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PubMed1982

Infant mortality: world estimates and projections, 1950-2025.

Although the infant mortality rate is considered 1 of the preferred indicators for describing both demographic conditions and the overall and social economic well-being of a country, comparable and consistent estimates and projections of infant mortality for all countries of the world have been lacking. In an attempt to improve this situation, the UN Population Division, with the support and encouragement of the UN Children's Fund and the assistance of the World Health Organization and the UN regional commissions, has recently completed a comprehensive project which provides estimates and projections of infant mortality for all world countries for the period 1950-2025. This article reviews the estimates and projections produced by this project. The various sources and the quality of the data, as well as the methods employed to estimate current and past levels of infant mortality and to project future trends, are reviewed and evaluated. The article concludes with a discussion of the results vis-a-vis the goals set for infant mortality by the World Population Plan of Action and the International Development Strategy for the 3rd UN Development Decade.

Data Collection↗
PubMed1981

The historiography of hunger: changing views on the world food problem, 1945-1980.

The author discusses changing views on the world food problem since 1945. "The extent of the problem has been a matter of debate as hunger cannot be directly measured; estimated minimum requirements for energy have been reduced since 1945 and the causes of malnutrition reappraised. World food production has kept up with population growth since 1945, as it has in all major regions except Africa. But when individual countries are considered, food output per head has been declining since 1961-5 in many countries in Africa and Asia. Food output has been increased in the developing countries by expanding the area under cultivation and by increasing yields." In addition the author concludes that "the Green Revolution has however not achieved early expectations and has had some adverse economic and social consequences. Because world food output per caput has risen considerably since 1945, some have argued that the world food problem is one of distribution, not production. Data on food output per caput suggest this is not always so."

Agriculture↗
PubMed1991

Acute respiratory infections in children in the developing world.

The profound decline in death rates from respiratory infections in recent decades in the developed countries of the world is a complex phenomenon that probably results from a combination of socioeconomic and environmental change and modern medical care. Death rates from respiratory infections in the developing world are very variable, and there is evidence that they can decrease dramatically when effective health services are engrafted onto a social environment in which mothers are literate and trained to observe their children's health. A worldwide case management program aimed at making lifesaving antibiotics and oxygen available for treatment of children in deprived areas is currently being spearheaded by the World Health Organization and rests on simplified approaches to diagnosis that are widely disseminated to parents and primary health workers. These guidelines have been shown in field studies to contribute to changes in child mortality. The epidemiology of pneumonia in childhood seems similar worldwide. Most children suffer five to eight respiratory infections annually if they live in the cities and fewer if they live in rural areas but, in deprived circumstances, pneumonia complicates the infection much more often and the principal organisms are pneumococcus and Haemophilus influenzae. A vaccine approach to these two organisms is attractive and needs further field testing. Meanwhile, a case management approach, making antibiotics available on a rational basis worldwide, is capable of saving lives. Until mothers in the developing world have confidence in the survival of their children, they are unlikely to be attracted to control of their fertility.

Bacterial Vaccines↗
PubMed1985

[Evaluation of world health: current status].

In this first article dedicated to the balance of the world health, the author gives the main reasons which explain the spectacular growth of the world population. From 1950 to 1984, population increased by 93% shifting from 2.5 to 4.8 thousand millions among which 3.5 are living in Third World countries and 1.3 in industrialized ones. Then he studies the factors which originate the inequality of men in the face of disease and death, and gives some details on causes for mortality to-day. In industrialized countries, three fourth of deaths are due to two diseases, which are cardio-vascular diseases (48%), and cancer (19%), while in Third World countries, the major risk factors are transmissible diseases, malnutrition and lack of environmental hygiene. Infantile mortality makes it clear; out of 122 millions children born in 1980, according to WHO evaluation, more than 10 millions die before they get one year old, and 5 millions between one and five years of age. This inequality of people in the face of life and death is one of the biggest scandals of our time, especially because we have the technical means to reduce it. It will require a considerable effort from governments, international organizations and NGOs to reach the WHO object of "Health for All by the year 2000". These prospects for the future will be developed in the second part of this article to be published in a next issue of Hygie.

Child, Preschool↗
PubMed1977

[Global review of tuberculosis morbidity and mortality in the world (1961-1971)].

