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PubMed2004

New woody and ambery notes from cedarwood and turpentine oil.

The development of a new product in the chemical industry is still driven by needs like technical properties, price/performance ratio, biodegradability, or product safety. However, in terms of improving more and more on ecological criteria, summarized under such catchphrases as sustainable development or green chemistry, another important aspect is to use renewable resources as starting materials. This is not significantly new in fragrance chemistry, and there are a lot of raw materials in the perfume oils that are derived from molecules of renewable resources. Two commonly used materials are: longifolene (from turpentine oil) and cedrene (from cedarwood oil). These compounds are very suitable for the synthesis of woody and ambery notes, and even though it seemed that all possibilities were exhausted, it is actually still feasible to discover new molecules with excellent olfactory properties such as Ambrocenide (50a), which is available in three steps from alpha-cedrene. Some of these molecules will be treated in this review, both with respect to synthesis as well as structural and sensory aspects.

Oils, Volatile↗
PubMed1986

Normal computerized tomography scans in severe head injury. Prognostic and clinical management implications.

The authors analyze the clinical course of 46 severely head-injured patients who had completely normal computerized tomography (CT) scans through the immediate posttraumatic period (1 to 7 days after trauma). These patients represent 10.2% of a consecutive series of 448 cases of severe head injuries and two-thirds of the cases showing a normal CT scan on admission (the other one-third of the cases developed new pathology). The usual course in these 46 patients after the initial coma was toward progressive neurological improvement, and 35 patients (76%) achieved a functional level of survival. Nine patients (19.5%) remained comatose for several weeks and developed severe disability. There were two fatalities due to medical complications. The final outcome was more closely related to the duration of coma (the longer the duration the worse the result) than to the initial Glasgow Coma Scale (GCS) score. In fact, 26% of the patients in the lower GCS score ranges (3 to 4 points) made a good recovery and 46% developed moderate disability only. These findings indicate that the grim prognostic significance of deep posttraumatic coma is tempered in the presence of a normal scan. However, the absence of CT abnormalities in severely head-injured patients cannot be equated with a good prognosis because in one-fifth of the cases serious permanent disability develops. Sustained elevation of the intracranial pressure (ICP) was not seen in these patients, indicating that ICP monitoring may be omitted in cases with a normal scan. However, since one-third of the patients with a normal admission scan developed new pathology within the first few days of injury, a strategy for control scanning is recommended. Control CT scans performed more than 6 months after injury showed a significantly higher incidence of brain atrophy in patients developing permanent disability than in those who made a good recovery.

Adult↗
PubMed2002

[Important ecological topics on regional scale ecosystem management in China].

Ecosystem management is a synthetic applied ecology concerning ecosystem management theories, practical technologies, relevant policies and management strategies. It is not only an urgent need for the sustainable development of human society, but also an important tendency and scientific task of ecosystem management to develop integrated studies on models of global or regional scale ecosystem management and the relevant scientific problems. For this reason, we systematically expounded a series of important ecological topics, such as the synthetic evaluation and ecological mechanism of the services, sustainability, complexity, and indeterminacy of ecosystem, the ecological basis of natural resources conservation, ecosystem health, and the rehabilitation of degraded ecosystem, basic ecological processes for ecosystem management, theories and practice on adaptive management of ecosystem, ecosystem network study, monitor, and achievement integration, as well as synthetic special topic studies on regional scale ecosystem management etc. Research advances and tendencies of these topics at home and abroad were also reviewed.

China↗
PubMed1998

[Environmental primary care for the 21st century].

Primary environmental care combines the original strategy proclaimed at Alma-Ata as primary health care and the conception of integral rural development that emerged from the agrarian policies of Third World countries during the seventies. Within the renewed goal of health for all in the 21st century, the primary environmental care strategy may be considered as all those actions necessary to improve and protect the local surroundings through foresight and prevention of possible problems, with tasks institutionalized at the local level. Analysis and practice of this strategy are based on a model focused on the promotion of human beings, the environment, and social development. Furthermore, it is founded on critical theory and has a holistic perspective. This operational frame encourages participation and action, thus endowing individuals, communities, and societies with the power to make decisions. In this way, leadership is created for the sustainable development of nations.

