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PubMed1999

Relationship between myocardial tissue density measured by microgravimetry and sound speed measured by acoustic microscopy.

If myocardial tissue can be assumed to be fluid-like, myocardial tissue elasticity can be estimated by the sound speed of tissue based on the equation K = rho(c)2, where K is the elastic bulk modulus, rho is density, and c is the sound speed of tissue. However, little data exist regarding the relationship between the sound speed of tissue and tissue density. The purpose of the present study was to evaluate the relationship between the sound speed of tissue and tissue density of various diseased myocardia. Myocardial tissue specimens at autopsy were obtained from 10 control patients without cardiovascular disease, 8 patients with pressure overload left ventricular hypertrophy (POLVH), and 8 patients with cardiac amyloidosis (AMD). Myocardial tissue sound speed was measured using a scanning acoustic microscope operating in the frequency of 450 MHz, and tissue density was measured by microgravimetry. The sound speed in POLVH (1639 +/- 17 m/s) was higher and that in AMD (1565 +/- 11 m/s) was lower than that in control patients (1615 +/- 15 m/s) (p < 0.001) at the temperature of 20-22 degrees C. The density in POLVH (1.087 +/- 0.004 g/cm3) was higher and that in AMD (1.072 +/- 0.003 g/cm3) was lower than that in control patients (1.082 +/- 0.003 g/cm3) (p < 0.001). Tissue density correlated with sound speed in all three groups (r = 0.96, p < 0.001). Therefore, myocardial tissue sound speed data obtained by acoustic microscopy enabled us to evaluate tissue elasticity without measuring tissue density directly.

Acoustics↗
PubMed2005

Cortical responses in rats predict perceptual sensitivities to complex sounds.

The common assumption that perceptual sensitivities are related to neural representations of sensory stimuli has seldom been directly demonstrated. The authors analyzed the similarity of spike trains evoked by complex sounds in the rat auditory cortex and related cortical responses to performance in an auditory task. Rats initially learned to identify 2 highly different periodic, frequency-modulated sounds and then were tested with increasingly similar sounds. Rats correctly classified most novel sounds; their accuracy was negatively correlated with acoustic similarity. Rats discriminated novel sounds with slower modulation more accurately than sounds with faster modulation. This asymmetry was consistent with similarities in cortical representations of the sounds, demonstrating that perceptual sensitivities to complex sounds can be predicted from the cortical responses they evoke.

Acoustics↗
PubMed2005

Tuning for spectro-temporal modulations as a mechanism for auditory discrimination of natural sounds.

Vocal communicators discriminate conspecific vocalizations from other sounds and recognize the vocalizations of individuals. To identify neural mechanisms for the discrimination of such natural sounds, we compared the linear spectro-temporal tuning properties of auditory midbrain and forebrain neurons in zebra finches with the statistics of natural sounds, including song. Here, we demonstrate that ensembles of auditory neurons are tuned to auditory features that enhance the acoustic differences between classes of natural sounds, and among the songs of individual birds. Tuning specifically avoids the spectro-temporal modulations that are redundant across natural sounds and therefore provide little information; rather, it overlaps with the temporal modulations that differ most across sounds. By comparing the real tuning and a less selective model of spectro-temporal tuning, we found that the real modulation tuning increases the neural discrimination of different sounds. Additionally, auditory neurons discriminate among zebra finch song segments better than among synthetic sound segments.

Acoustic Stimulation↗
PubMed2002

Magnetic oscillatory responses to lateralization changes of natural and artificial sounds in humans.

Oscillatory signals in human magnetoencephalogram were investigated as correlates of cortical network activity in response to sound lateralization changes. Previously, we found lateralized presentations of a monosyllabic word to elicit posterior temporo-parietal gamma-band activity, possibly reflecting synchronization of neuronal assemblies in putative auditory dorsal stream areas. In addition, beta activity was decreased over sensorimotor regions, suggesting the activation of motor networks involved in orientating. The present study investigated responses to lateralization changes of both a barking dog sound and a distorted noise to test whether beta desynchronization would depend on the sound's relevance for orientating. Eighteen adults listened passively to 900 samples of each sound in separate location mismatch paradigms with midline standards and both right- and left-lateralized deviants. Lateralized distorted noises were accompanied by enhanced spectral amplitude at 58-73 Hz over right temporo-parietal cortex. Left-lateralized barking dog sounds elicited right and right-lateralized sounds elicited bilateral temporo-parietal spectral amplitude increases at approximately 77 Hz. This replicated the involvement of posterior temporo-parietal areas in auditory spatial processing. Only barking dog sounds, but not distorted noises, gave rise to 30 Hz desynchronization over contralateral sensorimotor areas, parieto-frontal gamma coherence increases and beta coherence reductions between sensorimotor and prefrontal sensors. Apparently passive listening to lateralized natural sounds with a potential biological relevance led to an activation of motor networks involved in the automatic preparation for orientating. Parieto-frontal coherence increases may reflect enhanced coupling of networks involved in the integration of auditory spatial and motor processes.