The main objective of gathering available world-wide information on tuberculosis is to present an overall picture of how tuberculosis infection, morbidity and mortality, can be reflected today and to suggest the necessity to improve international epidemiological statistical intelligence. The highest levels of tuberculosis infection in the world (i.e. 60-80% in children 14 years old) may be found in eastern Asia, Oceania and in several areas in Africa. Considerable differences still do exist between the highest and lowest prevalence level within each continent. The ratio between the highest and lowest prevalence level of infection is varying from 1 to 2 in the Americas, to 1 to 10 in Europe. While, in general, in developed countries the annual infection rate reached 0.5% (1969-1972), in developing countries, annual infection rates of 2% or more were reported. The decrease of the annual infection rate in developed countries is, in general, 10% each year, whereas in the developing part of the world the fall in the rates has been slower or the level even remained constant for the last ten years. The information concerning tuberculosis morbidity is sometimes incomplete or inconsistent because of the lack of standard criteria for diagnosing and reporting tuberculosis. Although the bacteriological confirmation of tuberculosis cases has an important bearing on the recording system, official reports are particularly deficient in this respect. Estimating the total number of newly registered tuberculosis cases, one may say that more than 3.8 million, and approximately 4 million cases could have occurred 1967 and 1971 respectively. The prevalence of tuberculosis cases can be estimated to be around 6-8 in 1967 and 8 million cases in 1971. The highest incidence rates reported in 1971 were in Asia, Oceania and in some African countries (i.e. 250-523 per 100000 population). In Europe and America, tuberculosis incidence did not exceed a level of 200 per 100000 population. The average tuberculosis incidence rate for 1971 in the world may be estimated to be 111.5 per 100000 population (111.4 in 1967).

Adolescent↗
PubMed1980

[The world is free of pox - Implementation and success of a grandiose program].

At the beginning of this century the compulsory vaccination and revaccination which was legally founded after the introduction of the vaccination by Jenner (1796) led to the removal of the smallpox in Europe and Northern America. However, up to the sixties in the developing countries of Asia, Africa as well as of Southern America and Middle America still fell ill and died of small-pox millions of people. Between 1953 and 1973 importations into countries of Europe and Northern America took place in 51 cases. In 1959 on the motion of the USSR the WHO decided performance of a world-wide eradication programme of small-pox which could be led to success with comprehensive personal, material and financial support of many countries. Flanking scientific, technological and methodical measures were of essential importance. In May 1980 the World Health Assembly in Geneva announced in solemn form the world-wide eradication of the small-pox and gave recommendations to the member countries for concluding measures concerning the small-pox vaccination, the foundation of vaccine reserves and the control of the epidemiological situation in the world. Also in the GDR the small-pox vaccination in childhood could be abolished.

Developing Countries↗
PubMed1997

[BCG vaccines for the prevention of tuberculosis in the world].

The BCG vaccines will celebrate the 100th anniversary of their discovery in a decade at the beginning of the next century since Albert Calmette and Camille Guerin had presented it before the Academie des Sciences in 1908. At present tuberculosis kills more people than any other infectious disease about 3 million people a year, including almost 300,000 children under 15, and is producing over 7,000 deaths and over 24,000 new cases every day. Therefore, WHO declared a global health emergency in 1993. More worse, recently multi-drug resistant tubercle bacilli are emerging rapidly making TB patients incurable. Under these situations we need a potent anti-tuberculosis vaccine. So first of all, we must check the century-old BCG before proceeding further. At moment, the BCG vaccines are being used worldwide in the largest quantities in the world, but still most controversial vaccines anywhere. I would like to describe here their success and failure in the combat against the white plague. 1. The Expanded Programme on Immunization (EPI). In 1974, when the EPI was launched by WHO, less than 5% of the world children were immunized against six infectious diseases including tuberculosis. In 1995 statistics, BCG gave the highest vaccination coverage, 87% higher than any other 5 vaccines of EPI for children. The BCG in EPI must have saved a lot of infants as the vaccine, has been proved to be most effective against the blood-born tuberculosis of child type. 2. The efficacy of BCG vaccination against tuberculosis. Results of each 10 of randomized controlled trials (RCT) and Case-control studies (CCS) showed the protective efficacy against tuberculosis as uncertain, unpredictable, as protective efficacy varied from 80% to 0%. More recently, a Meta-analysis of selected papers on BCG field trials which were so far collected. They recalculated vaccine protective effect separately for pulmonary TB and for meningeal/miliary TB in the trials. As the result, it was found that protective effect against pulmonary TB could not be calculated, but protective effect against meningeal and miliary TB was calculated as 86%, 75% respectively, in RCT and CCS, being higher than against pulmonary TB. 3. The duration of BCG efficacy against tuberculosis was confirmed to continue for 15 years after vaccination. The incidence of every form of tuberculosis decreased steeply during the 15 years following vaccination. 4. BCG revaccination. A WHO statement was issued in 1995 mentioning that there is no definitive evidence that repeated BCG vaccination confers additional protection against tuberculosis. Therefore WHO has not recommended to repeat BCG vaccination because of no scientific evidence to support this practice. Multiple BCG revaccinations are not indicated in any persons. 5. Complications with BCG Second IUATLD study (1988) on complications induced by BCG was reviewed, especially following two points: 1-2) Regional suppurative lymphadenitis 3) Generalized lesions: fatal cases 1-2 Several African regions had experienced that the risk of outbreak of suppurative BCG lymphadenitis was low for vaccines with Glaxo and Japanese strains, but much higher for vaccines with Pasteur. This experience in nineteen eighties has led EPI to replace the Pasteur BCG vaccine with less reactogenic BCG, Japanese or Glaxo BCG to solve the outbreak of suppurative adenitis complication. 3 At moment, the only contra-indication of EPI BCG vaccination is symptomatic HIV infection (AIDS), but in the future asymptomatic HIV infection should be placed on alert, because fatal BCG generalized disseminations have already been experienced by HIV positive vaccinees although in a few cases in USA. 6. BCG seed lots for use of vaccination in the world. Nearly 10 seed lots (BCG) are being used in the world at present. However, they are more or less different each other in various characteristics: morphological, biochemical, biophysical, immunological, vaccinological and so on. None of them is the same

