[Perihepatitis in chlamydia salpingitis. A review and report of 4 cases caused by C. trachomatis].
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Four serological tests, viz. indirect hemagglutination (IHA), metabolism inhibition (MI), immunofluorescence (IMF), and a modification of the growth-inhibition (GI) test have been compared for the detection of antibodies against Mycoplasma hominis in female grivet monkeys with experimentally induced pelvic inflammatory disease. Moreover, cold hemagglutinins (CHA), and immunoglobulins, M, G, and A have been determined. The IHA test was found to be superior to the other methods used. The antibodies were present in all inoculated monkeys two weeks after the inoculation and a maximum in titre occurred one week later. Antibodies detected by the modified GI test occurred in all monkeys inoculated with the organism together with the IHA antibodies, but the maximum in titre was less marked. The IMF test was less sensitive than the GI test; the antibodies generally occurred later and disappeared faster. Using the MI test, no antibodies could be detected in any of the monkeys during the experimental period and no CHA antibodies were found in any of the sera. IgM rose earlier and declined more rapidly than IgG. It is concluded that the IHA test is most suitable for the measurement of serum antibodies caused by infection with M. hominis in grivet monkeys. The modified GI test, although less sensitive, may also be useful because of its simplicity in performance.
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Referring to a recent report given in Acta Chirurgica Scandinavica of 14 cases of acute perihepatitis in young females with genital inflammation, the pathogenesis of which was claimed unknown, a recapitulation is given of previously published investigations on the clinical significance of the absorption of exudates and particulate matters from the peritoneal cavity in man through the lymphatics of the diaphragm. The pathogenesis of metastases in the supraclavicular nodes (Virchow) and of ascites in peritoneal carcinomatosis is mentioned.
Previous reports have implicated the Dalkon shield intrauterine device (IUD) in septic second trimester abortion and maternal death from sepsis. In the case reported here, Fusobacterium necrophorum, a rarely pathogenic vaginal anaerobe, gained access to the uterus in a woman wearing a Dalkon shield and caused acute parametritis, overwhelming peritonitis, systemic sepsis, and death. It is well known that IUDs can contribute to the development of serious pelvic infections, and in this case it is possible that the Dalkon shield was the cause of the ascending infection into the uterus.
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An adult female Japanese quail (Coturnix coturnix japonica) was received for postmortem examination. Necropsy revealed the presence of white to grayish nodules 2-5 mm in diameter on the serosal surface of the oviduct. Aspergillus flavus was isolated from these nodules in pure culture. Histologically, these nodules were medium to large granulomatous lesions in serosa and the muscular wall of the oviduct. The lesions contained a large central necrotic core surrounded by giant cells, macrophages, and mononuclear cells. Similar cells in addition to heterophils also infiltrated the serosa, muscular layer, submucosa, and mucosa to varying degrees. Branched septate hyphae predominantly invaded the central caseous mass and to some extent invaded the surrounding areas of the nodules.
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