Acoustic Stimulation↗
PubMed2003

Speech-sound-selective auditory impairment in children with autism: they can perceive but do not attend.

In autism, severe abnormalities in social behavior coexist with aberrant attention and deficient language. In the attentional domain, attention to people and socially relevant stimuli is impaired the most. Because socially meaningful stimulus events are physically complex, a deficiency in sensory processing of complex stimuli has been suggested to contribute to aberrant attention and language in autism. This study used event-related brain potentials (ERP) to examine the sensory and early attentional processing of sounds of different complexity in high-functioning children with autism. Acoustically matched simple tones, complex tones, and vowels were presented in separate oddball sequences, in which a repetitive "standard" sound was occasionally replaced by an infrequent "deviant" sound differing from the standard in frequency (by 10%). In addition to sensory responses, deviant sounds elicited an ERP index of automatic sound-change discrimination, the mismatch negativity, and an ERP index of attentional orienting, the P3a. The sensory sound processing was intact in the high-functioning children with autism and was not affected by sound complexity or "speechness." In contrast, their involuntary orienting was affected by stimulus nature. It was normal to both simple- and complex-tone changes but was entirely abolished by vowel changes. These results demonstrate that, first, auditory orienting deficits in autism cannot be explained by sensory deficits and, second, that orienting deficit in autism might be speech-sound specific.

Auditory Diseases, Central↗
PubMed2002

A unified model for the speed of sound in cranial bone based on genetic algorithm optimization.

The density and structure of bone is highly heterogeneous, causing wide variations in the reported speed of sound for ultrasound propagation. Current research on the propagation of high intensity focused ultrasound through an intact human skull for non-invasive therapeutic action on brain tissue requires a detailed model for the acoustic velocity in cranial bone. Such models have been difficult to derive empirically due to the aforementioned heterogeneity of bone itself. We propose a single unified model for the speed of sound in cranial bone based upon the apparent density of bone by CT scan. This model is based upon the coupling of empirical measurement, theoretical acoustic simulation and genetic algorithm optimization. The phase distortion caused by the presence of skull in an acoustic path is empirically measured. The ability of a theoretical acoustic simulation coupled with a particular speed-of-sound model to predict this phase distortion is compared against the empirical data, thus providing the fitness function needed to perform genetic algorithm optimization. By performing genetic algorithm optimization over an initial population of candidate speed-of-sound models, an ultimate single unified model for the speed of sound in both the cortical and trabecular regions of cranial bone is produced. The final model produced by genetic algorithm optimization has a nonlinear dependency of speed of sound upon local bone density. This model is shown by statistical significance to be a suitable model of the speed of sound in bone. Furthermore, using a skull that was not part of the optimization process, this model is also tested against a published homogeneous speed-of-sound model and shown to return an improved prediction of transcranial ultrasound propagation.

Algorithms↗
PubMed1992

Differences in male mating response and female flight sounds in Aedes aegypti and Ae. albopictus (Diptera: Culicidae).

Aedes aegypti (L.) and Ae. albopictus (Skuse) showed similar rates and timing of insemination in the laboratory. Laboratory attempts at interspecific mating were unsuccessful. Because Ae. aegypti males are known to locate females by flight sounds, male response to sound was compared in the two species. Ae. aegypti males responded to female flight sounds with stereotypical orientation and mating behavior, whereas Ae. albopictus males seldom responded. Recorded flight sounds of females were sampled via computer digitization and compared. Ae. aegypti females produced louder sounds with more harmonics than Ae. albopictus. Males were tested for their ability to discriminate between the sounds of the two species. Ae. albopictus males did not respond to recordings of either Ae. albopictus or Ae. aegypti females. Ae. aegypti males responded preferentially to the recorded sounds of Ae. aegypti females. Thus, males of the two species use different mechanisms in locating mates. Ae. aegypti males rely more on sound than do Ae. albopictus males.

