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The bronze baby syndrome.

Phototherapy with either daylight or blue lamps resulted in the development of the bronze baby syndrome in 13 infants. 'Thermotherapy' with an incandescent bulb emitting light mainly in wavelengths not effective for phototherapy caused this syndrome in the 14th infant with respiratory failure. Hepatic dysfunction was present in all infants. The infants were well in spite of the bronzing, after their initial condition had improved. Bronzing disappeared within two months in all but one infant; in eight infants with regular blood examination, the hepatic function became normal by ten months of age, but spectroscopy demonstrated the presence of the pigment(s) even at one year. Normal development was observed.

Bilirubin↗

Minocycline and oral pigmentation.

Minocycline is a semisynthetic tetracycline used in the treatment of inflammatory acne because of its broad spectrum of activity, less common development of resistant organisms, and its anti-inflammatory effects. A number of adverse reactions are reported, including skin and oral pigmentation. This paper details the pharmacology of minocycline and describes the pigmentation and likely mechanisms active in both hard and soft tissues. Oral pigmentation usually involves the hard tissues only and presents typically as a discrete band occupying the central zone of the alveolar mucosa and palate. As with other sites, it may persist following withdrawal of the drug. Early recognition by the dental practitioner may allow an alternative form of therapy to be sought, minimizing the likelihood of a long-term aesthetic problem.

Acne Vulgaris↗

Congenital nystagmus among the Red-skins of the Highlands of Papua New Guinea.

Sixty-four people with pigmentary anomalies of the skin were examined in the Eastern Highlands of New Guinea. Thirty-one had a bronze-red skin colour which appears to be unique to New Guinea. Eighteen of the Red-skins had congenital nystagmus which was not associated with impairment of visual acuity. The fundi were normal. The pigmentary anomaly is recessively inherited, and the gene responsible for the nystagmus appears to be associated with those controlling skin colour. The condition appears to be a unique form of albinism and confers no disadvantage on those who have it.

Adolescent↗

Incontinentia pigmenti (Bloch-Sulzberger syndrome): seven case reports from one family.

Seven members from a large family who showed signs of incontinentia pigmenti were examined. A clear X-linked dominant transmission was demonstrated, lethal in males. Study of this family shows that vascular abnormalities of the retina and disorders of the retinal pigment epithelium are the most important ocular lesions in the Bloch-Sulzberger syndrome.

Adult↗

Pigmented scars.

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Cicatrix↗

Occupational absorption of tellurium: a report of two cases.

Industrial uses of tellurium are limited, and reported cases of tellurium absorption of occupational origin are rare. Two such cases are reported here. Both showed typical signs and symptoms of intoxication; in particular, the stench of sour garlic was noted on breath and from excreta. An unusual feature was the bluish-black discoloration of the webs of the fingers and streaks on the face and neck. Full hospital investigation was negative. No permanent damage resulted and each patient made a spontaneous recovery without treatment.

Adult↗