Environmental Health↗
PubMed2005

Soil health -- a new challenge for microbiologists and chemists.

Soil health refers to the biological, chemical, and physical features of soil that are essential to long-term, sustainable agricultural productivity with minimal environmental impact. Thus, soil health provides an overall picture of soil functionality. Although it cannot be measured directly, soil health can be inferred by measuring specific soil properties (e.g. organic matter content) and by observing soil status (e.g. fertility). There is also increased interest in studying soil microorganisms in their particular environments, as microbial diversity is intimately related to soil structure and function. One of the key objectives in determining soil health is to acquire indicators that can be used to evaluate the soil's current status and hence to develop sustainable agricultural systems. In this regard, significant progress has been made over the last few years in the development of specific biomarkers and macromolecular probes, enabling rapid and reliable measurements of soil microbial communities. In addition, modern molecular biological techniques, such as fluorescence in situ hybridization (FISH), reverse transcriptase polymerase chain reaction (RT-PCR), denaturing gradient gel electrophoresis (DGGE), and terminal restriction fragment length polymorphism (T-RFLP), have facilitated the analysis of microbial biodiversity and activity, whereas the application of modern analytical techniques, such as nuclear magnetic resonance (NMR) and pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS), have provided data on soil chemistry. The combination of these two approaches offers promise in determining soil health status.

Bacteria↗
PubMed1989

The pharmacokinetics of a new sustained-release form of diclofenac sodium in humans.

In the present study, two sustained release diclofenac preparations were administered every 12 hours over 4 days to ten human volunteers. Diurnal profiles were recorded on the 1st and 4th days, from which pharmacokinetic parameters were calculated: particular attention was given to cumulation. One, a newly developed sustained release formulation, had a MRT of 5.5 hours, and showed surprisingly small variation coefficients [AUC ss (72-84 hrs) +/- 26%; Cmax ss (72-84 hrs) +/- 19%] after 7 administered doses; accordingly, the maximum concentrations were within a very narrow time window [tmax ss (72-84 hrs) range: 1.5-2.5 hours after administration]. Due to the selected release profiles with this formulation, there was no danger of cumulation in spite of administration every 12 hours [AUC 0-12 hrs, mean value = 1555 ng/ml x h; AUC ss 72-84 hrs, mean value = 1750 ng/ml x h].

Adult↗
PubMed1994

Developing a clinical information system: the role of the chief information officer.

BACKGROUND: Chief information officers (CIOs) must play a pivotal role in the formation and implementation of a clinical information system, the subset of an organizational information system that deals specifically with support of clinical care activities. MAJOR ELEMENTS OF A CLINICAL INFORMATION SYSTEM: Major elements include the applications software, technology and data architecture, databases, and analysis. The organizational structures and processes that manage the development of improvement activities, including the clinical information system itself, are just as vital to the design of an information system as the hardware and software. THE ROLE OF THE CIO: To develop, sustain, and advance an information infrastructure, the CIO must help establish certain organizational precursors, such as medical staff involvement, experience with quality improvement, and ability to meet data needs. The CIO must then work with the senior administrative and medical leadership in developing a vision for the information system. The CIO must also create new roles and knowledge for information system and medical staff members. Interaction between information services and medical staff is vitally important to the success of a clinical information system. Organizational committees and structures that Brigham and Women's Hospital in Boston put in place to formalize the relationship between information systems and medical staff include the Clinical Initiative Development Program and the Center for Applied Medical Information Systems Research. CONCLUSION: Improving the clinical management of care and the efficacy of care processes involves complex changes in organizational culture and processes, medical practice and information system applications, technologies, staff, and data.

Academic Medical Centers↗
PubMed2005

Social sustainability and collaborative learning.

The social dimension is central to sustainable development of agri-food systems. If farmers are not satisfied with their situation or motivated to continue farming, many of today's environmental goals will be impossible to achieve. Between 1997 and 2003, several case studies were carried out on social sustainability, the importance of recognition in the farming system, and the potential role of increased collaboration between actors. The main hypothesis was that improved recognition is a basis for sustainable social conditions. Our findings show that many farmers today perceive an impoverished social situation. They believe they lack control over decisions, which hinders their ability to continue farming. Public images and political decisions show a lack of respect for farmers' skills and knowledge. However, increased collaboration among actors is believed to be one important way forward, creating stronger relationships and networks, as well as a stronger identity for farmers. Our findings emphasize the need for authorities and other organizations to support farmers and to facilitate collaborative learning and decision-making processes for socioecological sustainability.

