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PubMed1982

Copper and zinc in human serum in Norway. Relationship to geography, sex and age.

Serum samples were collected from the adult population, age groups from 20 to 54 years, in 11 different Norwegian municipalities and analysed for zinc and copper by atomic absorption spectroscopy. Significant differences were found between several of the municipalities when the mean concentration of zinc in serum in 200 randomized samples were compared, with only two municipalities being different for copper. The values for zinc ranged from 13.8 to 18.3 mumol/l and copper varied between 16.3 and 19.2 mumol/l. An age related increase in the copper concentration was evident in the male population, and age-adjusted means showed a slight, but significantly higher serum copper concentration in females (18.4 mumol/l) than in males (16.5 mumol/l). For zinc the opposite sex-relationship was indicated with the highest values in males, 15.8 compared to 15.1 mumol/l in serum from females. No significant correlations were found between the concentrations of zinc and copper in serum. In all age groups of women, however, a small negative correlation was found giving a significant tendency.

Adult↗
PubMedDate not supplied

Classical polymorphisms in Berbers from Moyen Atlas (Morocco): genetics, geography, and historical evidence in the Mediterranean peoples.

BACKGROUND: Mediterranean population relationships have recently been reviewed through the analysis of classical and DNA markers. The differentiation between Berbers and Arabic-speakers to the south, and the genetic impact of the seven centuries of Muslim domination in the Iberian Peninsula have been among the most interesting questions posed in these studies. AIM: The present study seeks to assess the degree of genetic affinity between the two main population groups of Morocco: Berbers and Arabic-speakers. Data from the Berber study population were also compared with published information on 20 circum-Mediterranean groups. SUBJECTS AND METHODS: A Berber sample of 140 individuals from Moyen Atlas (Morocco) has been characterized using 15 classical markers (ABO, Duffy, MNSs, Rh, ACPl, AKl, ESD, GLOI, 6-PGD, PGMl, GC, HP, PI, PLG and TF). RESULTS: Allele frequencies in the Berbers fit well into the general southern Mediterranean ranges, albeit with some peculiarities, such as the high FY*A, ACPl*C, and PI*S values. The general pattern of relationships among Mediterranean peoples tested by genetic variance analysis was compatible with a north-south geographical differentiation. Spatial auto-correlation analysis in the different geographical regions of the Mediterranean reveals that the highest degree of association between allele frequencies and geographical distances corresponds to the western (41% of significant correlograms) and northern Mediterranean populations (33%). When only southern Mediterranean groups were considered, the degree of geographical structure considerably decreases (11% of significant correlograms). CONCLUSIONS: The different loci studied revealed close similarity between the Berbers and other north African groups, mainly with Moroccan Arabic-speakers, which is in accord with the hypothesis that the current Moroccan population has a strong Berber background. Differences in the spatial pattern of allele frequencies also are compatible with specific population histories in distinct Mediterranean areas, rather than general population movements across the whole region.

Alleles↗
PubMed1977

The geography of marriage in Britain, 1920-1960.

In 1959 the Population Investigation Committee at the London School of Economics instituted a nationwide survey of attitudes of marriage, contraception and family size. Questions were also asked about the birthplace of the partners and where they were living when they first met each other. These four place names provide the basis for marital mobility data whose geographical distribution is described here. A simple model of marital mobility is presented and the data are analysed according to (1) the propensity to marry outside the individual's birthplace or home town and (2) the distribution of the distan(e separating the partners when they come from different places. The data are very heterogeneous, so they are broken down for further analysis according to the population sizes of the birthplaces and home towns of each partner. The propensity to marry within the same place is strongly and positively associated with its population size. If the partners come from different places when the distance between their birthplaces, or between their home towns when they met, is associated with the population size of these places. Similar associations were found between the probability of migration from the birthplace, the distance moved, and population size. Men are more likely to move from their birthplaces than are women, and if they move they are more likely to move further. Marriage distance, as defined here, is also strongly influenced by population size. The geographical theory of central places offers a suitable framework for understanding the relation of marital mobility and population size and the results of this study are discussed in the context of geographical theories.

Adult↗
PubMed2005

The geography of COPD hospitalization in California.

