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PubMedDate not supplied

Effects of battlefield display frames of reference on navigation tasks, spatial judgements, and change detection.

This paper describes an experiment which illustrates the cause of 'cognitive tunnelling' as it affects information gathering and perception-based task performance in computer-generated terrain displays of varying frames of reference. Cognitive tunnelling refers to the effect where observers focus attention on information from specific areas of a display to the exclusion of information presented outside these areas. Previous research suggests that cognitive tunnelling is induced by more immersive or egocentric visual displays. Results from our preceding study suggested that an immersed split-screen display induces cognitive tunnelling and results in poorer information extraction and situation awareness than an exocentric display of the same information. The current study determined that failure of the observers to integrate information across the two views of the immersed display led to the cognitive tunnelling effect. Cognitive tunnelling was also affected by primacy of information initially presented within the larger egocentric view in the immersed display.

Adult↗
PubMed2005

Altered temporal profile of visual-auditory multisensory interactions in dyslexia.

Recent studies have demonstrated that dyslexia is associated with deficits in the temporal encoding of sensory information. While most previous studies have focused on information processing within a single sensory modality, it is clear that the deficits seen in dyslexia span multiple sensory systems. Surprisingly, although the development of linguistic proficiency involves the rapid and accurate integration of auditory and visual cues, the capacity of dyslexic individuals to integrate information between the different senses has not been systematically examined. To test this, we studied the effects of task-irrelevant auditory information on the performance of a visual temporal-order-judgment (TOJ) task. Dyslexic subjects' performance differed significantly from that of control subjects, specifically in that they integrated the auditory and visual information over longer temporal intervals. Such a result suggests an extended temporal "window" for binding visual and auditory cues in dyslexic individuals. The potential deleterious effects of this finding for rapid multisensory processes such as reading are discussed.

Acoustic Stimulation↗
PubMed1997

Situation models and abstract ownership relations.

Six experiments used a fan-effect paradigm to test whether people can use the abstract relation of ownership to help integrate information into situation models. People studied sentences of the form The [person] owns/is buying the [object] for a later recognition test. The integration of sentences into a situation model (as evidenced by an attenuated or absent fan effect) was observed when the verb phrase referred to a specific event (is buying) and the objects could all be bought in the same place (e.g., a drugstore). This organization did not occur either when the verb phrase referred to general ownership (owns) or when the items were unlikely to be purchased in a single location (e.g., television and car). It was concluded that although abstract relations can be used to segregate information into sets that can be integrated into situation models, this integration is more likely when it can be embedded within a spatial-temporal framework.

Attention↗
PubMed2000

Informational aspects of telepathology in routine surgical pathology.

Application of computer and telecommunication technology calls serious challenges in routine diagnostic pathology. Complete data integration, fast access patients' data to usage of diagnosis thesaurus labeled with standardized codes and free text supplements, complex inquiry of the data contents, data exchange via teleconsultation and multilevel data protection are required functions of an integrated information system. Increasing requirement for teleconsultation transferring a large amount of multimedia data among different pathology information systems raises new questions in telepathology. Creation of complex telematic systems in pathology requires efficient methods of software engineering and implementation. Information technology of object-oriented modeling, usage of client server architecture and relational database management systems enables more compatible systems in field of telepathology. The aim of this paper is to present a practical example how to unify text based database, image archive and teleconsultation in a frame of an integrated telematic system and to discuss the main conceptual questions of information technology of telepathology.

Humans↗
PubMed2004

Clinical validation of the normalized mutual information method for registration of CT and MR images in radiotherapy of brain tumors.

Image registration integrates information of different imaging modalities and has the potential to improve target volume determination in radiotherapy planning. This paper describes the implementation and validation of a 3D fully automated registration procedure in the process of radiotherapy treatment planning of brain tumors. 15 Patients with various brain tumors received CT and MR brain imaging before the start of radiotherapy. The normalized mutual information (NMI) method was used for image registration. Registration accuracy was estimated by performing statistical analysis of coordinate differences between CT and MR anatomical landmarks along the x-, y- and z-axes. Second, a visual validation protocol was developed to validate the quality of individual registration solutions and this protocol was tested in a series of 36 CT-MR registration procedures with intentionally applied registration errors. The mean coordinate differences between CT and MR landmarks along the x- and y-axes were in general within 0.5 mm. The mean coordinate differences along the z-axis were within 1.0 mm, which is of the same magnitude as the applied slice thickness in scanning. Second, the detection of intentionally applied registration errors by employment of a standardized visual validation protocol resulted in low false-negative and low false-positive rates. Application of the NMI method for the brain results in excellent automatic registration accuracy and the method has been incorporated in daily routine within our institute. A standardized validation protocol is proposed that ensures the quality of individual registrations by detecting registration errors with high sensitivity and specificity. This protocol is proposed for the validation of other linear registration methods.

