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PubMedDate not supplied

Hypericum perforatum (St John's wort) in depression: pest or blessing?

St John's wort (SJW) was introduced into Australia during the 1880s for medicinal purposes, but was subsequently declared a noxious weed. There is now a resurgence of interest in the therapeutic properties of this herb. In particular, use of SJW as an antidepressant has increased in recent months owing to reports of its effectiveness and safety. Nevertheless, the controlled trials available have limitations. Increasing use of SJW in the community poses a variety of questions. For example, should medical practitioners become more knowledgeable about the effects and interactions of alternative remedies? What are the ethical and medical implications of "antidepressant" prescribing by non-medical persons? Who is to fund further research and treatment studies? How can quality of SJW preparations be guaranteed?

Adult↗
PubMedDate not supplied

St. John's Wort for depressive disorders: results of an outpatient study with the Hypericum preparation HYP 811.

The efficacy and tolerability of a high-dose formulation of St. John's Wort extract, HYP 811, was tested in 607 patients in a 6-week, prospective, multicenter, postmarketing surveillance study. Severity of depression was assessed by physicians using the Hamilton Depression Scale; patient self-evaluation was performed using the von Zerssen Depression Scale. After 6 weeks of treatment, both scores improved by approximately 60%, on average. Disturbances in well-being, such as dejection, loss of interest, and generalized physical complaints, diminished during therapy. The tolerability of HYP 811 was rated "very good" and "good" in 89.4% of cases. After 3 weeks of treatment, dosage in 128 patients (21.1%) was successfully reduced to one capsule daily.

Adolescent↗
PubMed1999

Hypericum.

Explore the source record for details and available documents.

Depression↗
PubMed2004

Antinociceptive activity of methanolic extracts of St. John's Wort (Hypericum perforatum) preparation.

The analgesic effect of St. John's Wort plant preparation was evaluated using chemically induced pain models in adult albino mice. The intraperitoneal (i.p.) administration of 30-100 mg/kg of the preparation produced significant analgesic effect (75%) in acetic acid induced writhing and formalin licking tests. Based on its inhibitory effects on acetic acid induced writhes and both phases of the formalin test, the plant preparation seems to have central and peripheral analgesic properties. Its effect was found twice more potent than ibuprofen (100 mg/kg), a standard reference drug, in the acetic acid induced writhing test.

Journal Article↗