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PubMedDate not supplied

Medical maxims: two views of science.

Clinicians are beings with finite minds and thus need to use simplified models of the world in making decisions [1]. However, these models need not be oversimplified, as are the models encouraged by the prevalent view of science, the Mechanistic Paradigm, which are articulated as rigid maxims. A more current view of science, the Probabilistic paradigm, encourages more complex models, which can be articulated as the more flexible maxims used with insight by the wise clinician.

Models, Biological↗
PubMed1979

[Immunopathologic implications of cryoglobulins (author's transl)].

Cryoglobulins are proteins which appear in the serum of some patients. Their basic characteristic is their power to precipitate at low temperatures. In this work a review is made of the data presented by several authors in regard to the origin, isolation, classification, and precipitation mechanism, as well as of the factors which influence the cryoprecipitability. We also set out the most probable etiopathogenic theories and the possible clinical findings in those patients who have these proteins altered in their serum. Finally we comment on the treatment with special reference to penicillamine.

Cryoglobulins↗
PubMed1978

Infant mortality in SMSAs before Medicaid: test of a causal model.

Path analysis is applied to data on infant mortality, supplies of physicians and hospital beds, and population percentages of blacks and low-income families in 201 standard metropolitan statistical areas (SMSAs) to test the hypothesis that medical resources mediate the effects of racial composition and low income on infant mortality rates. The hypothesis is not supported for the SMSA data: direct effects of racial composition and low income on infant mortality are stronger than indirect effects. The use of SMSA data for analysis is contrasted with the use of county data in a discussion of study by Anderson, from which the hypothesis was drawn.

Black or African American↗
PubMed1983

The derivation of the gamma-variate relationship for tracer dilution curves.

Tracer dilution curves are useful for describing blood flow through vessels and organs. Empirically determined curves for flow through nonbranching vessels have been shown to correspond to a mathematical function called the gamma variate. This paper presents a derivation of the gamma-variate relationship, discusses some of the properties of the gamma variate and its use in problems involving organ blood flow and recirculation.

Humans↗
PubMed1983

[Thymic seminoma. Apropos of a case diagnosed in a woman].

Primary thymic seminoma is a rare germ cell neoplasm histologically identical to testicular seminoma. About 100 cases have been reported in the world literature. The most probable pathogenic theory is abnormal migration of germinal cells from the vitelline sac to the embryonic thymus. Management involves surgery and radiotherapy. The extreme radiosensitivity of the tumor is responsible for a 5-years survival rate of 75 per cent. Thymic seminomas are usually found in young men. We report the case of a 49 year female in whom the combination of surgery and radiotherapy followed by chemotherapy provided excellent results.

Combined Modality Therapy↗