Algorithms↗
PubMedDate not supplied

All you need to know about a PACS RFP, you learned in kindergarten.

Key to purchasing any picture archiving and communications system (PACS) is the generation of a request for proposal (RFP), which defines the system's requirements. An RFP is not difficult to create and, in fact, one can follow simple rules such as outlined in Robert Fulghum's book, All I Really Need to Know, I Learned in Kindergarten. "Take time to look" is the first rule--don't jump into new adventures. Instead, start with a mission statement and clear objectives. Define the stakeholders and assemble the team. "Share everything" is the second rule to follow. This includes information, objectives and definitions of the problem. You'll want to define your specifications. What are the component requirements? How will you integrate information systems at your facility? What about performance--how is it defined and what is expected? Warm cookies and cold milk--or common sense--is another rule, particularly around issues that may seem obvious such as training and service. Who is going to do it, and what is required? "Watch out for traffic and hold hands." This rule, as applied to PACS and an RFP, means stick together. Create a partnership with your vendors. Talk to as many vendors and other users as possible. Last, "be aware of wonder." Fulghum's Rule, as applied here, means performance will speak for itself, particularly when there is significant improvement in the service you provide to your users.

Competitive Bidding↗
PubMed1978

Testing toxic substances for protection of the environment.

The Toxic Substances Control Act requires pre-production testing of chemicals for potential hazards to human and environmental health. Effective control of chemicals requires evaluations of chemical hazard that go beyond determinations of toxicity to humans to include the effects, transport, and fat of chemicals in the environemnt. Formulation of meaningful hazard evaluations depends on integrating information from tests of chemical effects, transport, and fate or by developing testing tools that integrate these factors during experimentation. Chemical effects may be acute or chronic and they may be observed individual organisms, populations or organisms, or in total ecosystems. Chemical transport through the environment depends on physico-chemical characteristics of the chemical and the medium (soil, water, or air) as well as environmental factors and biotic processes. The ultimate fate of chemicals (persistence, transformation, or degradation) is determined by numerous physical and biological processes occurring in the environment, and must be acknowledged to effectively determine the hazard. Many techniques are available for the separate and routine evaluation of the effects, transport and fate of environmental contaminants. However, separate identification of the importance and magnitude of each of these factors limits their utility in assessments of chemical hazard. The microcosm (model ecosystem) method integrates many of these tests in replicable experimental units, and may provide substantial information on chemical hazard in ecosystem context.

Chemical Phenomena↗
PubMed2004

Perspectives on integrated child health information systems: parents, providers, and public health.

The efforts of families, health care providers, and public health programs to optimize health care and health outcomes for children are often limited by the lack of timely, complete, and accurate health information. Families frequently serve as the messenger between providers in providing clinical details that they may not understand, because the paper record of previous care is unavailable. Providers believe in the value of good information, but haven't the time, training, or financial resources to create better data sharing methods. Public health programs often must rely on unacceptably slow, redundant, or otherwise limited data collection efforts to provide population-based assessments of child health problems that inform public policy and program development. Integrated child health information systems allow the appropriate, secure sharing of health data that are critical to improving these processes. Developing such systems will require a strong commitment from these 3 stakeholder groups and attention to human values as well as technical challenges.

Attitude↗
PubMed1997

Normal fusion for three-dimensional integrated visualization of SPECT and magnetic resonance brain images.

UNLABELLED: Multimodality visualization aims at efficiently presenting integrated information obtained from different modalities, usually combining a functional modality (SPECT, PET, functional magnetic resonance imaging) with an anatomical modality [CT, magnetic resonance imaging (MRI)]. This paper presents a technique for three-dimensional integrated visualization of SPECT and magnetic resonance brain images, where MRI is used as a framework of reference for the display of the SPECT data. METHODS: A novel technique for three-dimensional integrated visualization of functional and anatomical information, called normal fusion, is presented. With this technique, local functional information is projected onto an anatomic structure. RESULTS: The normal fusion technique is applied to three cases of SPECT/MRI integration. The results are presented, discussed and evaluated for clinical relevance. CONCLUSION: The results for three-dimensional integrated display of SPECT and MR brain images indicate that the normal fusion technique provides a potentially comprehensive and diagnostically valuable presentation of cerebral blood perfusion in relation to the anatomy of the brain.

Autistic Disorder↗
PubMed2002

IMGT, the international ImMunoGeneTics database: a high-quality information system for comparative immunogenetics and immunology.

