SEARCH · Search PubMed

Results for “MENTAL RETARDATION”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

SourceResearch connectionFrom yearThrough year

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 577 records · Page 32Linked to original sources

PubMed2004

Treatment of behavior disorders in mental retardation: report on transitioning to atypical antipsychotics, with an emphasis on risperidone.

BACKGROUND: Mental illnesses are more common in people with mental retardation and developmental disabilities than in the general population. Due to the difficulty of making specific psychiatric diagnoses in these patients, the target of medication is often a behavioral symptom. For many symptoms, antipsychotic medications are effective, but the serious side effect profile of conventional antipsychotics renders their use problematic. Recent findings concerning the safety and efficacy of atypical antipsychotics for control of certain disruptive behaviors in adults and children led a Special Topic Advisory Panel to draw up guidelines for transitioning patients with specific symptoms from classical antipsychotics to risperidone and, by extrapolation, to other atypical agents. PARTICIPANTS: Participants were chosen by Janssen Pharmaceutica, based on individual achievements and lifetime experience. The Special Topic Advisory Panel on Transitioning to Risperidone Therapy in Patients With Mental Retardation and Developmental Disabilities comprised academic clinicians with at least 10 years' experience in the field of mental retardation and developmental disabilities. It included a clinical pharmacist, consultant pharmacists, a certified developmental disabilities nurse, psychiatrists, a family physician, and a psychologist. EVIDENCE: The Panel considered recent studies of the efficacy and tolerability of risperidone and other atypical antipsychotics in adults and children with mental retardation and developmental disabilities. MEDLINE searches were conducted using the name of each atypical antipsychotic and the following terms: mental retardation, developmental disabilities, and behavior disorders. Searches were conducted starting in July 2002 and done periodically through April 2004 to capture new additions to the literature. Searches were confined to English. GUIDELINES PROCESS: The Panel reviewed the available evidence, identified optimal doses and titration schedules, considered instruments and rating scales for assessing symptoms, and developed guidelines. CONCLUSIONS: The guidelines set forth initial and target doses and titration schedules of risperidone therapy for some behavioral symptoms and provide recommendations concerning withdrawal of previous medications and for procedures and rating scales for assessing symptoms. In patients with severe retardation, the goal is often to identify specific target behaviors rather than to pursue an exact diagnosis, which may be unattainable.

Adult↗

PubMed1999

Isokinetic knee muscle strength of individuals with mental retardation, a comparative study.

The purpose of this study was to assess differences in isokinetic muscle torque in the knee among mentally retarded individuals with Down syndrome, mentally retarded individuals without Down syndrome, and sedentary subjects without mental retardation (ns of 7, 8, and 12, respectively). Subjects performed strength tests to knee extension and flexion on a Cybex II isokinetic dynamometer. The measure was peak torque at angular velocities of 60, 120, and 300 degrees/sec. For the Mentally Retarded subjects with and without Down syndrome, the test was performed on two separate days 24 hr. apart. For Sedentary subjects, testing was performed on one day. Their scores indicated significantly higher values of torque than the two other groups. Also, subjects with Down syndrome had inferior muscle torque of lower extremities than peers in the Mentally Retarded Group.

Adult↗

PubMed1977

Astigmatism among institutionalized and noninstitutionalized mentally retarded.

Astigmatism was measured retinoscopically for 709 subjects residing in an institution for the mentally retarded and for 56 noninstitutionalized mentally retarded subjects at a community training center. About 60% of the subjects were between 15 and 45 years old. Compared to an intellectually normal sample of young men, astigmatism in the mentally retarded was greater in frequency and degree. For subjects with greater degrees of mental retardation, the prevalence of high astigmastism was significantly greater for whites than for nonwhites. There was no difference in astigmatism between institutionalized retardates and those living in a community setting, a finding that implies that the institutional environment was not the cause of the astigmatic differences between retarded and normal subjects.

Adolescent↗

PubMedDate not supplied

[Personal experience in the treatment of pulmonary tuberculosis in mentally retarded persons].