BCG Vaccine↗
PubMed1994

Harvey Cushing, Gordon Holmes, and the neurological lessons of World War I.

As the gunshots that fatally wounded Archduke Franz Ferdinand and Countess Sophie of Austria resounded from Sarajevo across Europe to become the deafening roar of artillery on the Western Front in August 1914, Harvey Williams Cushing was the world's preeminent neurosurgeon and Gordon Morgan Holmes was arguably the foremost neurologist in the world. The 45-year-old Cushing, and Holmes just 38 years old, would strive to respond to the neurological challenges of World War I. They distinguished themselves amidst the redoubtable efforts of workers such as Walter Cannon, George Riddoch, Charles Sherrington, Henry Head, Victor Horsley, Walther Poppelreuter, and Robert Barany. Even the intense martial spirit of the time would be held in abeyance by the contributions of such men of science, as when the intercession of Prince Carl of Sweden secured the release of Barany from a Russian prisoner-of-war camp and allowed him to accept the 1916 Nobel Prize for his exposition of vestibular physiology. Such respite from the brutality of war was all too brief, and if we are to grasp the significance of the different approaches of Holmes and Cushing to the terrible problems of World War I, we must examine some of the harsh medical realities that they confronted in the "war to end all wars."

Brain Injuries↗
PubMed2002

Tracheoesophageal speech in a developing world community.

OBJECTIVES: To determine the tracheoesophageal speech results in a Third World medical practice; to examine the impact of socioeconomic status, literacy, and proximity to specialist services on tracheoesophageal speech; to assess whether these factors should affect patient selection for fistula speech; and to determine guidelines for voice prosthesis selection. DESIGN: Retrospective analysis. SETTING: Groote Schuur Hospital, Cape Town, South Africa, which serves a Third World community. PATIENTS: Ninety-seven consecutive patients who underwent total laryngectomy between January 1, 1996, and October 1, 1998. Patients who undergo total laryngectomy routinely have a primary tracheoesophageal fistula created for speech. MAIN OUTCOME MEASURES: Speech outcomes after total laryngectomy; tracheoesophageal speech in relation to social class, literacy, and proximity to specialist services; and experience with removable and indwelling valves. RESULTS: Fifty-nine (81%) of 73 patients acquired useful speech. Speech outcome was not affected by employment status or proximity to specialist services. Although speech was affected by literacy and housing, several illiterate shack dwellers acquired good speech. Average device life of removable prostheses was 16 weeks (>4 months in 35% [64/183]). Indwelling prostheses had an average life of 28 weeks. CONCLUSIONS: Tracheoesophageal speech results in a Third World community equate with those in the Developed World. All patients who undergo laryngectomy and have adequate manual dexterity and cognitive function should be given a trial of fistula speech. Removable voice prostheses can successfully be used as indwelling prostheses.