Exposure to tobacco smoke is an important risk factor for chronic obstructive pulmonary disease. We investigated the relationship between chronic obstructive pulmonary disease hospitalization counts (and hospitalization-related charges) in California and sociodemographic and smoking measures, employing geospatial techniques that permit more sensitive scrutiny at the zip code level while controlling for spatial confounding. We analyzed 1,707 zip code tabulation areas in California for chronic obstructive pulmonary disease hospitalization rates and related hospitalization charges (using 1999 hospital discharge data). After controlling for spatial auto-correlation, positive relationships were found for age, percentage Hispanics, number of tobacco outlets and level of smoking. Inverse relationships were found for percentage with undergraduate degrees and income level. When examining "hotspot" zip code tabulation areas (those with higher than expected model-based chronic obstructive pulmonary disease hospitalization counts), minority/immigrant status, depressed socioeconomic measures, and elevated tobacco use were clearly associated, suggesting the need for increased intervention among the poor and persons of color. Although limited by the availability of air pollution monitoring data, a preliminary descriptive analysis indicated that the numbers of particulate matter exceedances mirrored both the hotspots of the Los Angelesair basin and coldspots in the San Francisco Bay Area.

Aged↗
PubMed1996

Serogroup-specific epidemiology of Streptococcus pneumoniae: associations with age, sex, and geography in 7,000 episodes of invasive disease.

A study sample of 7,010 episodes of invasive Streptococcus pneumoniae disease was obtained by combining 13 existing datasets. Disease episodes due to each of 12 pneumococcal serogroups (1, 3-9, 14, 18, 19, and 23) were then compared with episodes in a constant internal control group to describe serogroup-specific variations in disease frequency by age, sex, and geographic origin. The results are presented as odds ratios (with 95% confidence intervals) derived by logistic regression, with adjustment for the major confounders, including dataset of origin. Variation in the male:female ratios between serogroups is small, suggesting that capsular characteristics are an unlikely explanation for the male preference of S. pneumoniae. Serogroups associated with higher nasopharyngeal prevalence (e.g., 19 and 24) are relatively more common in Europe and North American, while the invasive serotypes 1 and 5 are much more common in South America. The custom of reporting serogroup frequencies in two age groups, children and adults, conceals much of the variation in the age distributions across the whole span of life. The reduction of risk associated with serogroups 6, 14, 18, 19, and 23 beyond childhood follows different gradients, being most abrupt in serogroups 14 and most gradual in serogroup 18. The relative risk of disease with serotype 1 declines steadily throughout life, while with serotypes 3 and 8 it increases over middle age. Serogroups 7 and 23 are found unusually frequently in the third decade of life. Because of the wide differences in the epidemiology of individual serogroups of S. pneumoniae, it is questionable whether pneumococcal infection should continue to be classified as a single disease entity.

Adolescent↗
PubMedDate not supplied

Syphilis, historical and actual: cultural geography of a disease.

Nineteenth-century Russian physicians identified two forms of syphilis, venereal and endemic, which they associated with the difference between city and country life. Modern medical authorities have generally rejected Victorian ideas of nonvenereal contagion, but students of preindustrial societies have found evidence that endemic syphilis does in fact occur. Because it was hard to distinguish one form from the other, however, prerevolutionary Russian doctors allowed their cultural preconceptions to guide them where evidence was weak. Their view of syphilis thus provides the historian with a remarkable guide to attitudes toward class, gender, and social change. Modern neglect of the nonvenereal variant demonstrates not merely the progress of scientific knowledge but also the cultural restriction on our own view of the world.

Civilization↗
PubMed2026

Ruminosignatures associated with methane emissions and feed efficiency across geographies and cattle breeds.

