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PubMed1985

[Clinical and bacteriological evaluation of TMS-19-Q in superficial suppurative skin and soft tissue infection].

Clinical effectiveness of TMS-19-Q, a new macrolide antibiotic, was evaluated in superficial infectious diseases classified into 6 groups at 13 departments of dermatology. The results obtained were as follows: Final global improvement rating in 311 cases were excellent in 91, good in 158, fair in 45 and poor in 17 and the effective rate was 80.1%. Effective rates in each group were 71.1% in 1st group (folliculitis and acne pustulosa), 78.6% in 2nd group (furuncle, furunculosis and carbuncle), 100% in 3rd group (impetigo), 76.9% in 4th group (phlegmone, superficial lymphangitis, erysipelas and infectious paronychia), 88.7% in 5th group (inflammatory atheroma, subcutaneous abscess, hidradenitis suppurative and acne conglobata) and 77.3% in 6th group (secondary infection). Dominant strains isolated were S. aureus (40.7%), S. epidermidis (26.9%) and anaerobic bacteria (20.8%). S. aureus was frequently isolated from most of all disease. On the other hand, S. epidermidis and anaerobic bacteria were isolated mainly from 1st and 5th group. Optimum daily doses would be over 600 mg. Slight adverse reactions such as gastrointestinal disorders, eruption and malaise were observed in 12 cases.

Adolescent↗
PubMed1985

[Surgical pulmonary biopsy in children].

During the last 2 years an open lung biopsy was performed in 16 children aged from 2 to 14 years. Fourteen of these had a chemotherapeutic induced immunodeficiency and a radiological picture of diffuse pulmonary infiltrate. A definite diagnosis was established in 11 cases: 5 pneumocystis carinii pneumonitis, 2 CMV infections, 2 pneumocalcinosis, 1 neoplastic pulmonary lymphangitis and 1 staphylococcal infection. Three had a non-specific interstitial pneumonitis. In this series there was no post-operative death and the single complication was a wound infection. The tracheal tube could be removed within the hours following the intervention in 14 of the 16 children. The review of the recent literature suggests that the open lung biopsy is a safe and accurate way for the diagnosis of pulmonary infiltrates in pediatric immunocompromised patients. It is however a very invasive procedure and it is expectable that in the next year the bronchoalveolar lavage with a fiberoptic flexible bronchoscope will be systematically attempted prior to the open biopsy.

Adolescent↗
PubMed1974

Staged treatment of lymphedema praecox.

Lymphedema of the lower extremities poses a challenging problem in management. Gross deformities may be encountered in patients with filarial infestation. This degree of involvement is rare in native North Americans suffering from primary lymphedema.A case is presented of a patient with changes similar to those seen in filariasis, due to several episodes of acute lymphangitis over a period of years. The involved tissue was excised and the defects skin-grafted, employing a modified Charles procedure. The magnitude of the excision was such that it was carried out in three widely spaced stages. The result was satisfactory from a functional viewpoint, and also represented a marked cosmetic improvement.

Adult↗
PubMed1979

[Morphometric studies on lymphatic vessels of the axillary region].

Axillary lymph vessels of 94 autopsy cases (42 female, 52 male) have been investigated histologically in serial slices. Total diameter of the lymph vessels, vascular wall diameter, diameter of the medial connective tissue, finally that one of the artificial tissue spaces were measured in almost 8000 single measurements. The mean values of counts for the different vascular wall components were assessed statistically with the aid of a computer. By reason of the enormous individual variation of the number and the size in lymph vessel system a direct comparison of the measurement data from the different wall components was impossible. Therefore, the ratio of connective tissue to smooth muscle within the vascular media was regarded as a significant parameter for the development of a lymphangiosclerosis. The connective tissue/smooth muscle gradient increased from decade to decade with a slighter progression in groups with higher age A significant increase of lymphangi osclerosis was noted in cases with right heart insufficiency in correlation to the degree of heart insuffiency. Severe lymphangiosclerotic alterations were developed after radical mastectomy and radiotherapy of the axilla, after radiotherapy of other malignant tumors, and in cases with heart failures or vascular dysplasia. Morphometric investigations were not possible in cases with floride lymphangitis and in one case of general vascular amyloidosis.