Agriculture↗
PubMedDate not supplied

Recent trends and developments in the EU in the environmental control and management of chemicals.

In the further development and implementation of European legislation on chemicals and related products the following aspects and trends can be identified: (1) refinement and adaptation of existing legislation and guidelines to technical progress (including extension of testing and risk assessment strategies), (2) preparation and implementation of new directives and regulations, (3) increasing application and further development of screening methods and model approaches, and (4) global harmonization of hazard and risk assessment criteria and procedures in the frame of the International Forum on Chemical Safety (chapter 19 of Agenda 21). The increasing use of evaluation and screening models can be illustrated by the further development and application of specific models such as EUSES and EASE to predict effect and exposure data. On the effects assessment side, models are available or under development to predict the phototoxicity and potential endocrine disruptors (estrogen/androgen binding affinity) of industrial chemicals. Finally, the emphasis that is given worldwide to the global harmonization procedures initiated under chapter 19 of Agenda 21, agreed at the UNCED conference for the environment and sustainable development in 1992, cannot fail to influence further developments in Europe.

Environmental Health↗
PubMed1995

Atrial ectopic activity and atrial fibrillation/flutter after coronary artery bypass surgery. A case-base study controlling for confounding from age, beta-blocker treatment, and time distance from operation.

To evaluate the impact of ectopic atrial activity and cardiac autonomic function for development of atrial fibrillation or flutter we studied 128 consecutive patients undergoing elective coronary artery bypass grafting. The patients were Holter monitored during a 96-h postoperative period. Autonomic balance was estimated by heart rate variability measurement. Thirty-eight (30%) patients developed sustained atrial fibrillation or flutter. Holter recordings were analyzed in a case-base design matching for age, beta-blocker treatment, and time elapsed after the operation. The number of supraventricular ectopic beats/h was increased (P < 0.01) in the case group during each of the last 7 h before onset of atrial fibrillation or flutter. Episodes of supraventricular tachycardia 62% vs. 26%; cases vs. controls (P = 0.007), episodes of non-sustained atrial fibrillation 29% vs. 0% (P = 0.0009), and episodes of non-sustained atrial flutter 15% vs. 0% (P = 0.05) were significant predictors of atrial fibrillation or flutter. Mean heart rate/h was increased in each of the 24 h preceding the arrhythmia. However, indexes of autonomic heart function did not differ significantly between groups. Patients developing atrial fibrillation or flutter after coronary artery bypass surgery present 'warning' atrial arrhythmias: numerous supraventricular ectopic beats, paroxysmal supraventricular tachycardia, and episodes of nonsustained atrial fibrillation and flutter.

Adrenergic beta-Antagonists↗
PubMed2005

The effects of 5-HT4 receptor blockade and stimulation, during six hours of atrial fibrillation.

AIMS: Stimulation of atrial 5-HT4 receptors is associated with arrhythmias. Their blockade prolongs atrial effective refractory period (ERP), following short runs of atrial fibrillation (AF). The role of 5-HT4 receptors during longer periods of AF is unknown. In this study, we investigated the effects of the selective 5-HT4 receptor stimulation and blockade on porcine atria, during 6 h of AF. METHODS: Atrial ERP, monophasic action potential (MAP) duration, time to sinus rhythm restoration (TSRR) and ERP/MAP ratio were assessed in 27 pigs, at baseline and every hour, during 6 h of AF, induced by rapid atrial pacing. Ten animals were used as controls, 10 were administered the selective 5-HT4 antagonist SB203186 and seven were administered the selective 5-HT4 agonist RS67333. RESULTS: During the first few hours of fibrillation, ERP, MAP and TSRR were preserved in SB203186-treated pigs, while they were shortened in controls and RS67333-treated animals. After 6 h of arrhythmia, ERP and MAP were shortened in all three groups, but the decrease was less in SB203186-treated pigs. ERP/MAP ratio increased in controls and RS67333-treated animals, while it remained unchanged in SB203186-treated pigs. Towards the end of the AF period, four of the SB203186-treated pigs developed sustained atrial tachycardia. CONCLUSION: Following short periods of AF, 5-HT4 receptors' blockade protects the porcine atria against ERP and MAP shortening, while their stimulation has the opposite result. This beneficial effect, though, is gradually diminished following longer periods of AF and atrial tachycardia may develop.

