Prophylaxis in allergic disease and management of the eczematoid dermatoses of infancy and childhood.
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By judicious consideration of the clinical appearance, by direct examination with magnification, and by culture results, skin biopsy, and other laboratory results, the clinician is able to diagnose most pathological conditions of the scalp. The scalp participates in many systemic disorders and frequently is the chief site of involvement. Similarly, many generalized disorders limited to the skin exhibit their most typical manifestations in the scalp. Whenever a diagnosis eludes the investigator, more than likely he or she has not considered all of the etiological possibilities or has not pursued an adequate laboratory investigation. A few scalp diseases initially present nonspecific clinical pictures. By utilizing follow-up examinations at appropriate intervals, the diagnosis can eventually be made. Once a diagnosis is made, appropriate treatment will generally produce satisfactory improvement or cure. Nevertheless, a few generally rare conditions will defy the physician's most enlightened and aggressive therapy.
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In the present study, 40 patients with facial skin lesions and Demodex folliculorum (DF) mite density > 5/cm(2) by SSSB were evaluated for their immune response through counting T-cell subsets (CD3-CD4-CD8) and NK cells (CD16) numbers and IgG, M, D concentrations in peripheral blood in relation to DF mite density. They were 26 females and 14 males with overall mean age was 48.57+/-15.33 years. A control group of 40 healthy individuals without any skin diseases was enrolled. The mean DF mite density (MD) was 11.82+/-3.72/cm(2) in patients compared to 1.77+/-2.39 /cm(2) and a prevalence of 47.5% in controls. The difference was statistically significant. MD significantly correlated with age both in study and controls, but not with sex. A significant decrease in the absolute numbers of lymphocytes, T-cell subsets and NK cells was found in the study group in comparison with controls. Mean IgM level was significantly higher in patients. No significant correlation was observed between MD and the immune response. So, DF mites modulate the host cellular immune response to their advantage, as T-cell subsets and NK cells seem to be the target of immuno-suppression, favouring dermatosis development.
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This is a report of 2 patients with pigmented purpuric dermatosis treated successfully with Psoralen photochemotherapy (PUVA). Treatment for pigmented purpuric dermatosis is generally unsatisfactory, and we believe this to be the first report of successful response of this condition to PUVA.
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The authors proceeded to a skin examination of 1,194 consecutive workers in a cutlery industry with 3,692 employees, in order to detect any cutaneous alterations among them. Only 223 (18.7%) had no skin pathology. Most of them, 971 (81.3%) presented some cutaneous disorder, related or not with their work. Hyperkeratosis of the fingers and hands (262 cases) caused by repeated traumas due to the manipulation of the instruments of work were the most noticeable and specific occupational skin alteration. In second place in order of frequency were the intertriginous mycotic inflammation of the toes: 255 cases. The authors call attention to the low incidence of the sexually transmitted diseases as well as of scabies, pediculosis and impetigo.
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Diseases of the skin related to the use of swimming pools do not appear very often in medical reports. In this review of such diseases we designate changes in the skin and hair as being infectious, toxic or allergic in origin. Particular attention is given to allergenic additives in the water. There is no indication that public swimming pools in the Federal Republic of Germany present any danger to the skin.
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