Adolescent↗
PubMed1983

[Case of hepatocellular carcinoma with a marked reduction in the tumor size induced by PSK administration alone].

A 56-year-old man was admitted to our hospital because of right abdominal pain. The edge of the liver was felt 4.5 fingers breadth below the xiphoid process. AFP was 20100 ng/ml and CEA was 5.6 ng/ml. The chest X-ray indicated existence of lymphangitis and some nodular density suggesting lung metastasis in the both lower-lung fields. 99mTc-phytate liver scan showed a large defect along the antero-inferior margin of the right hepatic lobe, which revealed an abnormal uptake of 67Ga-citrate. Ultrasonograms demonstrated a solid mass, 8 X 9 cm, in the right lobe of the liver. A CT-scan of the abdomen also showed a large, rounded, low attenuation mass with central necrosis in the right hepatic lobe: the pancreas and the remaining retroperitoneal structures appeared normal. Following the administration of PSK alone, 3 g daily, for three months, a remarkable regression of both hepatomegaly and lung metastasis was observed. Liver scan, ultrasonograms and CT-scan showed a striking resolution of the intrahepatic mass except central necrosis. AFP decreased to 33.7 ng/ml and CEA was 8.2 ng/ml. After about one year, however, ultrasonogramms showed a newly growing solid mass, 3.5 X 3.5 cm, in the left lobe of the liver. A needle biopsy specimen was taken from the intrahepatic mass, and it was interpreted as hepatoma. He is now healthy.

Carcinoma, Hepatocellular↗
PubMed1984

Mondor's phlebitis of the penis: a study with factor VIII related antigen.

Four patients with so-called non-venereal sclerosing lymphangitis of the penis are reported. It was suggested that the affected vessels were veins by positively stained factor VIII related antigen with the unlabeled peroxidase-antiperoxidase method. If cord-like linear subcutaneous swelling observed in the coronary sulcus or dorsal region of the penile shaft originate from the vein, it seems correct to call this disease as Mondor's phlebitis of the penis.

Adult↗
PubMed1978

Hand infections.

Superficial infections include paronychia, cellulitis and lymphangitis. Grave infections include felon, purulent tenosynovitis, thenar infections, septic arthritis and human bites. Treatment by incision and drainage, moist heat, elevation, splinting and specific antibiotics or other agents applies to most hand infections. When pus is found, adequate drainage usually gives good results. Without drainage, pressure necrosis and gangrene often follow. Rest for the infected part and for the patient is as important as any other facet of treatment.

Bites, Human↗
PubMed1983

[Extension modes in Borrmann-4 stomach carcinoma estimated by macroscopic appearances].

The clinico-pathologic findings on 91 patients with Borrmann-4 gastric carcinoma were studied. Based on macroscopic appearance of the gastric lesions, Borrmann-4 carcinoma was classified into 4 subtypes; (1) giant rugae type, (2) IIc surface type, (3) erosion type and (4) stricture type. According to the clinico-pathological characteristics of each subtype, these main modes of cancerous extension are suggested: Carcinoma of the giant rugae type develops from a small lesion at the gastric body into peritoneal sclerosing infiltration, cancer of the stricture type originates from the gastric antrum and progresses to peritoneal sclerosing infiltration, cancer of the IIc surface type and erosion type develops from large erosive lesions into lymphangitis carcinomatosa.

Female↗
PubMed1981

Tropical infections contracted in Papua New Guinea and imported into Western Australia.

Diseases contracted in Papua New Guinea (PNG) and observed in Western Australia (WA) have comprised malaria, amoebiasis, ancylostomiasis, filariasis and leprosy. This small series of cases demonstrates the prolongation of incubation periods of malaria following chemoprophylaxis, the spread of chloroquine-resistant strains of Plasmodium falciparum (both to Western and Eastern regions of PNG), the ineffectiveness of chloroquine against Entamoeba histolytica in the intestine and the value of oral penicillin as a prophylactic for filarial lymphangitis.

Aged↗
PubMed1981

Cellulitis: analysis of 101 cases and review of the literature.

