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Molecular genetic study of the gutter shaped root (GSR) on mouse chromosome 17.

In this study, a genetic factor affecting the appearance of the gutter-shaped root (GSR) in mice was examined using two inbred strains of mice, C57L/J and C57BL/6J, and the genetic crosses of these strains. 120 Mit markers, which exist on mouse chromosome 17, have been investigated to select polymorphic markers between the two strains. Nine Mit markers with polymorphism between the two strains were obtained using polymerase chain reaction (PCR). To detect the individual genotype of 66 backcross mice, simple sequence length A polymorphism (SSLP) analysis was performed. From the results of individual genotyping using 9 informative markers, the highest linkage was determined at D17Mit260. Based on these findings, it was suggested that the gene causing the mouse GSR might be located on mouse chromosome 17 and nearby D17Mit260.

Animals↗

Prevalence of malocclusion in 6-year-old Icelandic children.

The prevalence of different malocclusion features was investigated in 396 6-year-old Icelandic children, using the epidemiologic registration method described by Björk et al. in 1964. Girls were ahead of boys with regard to dental stage (P < 0.01). One or more permanent teeth were congenitally missing in 5% of the children. Postnormal occlusion was found in 27% of the boys and in 31% of the girls, and prenormal occlusion was found in 6% and 5%, respectively. Straight terminal plane at the second deciduous molars was found in individuals with either normal or postnormal occlusion. Thus, it can be misleading to use the relation of the terminal planes as a measurement of the sagittal relation between the jaws. The prevalence of hypodontia was much lower than has been reported previously for Icelandic children.

Age Determination by Teeth↗

Non-syndrome multiple supplemental supernumerary teeth.

Multiple supernumerary teeth without any associated systemic conditions or syndromes are not common. We document a case of non-syndrome multiple supplemental supernumerary teeth in mandibular premolar region of an adolescent male patient, an incidental findings during routine radiographic examination. Periodic examination is recommended to monitor the clinical behavior.

Adolescent↗

Compound composite odontome associated with an unerupted deciduous incisor--a rarity.

Odontomes are considered to be hamartomatous malformation rather than true neoplasm and are generally asymptomatic. Here is a case presentation of compound composite odontome with impacted deciduous teeth in an 11-year-old girl. A calcified mass was revealed in the radiograph and the case was finally diagnosed to be compound composite odontome. The mass was surgically excised.

Child↗

Dilacerated unerupted central incisor: A case report.

Dilaceration of permanent successors is one of the most common complications of trauma to the deciduous teeth. It is advisable to keep these patients under observation post-trauma and to consult an orthodontist at an early stage to prevent unfavorable sequelae. Presented here is a typical case of dilaceration.

Child↗

[Recombinant study of mouse enamel organ and dental papilla by renal transplantation: effects of discrepancy in number of these two components].

Interactions between the epithelium and mesenchyme were very important in tooth development. When these relationships changed qualitatively or quantitatively, developmental tooth abnormalities or odontogenic lesions might develop. In order to clarify this hypothesis, we examined the effects of discrepancy in the number of enamel organs and dental papilla on histo- and morpho-differentiation of the recombinants by renal subcapsular transplantation. Five kinds of recombinants were prepared from the enamel organs(E) and dental papilla (M) of the mandibular first molars of 17-gestational-day C3H mice: group 1 (E/M = 2/6), group 2(E/M = 3/5), group 3(E/M = 4/4), group 4 (E/M = 5/3) and group 5 (E/M = 6/2). After 28 days of transplantation, all the grafts were harvested and examined roentogenographically and histopathologically. All the grafts developed into teeth. The teeth of groups 1 and 5 were independent from each other and the teeth of groups 2, 3 and 4 fused with each other by dentin. The number and size of the teeth depend on the number of M and the differences between E and M of the recombinants, respectively. The smaller the difference, smaller was the teeth size. The cysts lined by the keratinizing squamous epithelium developed from E-rich recombinants. These could be comparative to the compound odontoma, fused teeth and odontogenic keratocyst of the human being respectively. It might be speculated that the histogenesis of these lesions might be related to the quantitative change in the epithelial-mesenchymal interactions of odontogenesis.

Animals↗