The results of the therapy of pulmonary tuberculosis in 90 mentally retarded patients in various forms and degrees of retardation are presented. General and clinical condition of 62 patients was very bad prior to the onset of antituberculotic therapy and most of them were immobile due to the mental retardation and dissemination of pulmonary tuberculosis. In 30 patients advanced form of tuberculosis, in 54 patients mild form and in 6 patients a minimal degree of tuberculosis were found. In hospitalized patients all clinical forms of pulmonary tuberculosis were found. The therapy started with triplicate antituberculotic therapy and the patients were also administered other drugs due to their mental retardation. During the first two months of antituberculotic therapy a high mortality rate was registered (27 or 30%) especially in younger patients. The reason for such high rate cannot be attributed only to pulmonary tuberculosis but also to the primary disease as was the main reason of patients' hospitalization at the institute for mentally retarded persons. Many complications in antituberculotic use could not be registered since many of the basic data could not be obtained from mentally retarded subjects. The complete recovery or improvement of pulmonary tuberculosis was achieved in 63 patients.

Adult↗

PubMedDate not supplied

Grief in adults with mental retardation: preliminary findings.

Structured direct interviews of 43 adults with mental retardation were conducted to evaluate how they express grief and deal with loss. In addition, 100 providers, social workers, and clergy were surveyed to assess their views of how adults with mental retardation cope and respond during a grief situation. Adults with moderate to severe mental retardation display grief responses similar to all adults: a mixture of sadness, anger, anxiety, confusion, and pain. Individuals continue to experience emotional turmoil 1 year beyond the initial death and personal loss. Caregivers and professionals were mixed on how long a grief reaction continues before it can be viewed as dysfunctional. Intense behaviors, such as self-injury, were noted by respondents in 10-15% of grief reactions. Ability to "feel" or display emotional behavior during grief is not contingent only on a conceptual level. Common reactions include a depressive response (crying, fatigue, sleep disruption, loss of appetite) of moderate intensity. Adults with significant mental retardation verbalized an understanding of the irreversibility of death, and their responses reflect personal beliefs as well. An unknown group of these adults may have been exhibiting a depressive disorder.

Adult↗

PubMed1994

Cardiovascular risk factor levels in adults with mental retardation.

Cardiovascular risk factors in a population of adults with mental retardation were examined. The subjects resided in three types of settings (16+ bed facility, group home, and natural family) and were measured on the following parameters: blood lipids, obesity, and smoking. The data were compared to a nonretarded population and to the guidelines established by the National Cholesterol Education Program. Results indicated that adults with mental retardation had cardiovascular risk profiles similar to those of individuals without mental retardation in the Framingham Offspring Study and that to the extent that cardiovascular health is a concern to the general population, it must also be a concern for individuals with mental retardation.

Adolescent↗

PubMed1998

[Forensic psychiatric examinations of the mentally retarded].

3,343 forensic psychiatric examinations were recorded in Norway from 1980 to 1996. 294 patients were diagnosed as mentally retarded. The annual number of mentally retarded persons increased during the observation period, but the relative percentage remained stable. The majority of the retarded persons being discussed had been charged with sexual felony, and some with arson. About half had previous convictions. Few had problems with alcohol or other intoxicants. Every fourth retarded person examined was considered not only to be mentally retarded, but also to suffer from other psychiatric disorders. We discuss to what extent deinstitutionalization of retarded persons and the accompanying social isolation they experience could contribute to the increase in maladaption and criminal behaviour. It is stressed that many of the sexual felonies may be explained by the fact that the mentally retarded are mentally immature.

Female↗

PubMedDate not supplied

Attention deficit-hyperactivity disorder among mentally retarded children.

Teachers completed the Connors' Teacher Rating Scale (CTRS-39) on 100 boys assigned to one of four groups based on an IQ screen and scores on a DSM-III-R checklist of the symptoms for Attention Deficit-Hyperactivity Disorder (AD-HD). The groups included children rated high on AD-HD, mentally retarded children, mentally retarded children rated high on AD-HD, and a normal control group. Using the CTRS-39, there were no significant differences between the normal IQ AD-HD group and the mentally retarded AD-HD group on all but one of the factors. Mentally retarded children in general were found to be more anxious than their normal peers, whereas normal IQ AD-HD children were rated higher than the other groups on the Asocial factor. Implications of these data and future directions are discussed.

