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At least 595 records · Page 33Linked to original sources
PubMed1986

Controlled trial of calcitriol in hemodialysis patients.

We report on a 5-year, prospective, double-blind trial of 1,25 dihydroxycholecalciferol (calcitriol) versus placebo in 76 hemodialysis patients without biochemical or radiological evidence of bone disease. Calcitriol, 1 microgram daily, regularly induced hypercalcemia. Doses of 0.25 microgram daily or less proved satisfactory in most patients. During calcitriol treatment, plasma calcium concentration was significantly higher and serum parathyroid hormone concentration significantly lower than on placebo. There was no difference in the rates of development or of progression of vascular calcification in the two groups. Significantly more patients on placebo (17 vs. 6, p less than 0.05) developed a sustained elevation of plasma alkaline phosphatase concentration. Calcitriol appeared to protect against the development of histological evidence of osteitis fibrosa but not of osteomalacia, but accumulation of aluminum in bone occurred during the study. We conclude that calcitriol delays and may prevent the development of osteitis fibrosa in patients receiving regular hemodialysis and may reasonably be prescribed routinely in hemodialysis patients without biochemical or radiological abnormality, unless there is a substantial prospect of early renal transplantation.

Adolescent↗
PubMedDate not supplied

[Suicide: study of events related to patterns of mental functioning of certain subjects at high risk for suicide. Data from the emergency service of a general hospital].

The events implicated during a suicidal crisis reveal different depressive patterns sometimes unknown before the suicide: pathological idealisation, pathology of mourning, suicidal identification, Tellenbach's melancholic personality, non-acceptance of growing old, anaclitic depression produce a large number of serious suicides, often facilitated by alcohol intoxication. The mechanisms of violence which persist after the suicidal act and the imaginary position of the person in relation to death are also important risk factors.

Adolescent↗
PubMed1985

Cruelty and narrowmindedness.

The contention of this paper is that human understanding modifies cruelty, and that in order that cruelty can remain unmodified various mechanisms are employed. The most important processes include the worship of omnipotence which is felt to be superior to human love and forgiveness, the clinging to omnipotence as a defence against depression, and the sanctification of grievance and revenge. In order to avoid conscious guilt, the perceptions of the mind are narrowed to give ostensible justification to the cruelty, and the obviation of redeeming features in the object. The paper explores how these processes operate and how by virtue of projection the analyst's interpretations are perceived as cruel, and how the patient arranges to be locked in this vicious circle. Technical problems of dealing with these forces are explored together with the task of bringing alive the human concern that modifies cruelty.

Adult↗