Aedes↗
PubMed1992

Philosophy and stimulus design for neuroethology of complex-sound processing.

In research on the neural mechanisms for the processing of biologically important sounds such as species-specific sounds and sounds produced by prey and predators, it is necessary to study responses of central auditory neurons to biologically important sounds, information-bearing elements (IBEs) in them, and tone bursts. The tone bursts or constant-frequency (CF) components can be an IBE in many species of animals. Information-bearing parameters characterizing these sounds must be systematically varied, and tuning of neurons to individual parameters must be studied. The measurement of a tuning curve must be performed not only for excitatory responses, but also for inhibitory and facilitative responses, if any. The selectivity of a neuron to a particular type of sound must be tested for whether it is level-tolerant. Responses to complex sounds can probably be explained on the basis of those to IBEs and tone bursts, so that the use of the tone bursts, even though they are not IBEs, is as essential as that of the biologically important sounds.

Animals↗
PubMed2006

Speech- and sound-segmentation in dyslexia: evidence for a multiple-level cortical impairment.

Developmental dyslexia involves deficits in the visual and auditory domains, but is primarily characterized by an inability to translate the written linguistic code to the sound structure. Recent research has shown that auditory dysfunctions in dyslexia might originate from impairments in early pre-attentive processes, which affect behavioral discrimination. Previous studies have shown that whereas dyslexic individuals are deficient in discriminating sound distinctions involving consonants or simple pitch changes, discrimination of other sound aspects, such as tone duration, is intact. We hypothesized that such contrasts that can be discriminated by dyslexic individuals when heard in isolation are difficult to identify when occurring within words or structurally similar complex sound patterns. In the current study, we addressed how segments of pseudo-words and their non-speech counterparts are processed in dyslexia. We assessed the detection of long-duration differences in segments of these stimuli and identified the brain processes that could be associated with the behavioral results. Consistent with previous studies, we found no early cortical sound-duration discrimination deficit in dyslexia. However, differences between impaired and non-impaired readers were found in the brain processes associated with sound-change recognition as well as in the behavioral performance. This suggests that even when the early, automatic, sound discrimination processes are intact in dyslexic individuals, deficits in the later, attention-dependent processes may lead to impaired perception of speech and other complex sounds.

Acoustic Stimulation↗
PubMed2005

ERPs differentiate syllable and nonphonetic sound processing in children and adults.

We examined maturation of speech-sound-related indices of auditory event-related brain potentials (ERPs). ERPs were elicited by syllables and nonphonetic correlates in children and adults. Compared with syllables, nonphonetic stimuli elicited larger N1 and P2 in adults and P1 in children. Because the nonphonetics were more perceptually salient, this N1 effect was consistent with known N1 sensitivity to sound onset features. Based on stimulus dependence and independent component structure, children's P1 appeared to contain overlapping P2-like activity. In both subject groups, syllables elicited larger N2/N4 peaks. This might reflect sound content feature processing, more extensive for speech than nonspeech sounds. Therefore, sound detection mechanisms (N1, P2) still develop whereas sound content processing (N2, N4) is largely mature during mid-childhood; in children and adults, speech sounds are processed more extensively than nonspeech sounds 200-400 ms poststimulus.

Acoustic Stimulation↗
PubMed1993

Composite indicators of dental health: functioning teeth and the number of sound-equivalent teeth (T-Health).

This study investigated whether two new composite dental indicators--"the number of functioning teeth" and "the number of sound-equivalent teeth"--are more efficient than the conventional DMFT index in revealing the social and behavioural factors which are significantly related to oral health status. The arbitrary set of weights given to the T-Health indicator was also evaluated. The number of functioning teeth was defined as the aggregate of filled (otherwise sound) and sound teeth. The T-Health was defined as a weighted average of sound teeth, filled (otherwise sound) teeth and teeth with some decay, the weights intended in principle to represent the relative amounts of sound tissue in these three categories of teeth. An arbitrary set of weights was used: 4, 2, and 1 for sound, filled, and decayed teeth, respectively. 164 families (father, mother and at least one 13-yr-old child) from Belo Horizonte, Brazil, were randomly selected from 13-yr-old children from private and state schools. The parents' ages ranged from 35 to 44 yr. Socio-economic status, area of residence, level of education, family income, sugar consumption, toothbrushing frequency and type of dental attendance were the social and behavioural oral health risk-factors considered in this study. The results indicated that the two new dental indicators are more sensitive to the influence of social and behavioural factors, such as those investigated here, than is the traditional DMFT index. A different set of weights (4, 1, and 1 for sound, filled, and decayed) was suggested for the construction of the T-Health.