Attention Deficit Disorder with Hyperactivity↗

PubMed1992

Health care concerns among parents of children with mental retardation.

This preliminary study compared concerns of parents of children with moderate mental retardation and parents of children with severe mental retardation, on four health care variables, using a questionnaire format. Parents of children with severe impairments and those with school-aged children, had significantly more concerns regarding the hospitalization of those children, than did parents of children with moderate mental retardation or those with preschool children. Similarly, parents of children with severe disabilities had significantly more concerns on the parent-professional relationship variable than did individuals with moderately affected offspring. A high level of concern on the professional competence variable was expressed by all respondents. Study results suggested that severity of intellectual impairment is an important determinant of the number and nature of concerns that are experienced by parents when seeking health care services for their children with mental retardation. Suggestions for improving professional knowledge and service delivery are provided.

Alberta↗

PubMed1991

Comparison of idiom comprehension of normal children and children with mental retardation.

This study compared the comprehension of 20 idioms of normal children with children exhibiting mild mental retardation. Sixty-six children comprised three groups: normal 9-year-olds, 9-year-old children with mild mental retardation, and younger normal children matched with the mentally retarded children by receptive vocabulary age. The assessment included both literal and idiomatic contexts with accompanying picture stimuli. The three groups demonstrated high accuracy with the literal contexts. On the idiomatic contexts, the normal children comprehended significantly more idioms than the children with mental retardation, and the mentally retarded children performed significantly better than the younger normal children.

Child↗

PubMed2000

Caring for the patient with mental retardation in the emergency department.

There are approximately 6 million individuals with a diagnosis of mental retardation in the United States. Because of deinstitutionalization of patients with mental retardation, coupled with an increase in their life expectancy, emergency physicians are increasingly encountering and managing patients with mental retardation in the emergency department. Many emergency physicians are uncomfortable when interacting with individuals with mental retardation, which often carries over to the assessment and management of these patients in the ED. The purpose of this review is to aid the emergency physician in understanding the patient with mental retardation, their comorbid conditions, and the approach to evaluating and managing these patients in the ED.

Attitude of Health Personnel↗

PubMed2004

Incidence and prevalence of dementia in elderly adults with mental retardation without down syndrome.

Rates of dementia in adults with mental retardation without Down syndrome were equivalent to or lower than would be expected compared to general population rates, whereas prevalence rates of other chronic health concerns varied as a function of condition. Given that individual differences in vulnerability to Alzheimer's disease have been hypothesized to be due to variation in cognitive reserve, adults with mental retardation, who have long-standing intellectual and cognitive impairments, should be at increased risk. This suggests that factors determining intelligence may have little or no direct relationship to risk for dementia and that dementia risk for individuals with mental retardation will be comparable to that of adults without mental retardation unless predisposing risk factors for dementia are also present.

Aged↗

PubMed1988

Issues in the classification of mental retardation: differentiating among organic etiologies.

Many researchers of mental retardation fail to take etiological differences into account, although the value of distinguishing between organic and familial mental retardation has long been discussed. The argument is made that even the two-group approach needs to be extended so that groups with different organic etiologies are studied separately. Taking etiological distinctions into account will allow for more precise research and a better understanding of mental retardation. Evidence for the utility of differentiating retarded persons by etiology is provided by a research review showing examples of behavioral differences between organically retarded groups. It is concluded that such differentiation also has clear implications for intervention.

Child↗

PubMed1979

Legal implications of sterilization of the mentally retarded.

For more than 50 years, sterilization of mentally retarded persons was an accepted practice in many states as a way to reduce the number of persons born with mental defects. In recent years, the practice has come under heavy challenge, both medically and legally. At present, only 19 states have statutes that allow sterilizations for eugenic reasons. This article examines important court decisions regarding eugenic sterilization laws and the legal status of sterilization of mentally retarded adults and minors, as well as the consequent legal implications for physicians. Federal funding restrictions on sterilization of mentally impaired persons are discussed. The requirement of voluntary, informed consent is considered in light of an increasing emphasis on the rights of mentally retarded persons as well as greater awareness of the psychological effects of involuntary sterilization.