IMGT, the international ImMunoGeneTics database (http://imgt.cines.fr), is a high quality integrated information system specializing in Immunoglobulins (IG), T cell Receptors (TR) and Major Histocompatibility Complex (MHC) of human and other vertebrates, created in 1989, by LIGM, at the Université Montpellier II, CNRS, Montpellier, France. IMGT provides a common access to standardized data, which include nucleotide and protein sequences, oligonucleotide primers, gene maps, genetic polymorphisms, specificities, 2D and 3D structures. IMGT includes several databases (IMGT/LIGM-DB, IMGT/HLA-DB, IMGT/3Dstructure-DB), Web resources ('IMGT Marie-Paule page') which comprise IMGT Scientific Chart, IMGT Repertoire, IMGT Bloc-notes, IMGT Education, IMGT Aide-mémoire and IMGT Index, and interactive tools (IMGT/V-QUEST, IMGT/JunctionAnalysis). These expertly annotated data on the genome, proteome, genetics and structure of the IG, TR and MHC are of high value for comparative genome evolution studies of the adaptative immune response.

Animals↗
PubMed1985

Spatial EEG patterns, non-linear dynamics and perception: the neo-Sherringtonian view.

Spatial analysis with preamplifier arrays and computers offers fresh perspectives on brain function. Realization of its potential depends on development of appropriate procedures for data processing and display, experimental paradigms to serve as benchmarks, and theories of brain function to predict what to look for and how to distinguish valid results from artifacts. Measurement of EEGs from arrays of 64 electrodes chronically implanted on the olfactory bulbs of rabbits that are trained to discriminate odorant conditioned stimuli show that the odorants induce spatially distinctive amplitude patterns of neural activity. The odor-specific information density is inferred to be uniform over the whole main bulb. The neural dynamics that produce these activity patterns emerge from the synaptically interactive sheet of excitatory mitral and inhibitory granule cells with distributed input and output tracts and with static nonlinearities deriving from the nerve impulse mechanism. Excitatory synapses between mitral cells are subject to modification when odorants are paired with unconditioned stimuli, thus forming nerve cell assemblies. Odorant-specific information established by a stimulus locally in the bulbar unit activity is integrated with past experience by an assembly, disseminated over the entire bulb on the order of 100 mm2 in area in a time period of 2.5 ms, and sustained for a time period on the order of 0.1 s. An arbitrary spatial sample on the order of 20% of bulbar EEG activity captures the entire integrated information albeit at lesser resolution than the whole. This synaptic mechanism of local input and global output may be common to all of the cerebral cortex. The implications are discussed for neocortical sensory systems, motor pattern generators, and goal-directed behavior in the context of self-organizing non-linear dynamic systems.

Aging↗
PubMed2006

Disturbances of time consciousness from a phenomenological and a neuroscientific perspective.

The subjective experience of time is a fundamental constituent of human consciousness and can be disturbed under conditions of mental disorders such as schizophrenia or affective disorders. Besides the scientific domain of psychiatry, time consciousness is a topic that has been extensively studied both by theoretical philosophy and cognitive neuroscience. It can be shown that both approaches exemplified by the philosophical analysis of time consciousness (Husserl) and the neuroscientific theory of cross-temporal contingencies (binding of cognitive processes over time) as the neurophysiological basis of human consciousness implemented in the prefrontal cortex (Fuster) converge in 2 respects. Firstly, a tripartite conception of consciousness divides human cognition in 3 different temporal domains comprising retention, presentation, and protention (Husserl) and the past, the present, and the future corresponding to working memory, interference control, and preparatory set (Fuster). Secondly, both concepts refer to the present as an extended duration that integrates information from the recent past and the future. We propose that the integration of phenomenological and neuroscientific approaches can stimulate the development of enriched pathophysiological concepts of mental disorders. This approach appears to be particularly fruitful with respect to schizophrenia that is interpreted as a structural disturbance of time consciousness.

Awareness↗
PubMed1999

Does your gaze direction and head orientation shift my visual attention?

The effects of another person's gaze direction and head orientation on the observer's attentional processes were investigated. Subjects responded to visual, laterally presented reaction signals. The presentation of the reaction signal was preceded by a facial cue stimulus signaling a direction which was either congruent, neutral, or incongruent with the laterality of the reaction signal. A head (front and profile views) with an averted gaze affected the response times in comparison to the front view of a face with a straight gaze. In contrast, a profile view of a head with a compatible gaze direction did not result in such an effect. The results indicate that visual information from the other individual's gaze direction and head orientation is integrated, and the integrated information is fed to the brain areas subserving visual attention orienting.

Adult↗
PubMed1995

CDC's Information Network for Public Health Officials (INPHO): a framework for integrated public health information and practice.

To strengthen the public health infrastructure, the Centers for Disease Control and Prevention (CDC) initiated the Information Network for Public Health Officials (INPHO). CDC INPHO has three goals: (1) to make communication among public health practitioners throughout the United States easy, (2) to make information accessible, and (3) to make secure data exchange as swift and smooth as contemporary technology will allow. Based on a systems approach to supporting the core functions of public health, CDC INPHO achieves its goals by creating a flexible and user-responsive infrastructure of open communications and information exchange.

