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At least 595 records · Page 33Linked to original sources
PubMed1983

[Proliferative myositis, a muscular pseudo-sarcoma. Apropos of a case with an ultrastructural study].

A 40-year old woman with a history of rapidly growing tumor of the brachio-radialis muscle is described. By light microscopy, the tumor had typical features of proliferative myositis, with alternating areas of well preserved muscular fibres and strands of proliferating spindle shaped cells and ganglion like cells. Electron microscopic study showed non specific degenerative muscle changes, fibroblasts and giant cells. The histogenesis and the nosologic place of proliferative myositis are discussed.

Adult↗
PubMed1983

Relapsing eosinophilic myositis.

We report 3 male patients with a unique eosinophilic myositis of unknown etiology who appear to have a benign course. The most striking feature in 2 patients was relapsing myalgias with lower extremity predilection and tendency for spontaneous recovery. Laboratory studies showed peripheral eosinophilia, elevated CPK, and EMG consistent with a myositic pattern. Muscle biopsies showed myositis characterized by focal necrosis and degeneration with an inflammatory infiltrate predominantly composed of histiocytes and eosinophils. Skin and fascia were normal.

Adult↗
PubMed1980

Pseudomalignant myositis ossificans: heterotopic new-bone formation without a history of trauma.

Circumscribed heterotopic new-bone formation without a history of trauma is termed pseudomalignant myositis ossificans due to the diagnostic confusion of this benign lesion with malignant lesions. In 20 per cent of the published cases in which there were diagnostic problems, the patient underwent a radical procedure. Roentgenographically, pseudomalignant myositis ossificans is a circumscribed, radiopaque lesion with a central lucent zone that is separated from the underlying cortex by a radiolucent line. Histologically, a characteristic zoning pattern of peripheral maturation is present, the central proliferating zone usually causing the diagnostic problems. The ultrastructure of the lesion shows a regular mineralization front but an abnormal collagen periodicity of 300 angstroms. Excision is indicated for diagnosis and for relief of mechanical block or pain.

Adolescent↗
PubMedDate not supplied

Localized nodular myositis.

Two patients presenting with painful, localized swelling in a single muscle are described. Biopsies of involved areas showed inflammatory changes characteristic of polymyositis, but serum levels of muscle-derived enzymes were consistently normal. Both patients later developed evidence of mild diffuse myositis. A review of 4 similar cases in the literature suggests that localized nodular myositis is a heterogeneous condition, in which vascular inflammation may be a prominent feature, with frequent evolution into a generalized myopathy.

Adult↗
PubMed1995

[Traumatic myositis ossificans. Posttraumatic non-neoplastic heterotopic ossification].

Myositis ossificans traumatica (MOT) is a nonneoplastic, heterotopic ossification of soft tissues i.e. skeletal muscle, tendons, aponeuroses and fascia. It is often encountered in young male athletes participating in contact sports as a result of a single or repeated contusion. MOT tends to be solitary, localized and well circumscribed with a self-limited growth potential that may culminate in regression. The pathogenesis of MOT is still enigmatic. Recent animal experiments have led to a theory that mesenchymal connective tissue cells, undergo metaplasia induced by trauma and probably osteogenic proteins, to fibroblasts and osteoblasts. These cells deposit and structure osteoid centripetally in the lesion. As the lesion matures, cancellous bone develops into mature, lamellar bone in the periphery of the lesion. In its earlier stages MOT is easily cytologically and radiologically confused with osteogenic sarcoma. The management of MOT is largely conservative and the principles are of considerable value to physicians and physiotherapists engaged in the treatment of sports injuries. This article reviews the various forms of myositis ossificans as well as the pathology, diagnosis and treatment options.

Adolescent↗
PubMed1995

[A case of inclusion body myositis (IBM) associated with lipid-storage vacuoles].