Adolescent↗

PubMed1990

Mental retardation and perception of global motion.

We have found that mildly mentally retarded adults are impaired in their perception of global stereoscopic forms (Fox & Oross, 1988) in ways that cannot be attributed to peripheral visual deficits or failures to comprehend. To assess the generality of that result, we measured the ability of mentally retarded adults to perceive kinematographic forms. Mentally retarded and nonretarded adults were presented with a two-choice, forced-choice detection task requiring the location of a target's spatial position. The discriminability of the forms was varied by systematic reductions in both element density and temporal correlation. We found that, relative to nonretarded adults, mentally retarded adults exhibited large qualitative deficits in their ability to discriminate these kinematographic forms when either density or correlation was reduced. After considering a number of alternative interpretations of these data based on factors such as peripheral visual impairment and a failure to attend, we could find none more compelling than a perceptual interpretation, which posits a deficit within the short-range motion system.

Adult↗

PubMed1983

Genetic services for patients with severe mental retardation. The South African situation.

In South Africa mental retardation is still ill-defined as regards the aetiology and general epidemiology. A systematic diagnostic/genetics programme implemented at various institutions for the mentally retarded within the framework of a comprehensive genetic service is described. The progress made is reported and the contribution of genetic services to the prevention and the management of mental retardation highlighted.

Adolescent↗

PubMed2006

Adjunctive lamotrigine for refractory epilepsy in adolescents with mental retardation.

Epilepsy is a major comorbid condition in adolescents with mental retardation and is often characterized by multiple seizure types that are refractory to treatment. This study (n = 22) describes a subanalysis of data from a larger multicenter study of adjunctive lamotrigine therapy in patients with mental retardation and refractory epilepsy and focuses on the outcome measures of seizure reduction, safety and tolerability, and impact on behaviors in adolescents with mental retardation and refractory epilepsy. The study kept baseline antiepileptic drugs constant and titrated lamotrigine over 8 weeks to the target dose, followed by an 8-week maintenance phase and then a 12-week optimization phase during which all antiepileptic drugs and lamotrigine could be altered as clinically indicated. Sixty percent of subjects had a 50% decrease in seizures by the end of the maintenance phase and a mean 39% reduction in seizure frequency by the end of the maintenance phase (25% by end of study) compared with baseline. Global improvements were observed in most patients, with statistically significant improvements in the Aberrant Behavior Checklist and the Habilitative Improvement Scale, which is predictive of less need for supportive care in activities of daily living and thus enhanced potential for greater independence. Lamotrigine-associated improvements in behavior can be attributed to improved control of seizures, a reduction in concomitant antiepileptic drugs, and/or direct mood-stabilizing and behavior-enhancing properties independent of the antiseizure effects of the drug. The results of this study suggest that lamotrigine is an important treatment option in adolescents with mental retardation and comorbid epilepsy.

Adolescent↗

PubMed1987

Frequency of the fragile X syndrome in institutionalized mentally retarded females in Japan.

The fragile X [fra(X)] syndrome was screened on 190 Japanese institutionalized females with moderate to severe mental retardation. Two inmates with severe mental retardation (IQ 20) had the fra(X) chromosome in 26% and 15% of the cells examined, indicating that the prevalence of the fra(X) syndrome was about 1% in all female inmates and was about 3.27% in severely mentally retarded females without known causes. However, no female with fra(X) syndrome was found in 35 moderately retarded females. Both had brothers with the fra(X) syndrome and the prevalence was 10% in females with a family history of mental retardation. In addition, the replication study of the fra(X) chromosome in the patients supported the proposal that an excess of the early replicated fra(X) chromosome is related to the mental capacity in heterozygous females. Therefore, the fra(X) syndrome should not be ignored even in severely mentally retarded females with a family history, though the heterozygotes are commonly normal to subnormal in their mental development. In addition, the replication study of the fra(X) chromosome may help to estimate mental development in the carrier children.

Adolescent↗