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At least 577 records · Page 32Linked to original sources
PubMed1975

Nitrofuran-reducing enzymes of Euglena.

Euglena gracilis strain Z, green, dark-brown, and "bleached" with N-methyl-N-nitro-N-nitrosoguanidine, was found to contain 2 soluble enzymes which reduce nitrofurans. A small amount of activity was demonstrated also in a particulate fraction of sonic extracts, but none in isolated chloroplasts. The reduction of 5 nitrofurans, having widely differing bleaching activities, by each of the 2 enzymes was examined.

Chloroplasts↗
PubMed1980

Streptococcus mutans-like bacteria from human dental plaque in a Sri Lanka (Ceylon) population.

This paper reports on the presence of low numbers of Streptococcus mutans among the oral streptococci present in human dental plaque in a Sri Lanka (Ceylon) population, where the caries activity is low and a low sucrose intake is combined with the presence of heavy plaque deposits. Plaque samples of unknown age were collected from 10 individuals in a tea estate, and another 10 samples were collected from dental students 19 days following interruption of oral hygiene. Of 670 such strains of oral streptococci studied, none showed typical "frosted glass" colony morphology on Mitis Salivarius agar. However, when subjected to physiological tests 14 of them were classified as S. mutans.

Adult↗
PubMed1977

The influence of additives on the presentation of a drug in hard gelatin capsules.

The influence of the concentration of lactose, magnesium stearate and sodium lauryl sulphate in the in vitro dissolution and the drug content of hard gelatin capsules filled under conditions which result in a maximum tapped bulk density, has been evaluated by a factorially-designed experiment. The 3 factors have a significant effect on both drug release and capsule filling. Interactions between the 3 factors, however, limit the exact quantification of the magnitude of their influence by a simple linear model. A quadratic relation, when only 2 factors are considered, can be used to provide a prediction of the influence of these factors. The relations between 2 factors are demonstrated as contours of equal in vitro drug release and equal drug content of capsule, at constant concentrations of the third factor. The contours show the important influence of lactose concentration drug release and capsule filling, and the large changes in response which can occur by the addition of a third factor. They also provide a clear guide to the formulation of hard gelatin capsules.

Capsules↗
PubMed2005

Microplate Alamar blue assay for Staphylococcus epidermidis biofilm susceptibility testing.

Biofilms are at the root of many infections largely because they are much more antibiotic resistant than their planktonic counterparts. Antibiotics that target the biofilm phenotype are desperately needed, but there is still no standard method to assess biofilm drug susceptibility. Staphylococcus epidermidis ATCC 35984 biofilms treated with eight different approved antibiotics and five different experimental compounds were exposed to the oxidation reduction indicator Alamar blue for 60 min, and reduction relative to untreated controls was determined visually and spectrophotometrically. The minimum biofilm inhibitory concentration was defined as < or = 50% reduction and a purplish well 60 min after the addition of Alamar blue. All of the approved antibiotics had biofilm MICs (MBICs) of >512 microg/ml (most >4,096 microg/ml), and four of the experimental compounds had MBICs of < or = 128 microg/ml. The experimental aaptamine derivative hystatin 3 was used to correlate Alamar blue reduction with 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) reduction and viable counts (CFU/ml) for S. epidermidis ATCC 35984, ATCC 12228, and two clinical isolates. For all four strains, Alamar blue results correlated well with XTT (r = 0.83 to 0.97) and with CFU/ml results (r = 0.85 to 0.94). Alamar blue's stability and lack of toxicity allowed CFU/ml to be determined from the same wells as Alamar blue absorbances. If the described method of microplate Alamar blue biofilm susceptibility testing, which is simple, reproducible, cost-effective, nontoxic, and amenable to high throughput, is applicable to other important biofilm forming species, it should greatly facilitate the discovery of biofilm specific agents.

Anti-Bacterial Agents↗