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Results for “FIBROSITIS”

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At least 595 records · Page 33Linked to original sources
PubMed1985

Fibrosing peritonitis in a drug abuser.

We report a case of fatal fibrosing peritonitis in a 28-year-old drug abuser. The extensive fibrosis, which was limited to the abdominal cavity, contained birefringent material. Silica was identified by spectrophotometric analysis. Silica is a component of talc (magnesium silicate) used as a drug filler. Relatively small amounts are known to induce fibrosis. The manner of introduction of this material into the peritoneal cavity is hypothetical and includes accidental direct peritoneal contamination during subcutaneous injections, a method used by drug abusers.

Adult↗
PubMedDate not supplied

Fibrosing mediastinitis complicating coronary artery surgery. Use of the descending thoracic aorta.

This case illustrates the previously unreported combination of severe fibrosing mediastinitis involving the entire intrapericardial aorta, pulmonary artery, and innominate artery in a patient requiring coronary revascularization for chronic angina and multivessel coronary artery disease. Due to the mediastinal fibrosis, normal revascularization procedures and myocardial preservation techniques were altered and are described.

Aorta, Thoracic↗
PubMed1985

A double blind crossover trial of prednisone versus placebo in the treatment of fibrositis.

Twenty patients with a diagnosis of fibrositis were entered into a double blinded crossover study to compare the effects of prednisone versus placebo. Each patient was randomly assigned to either prednisone 15 mg/day or placebo for 14 days of therapy and then therapy was switched for a further 14 days. The following measurements were assessed at baseline, end of Week 2 and end of Week 4: analogue scores for pain, sleep disturbance, morning stiffness and fatiguability, and dolorimetry readings of pain tolerance over 14 representative tender points. Overall there was no improvement while taking prednisone, indeed most measured variables showed a trend towards deterioration with this therapy.

Adult↗
PubMed1985

[Chronic fibrosing alveolitis and lung fibrosis--frequency and distribution of radiographic symptoms].

In 95 patients with histologically or immunologically diagnosed interstitial lung diseases (44 pts. with chronic fibrosing alveolitis, 6 with allergic alveolitis, 11 with chronic diffuse fibrosis, 34 pts. with localized fibrosis) the radiographic symptoms of interstitial and accompanying alveolar and pleural alterations are estimated by a semiquantitative score, with regard to location and intensity. No diagnosis-relevant differences are found. Nodular densities are seen on the radiographs of all patients. In most of the cases (82%) they are accompanied by reticular shadows. Irreversible "honeycomb"-cysts are found in 27% of patients, alveolar and pleural reactions in 22% and 28% respectively. An impressive shrinkage is found in 16%.

Alveolitis, Extrinsic Allergic↗
PubMed1984

[Bronchiolar-alveolar cancer in idiopathic fibrosing alveolitis].

An observation of bronchiolo-alveolar carcinoma that developed in the presence of the idiopathic fibrosing alveolitis (IFA) in a woman of 57, is described. The duration of IFA was 12 years. Diffuse pneumosclerosis with the development of the so-called "honey-comb" lungs was observed. Numerous confluent foci of the bronchiolo-alveolar carcinoma in both the lungs are found in the presence of alterations typical for IFA (diffuse sclerosis of alveolar septa, microcystosis). The cause of death was progressing respiratory deficiency.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1983

Cryptogenic fibrosing alveolitis associated with peripheral neuropathy.

Eight patients who presented with fibrosing alveolitis and developed peripheral neuropathy are described. Seven had a positive rheumatoid factor, but only one had arthritis. The neuropathy affected both motor and sensory fibres. Two patients underwent peripheral nerve biopsy, one showing vasculitis and the other an axonal neuropathy. The two disorders responded differently to corticosteroid therapy, and immunosuppressant drugs may be useful in treating the neuropathy. The similarities of the patients suggests that this uncommon association is a real category.

Aged↗
PubMed1984

Fibrosing alveolitis associated with amiodarone.

We report a patient with fibrosing alveolitis associated with amiodarone therapy. Review of the literature suggests that amiodarone induced pulmonary disease generally occurs on a maintenance dose of at least 400 mg of amiodarone daily; there is however a wide range in the duration of therapy or total dose administered prior to presentation.

Aged↗
PubMed1984

[Clinico-functional characteristics of idiopathic fibrosing alveolitis (Hamman-Rich syndrome)].

