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PubMed1984

[Protective properties of Proteus ribosomal vaccine].

The results of the study of the protective properties of Proteus ribosomal vaccine prepared from P. vulgaris museum strain F-30 are presented. The vaccine showed protective effect even in a dose of 0.0001 microgram of protein per mouse; when used in immunization doses of 1 and 10 micrograms of protein per mouse, the vaccine completely protected the animals, ensuring their survival. Experiments aimed at the determination of the maximum protective effect of the vaccine were carried out. The ribosomal vaccine injected in a dose of 1 microgram of protein per mouse protected 50% of mice challenged with 10 LD50; in a dose of 10 micrograms of protein per mouse the vaccine protected 100% of the animals challenged with 3.7 and 10 LD50. Proteus ribosomal vaccine prepared from P. vulgaris museum strain was shown to render protective effect with respect to P. vulgaris and P. mirabilis clinical strains.

Animals↗
PubMed1984

[Proteus mirabilis brain abscess in a neonate].

A case of neonatal brain abscess was reported. This female infant was born by spontaneous vertex delivery at 38 weeks gestation, weighing 3.1 kg. There were no antenatal and perinatal complications. The Apgar's score was 8 points and her head was 32.8 cm in circumference. Fifty-six hours after birth, she had a clonic general convulsion for about 3 minutes. On the next morning, convulsion recurred, and she was transferred to our hospital. When admitted to the Pediatrics, she was exhausted and irritable. But after hospitalization, she improved without convulsions. CT scan, performed 7 days after birth, revealed large low density areas in both frontal lobes. Electroencephalography showed spike discharge at all leads. The head circumference gradually increased and subsequent CT scans revealed enlargement of the bifrontal low density areas. The first operation was done 28 days after birth. A large amount of yellowish grey pus was aspirated from both sides and the cavity was irrigated. Tobramycin was administered into the abscess cavity. Culture of the pus grew proteus mirabilis. The postoperative conditions were good. But two weeks later her head started to enlarge with the bulging fontanelle. CT scan revealed marked dilation of the ventricles and enlargement of the left frontal abscess. At 2 months of age, second operation was done. Left frontal abscess was punctured and serous pus was aspirated. Proteus mirabilis was cultured again from the pus. Tobramycin was administered into the cavity via the drainage tube every day for a week. As the content of the abscess cavity became clear, V-P shunt and cyst-peritoneal shunt were performed. After shunting procedure, the increase of head circumference stopped and the fontanelle became flat and soft.(ABSTRACT TRUNCATED AT 250 WORDS)

Brain Abscess↗