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At least 577 records · Page 32Linked to original sources
PubMed1962

Precipitin reaction between serum and lysed erythrocytes.

The albumin fraction of all normal sera contains a factor which precipitates with part of the normal haemoglobin molecule, the reaction occurring in the proportions of 1 ml. serum to 6 to 15 mg. haemoglobin.

Antigen-Antibody Reactions↗
PubMed1969

Influence of various parameters on the sensitivity of precipitin tests in farmer's lung by immunodiffusion and immunoosmophoresis.

Dilutions of a standard serum were made in saline and in negative sera, and comparative tests by immunodiffusion and by immunoosmophoresis were made against one antigenic component of Micropolyspora faeni (Thermopolyspora polyspora). The endpoint dilution of the standard serum in saline and serum in wells of different sizes was ascertained in each test. The endpoint dilution was unaffected by the distance of separation (from 1.5 mm to 6 mm) between the origins of serum and antigen, provided that the tests were read at times appropriate to each separation, the greater separations requiring longer periods of development. Higher endpoint dilutions were obtained by the use of 1% Noble agar in immunoosmophoresis than with 1% Ionagar no. 2 (Oxoid). This difference was more noticeable when low osmophoresis potentials were used.

Antigens↗
PubMed1976

A case of unusual SLE related syndrome characterized by erythema multiforme, angioneurotic edema, marked hypocomplementemia, and Clq precipitins of the low molecular weight type.

Our patient and those of Agnello et al. had identical clinical symptoms such as erythema multiforme, arthralgias and angioneurotic edema and both differed from systemic lupus erthematosus in several important points, i.e., in spite of marked hypocomplementemia the nephropathy is not prominent and it needs high-dose steroids to eliminate the clinical and serological abnormalities. In addition to the features reported by Agnello et al. we found increased viral antibody titers in our patient's sera.

Adult↗
PubMed1985

Detection of immunoglobulin E in feces by immunoprecipitation, and characterization of associated non-immunoglobulin precipitins.

All concentrated human fecal extracts tested formed precipitates in double immunodiffusion with goat antiserum to IgE, as well as with normal goat sera. However, no such precipitates were formed by fecal extracts and rabbit sera. IgE precipitates obtained with both goat and rabbit antisera to IgE showed reactions of non-identity with the former precipitates which seemed to represent complexes of trypsin or chymotrypsin in feces and an alpha-protein in goat sera. This alpha-protein, which was responsible for the non-immunoglobulin precipitations, was different from human alpha 1-antitrypsin. The trypsin-like components in feces had low molecular weights, and might represent degradation products of trypsin or chymotrypsin. After using a second labelled antiserum, precipitates between rabbit antiserum to IgE and extracts of feces could be visualized by means of autoradiography. They were seen in fecal extracts in which IgE could also be determined by a double-antibody paper radioimmunoassay technique (paper radio immunosorbent test; PRIST). Since the concentrations measured by a radioactive single-radial immunodiffusion method correlated to some extent with the PRIST concentrations, the latter precipitates were likely to represent IgE in feces.

Animals↗