Adolescent↗
PubMed1978

A phonocardiographic study of equine heart sounds.

The occurrence and timing of heart sounds were examined from phonocardiograms taken from the mitral, aortic and tricupsid recording areas in each of 18 horses. 10 sound events could be identified with each cardiac cycle. Atrial contraction produced up to 3 sound events. The first heart sound consisted of 4 components whereas the second sound was single. Two sound events were associated with the 3rd heart sound in early diastole. The occurrence of third and fourth heart sound components varied between horses and between recording areas. The mitral recording area was considered most satisfactory for routine phonocardiographic studies in horses.

Animals↗
PubMed2002

MRI gradient coil cylinder sound field simulation and measurement.

High-field, high-speed Magnetic Resonance Imaging (MRI) generates high sound levels within and nearby the scanner. The mechanism and process that produces the gradient magnetic field (a cylindrical electro-magnet, called the gradient coil cylinder, which produces a spatially and temporally varying magnetic field inside a static background magnetic field) is the primary source of this noise. This noise can cause difficulties in verbal communication in and around the scanner, heightened patient anxiety, temporary hearing loss and possible permanent hearing impairment for health care workers and patients. In order to effectively suppress the sound radiation from the gradient coil cylinder the sound field within and nearby the gradient coil needs to be characterized This characterization may be made using an analytical solution of the sound pressure field, computational simulation, measurement analysis or some combination of these three methods. This paper presents the computational simulation and measurement results of a study of the sound radiation from a head and neck gradient coil cylinder within a 4 Tesla MRI whole body scanner. The measurement results for the sound pressure level distribution along the centerline of the gradient coil cylinder are presented. The sound pressure distributions predicted from Finite Element Analysis of the gradient coil movement during operation and subsequent Boundary Element Analysis of the sound field generated are also presented. A comparison of the measured results and the predicted results shows close agreement. Because of the extremely complex nature of the analytical solution for the gradient coil cylinder, a treatment of the analytical solution and comparison to the computational results for a simple cylinder vibrating in a purely radial direction are also presented and also show close agreement between the two methods thus validating the computational approach used with the more complex gradient coil cylinder.

Computer Simulation↗
PubMed1985

Penalty for impulse noise, derived from annoyance ratings for impulse and road-traffic sounds.

In the laboratory, four groups of 16 subjects rated the annoyance caused by three types of impulse sounds (regular and irregular gunfire noise and metal-construction noise) and by road-traffic sounds, all presented in background noise. The subjects were presented with the sounds for 5-min periods. The annoyance ratings were related to the A-weighted equivalent level (Leq) of the sounds. From these annoyance ratings a correction term or penalty was derived, which, added to the Leq of the impulse sounds, gives the level of equally annoying traffic noise. The correction was determined for conditions in which (1) only the annoyance caused by specific sources, or (2) the annoyance caused by the total sound (specific source plus background) had to be rated. In addition, the indoor Leq of the constantly present background noise was 35 or 55 dB(A) by and large, the results showed that for lower levels of the sounds an impulse-noise correction of at least 10 dB was required, whereas for higher levels the derived correction was about equal to the ISO/R 1996 penalty of 5 dB. This conclusion, based on the relation between Leq and annoyance ratings, is consistent with the correction based on Leq and the percentage of subjects who reported to be "very much annoyed." For equivalent levels of the impulse sounds at which 33% of the subjects claimed to be very much annoyed, the correction was 10 dB for the conditions in which the indoor Leq of the background noise was 35 dB(A), and 5 dB when this Leq was 55 dB(A).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1990

On the level-dependent penalty for impulse sound.