Adult↗
PubMed1999

A world from brave to new: Talcott Parsons and the war effort at Harvard University.

This article argues that for Parsons and some of his colleagues at Harvard, the Second World War and the post-war period provided a context in which their work contributed to the transformation from totalitarianism to democracy in Central Europe (especially Germany) and Japan. The various agendas of Parsons' work are shown, supplemented by that of three of his colleagues with whom he collaborated (Gordon W. Allport, Carl J. Friedrich, Clyde Kluckhohn). The immediate effect of this work, for Parsons, however, meant frustration rather than fame, and his eventual reputation, I maintain, came unexpectedly with the third of his three attempts in the immediate post-war period to sum up what he believed were crucial insights that the Second World War had yielded concerning the ways in which sociology could contribute to the analytical understanding of democracy. The significance of this work is that it was both political and scientific. Because of the world situation of the 1940s, when the Holocaust in Germany was the nadir of civilization, Parsons believed that social science could contribute to the cause of making the world safe for future democracy. In the 1940s, this future depended on brave citizens, or such might have been Parsons' worldview. Targets envisaged for the 1950s, then, were community and citizenship in the newly democratic societies such as (West) Germany, the land that defeated Nazism.

Democracy↗
PubMed2000

Humans and old world monkeys have similar patterns of fetal globin expression.

The expression of epsilon- and gamma-globin mRNA and protein has been determined in three Old World monkey species (Macaca mulatta, Macaca nemestrina, and Cercopithecus aethiops). Using RT-PCR with primers for epsilon- and gamma-globin, both mRNAs were detected in early fetal stages, whereas at 128 days (85% of full term), only gamma was expressed. High-performance liquid chromatography was used for separation and quantitation, and matrix-assisted laser desorption/ionization mass spectrometry was used for identification of globin polypeptides. An alpha-globin polymorphism was observed in all of the species examined. During fetal life, gamma-globin was the predominant expressed beta-type globin. The red blood cells of infants still contained substantial amounts of gamma-globin, which declined to negligible levels in 14 weeks as beta-globin expression reached adult values. The ratio of gamma1- to gamma2-globins (equivalent to Ggamma/Agamma in humans) was approximately 2.5, similar to the Ggamma/Agamma ratio observed in humans. Thus, gamma-globin gene expression in these Old World monkeys species has three features in common with human expression: expression of both duplicated gamma genes, the relative preponderance of gamma1 over gamma2 expression, and the delay of the switch from gamma- to beta-globin until the perinatal period. Thus, the catarrhines seem to share a common pattern of developmental switching in the beta-globin gene cluster, which is distinct from the timing of expression in either prosimians or the New World monkeys. Our results indicate that an Old World monkey, such as Rhesus, could serve as a model organism (resembling humans) for experimentally investigating globin gene expression patterns during the embryonic, fetal, and postnatal stages.

Animals↗
PubMed1979

Human treponematosis and tuberculosis: evidence from the New World.

The purpose of this study has been first, to critically review the evidence for the presence of human treponematosis and tuberculosis in the skeletal remains of prehistoric natives in the New World, and second, to report on nine new cases dated to before contact and suggesting the presence of these two disease conditions. A review of the medical history and findings by human paleopathologists leaves little doubt that both diseases originated in the Old World. The findings of this study lend further support to the fact that, although rare, human treponematosis and tuberculosis were indeed endemic in the pre-Columbia New World before contact. There is no evidence that these two diseases could have arisen independently and de novo, especially during the relatively short time since man's arrival in the New World. Where a disease has been endemic for quite some time as appears to be the case with human treponematosis and tuberculosis, milder forms of the disease and improved host response could have developed in which only the most severe cases would be observable. This explains the rarity of skeletal lesions suggestive of these two human disease conditions in prehistoric human populations.

Adult↗
PubMed1982

The functional morphology of caudal vertebrae in New World monkeys.

New World monkeys vary considerably in the manner and degree to which they use their tails. There ought to arise a corresponding variation in the stresses on caudal vertebrae. Consequently, different behavior types will have contrasting caudal morphologies. This study investigates caudal morphology of several New World monkeys representing the large range of ability from totally nonprehensile tails to the dexterous fifth limb of spider monkeys. One large-bodied, nonprehensile-tailed Old World monkey is included to offset the correlation between size and degree of prehensility in New World monkeys. These monkeys vary both within and between species as to the number of caudal vertebrae and the length of individual vertebrae. Despite this variation, the length of caudal vertebrae within a given tail decreases at a constant rate across species. The width of the vertebrae at two points, midbone and the proximal end, separates the monkeys with prehensile tails from those with nonprehensile tails. The middle of the vertebrae is wider and more robust in prehensile-tailed forms. This is associated with stronger bones in tails subject to greater stress. THe proximal width of each bone is also greater in the prehensile-tailed monkeys. This measure reflects the lateral development of the proximal transverse process. This provides a larger lever arm for M. caudalis lateralis, implying greater rotational ability.

