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Experimental congenital cytomegalovirus labyrinthitis and sensorineural hearing loss.

Cytomegalovirus is a leading cause of human congenital viral infection and hearing loss. The pathogenesis of human congenital cytomegalovirus infection is poorly understood. We have developed a reproducible model of congenital cytomegalovirus-induced sensorineural hearing loss in guinea pigs. This report reviews our previously published results and provides additional new information about this model.

Animals↗
PubMed1989

Vestibular hair cells isolated from guinea pig labyrinth.

Living sensory cells were isolated from the cristae ampullaris and macula utriculi of the guinea pig. Enzymatic and mechanical dissociation were used to obtain different populations of hair cells, the most predominant being type I cells. Their form varied: cell body of variable roundness, and neck and cilia of different lengths. The observation of many tilted cuticular plates supports the hypothesis of active mechanisms regulating mechanotransduction at the apex of these cells. Cell viability was verified by double fluorescent labeling (FDA-PI), which indicated that under correct conditions about 90% of the sensory cells could be maintained in vitro for several hours after dissociation. The detection of actin in the cuticular plate and cilia shows that the technique has various potential applications in morphological studies, and can contribute to investigations on the physiology of mammalian vestibular cells.

Animals↗
PubMed2002

Decreased expression of calretinin and calbindin in the labyrinth of old gerbils.

Calretinin and calbindin staining were compared in the vestibular periphery of old (35-48 months) and young (4-12 months) animals. Both stain calyx-only afferents; calbindin stains additional terminals in the apex [Brain Res. 928 (2002) 8-17]. In six of seven pairs of animals, calretinin and calbindin staining was diminished or absent in the old animals. These changes suggest that a reduction in certain calcium-binding proteins may be a characteristic of aging animals.

Aging↗