.

Protein name recognition aims to detect each and every protein names appearing in a PubMed abstract. The task is not simple, as the graphic word boundary (space separator) assumed in conventional preprocessing does not necessarily coincide with the protein name boundary. Such boundary disagreement caused by tokenization ambiguity has usually been ignored in conventional preprocessing of general English. In this paper, we argue that boundary disagreement poses serious limitations in biomedical English text processing, not to mention protein name recognition. Our key idea for dealing with the boundary disagreement is to apply techniques used in Japanese morphological analysis where there are no word boundaries. Having evaluated the proposed method with GENIA corpus 3.02, we obtain F-measure of 69.01 on a strict criterion and 79.32 on a relaxed criterion. The result is comparable to other published work in protein name recognition, without resorting to manually prepared ad hoc feature engineering. Further, compared to the conventional preprocessing, the use of morphological analysis as preprocessing improves the performance of protein name recognition and reduces the execution time.

Abstracting and Indexing↗
PubMed2004

Using name-internal and contextual features to classify biological terms.

There has been considerable work done recently in recognizing named entities in biomedical text. In this paper, we investigate the named entity classification task, an integral part of the named entity extraction task. We focus on the different sources of information that can be utilized for classification, and note the extent to which they are effective in classification. To classify a name, we consider features that appear within the name as well as nearby phrases. We also develop a new strategy based on the context of occurrence and show that they improve the performance of the classification system. We show how our work relates to previous works on named entity classification in the biological domain as well as to those in generic domains. The experiments were conducted on the GENIA corpus Ver. 3.0 developed at University of Tokyo. We achieve f value of 86 in 10-fold cross validation evaluation on this corpus.

Abstracting and Indexing↗
PubMed2006

Retrieval pathways for common and proper names.

Paradigmatic cases of proper name anomia and proper name selective sparing are reviewed from relevant neuropsychological literature. Available evidence supports the existence of functionally and anatomically distinct retrieval pathways for the categories of proper and common names. An information processing model whose main feature lies in the relative independence within the semantic-conceptual system of information concerning individual entities may account for most of the observed phenomena. Localization studies seem to indicate that a complex neural network sustains various tasks implied in proper name processing. A dedicated module dealing with proper name retrieval is probably there, but its location within the left hemisphere is not at present fully understood. The proper name specific retrieval process is shown, in keeping with current philosophical and linguistic theories, to be intrinsically fragile and source-consuming.

Anomia↗
PubMed1991

Relationships among given names in the Scilly Isles.

The pseudo-genetic analysis of given names shows that, in the Scilly Isles, coefficients of relationship of first names are similar on St Mary's, the Outer Isles, and in the total sample of 5666 individuals married there in two and a half centuries. Comparable coefficients of relationship of a sample of 1658 given names in marriages in England and Wales in 1975 are considerably smaller, but similar within and between districts. The coefficients of relationship of given names on the Scilly Isles decreases during the 19th and especially the 20th centuries in parallel with decreases in random relationship from surnames. The genetic versus cultural-linguistic factors cannot be distinguished in the temporal variation in names, but the geographic differentiation virtually always reported in surnames is not present in these examples of given names and the geographic pattern in the surnames thus seems to result from the hereditary aspect of surnames. This result supports the validity of use of surnames in models of human genetic geography.

England↗
PubMed2003

I sell seashells by the seashore and my name is Jack: comment on Pelham, Mirenberg, and Jones (2002).

According to a new hypothesis based on implicit egotism, people gravitate toward cities, states, and careers with names similar to their own names. To support this hypothesis, B. W. Pelham, M. C. Mirenberg, and J. T. Jones (2002) reported a series of results regarding distributions of names in different cities, states, and jobs. In the present article, new analyses of the original data are reported, showing that the hypothesis is not supported for the large majority of names considered by the authors, and for some names even the opposite result is found. In addition, a meta-analysis reveals that either the data are unreliable, or the hypothesis cannot be supported in the whole population of names. Overall, the original data give no support of the idea that implicit egotism influences major life decisions.

Career Choice↗
PubMed2005

Proper names get stuck on bilingual and monolingual speakers' tip of the tongue equally often.

Bilinguals' virtually doubled processing load could lead to general difficulty producing all word forms or to difficulty only in specific conditions. In Experiment 1, bilinguals and monolinguals completed diaries of naturally occurring tip-of-the-tongue states (TOTs), and in Experiment, 2 Spanish-English bilinguals and monolinguals produced the names of pictured objects and people's names given their descriptions. Bilinguals reported the same number (or fewer) TOTs for proper names but significantly more TOTs than did monolinguals for other words. With monolinguals as a baseline, proper names were harder to produce; thus, for a harder task, bilinguals showed relatively better performance. Bilingual disadvantages may be limited to representing multiple forms for individual meanings; proper names improved naming because they have essentially the same form across languages.

Adolescent↗
PubMed1999

Retrieving familiar people's names in patients with severe closed-head injuries.

Patients with closed-head injury frequently complain about difficulties with retrieving the names of familiar people, but very few studies have investigated these complaints by objective measurements. Three experiments are reported that compared personal name retrieval in patients with severe closed-head injuries and normal controls. The patients more frequently failed to produce the names of famous persons, and had longer naming latencies than the controls. Accuracy of recognizing familiar persons was normal in the patients, even though they were slower in this task than the controls. The patients' main problem appeared to involve a disturbance in activating the stored name information. The patients' response pattern shows clear resemblance with simulations of the effects of brain damage in models for person naming.

Adult↗
PubMed1993

Spontaneous mnemonic strategies used by older and younger adults to remember proper names.

Little attention has been focused on the spontaneous mnemonic strategies that people use to remember proper names. In the experiment reported here, groups of younger (< 25 years old) and older subjects (> or = 55 years old) were shown a series of 12 name-face pairs and instructed to remember them. In a subsequent test, they were shown the same faces and asked to recall the corresponding names. After the recall task, subjects completed a questionnaire about the mnemonic strategies they used. Our analyses revealed not only that the younger subjects recalled more names than did the older subjects, but also that older and younger subjects reported using certain strategies more frequently than other strategies. Moreover, regression analyses indicated that use of certain mnemonic strategies accounted for a significant proportion of recall performance beyond that accounted for by age alone. Older-old subjects (> or = 70 years old) recalled fewer names than did younger-old subjects (> or = 55 and < 70 years old), but they did not differ in the extent to which they used specific mnemonic strategies. Our results suggest that the use of spontaneous mnemonic strategies may play a role in the difference in proper name recall between younger and older adults.

Adult↗