The clinical and functional features of idiopathic fibrosing alveolitis (IFA) were analyzed in 31 patients. In 24 patients, the diagnosis was confirmed by histological study of the pulmonary tissue obtained by means of open lung biopsy or at autopsy. Progressive dyspnea was the earliest clinical symptom of IFA. High temperature, weight loss, cyanosis and other symptoms were characteristic of an acute disease course. Crepitation was the most characteristic symptom as far as the objective data are concerned. Detailed examination of respiratory function with the use of spirography, general plethysmography, forced oscillation technique, study of the diffuse capacity of the lungs and blood gases, and other methods showed that the most characteristic functional features of pulmonary respiration in IFA involved a decrease in the static pulmonary volumes, an increase in elastic pulmonary resistance, normal patency of the large and medium bronchi, and a diminution of the diffuse capacity of the lungs during respiratory arrest, as well as that of the diffuse capacity of the alveolocapillary membrane. The data obtained indicate that today one can discuss only the most characteristic rather than the pathognomonic clinical and functional symptoms of IFA.

Adolescent↗
PubMed1983

Regional muscle tension and pain ("fibrositis"). Effect of massage on myoglobin in plasma.

In thirteen patients, all women, with regional muscle tension and pain ("fibrositis") plasma myoglobin concentration was measured before and after massage. A significant increase was observed in the plasma myoglobin concentration reaching a maximum three hours after the start of massage treatment (median 133 micrograms/l). A positive correlation was found between the degree of muscle tension and the increase in plasma myoglobin concentration. After repeated massage treatment a gradual decline could be demonstrated in the increase of the plasma myoglobin concentration in coincidence with the efficacy of the treatment. Opposed to this only normal levels of myoglobin were found in plasma when muscles without tenderness and pain were treated with massage. The observed increase of myoglobin in plasma after massage indicates a leak of myoglobin from the muscle fibres, which suggests that regional muscle tension and pain is associated with disorders in the muscle fibres.

Adult↗
PubMed1984

Hearing and vestibular abnormalities in primary fibrositis syndrome.

A prospective neurootological study of 30 cases of primary fibrositis syndrome (PFS) and 30 sex and age matched healthy volunteers was performed. Results showed that 70% of the PFS patients had decreased painful sound threshold, 40% hyperreactivity of perrotatory nystagmus without neurological or peripheral vestibular lesions, and 27% asymptomatic sensorineural hearing loss at low frequencies. Such abnormal data were not found in the matched controls. These findings suggest that otological problems may be part of the nonrheumatic features encountered in PFS.

Adult↗
PubMed1984

Fibrositis (Fibromyalgia) in rheumatoid arthritis.

We studied demographic socioeconomic and clinical characteristics of 38 patients with fibrositis (fibromyalgia) that occurred in association with rheumatoid arthritis (RAFIB) and 242 patients with rheumatoid arthritis (RA) alone. Fewer RAFIB patients were married (57.1%), and most (97.4%) were women. No statistically significant differences in income, medical expenditures or other demographic variables were identified. All measures of function, pain, disease activity and psychological status were more abnormal in RAFIB patients. The clinical characteristics that best differentiated RAFIB and RA patients were pain, depression, anxiety and erythrocyte sedimentation rate, in logistic and stepwise regression models. Evaluation of disease severity markers, including radiographic erosions and frequency of total joint replacement, suggested that disease severity in RAFIB and RA is similar.

Arthritis, Rheumatoid↗
PubMed1983

[Cardial sarcoidosis: fibrosing granulomatous myocarditis].

Report of an unusually advanced, fibrosing, granulomatous myocarditis due to generalized sarcoidosis which presented itself clinically as a congestive cardiomyopathy in a 45-year-old man with a one-year's remission before death. Clinically cardiac sarcoidosis takes often a silent course. There is no exact information on its true incidence. Sudden death is not uncommon, mostly in young and middle-aged adults of either sex. Various cardiac structures may be damaged, especially the ventricular septal myocardium. The diagnosis is seldom established clinically; histological evaluation of specimens from other organs may be indicative. The response to antiarrhythmic agents and corticosteroids is considered with sepsis.

Arrhythmias, Cardiac↗
PubMed1984

Cryptogenic fibrosing alveolitis. Clinical spectrum and treatment.

