[A case of laryngeal neurofibroma].
A rare case of laryngeal neurofibroma is presented. An enlarged chordectomy via laryngofissure was performed. The patient has survived 5 years with no symptoms of recurrence.
Humans↗
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A rare case of pulmonary neurofibroma: clinical and diagnostic evaluation and surgical treatment.
The authors report a rare case of a pulmonary neurofibroma treated by surgical excision. The case report is accompanied by a review of the literature and the discussion of the diagnostic problems posed by neurogenic tumors of the thorax.
Humans↗
Giant ocular nerve neurofibroma of the cavernous sinus: a series of 5 cases.
Five cases of giant cavernous sinus neurofibroma arising from the ocular cranial nerves are reported. These patients collected over a period of 5 years consisted of 3 males and 2 females with an age range of 9 to 40 years and a mean of 20.6 years. Clinically, all patients presented with ocular palsies over a long period (mean 3.4 years). All of them underwent a frontotemporal craniotomy along with an orbito-zygomatic osteotomy and excision of the tumour. In patients with extension of the tumour into the orbit, the superior orbital fissure was drilled, the tenon's capsule was cut and the intraorbital portion was excised. The management of these tumours is discussed and the literature reviewed.
Abducens Nerve Diseases↗
[Intra-parotid facial plexiform neurofibroma. Review of the literature].
It is being tumor developed from Schwann cells of peripheral nerves sheath. In its plexiform type it is a rare growth presenting solitary or in the context of von Recklinghausen's disease. The aim of this article is to present one plexiform neurofibroma localized in the parotid gland. At the same time we make a perusal on the literature of this kind of tumor.
Facial Nerve↗
Periungual myxoid neurofibroma.
A 34-year-old woman presented with a slow growing nontender nodule on her left index finger that had been present for 2 years. The tumor was excised and was histologically determined to be a myxoid neurofibroma. We report this case because of the rarity of both the tumor and its periungual location and to provide a review of the literature.
Adult↗
[Eyelid neurofibroma affecting a young woman].
A 43-year-old female patient had an amelanotic single tumor thickening the upper right eyelid and observed since early childhood. Clinically, it appeared as a firm mass, without sharp margins, giving a thickened appearance to the superior eyelid. The ophthalmic clinical examination was normal but some subcutaneous nodules attested to the diffusion of the disease recognized as a limited form of neurofibromatosis 1. Although well tolerated, it gave rise to a cosmetic disturbance and the patient was willing to undergo an excision. A complete surgical excision was performed on the lesions and the pathological study disclosed a typical neurofibroma. Regular observation of the different cutaneous nodules was recommended.
Adult↗
[A giant neurofibroma of the diaphragm].
A very rare case of giant neurofibroma located in the pleural cavity is reported. Such tumors may simulate malignant tumors and secondary tuberculosis.
Diaphragm↗
[Associated meningioma and neurofibroma at the same cervical level without clinical signs of neurofibromatosis: case report].
A 59-year-old woman presented with a history of progressive clumsiness and numbness in both hands. MRI suggested a solid mass extending, from the intradural extramedullary, extradurally at the left C1/2 level. However, intraoperative findings revealed the both the intradural tumor and the extradural tumor existed separately. Histopathological findings revealed coincident meningioma (intradural) and neurofibroma (extradural). These lesions were not associated with neurofibromatosis, and the patient did not have other tumors in either the brain or at other levels of the spine. The occurrence of different types of spinal tumors without clinical signs of neurofibromatosis is very rare. Only five cases have been reported in the literature. To our knowledge, this is the first case of occurrence of different types of spinal tumors at the same level.
Cervical Vertebrae↗
Clinics in diagnostic imaging (76). Left extradural-intradural lumbar neurofibroma.
A 62-year-old woman presented with weight loss, anoexia and back pain. She was found to have a palpable left abdominal mass. Radiographs, CT and MR imaging revealed a large left 3rd lumbar neurogenic tumour with both intra- and extradural components. A neurofibroma was excised and the diagnosis was confirmed histopathologically. The patient has no recurrence at six years follow-up. The pathological classifications, clinical and imaging features of neurogenic tumours are discussed. With the knowledge of characteristic imaging features, these tumours can be differentiated from other types of intradural-extramedullary tumours.
Diagnosis, Differential↗
[Neurinomas and neurofibromas of the jugular foramen: diagnosis and surgical treatment].
The paper analyzes the authors' experience in treating 16 patients with neurinomas and neurofibromas of the jugular foramen. A tumor was located intracranially (Type A) in 1 case, at the level of the base of the skull (Type B) in 7 cases, extracranially (type C) in 3 cases, and extra- and intracranially (Type D) in 5. All the patients were operated on. One-stage removal was performed in 15 patients, in 1 case a tumor was removed in 2 steps. By taking into account differences in the site of the tumors, the authors used the following accesses: retrosigmoid, supracondyllar, extreme lateral transcondylar, retroauricular transtemporal, extended retroauricular transtemporal, lateral cervical. While planning accesses, it is necessary to bear in mind not only the direction of growth of these tumors, but also the pathways of collateral venous blood flow.