Animals↗
PubMed2007

On the time scale of New World primate diversification.

New World primates comprise a diverse group of neotropical mammals that suddenly appeared in the Late Oligocene deposits of South America at around 26 million years ago (MYA). Platyrrhines seem to have separated from Old World anthropoids ca. 35 MYA, and their subsequent diversfication is not well documented in the fossil record. Therefore, molecular clock studies were conducted to unveil the temporal scenario for the evolution of the group. In this study, divergence times of all splits within platyrrhines until the generic level were investigated, using two different gene data sets under relaxed molecular clocks. Special attention was paid to the basal diversification of living platyrrhines and to the basal split of the modern Cebidae family, since these nodes were reported to be phylogenetically difficult to resolve. The results showed that analyses from various genomic regions are similar to estimates obtained by early single-gene studies. Living New World primates are descendants of ancestors that lived in the Early Miocene, at around 20 MYA, and modern Cebidae and Pitheciidae appeared ca. 16.9 and 15.6 MYA, respectively. The last common ancestor of living Atelidae is 12.4 million years old, making this clade the youngest New World primate family; at approximately the same time, modern Callitrichinae was evolving (11.8 MYA). The gap between the Platyrrhini/Catarrhini separation and the last common ancestor of living Platyrrhini may be as big as 20 million years. Paleontological and geoclimatological evidence corroborates that the sudden appearance of modern families may be a consequence of environmental changes during the Miocene.

Animal Migration↗
PubMed2006

Ipsilateral cortical connections of dorsal and ventral premotor areas in New World owl monkeys.

In order to compare connections of premotor cortical areas of New World monkeys with those of Old World macaque monkeys and prosimian galagos, we placed injections of fluorescent tracers and wheat germ agglutinin-horseradish peroxidase (WGA-HRP) in dorsal (PMD) and ventral (PMV) premotor areas of owl monkeys. Motor areas and injection sites were defined by patterns of movements electrically evoked from the cortex with microelectrodes. Labeled neurons and axon terminals were located in brain sections cut either in the coronal plane or parallel to the surface of flattened cortex, and they related to architectonically and electrophysiologically defined cortical areas. Both the PMV and PMD had connections with the primary motor cortex (M1), the supplementary motor area (SMA), cingulate motor areas, somatosensory areas S2 and PV, and the posterior parietal cortex. Only the PMV had connections with somatosensory areas 3a, 1, 2, PR, and PV. The PMD received inputs from more caudal portions of the cortex of the lateral sulcus and more medial portions of the posterior parietal cortex than the PMV. The PMD and PMV were only weakly interconnected. New World owl monkeys, Old World macaque monkeys, and galagos share a number of PMV and PMD connections, suggesting preservation of a common sensorimotor network from early primates. Comparisons of PMD and PMV connectivity with the cortex of the lateral sulcus and posterior parietal cortex of owl monkeys, galagos, and macaques help identify areas that could be homologous.

Animals↗
PubMed1987

Anatomical demonstration of ocular segregation in the retinogeniculocortical pathway of the New World capuchin monkey (Cebus apella).

We describe the architecture of the dorsal lateral geniculate nucleus and primary visual cortex (striate cortex; area 17) of the New World capuchin monkey (Cebus apella) on the basis of the distribution of cell bodies and cytochrome oxidase histochemistry. Changes in staining for cytochrome oxidase following unilateral enucleation served to indicate the organization of the representation of the two eyes in the retinogeniculocortical pathway. The number and disposition of eye-specific layers within the lateral geniculate nucleus of Cebus are consistent with the common plan of geniculate organization in anthropoid primates, and the radial organization of area 17 fits the pattern common to New World squirrel and Old World macaque monkeys, including the presence of cytochrome-oxidase-rich zones in supragranular and deeper cortical layers (Horton: Philos. Trans. R. Soc. Lond. [Biol.] 304:199-253, '84). Our principal finding is that cytochrome oxidase histochemistry following unilateral eye removal unequivocally reveals ocular dominance columns in the striate cortex of Cebus. As in the macaque (Hubel: Nature 292:762-764, '82), ocular dominance columns extend through the thickness of cortex and blobs are centered on columns, but the array of columns viewed tangentially is less orderly or more mosaic than in the macaque, and there is apparently significant overlap between columns. The presence of well-defined ocular dominance columns in Cebus, as in Ateles (Florence, Conley, and Casagrande: J. Comp. Neurol. 243:234-248, '86) but not in other New World monkeys examined previously, emphasizes the phylogenetic lability of binocular segregation in the primate visual cortex. In addition, the present results indicate significant differences with respect to the tangential organization of the ocular dominance domain between primate species in which ocular dominance columns are present.