Centers for Disease Control and Prevention, U.S.↗
PubMed2005

A 3D digitzation system for conventional radiation therapy.

While the majority of patients receiving external beam radiation therapy treatment are planned by CT simulation, a significant number of them are still planned using conventional simulators for various reasons. The information-collection process in a conventional simulation is often fragmented and done with primitive tools. For example, in many institutions body contours are still acquired using solder wires and tracing paper, a time-consuming and error-prone procedure. We have developed a 3D digitization system to assist the information-acquisition process at conventional simulations. The system consists of an infrared camera assembly, a wireless digitizer probe, and Windows-based software. The system can provide 3D coordinates of any points in space accessible by the probe with submillimeter accuracy. It can be used to capture body contours, to record the coordinates of portal points, and to take various measurements for dose calculations as well as for patient setup. The software can display all the captured data together with the planned treatment fields, providing a comprehensive geometric verification of the treatment configuration. The system can also transfer all the information to dose planning programs in DICOM-RT format, providing an integrated information flow from simulation to dose planning.

Equipment Design↗
PubMed1998

Molecular and genetic ecotoxicologic approaches to aquatic environmental bioreporting.

Molecular and population genetic ecotoxicologic approaches are being developed for the utilization of arthropods as bioreporters of heavy metal mixtures in the environment. The explosion of knowledge in molecular biology, molecular genetics, and biotechnology provides an unparalleled opportunity to use arthropods as bioreporter organisms. Interspecific differences in aquatic arthropod populations have been previously demonstrated in response to heavy metal insult in the Arkansas River (AR) California Gulch Superfund site (CGSS). Population genetic analyses were conducted on the mayfly Baetis tricaudatus. Genetic polymorphisms were detected in polymerase chain reaction amplified 16S mitochondrial rDNA (a selectively neutral gene) of B tricaudatus using single-strand conformation polymorphism analysis. Genetic differences may have resulted from impediments to gene flow in the population caused by mortality arising from exposure to heavy metal mixture pollution. In laboratory studies a candidate metal-responsive mucinlike gene, which is metal and dose specific, has been identified in Chironomus tentans and other potential AR-CGSS bioreporter species. Population genetic analyses using the mucinlike gene may provide insight into the role of this selectable gene in determining the breeding structure of B. tricaudatus in the AR-CGSS and may provide mechanistic insight into determinants of aquatic arthropod response to heavy metal insult. Metal-responsive (MR) genes and regulatory sequences are being isolated, characterized, and assayed for differential gene expression in response to heavy metal mixture pollution in the AR-CGSS. Identified promoter sequences can then be engineered into previously developed MR constructs to provide sensitive in vitro assays for environmental bioreporting of heavy metal mixtures. The results of the population genetic studies are being entered into an AR geographic information system that contains substantial biological, chemical, and geophysical information. Integrated spatial, structural, and temporal analyses of these parameters will provide invaluable information concerning environmental determinants that restrict or promote gene flow in bioreporter populations.

Aedes↗
PubMed1996

Temporal constraints in processing of nonverbal rhythmic patterns.

This study investigates the effect of a mental content of presented stimuli, normal aging and individual differences in cognitive abilities on temporal limits of an integration mechanism. Younger and older subject grouped together the beats generated by a metronome. Subjects were asked to listen to the beats of a metronome and to accentuate mentally every second, third, fourth...etc. beat, to create a subjective rhythm. This rhythm exists, in fact, only in subjects' mind and not objectively. Subjects reported verbally how many clicks they were able to integrate into a perceptual unit. On this basis, the time interval during which subjects were able to integrate temporally separated stimuli was calculated (number of beats reported as being integrated x time distance between beats) for different metronome frequencies. The results show, firstly, that the length of integration periods significantly depends on the frequency of presented metronome beats. When the frequency of metronome beats is high, the time interval during which the subjects integrate beats into a single perceptual unit is shorter. Secondly, older adults integrate information during a longer time interval than younger ones. Thirdly, the length of an integration period is related to a subjects' level of cognitive ability. These results suggest that the length of an integration period is not a constant, stable feature, but varies across the life span depending on the mental content of the information presented and individual factors.

Acoustic Stimulation↗
PubMed2005

Challenges in systematic reviews of economic analyses.

Economic analyses can provide valuable information for health care decision makers. Systematic reviews of economic analyses can integrate information from multiple studies and provide important insights by systematically examining how differences between models lead to different results. We use our experience in developing and implementing systematic reviews of economic analyses for the U.S. Preventive Services T ask Force, particularly our systematic review of the cost-effectiveness of colorectal cancer screening, to illustrate key methodologic challenges and suggest a framework for other researchers in this area.

Colorectal Neoplasms↗