The cattle rumen microbiota represents a complex and dynamic ecosystem whose organization and relationship to host phenotypes are important for food security and environmental sustainability. We analyzed rumen microbiota profiles from 2496 cattle representing five breeds and production systems across five countries, identifying microbial co-abundance groups termed Ruminosignatures. We detected 14 distinct Ruminosignatures, including 2 observed across all populations dominated by Prevotella and UBA2810. Additional Ruminosignatures showed breed- and diet-specific patterns and collectively explained 96%-99% of variance in rumen microbial composition. Integrative cross-country analysis confirmed 10 out of 14 Ruminosignatures identified in cohort-specific analyses. Several Ruminosignatures were associated with methane emissions and feed efficiency traits and were partially under host genetic control, with heritability estimates ranging from 0.09 to 0.58. Structural equation modeling revealed consistent negative genetic and phenotypic correlations between the UBA2810-dominated Ruminosignature (RS_UBA2) and methane emissions across cohorts (rg = -0.40 to -0.65), with structural coefficients concordant in sign across all populations, supporting the expected direction of phenotypic response to selection on RS_UBA2. Meta-analysis confirmed positive associations of RS_UBA2 with average daily gain and negative associations with methane-related traits and feed conversion ratio. Functional genome-based predictions suggested RS_UBA2 may reduce methanogenesis through alternative hydrogen utilization pathways competing with methanogenic archaea. Production system type influenced both Ruminosignature occurrence and relationships with host phenotypes, emphasizing the relevance of context-specific strategies for microbiome modulation. Our findings highlight the potential of the Ruminosignatures framework for microbiome-informed breeding programs aimed at improving feed efficiency while reducing the environmental impact of cattle production.

Animals↗
PubMed2005

A world apart: geography, Australian quarantine, and the mother country.

In many respects the Australian colonies were what one person called "the proud offspring of a grand old mother." Yet when it came to the prevention of imported infectious disease, Britain's Australian colonies were not a chip off the old block. British opposition to the lengthy and costly imposition of quarantine had intensified throughout the nineteenth century, eventuating in the abolition of human quarantine in 1896. The Australian colonies, on the other hand, which had based their first quarantine regulations on British law and remained constantly aware of changing medical trends in the mother country, gradually expanded the breadth and capabilities of their maritime quarantine as the century progressed. Although other European powers and British colonies progressively adopted systems of medical inspection more in line with British port prophylaxis and away from quarantine, the Australian colonies invested increasing amounts of time and money into more elaborate quarantine stations and regulations. In this article I examine some of the basic features of coastal disease prevention in the Australian colonies and how they differed from British controls. Australia's distance from Britain was emphasized in the quarantine debates geographically as well as in policy. I argue that the often controversial differences in quarantine policy were for the most part a product of Australia's geographical location. The natural prophylactic of Australia's remoteness was not a reason to minimize quarantine in the colonies but rather served to increase it; whereas, it was argued that "the geographical position of England deprived it of the advantages...derived from a comprehensive quarantine system." I discuss this seeming anomaly in light of other arguments that have claimed that the close proximity of a state to the acknowledged origin of a disease was likely to increase its eagerness to quarantine.

Asia↗
PubMed1997

Embryo research: the ethical geography of the debate.

Three basic political positions on embryo research will be identified as libertarian, conservative, and social-democratic. The Human Embryo Research Panel will be regarded as an expression of the social-democratic position. A taxonomy of the ethical issues addressed by the Panel will then be developed at the juncture of political and ethical modes of reflection. Among the arguments considered will be those for the separability of the abortion and embryo research debates; arguments against the possibility of the preembryo being a person, especially arguments associated with totipotency and the significance of the primitive streak; and the various reasons for regulating embryo research, including those associated with respect for the preembryo, the protection of traditional views of human procreation, and the prevention of commercialization.

Advisory Committees↗
PubMed1983

The geography of gonorrhea. Empirical demonstration of core group transmission.

The pattern of reported gonorrhea in Upstate New York (exclusive of New York City) in the years 1975-1980 is one of intense central urban concentration, with concentric circles of diminishing incidence. The relative risk for gonorrhea in these central core areas, compared to background state rates, is 19.8 for men and 15.9 for women, but as high as 40 in selected census tracts. Prevalence appears to approach 20% in some areas, the level postulated by current epidemiologic models for continuing endemic transmission. These core areas are characterized by high population density, low socioeconomic status and a male to female case ratio of one or lower. Contact investigation data suggest that sexual contact tends to exhibit geographic clustering as well. These observations provide support for narrow focusing of epidemiologic resources as a major disease control strategy.

Epidemiologic Methods↗