Aniline Compounds↗
PubMed1991

Lacidipine: prevention of vascular damage induced by hypertension.

Lacidipine is a long-lasting 1,4-dihydropyridine calcium antagonist that has been reported to protect salt-loaded Dahl-S rats from vascular damage and accelerated mortality when it is administered prophylactically at 0.1 and 0.3 mg/kg p.o. once a day (equivalent to the recommended dose in humans). The aim of this study was to investigate the vasoprotective properties of lacidipine in Dahl-S rats that had already developed sustained hypertension after 4 weeks of a salt-rich diet. Although none of the dosages of lacidipine (0.3, 1, and 3 mg/kg) reduced the elevated values of blood pressure, an almost complete protection from mortality was obtained. Moreover, lacidipine dose-dependently inhibited the development of macroscopic and microscopic alterations in the distal branches of mesenteric arteries and in the brain. A clear regression of vascular damage and cardiac hypertrophy was observed at the highest dose tested (3 mg/kg). These findings further support the assumption that the protective properties of lacidipine are not restricted to a reduction in blood pressure.

Animals↗
PubMed2006

Disaster risk, climate change and international development: scope for, and challenges to, integration.

Reducing losses to weather-related disasters, meeting the Millennium Development Goals and wider human development objectives, and implementing a successful response to climate change are aims that can only be accomplished if they are undertaken in an integrated manner. Currently, policy responses to address each of these independently may be redundant or, at worst, conflicting. We believe that this conflict can be attributed primarily to a lack of interaction and institutional overlap among the three communities of practice. Differences in language, method and political relevance may also contribute to the intellectual divide. Thus, this paper seeks to review the theoretical and policy linkages among disaster risk reduction, climate change and development. It finds that not only does action within one realm affect capacity for action in the others, but also that there is much that can be learnt and shared between realms in order to ensure a move towards a path of integrated and more sustainable development.

Disasters↗
PubMed2003

Electrophysiological mapping and histological examinations of the swine atrium with sustained (> or =24 h) atrial fibrillation: a suitable animal model for studying human atrial fibrillation.

OBJECTIVES: Interventional elimination of chronic persistent atrial fibrillation (AFib) remains difficult. An animal model mimicking the clinical situation is important. METHODS AND RESULTS: Twenty-five adult pigs were implanted with a high-speed atrial pacemaker. After continuous pacing at 600 bpm for 6 weeks, 20 (91%) of the 22 survivals developed sustained AFib lasting for at least 24 h. Epicardial dense mapping revealed multiple coexisting reentrant wavelets in the left and the right atrium (LA and RA, respectively; 10.6 +/- 2.9 vs. 7.6 +/- 2.4 wavelets/cm(2)/s; p < 0.002). The mean local A-A intervals were 87.2 +/- 14.6 ms in the LA and 103.3 +/- 19.0 ms in the RA (p < 0.0002). Acute termination of sustained AFib was successful in 3 of the 5 pigs by propafenone, but in none of the 6 by dl-sotalol. Epicardial cryothermal ablation failed to terminate any AFib by compartmentalization of the RA free wall alone (4 pigs) or together with the LA appendage (4 pigs). Electron microscopic examination demonstrated diffuse perinuclear myolysis, myofibrillar fragmentation and mitochondrial crystal disruption in the atrium. CONCLUSIONS: Pacing-induced sustained AFib (> or =24 h) in adult pigs is a feasible and efficient animal model with electrophysiological and histological characteristics closely similar to those seen in humans.

Animals↗
PubMed1994

Measles vaccine failures: lack of sustained measles-specific immunoglobulin G responses in revaccinated adolescents and young adults.