A retrospective study of 101 patients with cellulitis of the head and neck and extremities showed that cellulitis, predominantly a disease of males, occurred at all ages; the lower extremities were affected more frequently in the elderly, whereas upper extremity involvement prevailed in young adults. A clinical prodrome, most often including chills, was less common than is widely believed. Redness, heat, swelling, and tenderness were consistently present, and lymphangitis and lymphadenitis were less frequent. Fever was generally mild, and WBC counts were modestly elevated, if at all. Because needle aspirates and blood cultures were rarely helpful, delineation of specific cause was difficult. Therapy included rest, elevation, moist heat, analgesia, antibiotics (usually penicillinase-resistant penicillin or penicillin itself), and incision and drainage when indicated. Most patients improved rapidly. Prolonged course and complications were unusual and there were no deaths.

Adolescent↗
PubMed1980

[Lymphoedema and elephantiasis due to filariasis. Pathogenesis and clinical aspects (author's transl)].

Adult lymphatic filariae (Wuchereria bancrofti, Brugia malayi) can cause blocking of lymphatics producing obliterating endolymphitis lesions. The subsequent extravasation of lymph (or chyle when the obstruction is canal) is at the origin of the formation of lymphedema or elephantiasis, in which the main histological finding is great hypertrophy of collagen elements. This theory involving filaria only is not the full picture, and bacterial infection, mainly by streptococci, is an important factor. The association of filaria with microbes is particularly dangerous because the presence of the latter, or its toxins, causes death of local microfilariae and even adult worms, which are known to be more harmful dead than alive. The progression of the disease, especially in cases with lymphedema, which mainly affects the limbs and the genital organs, depends on three factors: the species of filaria, the degree of transmission, and the receptivity of the patient to the parasite. Large differences are found according to the region involved, and in the same endemic zone, according to the individuals affected. However, they almost always occur progressively in areas where there have been recurrent attacks of acute lymphangitis.

Bacterial Infections↗
PubMed1982

[Sporotrichoid infection caused by Nocardia brasiliensis].

A few days after a spine of one of his indoor cacti had pricked the fourth finger of his left hand, a 56-year-old man developed multiple inflammatory suppurating nodules and infiltrates and a cord-like lymphangitis on the left forearm and upper arm. Nocardia brasiliensis was cultivated from aspirated pus. Subsequently, both Nocardia brasiliensis and Nocardia asteroides were isolated from the cactus earth. This is the first report of an infection by Nocardia brasiliensis acquired in Germany.

Arm↗
PubMed1982

A study of the pathology of lumpy skin disease in cattle.

Microscopic lesions in cattle infected with the virus of the Neethling form of lumpy skin disease comprised a granulomatous reaction in the dermis and hypodermis which extended to the surrounding tissue. During the early stages of the lesions a vasculitis and lymphangitis with concomitant thrombosis and infarction resulted in necrosis and oedema. A hallmark of the acute to subacute stages of the lesions was the presence of intracytoplasmic eosinophilic inclusions in various cell types. The inclusions consisted of the viroplasm which was identified as aggregates of electron-dense, finely granular to fibrillar deposits in which membrane-enclosed virions and occasional groups of tubular structures were observed. Various cytopathogenic changes were observed in cells exhibiting viral proliferation. The morphogenesis of the virions is discussed in relation to the cytopathogenic changes.

Animals↗
PubMed1982

[Intralymphatic administration of BCG-CWS in advanced malignant melanoma].

BCG-CWS was administrated into lymphatic vessels in the treatment of advanced malignant melanoma metastasized to the lymph node of the posterior peritoneum. Side effects consisted of fever, lymphangitis, a decrease in urinary output and a slight rise in serum GOT, there being no serious side effects. Clinically, tumor mass in the abdomen cleared but metastases to the other organs increased, and the patient died of general dispersion of the disease. At autopsy, the abdominal mass became flat, with the cut surface of yellowish brown color. Histologically, this mass formed necrosis made up of destroyed tumor cells and histiocytes. BCG-CWS mediated histiocyte response appeared to destroy tumor cells. Thus, it is possible that local administration BCG-CWS could elicit a potent response even in advanced carcinoma. Since the contact of BCG-CWS with tumor cells produced this response, administration of BCG-CWS into the lymphatic vessels may be indicated where the lymph current to the metastasized lymph node is not obstructed. This treatment would be effective particularly in the case of micrometastasis, and there is a possibility that it could elicit a specific response.