Cryptogenic fibrosing alveolitis (CFA) is a relatively uncommon condition with a variable prognosis and a mean survival of less than 5 years. The prediction of responsiveness to corticosteroid treatment is difficult, but is highly desirable because of the range of beneficial and harmful effects encountered with this treatment. This review of the clinical details of 42 patients with CFA managed at the Respiratory Clinic at Groote Schuur Hospital over the past decade highlights this difficulty, and draws attention to features which may be helpful in predicting response and prognosis. Although 53% of patients experienced symptomatic improvement or had an initial objective response to treatment, only 28% showed sustained improvement on lung function tests. The outcome and pattern of disease of patients in this study are very similar to those reported from other centres.

Adult↗
PubMed1984

Digital vasculitis in patients with cryptogenic fibrosing alveolitis.

Twelve patients are described with features of cryptogenic fibrosing alveolitis (CFA) with associated florid digital vasculitis (DV). Nine patients had features of various 'connective tissue disorders' involving systems other than the lung, but three had no such features. The immunological features of these patients with DV have been compared with a group of 17 patients who had CFA alone ('lone CFA') and in whom the same range of special laboratory tests were being undertaken concurrently. The group with DV had a higher erythrocyte sedimentation rate and a higher serum IgM, but the most interesting immunological distinction was an increased prevalence of antinuclear antibodies with a nucleolar staining pattern. In addition, the group with DV also had a greater prevalence of single stranded DNA antibodies and of smooth muscle autoantibodies. Circulating immune complexes were not detected more frequently in the group with vasculitis. Ten of the 12 patients were initially treated with corticosteroids and neither the vasculitis nor the lungs improved. In eight the incapacitating DV responded to immunosuppressants (four) or penicillamine (four). In three of these eight patients the lungs also improved.

Adult↗
PubMedDate not supplied

A computer system for timing and acoustical analysis of crackles: a study in cryptogenic fibrosing alveolitis.

A system for recording and processing lung crackles is described. These are detected by a microphone on the chest wall and recorded simultaneously with flow rate, tidal volume and oesophageal pressure on a four-channel tape recorder. The sound signal is subsequently digitized by an analog-to-digital converter and processed by a minicomputer, using the Time Series Language and the fast Fourier transform algorithm. A preliminary study on seven patients with cryptogenic fibrosing alveolitis (CFA) confirms that crackles typically occur at the end of inspiration; timing seems to be well related to inspired volume and esophageal pressure. Inspiratory crackles of CFA have a well-defined waveform: it consists of a starting component and a damped oscillation, which probably depends on the resonant frequency of the lung. The crackle energy content is mainly concentrated in the frequency range between 100 and 2 000 Hz, the spectrum shape being determined by the energy distribution between the two components of the waveform. This recording and processing system gives more complete information about crackles than auscultation does, allowing their quantification and reproducibility. It may be used to compare crackles in different diseases, and may be simplified and standardized for routine clinical use as an additional noninvasive diagnostic technique.

Acoustics↗
PubMedDate not supplied

Hypothyroidism with presenting symptoms of fibrositis.

Eight patients who initially presented with signs and symptoms of the fibrositis syndrome, without overt hypothyroid disease, were found to have chemical evidence of hypothyroidism. Myalgic symptoms resolved in 6 of 8 patients treated with low dose thyroid replacement. In addition, another hypothesis of pathophysiology of the myalgic symptoms observed in patients with hypothyroidism related to sleep disturbance is offered.

Adult↗
PubMed1982

Impaired antibody-dependent cell-mediated cytotoxicity in cryptogenic fibrosing alveolitis (synonym: idiopathic pulmonary fibrosis).

Mononuclear cells from the blood of 26 patients with the 'autoimmune' connective tissue disorder cryptogenic fibrosing alveolitis (CFA) were examined in Chang cell cytotoxicity assays for their capacity to mediate antibody-dependent cell-mediated cytotoxicity (ADCC). The results showed an impairment for the group by comparison with a group of 45 normal healthy controls (P less than 0.01). The impairment was greater in patients with associated connective tissue disorders of other systems (CFA+CT) than in those having the lung disorder alone (lone CFA); (P less than 0.001). The reduction in ADCC showed a correlation with reducing counts of cells bearing Fc gamma G surface receptors (P less than 0.05), and with increasing levels of soluble immune complexes in the blood of these patients by C1q binding (P=0.05). Non-specific esterase staining indicated that the Fc gamma G rosetting cells were subpopulations of lymphocytes not monocytes. We therefore suggest that the observed ADCC impairment may be due to impairment of lymphocyte Fc receptor function, and we speculate that this may influence immune regulation.

Adult↗