Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “APUD Cells”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 595 records · Page 33Linked to original sources
PubMed1987

Morphogenesis and malformations of the skin NICHD/NIADDK research workshop.

Developmentally caused skin malformations constitute a spectrum of birth defects, some of which can be recognized prenatally by morphologic or biochemical means. The number of prenatally diagnosable skin diseases could be greatly expanded with an increased understanding of the molecular and cellular bases of skin development and the mechanisms that result in the generation of skin defects. The National Institute of Child Health and Human Development and the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, therefore, sponsored a workshop that recommended basic biologic studies combined with clinical investigations of normal and abnormal cutaneous development set forth in this article. Investigations resulting from these research recommendations are intended to contribute to the knowledge that should aid in the prevention of developmentally caused skin deformities.

APUD Cells↗
PubMed1979

Ultrastructure of the normal human urethra.

The normal ultrastructure of the prostatic, bulbar and penile urethra in the human is described. The human urethra contains both exocrine and what appear to be endocrine glands. Further study is in progress to define the nature and role of the secretion from these endocrine glands.

APUD Cells↗
PubMed1985

Immunoassay of the neuronal and neuroendocrine marker PGP 9.5 in human tissues.

An inhibitory, coated-well immunoassay for the neurone-specific protein PGP 9.5 has been devised and used to measure the concentrations of the protein in human tissues. Concentrations of PGP 9.5 between 40 ng/ml and 10 micrograms/ml could be measured using this assay. In brain PGP 9.5 was present at 100.58 +/- 16.18 micrograms/mg protein. Of the other organs examined only kidney and testis showed significant concentrations of PGP 9.5 (3.97 +/- 0.87 microgram/mg protein and 3.25 +/- 0.36 microgram/mg protein, respectively). All other organs contained less than 2% of the brain level. The tissue levels determined by coated-well immunoassay confirmed the tissue specificity of PGP 9.5 originally determined by high-resolution two-dimensional gel electrophoresis.

APUD Cells↗
PubMed1971

The G cells in pernicious anaemia.

An indirect immunofluorescence technique, using the globulin fraction of rabbit antihuman gastrin serum, was applied to formalin-fixed material obtained by suction biopsy from the fundic mucosa of nine cases of pernicious anaemia. Cytochemical tests for endocrine polypeptide cells of the APUD series, in which the G cell is included, were carried out in parallel with immunofluorescence and with ultrastructural observations.G cells were present, in large numbers, in five of the nine cases studied. In the remaining four cases the predominantly intestinalized glands contained only enterochromaffin in cells. Because of their low gastrin content (immunofluorescence), low secretion granule content (cytochemistry), and the associated ultrastructural findings, it is suggested that the G cells of the fundic mucosa are in a state of high synthetic and high secretory activity.

Anemia, Pernicious↗
PubMed2001

The neuroendocrine system and its tumors: an overview.

Neuroendocrine tumors comprise a family of neoplasms with a wide range of morphologic, functional, and behavioral characteristics. Their diagnosis depends on the recognition of characteristic morphologic features and on the presence of markers indicative of neuroendocrine differentiation. Neuroendocrine tumors can be grouped into epithelial and neural subtypes on the basis of the presence of cytokeratins or neurofilaments, respectively. The nomenclature of these tumors, particularly those of the epithelial type, remains controversial. For some tumor types, such as those of the anterior pituitary, thyroid, and parathyroid glands, the standard terminology is preferable to the terms neuroendocrine tumor or neuroendocrine carcinoma. The use of the term carcinoid, however, has become increasingly more inappropriate to describe the full range of neuroendocrine neoplasms of low to intermediate malignant potential. It is critical to convey in diagnostic teminology both the tumor type and its malignant potential. Diagnostic terms using neuroendocrine or endocrine together with information on grading and hormonal activity provide an optimal approach for the classification of these tumors. Additional studies, including gene expression profiling, will be critical for further advancing our understanding of the pathobiology and interrelationships of these neoplasms.

APUD Cells↗
PubMedDate not supplied

[The comparative characteristics of the pathogenic action of Vibrio cholerae of the non-O1 group O139 serovar and of the O1 group on the intestinal APUD system of suckling rabbits].

The comparative study of the enteropathogenic action of V. cholerae strains of group non-O1, serovar O139, and group O1 with different virulence on the APUD system of the intestine of suckling rabbits after intraenteral infection revealed that V. cholerae of group non-O1 induced inflammatory changes in the intestine and the pronounced toxic lesion of parenchymal organs. This was accompanied by a decrease in the number of apudocytes and an increase in the functional tension of the APUD system. After the infection of the animals with V. cholerae of group O1 changes in the APUD system and internal organs directly depended on the virulence of the microbes and the infective dose.

APUD Cells↗