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PubMed1989

[Excretion of porphyrin and porphyrin precursor during ethylene oxide inhalation].

The effect of chronic inhalation of ethylene oxide on urinary coproporphyrin and delta-aminolevulinic acid were studied. When Wistar male rats were exposed to 500 ppm ethylene oxide three times a week, daily urine volume was increased by 200-300% from the first week to the fifth week of the experimental period. After exposure, daily coproporphyrin excretion and urinary coproporphyrin per mg of creatinine increased by 250% and 141%, respectively. On the other hand, daily excretion of delta-aminolevulinic acid in urine tended to increase but did not increase significantly by creatinine-correction. We think this is the first report of ethylene oxide induced experimental porphyria.

Administration, Inhalation↗
PubMed1989

[The value of determining delta-aminolevulinic acid in urine (method II, East German occupational monitoring) as a screening procedure for the assessment of internal residues in occupational exposure to lead].

For the purpose of supervising workers exposed to lead the ratio of blood lead is determined several times per year. The withdrawal of blood samples from the vein necessary for this purpose as well as the comparatively high analytic expense make it essential to revise, whether it is possible to give up the analysis of blood lead at least partially in favour of other diagnostic measures less affecting the worker. Our investigation gave evidence of the fact, that the validity of a screening test for evaluating the blood lead concentration on the basis of the determination of delta-aminolaevulinic acid in urine (method II, AB-DDR; 2 nd morning urine) is insufficient.

Aminolevulinic Acid↗
PubMed1986

Factors affecting determination of delta-aminolevulinate by use of Ehrlich's reagent.

We investigated the formation of delta-aminolevulinic acid (ALA)-pyrrole and subsequent color development used in determining ALA in urine. Of three condensation reagents examined--acetylacetone, ethyl acetoacetate, and methyl acetoacetate--the last was the best. When the ALA-pyrrole is reacted with Ehrlich's reagent in ethyl acetate according to one procedure, the optimum concentration of perchloric acid in the reagent is 0.5 to 1.0 mol/L. Its optimum concentration is 1.0 to 2.3 mol/L when the reaction takes place in water.

Aminolevulinic Acid↗