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A portrait of AKT kinases: human cancer and animal models depict a family with strong individualities.

More than a decade after their discovery, the three AKT kinase family members have emerged as central players in the signaling cascades that regulate cell growth, proliferation, survival and various aspects of intermediary metabolism. The mechanisms of activation of AKT kinases have been defined in relatively precise terms and new substrates are currently being validated in vivo. However, it is presently unclear whether AKT1, AKT2 and AKT3 are functionally redundant or whether each one performs specific functional role(s). In this review, we will summarize the signaling properties and highlight the specificities of AKT kinases that have emerged from the study of human cancer and animal models. While AKT kinases are an attractive target for pharmacological intervention, knowledge of the precise individual roles of AKT family members will improve the design of highly specific AKT-based therapeutics having reduced toxicity and improved efficacy.

Cell Enlargement↗

Portrait of a plague.

Explore the source record for details and available documents.

Fatigue Syndrome, Chronic↗

Survey reveals portrait of today's healthcare CIO.

I/S executives in community hospitals across the United States have reason to celebrate! They are finally moving into the executive suite, with the titles, reporting status, staffing levels and salary to prove it.

Career Mobility↗

{Psychosocial portrait of students presenting with suicidal tendancies}.

The present article reports the results of a study of 550 Shawinigan Cégep students enrolled in their first year of college. The study attempts to establish the prevalence of suicidal behaviours and to describe predisposing factors identified by the authors such as family problems, lack of social support, depression, stressful events having a negative impact, and attitudes toward life and death. The information was gathered using a questionnaire combining several elements: (a) a questionnaire similar to the one used by Lamontagne (1986) and Tousignant, Bastien, Hamel, and Hanigan (1986) to identify family problems; (b) the Sarason, Levine, Basham, and Sarason (1983) Social Support Questionnaire, translated and adapted by De Man (1986), which evaluates social support; (c) the Aneshensel, Clark, and Fredrichs test (1983) which indicates the presence or absence of depression; (d) the Sarason, Johnson, and Siegel (1978) Life Experience Survey, measuring the quantity of stressful events experienced, and their impact on personal life; and (e) Beck's (1979) Scale of Suicide Ideation which measures attitudes toward life and death. Two questions were added for the present study: Did you ever attempt suicide? If yes, how many times? Three hundred and fifty-five students answered the questionnaire, making the level of participation 71% (355/550). Participants were divided into four groups: those having made a suicidal attempt (n = 28) or planned suicide (n = 16), those having a score of 30 or more on the test relating to suicidal ideation (n = 18), and those regarded as "normal" (n = 278). The cut-off point of 30 on the scale of of suicidal ideation was determined by averaging the scores of those who made a suicide attempt and confirmed by a discriminant analysis. The students who had attempted suicide had major family problems, lacked social support, presented depressive tendencies, and had experienced stressful events having a negative impact on their lives. Furthermore, they manifested problems in their attitudes toward life and death. However, the study did not determine the contribution of each variable. The participants who had planned suicide, at first sight, did not seem to present more problems than those designated "normal," which seems astonishing. This was explained by the fact that the planned suicide was not recent or was a cry for help which found a response.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