A 62-year-old woman, who has had slowly progressive muscle weakness and wasting of the four limbs for past 10 years, was evaluated by muscle biopsies; i.e. the deltoid, a moderately atrophic muscle, and the quadriceps femoris, a muscle that was only mildly involved. The specimen from the deltoid disclosed the basic muscle structures having been collapsed, containing many fibers undergoing degeneration. There were rimmed vacuoles and infiltration of macrophages and round cells into the muscle fibers and perimysial space. Inclusion bodies containing fibrillary structures were identified in sarcolemmal nuclei by electron microscopy. When the quadriceps femoris muscle was examined, however, a large number of vacuoles were interspersed between myofibrils that contained numerous lipid droplets. There were no pathological changes suggestive of IBM in this specimen. The case described here is unique in that the muscle biopsies from two separate muscle revealed a distinctly different pathology. Although we were unable to determine the cause of lipid-storage in this case, it is our impression that inclusion body myositis is not a uniform disorder but the characteristic pathology to this particular myositis might be an ultimate feature of several diverse degenerative and/or inflammatory muscle disorders.

Female↗
PubMed1995

Idiopathic eosinophilic myositis.

Eosinophilic myositis is a rare entity accompanying parasitic infection or other inflammatory disorders. Two cases are reported in which myalgia and eosinophilic infiltration of muscle occurred in the absence of associated disease, and twelve previously published cases of idiopathic eosinophilic myositis are reviewed. A classification system for idiopathic eosinophilic muscle disease is proposed, describing three distinct groups. Comparisons are drawn between these and other causes of eosinophilic muscle disease, outlining the differential diagnoses for each group.

Adult↗
PubMed1995

The treatment of myositis. How to approach resistant disease.

Idiopathic inflammatory myopathies, polymyositis, dermatomyositis, and inclusion body myositis, are increasingly recognized to cause long-term disability in certain subsets of patients. Because these diseases are infrequent, only retrospective analysis of most treatments are available. In this article, identification of subsets of patients with different prognoses and discussion of confounding factors for increasing weakness are emphasized. The advantages and disadvantages of different therapies for myositis and for extraskeletal muscle features are also discussed.

Humans↗
PubMed1994

Focal myositis in a patient with bilateral painful nodules.

A 30-year-old African-American man presented with painful lower extremities and bilaterally symmetrical dermal nodules. Examination of a biopsy specimen of one of the nodules showed focal myositis overlying a deeper defect. Subsequent excisions produced multifocal eruptive lipomas. The histopathologic findings of focal myositis are reviewed along with this previously unreported association.

Adult↗
PubMed1994

An experience of ischemic limb salvage associated with myositis ossificans of the left thigh.

A case of ischemic limb salvage associated with myositis ossificans of the left thigh in a 66-year-old man was reported. The patient had a medical history of cerebral palsy and a cervical spinal cord injury, and had an operative past history of hip arthroplasty for fracture of the left femoral neck 10 years before. He showed ischemic symptoms such as paleness, coldness, and loss of the left dorsal arterial pulsation in the left toe, and had a rapidly growing mass in the left thigh. Roentgenography and computed tomography showed a mass 10 cm by 10 cm by 8 cm in size with severe calcification in the left quariceps muscle. Occlusion of the left common femoral artery was found in the arteriogram. Surgery was carried out in order to establish an accurate diagnosis and to rescue the left lower limb. The arterial pulsation was recovered as the result of completely resecting the left quariceps muscle tumor. The pathohistological diagnosis was of myositis ossificans in the quariceps muscle of the thigh. Etidronate disodium was administered in order to prevent a recurrence postoperatively. The patient has been well for the 13 months since surgery.

Aged↗
PubMed1994

[Inclusion body myositis: its clinico-electrophysiological and morphological diagnosis].

The paper reports three cases of myositis. The findings at detailed electroneuromyographic, morphologic and ultrastructural tests were indicative of characteristic vacuole inclusions in the muscular fibers. Two patients had associated neuritic disorders diagnosed neurophysiologically and morphohistochemically. The neuritic component proved aggravating in the course of the disease. Diagnostic myographic and morphological criteria are analyzed which can distinguish myositis with inclusions from other muscular inflammatory disease.

