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At least 577 records · Page 32Linked to original sources
PubMed1989

Characteristics of Mongoloid populations and immunogenetics of various diseases based on the genetic markers of human immunoglobulins.

A clear genocline has been found for the distribution of Gm ag, Gm ab3st, and Gm afb1b3 haplotypes among the Mongoloid populations scattered in the world and characterized by the presence of four Gm haplotypes. Mongoloid populations are divided into two groups by an analysis of genetic distances and parametric multidimensional scaling: one is a northern group which is characterized by a high frequency of Gm ag and Gm ab3st and an extremely low frequency of Gm afb1b3 haplotype, and the other a southern group characterized by a remarkably high frequency of Gm afb1b3 and a low frequency of Gm ag and Gm ab3st haplotypes. The origin of the Gm afb1b3 characteristic of southern Mongoloids must exist in the Yunnan and Guangxi areas of southwest China. The origin of the Gm ab3st characteristic of northern Mongoloids must exist in Siberia, most likely in the Baikal area. The data which suggest the presence of Gm-associated pathogenic polygenes were obtained in the various diseases.

Asian People↗
PubMed1989

Immunogenetic studies of two recently contacted populations from Papua New Guinea.

We have examined the HLA profiles of the Hagahai and the Haruai people, two linguistic groups in the remote western Schrader mountains who have only recently had administrative contact, and compared them with those of other populations in Papua New Guinea. None of the antigens detected in the two groups was found missing in other populations although significant differences in allele frequencies exist. Recent contact history does not appear to have played any significant role in shaping these differences. Similarly, no evidence of differential selection pressures contributing to HLA heterogeneity was found. The genetic profiles of the Hagahai and the Haruai appear to be a result of recent admixture between unrelated, genetically disparate groups.

Culture↗
PubMed1987

An immunogenetic analysis of resistance to herpes simplex virus retinitis in inbred strains of mice.

Specific inbred strains of mice have been shown to vary considerably in their resistance and susceptibility to herpes simplex virus (HSV) infection. We injected 2 X 10(5) plaque forming units (PFU) of the KOS strain of HSV-1 intracamerally into one eye of BALB/c, C57Bl/6, and F1 (BALB/c X C57Bl/6) mice. HSV-1 antigens were localized in frozen sections of enucleated eyes at 10 to 14 days post-inoculation. Injected eyes of BALB/c mice showed an anterior uveitis with HSV-1 antigens in the anterior segment and an intact retina free of HSV antigens. The retina of the contralateral uninjected eye was necrotic and contained HSV-1 antigens. In both C57Bl/6 and F1 mice, HSV antigens were limited to anterior segment structures in the injected eye, whereas, in contrast to BALB/c mice, the contralateral retina appeared histologically normal and contained no viral antigens. The C57Bl/6 and F1 strains remained relatively resistant to retinal infection even if pretreated with up to 800 Rads of irradiation. The retinas of normal or sublethally irradiated C57Bl/6 and F1, but not BALB/c strains, were also resistant to intravitreal injection of HSV. These results suggest that resistance to HSV retinitis is a dominantly inherited trait, which depends only partly upon immunologic factors and may be heavily influenced by the inherent ability of host cells from different murine strains to support a productive viral infection.

Animals↗
PubMed1987

Immunogenetics of autoimmune thyroid disorders.

The loci determining polymorphism of genes involved in the immune response feature prominently in the susceptibility to autoimmune thyroid disease. However, disease phenotypes do not segregate perfectly with the genetic markers. The interaction between the influence of these loci on susceptibility is complex, and when taken in the context of the multilayered, multidirectional workings of the immune network and that of as-yet-unspecified environmental factors, our difficulty in predicting the susceptible phenotypes is not surprising.

Genetic Markers↗
PubMedDate not supplied

Primary biliary cirrhosis and rheumatic diseases: a clinical, immunological and immunogenetical study.

Clinical investigation of Primary Biliary Cirrhosis (PBC) patients showed an elevated frequency of rheumatic disorders, as well as their frequent appearance in asymptomatic PBC. Anticentromere region antibodies in PBC patients were pathognomonic for concomitant complete or incomplete CREST syndrome. These antibodies were only found on the HEp2 cell substrate. The constant finding of immune-complexes (IC) with IgM antibody component suggests that they play a role in the pathogenesis of PBC. No statistically significant correlation was found between the amount and classes of circulating IC, HLA class I antigens and rheumatic disorders during PBC.

Adult↗