At relatively low A-weighted equivalent levels (Leq), road-traffic sounds are rated to be less annoying than impulse sounds. The differences, however, decrease with increasing Leq of the sounds, which indicates that the penalty for impulse sound seems to be level dependent. It was questioned whether the decrease of the penalty with increasing Leq might, at least partly, have been a consequence of the use of the ten-point rating scale. In experiments 1 and 2, the relevance of the level-dependent correction was therefore studied further by using the method of adjustment. The mean results again showed that, at least for gunfire sounds (small arms), the penalty is level dependent. The drawing of firm conclusions, however, was hampered by a relatively large bias in the adjustments. In addition, the overall size of the penalty was lower than obtained in previous rating experiments. The question about the relevance of the level-dependent penalty was reopened in experiment 3 by applying the method of paired comparison. The results confirm the previous findings obtained with the rating experiments: For gunfire sounds at relatively low indoor Leq values, a penalty of about 10 dB is required, and a penalty lower than 5 dB can be applied only in conditions with rather high sound exposure. The results further showed that especially at indoor Leq values higher than about 45 to 50 dB(A), application of a negative penalty may become relevant for specific sounds such as those produced by the 0.50-in. machine gun. Consequently, acoustic measures from which to predict the value of the penalty are highly needed.

Adolescent↗
PubMed1995

The effects of breath sounds on the perception of synthetic speech.

When preparing to speak, talkers typically take a breath. The perceptual effect of adding naturally produced breath intake sounds to synthetic speech was examined. In experiment 1, subjects were better at transcribing synthesized sentences that were preceded by a breath sound than those that were not, in addition to the improvement due to practice that is typically found with synthetic speech. Experiment 2 found that replacing the breath with the spectrally similar sound of rustling leaves had no effect on the accuracy. Experiment 3 had breaths before randomly selected sentences. Only the practice effect was significant, though there was a tendency for sentences with the breath sounds to be remembered better. In experiment 4, we tested whether the appropriateness of the breath sound to the sentence size (relatively short or long) affected the use of the breath sound. Appropriateness had no effect, perhaps because the range of sentence durations was too small. Experiment 5 replicated experiment 1 but used leaf sounds rather than silence in the nonbreath sentences. The presence of breath was again found to aid recall. Overall, the current results indicate that adding the breath intake sound to synthetic sentences improves listeners' ability to recall those sentences.

Female↗
PubMed1998

Comparison between intensity and pressure as measures of sound level in the ear canal.

In-the-ear calibration of sound pressure level may be problematic at frequencies above 2 kHz, because the pressure can vary significantly along the length of the ear canal, due to reflection of sound waves at the eardrum. This issue has been investigated by measuring behavioral thresholds to tones in a group of human subjects (N = 61) for two different insertion depths of an insert earphone. The change in insertion depth was intended to alter the distribution of pressure in the ear canal, shifting the frequency at which spectral notches occur. The inset earphone or "probe" (Etymotic ER-10C) also contained a calibrated microphone, allowing the recording of sound pressure levels in the ear canal. Prior to the threshold measurements in each subject, the Thevenin acoustic source characteristics of the probe were determined by a special calibration procedure. This calibration allowed the expression of the sound level at threshold in terms of acoustic intensity (W/m2). The impact of changes in insertion depth was determined by measuring behavioral threshold at each depth. Because cochlear sensitivity remained constant, the level of sound entering the ear at threshold should have been the same (within measurement error) for both insertions. The difference in sound pressure level (SPL) at threshold between the two probe insertions was greatest at the notch frequency of the first insertion. At this notch frequency, the SPL at threshold increased by an average of 11.4 dB. The change in sound intensity level (SIL) at threshold was almost always less than the change in SPL. At the notch frequency, the SIL decreased, on average, by only 0.5 dB. These results suggest that SIL may be a better indicator than SPL of the sound level entering the ear, especially for frequencies in the 4-8 kHz range.

Auditory Perception↗
PubMed2004

Psychophysiology and psychoacoustics of music: Perception of complex sound in normal subjects and psychiatric patients.

Perception of complex sound is a process carried out in everyday life situations and contributes in the way one perceives reality. Attempting to explain sound perception and how it affects human beings is complicated. Physics of simple sound can be described as a function of frequency, amplitude and phase. Psychology of sound, also termed psychoacoustics, has its own distinct elements of pitch, intensity and tibre. An interconnection exists between physics and psychology of hearing.Music being a complex sound contributes to communication and conveys information with semantic and emotional elements. These elements indicate the involvement of the central nervous system through processes of integration and interpretation together with peripheral auditory processing.Effects of sound and music in human psychology and physiology are complicated. Psychological influences of listening to different types of music are based on the different characteristics of basic musical sounds. Attempting to explain music perception can be simpler if music is broken down to its basic auditory signals. Perception of auditory signals is analyzed by the science of psychoacoustics. Differences in complex sound perception have been found between normal subjects and psychiatric patients and between different types of psychopathologies.

Journal Article↗