Animals↗
PubMed2002

Antimutagenic effects of black tea (World Blend) and its two active polyphenols theaflavins and thearubigins in Salmonella assays.

Almost two thirds of the world population consume tea everyday. Tea is processed differently in different parts of the world to give green (20%), black (78%) or oolong tea (2%). The antimutagenic and anticarcinogenic activities of green tea were extensively investigated compared with those of black tea. Considering the potent antimutagenic effects of green tea we recognized the need to evaluate the antimutagenic effects of black tea (World Blend Tea, Southern Tea Co., Marietta, GA) in Salmonella strains TA97a, TA98, TA100 and TA102 in preincubation tests, both with and without S9 activation. Attempts have also been made to compare the results of the tea extracts with their two active polyphenols theaflavins and thearubigins. Antimutagenicity assays were carried out in bacterial plates treated with different concentrations (1%, 2.5%, 5%, 10% and 20%) of tea extracts against known bacterial mutagens sodium azide, 4-nitro-o-phenylenediamine, cumine hydroperoxide, 2-aminofluorene and danthron. A significant decrease in the number of revertant colonies was observed in the plates treated with 1% to 20% of tea extract plus positive mutagen when compared with positive mutagen only. Both the active polyphenols theaflavins and thearubigins extracted from the black tea (World blend) also showed significant antimutagenic effects against known positive compounds in these strains. In the experiments with S9 activation, the antimutagenic effects were significantly higher. These results indicate that black tea and its two polyphenols have significant antimutagenic effects in Ames Salmonella assays.

Animals↗
PubMed1993

Molecular phylogeny of the New World monkeys (Platyrrhini, primates).

Phylogenetic relationships among the 16 extant genera of Ceboidea (the New World monkeys) were examined using aligned epsilon-globin gene sequences from 19 New World monkeys (representing all 16 extant ceboid genera), and seven catarrhines (one Old World monkey and six hominoids) and tarsier as the outgroups. The consensus maximum parsimony tree found for these epsilon-globin sequences and the levels of support from parsimony and bootstrap analyses, for the clades in this tree, provided strong evidence for a cladistic classification with the following clusters. Subtribes Callitrichina (Callithrix, Cebuella), Callimiconina (Callimico), Leontopithecina (Leontopithecus), and Saguina (Saguinus) constitute subfamily Callitrichinae, and subfamilies Callitrichinae, Aotinae (Aotus), Saimiriinae (Saimiri), and Cebinae (Cebus) constitute family Cebidae. In turn, subtribes Chiropotina (Chiropotes, Cacajao) and Pitheciina (Pithecia) constitute tribe Pithecini, tribes Pitheciini and Callicebini (Callicebus) constitute subfamily Pitheciinae, tribes Atelini (Brachyteles, Lagothrix, Ateles) and Alouattini (Alouatta) constitute subfamily Atelinae, and subfamilies Pitheciinae and Atelinae constitute family Atelidae. The two families (Cebidae and Atelidae) constitute the Ceboidea, the only extant superfamily of infraorder Platyrrhini. The sister-group relationships of Brachyteles and Lagothrix, Saguinus and Leontopithecus, and Callimico with a Cebuella/Callithrix clade is not as well supported by the parsimony and bootstrap analyses. Therefore, these relationships are not incorporated in the proposed cladistic classification. On determining branch lengths for the ceboid phylogenetic tree from only the more freely evolving noncoding sequences at the epsilon-globin locus and taking the reference age of 35 million years ago (MYA) for the New World monkey-catarrhine branch point, we estimated the age of the atelid-cebid branch point as about 20 MYA, and the ages of the next branch points, those between the subfamilies in each family, as 19-16 MYA.

Animals↗