Aged↗
PubMed1982

[Pulmonary metastasis of the stomach cancer].

Despite the fact that the lungs have a plenty of blood and lymphatic supply, only 20-40% of pulmonary metastasis from the stomach cancer are found. Pulmonary metastases are most commonly described as well-circumscribed lesions complicated with hilar metastasis. However, the most important picture is that of diffuse lymphatic permeation, which may produce clinical and radiologic features of lymphangitis carcinomatosa showing a characteristic roentgenologic appearance, namely, a fine feathery interstitial streaking. Furthermore, pleuritis carcinomatosa is a common type of metastasis from the stomach cancer and often presents a difficult management problem. Instillation of cytotoxic or sclerosing agents into the pleural space can be effective in preventing recurrence.

Humans↗
PubMedDate not supplied

Microsurgical treatment of lymphedemas of the limbs.

Lymphaticovenous anastomosis for surgical treatment of lymphedema of the limbs has been performed for several years with good results. The authors report on their experience, gained since 1976, after having operated on primary or secondary lymphedemas (five upper and 15 lower limbs). Lymphaticovenous anastomosis was performed according to Degni's technique using a special needle by which lymphatic vessels are inserted in the vein and secured to its wall. Eighty-three per cent of the subjective results were good, and the percentage of mean volumetric reduction in the operated limbs was 43% in 16 controlled cases. The postoperative course of secondary lymphedemas of the upper limbs was sometimes complicated by sudden lymphangitis attacks. In dealing with primary lymphedemas, the best results were obtained when all the operated limbs had great volumetric reduction, allowing the patients to resume their normal activities. The authors conclude that, after a long period of preoperative anti-inflammatory and anti-microbial therapy and regardless of lymphographic patterns, it is always worthwhile to perform a surgical exploration of the crural lymph nodes.

Adolescent↗
PubMed1981

A mycobacteriosis in a sheep resembling paratuberculosis (Johne's disease).

In a sheep which was euthanased because of severe emaciation and weakness, slight thickening of the ileum was seen grossly. Microscopically there was a granulomatous ileitis with obliterative lymphangitis and lymphangiectasis. Granulomatous lesions were also present in the liver and some mesenteric lymph nodes. Large numbers of acid-fast bacilli were present within epithelioid macrophages in the lamina propria of the ileum. Although the identity of the Mycobacterium spp. involved was not established, the possibility of paratuberculosis is discussed. The apparent rarity of this disease in sheep in South Africa is considered. Particular attention is drawn to the absence of diarrhoea in this case, to the slightness of the gross changes and to the importance of submitting material for mycobacterial culture.

Animals↗
PubMed1980

[On the taxonomy of Actinobacillus, Haemophilus, and Pasteurella: DNA base composition, respiratory quinones, and biochemical reactions of representative collection cultures (author's transl)].

In a comparative study, 63 collection cultures representing 38 nomenspecies of, or assigned to, the genera Actinobacillus, Haemophilus, or Pasteurella were characterized by phenotypical features and deoxyribonucleic acid base composition. The latter was calculated from the thermal denaturation point. Biochemical reactions were tested in differential media commonly used for Enterobacteriaceae, and two test procedures were compared: (i) pure cultures with haematin and nicotine adenine dinucleotide added, where necessary, and (ii) xenocultures with an asaccharolytic Acinetobacter strain (ST 661/60). Furthermore, the respiratory quinones, and the effect of fumarate on oxygen-limited growth were considered. On the basis of these and some additional physiological and morphological criteria, a definition of the Actinobacillus-Haemophilus-Pasteurella group as a whole was established which appears to rank as a family. Several misclassified species, i.e. the so-called Actinobacillus actinoides, Haemophilus piscium, Haemophilus vaginalis, Pasteurella anatipestifer, and the organisms of the Bovine Lymphangitis group were eliminated, and the position of so-called Pasteurella piscicida was questioned. Some principles of subdivision of the group, and some of the practical identification procedures were discussed.

Actinobacillus↗