The measles-specific antibody responses of seronegative adolescents and young adults were evaluated after revaccination. Of 1650 previously vaccinated healthy volunteers between the ages of 10 and 30 years, 4.4% were found to be seronegative for measles antibodies and 9.9% had equivocal titers. Seronegative volunteers were revaccinated to measles and followed serially for development of measles-specific IgG. Of 43 subjects followed for at least 1 year, only 58% developed and maintained positive antibody titers; 12% never developed positive titers and 30% initially developed titers that fell below positive levels within 1 year. The peak titers achieved by those subjects who responded transiently were lower than those achieved by subjects who developed sustained responses. Thus even after the recommended two dose schedule of the current measles vaccine, some adolescents and young adults lack protective titers of measles-specific antibody.

Adolescent↗
PubMed2005

Ecological Sanitation--a way to solve global sanitation problems?

Today about 2.4 billion people in rural and urban areas do not have access to adequate sanitation services. Within 20 years, it is expected that an additional 2 billion will live in towns and cities, mainly in developing countries, demanding sanitation. Still over 90% of sewage in developing countries is discharged untreated, polluting rivers, lakes and coastal areas. Conventional sanitation concepts, based on flush toilets, a water wasting technology, are neither an ecological nor economical solution in both industrialized and developing countries. The water-based sewage systems were designed and built on the premises that human excreta are a waste; suitable only for disposal and that the environment is capable of assimilating this waste. A sanitation system that provides Ecological Sanitation (EcoSan) is a cycle--a sustainable, closed-loop system, which closes the gap between sanitation and agriculture. The EcoSan approach is resource minded and represents a holistic concept towards ecologically and economically sound sanitation. The underlying aim is to close (local) nutrient and water cycles with as less expenditure on material and energy as possible to contribute to a sustainable development. Human excreta are treated as a resource and are usually processed on-site and then treated off-site. The nutrients contained in excreta are then recycled by using them, e.g., in agriculture. EcoSan is a systemic approach and an attitude; single technologies are only means to an end and may range from near-natural wastewater treatment techniques to compost toilets, simple household installations to complex, mainly decentralised systems. These technologies are not ecological per se but only in relation to the observed environment. They are picked from the whole range of available conventional, modern and traditional technical options, combining them to EcoSan systems. The paper presents an introduction to EcoSan principles and concepts including re-use aspects (available nutrients and occurring risks), and case studies of EcoSan concepts in both industrialized and developing countries.

Conservation of Natural Resources↗
PubMed2003

Qualitative hydrological and land-use planning tool for the Israel Coastal aquifer.

Due to a variety of past and present land-usages on the aquifer ground surface, appropriate groundwater management should consider anthropogenic activities on the ground surface and the potential of unsaturated zone media to convey water and pollutants to the aquifer. The objective of this paper is to present an approach which generates guidelines and recommendations which can lead to sustainable development. This method assesses the lithological characteristics of the aquifer's vadose zone, indicating potential rechargeability, while weighting factors leading to potential groundwater pollution resulting from some land-use. Recommendations regarding land-use planning and aquifer recharge can then provide a qualitative ecological tool towards sustainable groundwater management. Owing to its location, its critical significance to the country's fresh water supply, and its available field data, Israel's Coastal aquifer is employed here as the study area for implementation of this approach.

Agriculture↗
PubMed2001

Veterinary epidemiology--a key to sustainable pig production in Switzerland.

Sustainable animal production requires a healthy production system including healthy animals producing wholesome products. Epidemiology as a discipline is concerned with the occurrence of disease or disease indicators in populations as well as with factors influencing disease occurrence. By providing this information, epidemiology contributes significantly to the development and maintenance of healthy livestock. This is illustrated with the example of the enzootic pneumonia (EP) eradication programme of Switzerland. A series of observational studies were conducted in order to obtain the necessary knowledge to implement an area-wide EP eradication programme. The issues of economical eradication strategies at the herd level and the risk of re-infections were addressed. Simulation modelling and economical analysis were also applied. These research projects led to the successful start of a national eradication programme. The example of the EP eradication programme illustrates that applied epidemiological research provides critical information for the planning, implementation and evaluation of disease control programmes and is thus a key tool in developing sustainable animal production.

Animal Husbandry↗