Action Potentials↗
PubMed1994

Gemfibrozil induced myositis: a case report with light microscopic and ultrastructural study.

A 49-year-old woman with chronic renal failure was given gemfibrozil for hyperlipidemia. She developed gemfibrozil-induced myositis which precipitated an acute compartment syndrome, necessitating emergency fasciotomy. The muscle biopsy showed prominent degeneration of the skeletal muscle fibers, associated with moderate chronic inflammatory infiltration. Electron microscopy revealed myofibrillary fragmentation and mitochondrial disorganization. The clinicopathologic features of gemfibrozil-induced myositis appear to be distinct from those of clofibrate-induced muscular syndrome. Extreme caution should be exercised in the use of gemfibrozil in patients with impaired renal function.

Biopsy↗
PubMed1994

Fracture through the bone of traumatic myositis ossificans. A report of three cases.

We describe three cases of traumatic myositis ossificans in which fractures occurred through a mature, quiescent ossification mass. None of the fractures reactivated the original pathological process, no callus was formed and union did not occur. The nonunion became painless over a period of months. This unusual late complication of myositis ossificans seems to require only symptomatic treatment by temporary splintage and subsequent mobilisation. We could find no previous report of a similar case.

Adolescent↗
PubMed1993

Masticatory muscle myositis.

This report examines a case of masticatory muscle myositis in a dog. Inflammatory disorders can affect the muscles of mastication. Two types of inflammatory myopathies have been described. The histopathology and immunochemical features of this case suggest an immune mediated basis for this disorder. The diagnosis and treatment are described for this immune mediated inflammatory myositis.

Animals↗
PubMed1994

Fine-needle aspiration biopsy cytology of myositis ossificans.

Increased utilization of fine-needle aspiration cytology to better define mass lesions before surgical excision can occasionally expose a cytologically worrisome yet biologically benign proliferative process. Such a proliferation may mimic a malignant neoplasm but is actually benign. Because of its limited exposure in the literature, we describe the cytopathology of two cases of myositis ossificans obtained by the fine-needle aspiration biopsy technique. Both lesions occurred in adolescents. One involved the deep muscle of the thigh, whereas the other was a superficial lesion of the anterior abdominal subcutaneous fat. In both instances a benign entity was favored, but in one case sarcoma could not be absolutely excluded by fine-needle aspiration cytology. Follow-up surgical excision in one case, and incisional biopsy in the other confirmed the diagnosis of myositis ossificans (MO). The cytologic differential diagnosis of this lesion is discussed.

Adolescent↗
PubMed1993

Circumscribed myositis ossificans. Report of nine cases without history of injury.

The clinical features of 9 patients with circumscribed myositis ossificans (CMO) are described and the effects of treatment with surgical removal of ectopic bone are assessed. The average age of these patients was 24.4 years, and the average follow-up period was 7.4 years. Early correct diagnosis remains unusual, mainly because myositis may be mistaken for bruising, sarcoma or mumps. Once histological diagnosis was established in biopsy, surgical resection of the mass was found in these series. Although spontaneous recurrence was found in this series. Although spontaneous regression of the clinical findings has been reported, we consider surgery to be necessary in CMO in order to establish the diagnosis; furthermore, when the clinical and radiological diagnosis is uncertain or when the lesion causes pain or mechanical blocking of a joint, the removal of the mass is mandatory.

Adolescent↗
PubMed1993

[Proliferative myositis--a little-known pseudomalignant lesion].

The leading symptom of proliferative myositis is a rapidly growing hard tumor in the muscle. The disease is rare and therefore widely unknown. We observed a case of proliferative myositis in a 54-year-old female. We initially interpreted the hard tumor in the left musculus sternocleidomastoideus and its rapid growth as a malignant disease. The histological findings finally led to the correct diagnosis. In the light of the literature of 78 reported cases, a presumptive diagnosis can already be suspected from the clinical examination. The addition of CT scan and fine needle aspiration is highly diagnostic.

Biopsy↗