Adolescent↗
Growth type of plexiform neurofibromas in NF1 determined on magnetic resonance images.
This article describes some types of growth in plexiform neurofibroma (PNF) on magnetic resonance images (MRI). This tumor is almost exclusively associated with NF1. On MRI, the tumor is depicted as a hyperintensive area on T2-weighted images. We distinguished 3 patterns of tumor growth: first, the superficial and non-invasive tumors, that are restricted to the cutis and subcutis, only eventually having outgrowth to the muscles beneath and are slow growing. Second, the displacing PNF that develop in deeper layers of the skin or within the body. They can grow to a large extent but do not invade adjacent muscles or skin. Thirdly, the invasive type with no visible margins that cannot be resected without adjacent structures or organs. A combination of these tumors can sometimes be noted, e.g. a displacing tumorous nerve developing in a large lumpy, non-invasive PNF. These categories might be used as a current guideline for medical advice, surgical treatment planning and medication trials.
Cell Division↗
[Duodenal neurofibroma as a cause of chronic bleeding from the gastrointestinal tract].
A rare case of chronic exacerbating gastrointestinal tract bleeding is reported which was caused by duodenal neurofibroma. The patient was successfully treated surgically.
Chronic Disease↗
The CT and MRI features of an unusual case of isolated orbital neurofibroma.
A 35-year-old woman developed painful proptosis of the left eye over a period of 3 weeks. Orbital computed tomography and magnetic resonance imaging revealed a well-circumscribed superior orbital tumor with variable density. The mass was removed entirely by way of a superior orbitotomy. Histopathologically, it was found to be a neurofibroma. The patient had no clinical findings of neurofibromatosis. The presence of extensive myxomatous degeneration and the dense collection of collagen bundles in the tumor are correlated with the unusual computed tomography and magnetic resonance imaging features.
Adult↗
[Isolated sub-orbital plexiform neurofibroma].
An unexpected finding on histology in a 73 years old patient was an isolated suborbital plexiform neurofibroma. Since this tumor is specific for von Recklinghausen's disease, the diagnosis was that of a minor form of the disease. The different cephalic manifestations of von Recklinghausen's disease are reviewed.
Aged↗
[Plexiform neurofibroma in the gingiva].
Neurofibromatosis type 1 is the most common autosomal dominant disorder of the nerve sheath and best defined phakomatosis. It usually affects skeletal system, central nervous system, eye, endocrine gland and cardiovascular system. Gingival involvement is very rare. We report radiological findings of three patients with plexiform neurofibroma who had diffuse, unilateral gingival involvement.
Adolescent↗
Anesthetic management of a patient undergoing segmental resection of trachea with an endotracheal neurofibroma and nearly total occlusion of trachea.
We report a case of endotracheal (ET) neurofibroma with resultant severe airway obstruction undergoing segmental resection of the trachea. After the extracorporeal membrane oxygenation system (ECMO) was set up handily for use and comprehensive monitoring system was established, ET intubation under fiberoptic bronchoscopy (FOB) was performed under mild sedation. Surgery and anesthesia proceeded uneventfully and she was discharged uneventfully. Thorough preoperative evaluation, comprehensively anesthetic planning, FOB-assisted ET intubation before induction of anesthesia were mandatory to achieve a safe and delicate anesthesia for such a patient. In critical situation, conduction of anesthesia after establishment of ECMO support would be another choice.
Adult↗
[A rare tumor of the sciatic nerve--myxoid neurofibroma. A case report].
The surgical resection of soft tissue tumors in peripheral nerves often poses problems, since the extent of resection depends on tumor dignity, determined by incisional biopsy. This case report is about a myxoid neurofibroma of the sciatic nerve. In the literature, this rare entity is a precursor of malignant neurilemoma. The choice is difficult between radical resection in view of possible locoregional recurrence or possible malignant transformation and preservation of the nerve. In this case, the sciatic nerve was encased in the pseudocapsule of the tumor and was nearly totally spared during surgical resection. Following surgery, there were no neurological defects.
Adult↗
Congenital melanocytic naevus with associated neurofibroma and schwannoma-like change.
Congenital melanocytic naevus and neurofibromatosis type 1 are distinct clinical entities. A diagnosis of neurofibromatosis is difficult to make in the presence of a congenital melanocytic naevus because nodules may arise in the naevus that have similar histopathological appearances to neurofibromata. A case is reported where nodules arising from a naevus were examined histologically and were found to have neurofibroma and schwannoma like elements but strong positivity for S100 protein in keeping with dermal melanocytes. Lisch nodules were also said to be found in the patient but may represent nodular naevi of the irides. It is important that histopathological findings are interpreted within a clinical context and S100 protein immunohistochemical stain is valuable in helping to differentiate these two conditions.
Child↗