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At least 577 records · Page 32Linked to original sources
PubMed1993

Contact immunotherapy with squaric acid dibutylester for warts [corrected].

The efficacy of squaric acid dibutylester (SADBE), a topical allergen, was investigated in the treatment of 20 patients with warts. All patients had multiple or warts recalcitrant to other therapies or hesitated to have the painful cryotherapy. The patients with warts present for a mean of 15.3 months (range 1-36) were successfully sensitized with 2% SADBE in acetone. Then the warts were treated with a 0.1 or 0.01% SADBE application once a week or every other week, so as to maintain a mild contact dermatitis. Twelve of the 20 patients (60%) were completely cured after an average of 6 applications (range 2-12). Five patients (25%) showed either a poor or no response even after 9-18 applications. Three patients (15%) exhibited contact dermatitis either at the sensitization or the treatment site. Our study shows that this therapy, although not always safe, is effective in treating warts in some patients, who either hesitate at conventional cryotherapy or have warts resistant to other therapies. The safety of this method remains to be evaluated.

Administration, Cutaneous↗
PubMed1991

Eccrine syringofibroadenomatous hyperplasia in a patient with bullous pemphigoid: a case report and review of the literature.

A 76-year-old man with multiple erythematous lesions on his palms and soles which appeared following bullous pemphigoid (BP) is the subject of this case report. The lesions were not raised above the normal skin level, and there were no nodules on the erythematous lesions. The lesions had the histologic appearance of eccrine syringofibroadenoma. This condition is considered to be not a true tumor but a hyperplasia of eccrine sweat ducts following recurrent subepidermal blister formation in BP.

Adenofibroma↗
PubMed1983

Locally injected bleomycin in the treatment of warts.

To evaluate the clinical effectiveness of intradermally injected bleomycin in saline and oil versus placebo, a double-blind study of 62 patients with 108 warts was made. Although bleomycin has been recommended in previous reports, we found no difference between the group treated with bleomycin and the placebo group.

Bleomycin↗
PubMed1983

Treatment of onychomycosis by ODT therapy with 20% urea ointment and 2% tolnaftate ointment.

20 patients with distal onychomycosis were given daily application of an ointment containing 2% tolnaftate and an ointment containing 20% urea under ODT. Following this, 17 of 20 patients developed onychomalacia and seven of these developed onycholysis 1 or 2 weeks later. The separated nails were cut as short as possible. Similarly to those patients with onychomalacia alone, occlusive dressing technique was continuously performed until the newly developed nails became macroscopically normal and no fungi were observed microscopically (responders). Following treatment, out of 20 patients, 14 responded. 5 patients who had a short course of treatment did not respond. Side-effects such as pain, hemorrhage and infection did not occur.

Administration, Oral↗
PubMed1983

Suppression of palmoplantar pustulosis symptoms with oral 8-methoxypsoralen and high-intensity UVA irradiation.

9 patients with long-standing palmoplantar pustulosis were treated with oral 8-methoxypsoralen and high-intensity UVA irradiation (PUVA, 46.2 mW/cm2). 20 irradiations with single doses of up to 14.8 J/cm2 resulted in good or excellent clearing in 4 out of 5 patients, while none of 4 patients receiving 5-6 irradiations of up to 5.2 J/cm2 improved significantly. Comparison with earlier investigations leads to the conclusion that systemic PUVA is more efficient than topical PUVA in the treatment of palmoplantar pustulosis. This may result from different skin distribution of psoralen or from a more rapid decline in the photosensitivity of topically medicated skin during prolonged irradiation as compared to skin sensitized by oral psoralen administration. The use of a high-irradiance UVA source diminishes the influence of this time factor and improves patient compliance.

Administration, Oral↗
PubMed1982

Treatment of onychomycosis by partial nail avulsion and topical miconazole.

13 patients with distal subungual onychomycosis in a total of 48 dermatophyte-infected nails were treated with chemomechanical, partial nail avulsion followed by topical miconazole for 8 weeks. On examination, 6 months after cessation of therapy, 42% of the nails were cured by clinical and mycological criteria. The therapeutic response was related to the pretreatment extension of subungual hyperkeratosis. Periungual skin irritation was common during the initial avulsion period. Miconazole solution was well tolerated and this treatment modality proved to be a valuable alternative to other remedies for the treatment of onychomycosis limited to a few number of nails.

Administration, Topical↗
PubMed1982

Infantile acropustulosis.

A case of infantile acropustulosis is described. The condition responded to sulfones while it was not affected by any other therapy. Histologically, subcorneal pustules were found; persistent modest eosinophilia and eosinophils were present in the vesicular content, a feature never observed before. The significance of this finding is discussed.

Dapsone↗
PubMed1984

Solcoderm as a tool for the plastic surgeon. The treatment of verrucae.

In 243 cases of verruca vulgaris, about 85% of the epidermal efflorescences caused by the wart virus were cured by two or more applications of Solcoderm in ambulant therapy. Of 127 cases of verruca plantaris treated, about 70% were cured after an initial course of four applications and 80% after further courses of treatment. More than 80% of recurrences responded to retreatment. A favorable effect on the pain caused by the plantaris warts was reported by 95% of the patients treated. No delayed complications were observed after the use of Solcoderm. The rate of incapacity for work after Solcoderm treatment, a total of 41 man-days, was extremely low when compared with that following cryosurgery and other surgical measures which, unlike Solcoderm therapy, often require immobilization, dressings or avoidance of soap and water.

Acetates↗
PubMed1980

Plasma zinc concentration in palmoplantar pustulosis.

In 18 ambulant patients with palmoplantar pustulosis low plasma zinc concentrations were observed. During treatment with an all-trans aromatic retinoid (RO-10-9359) the values increased while at the same time the skin condition improved in particular with regard to the pustule formation. The observed low plasma zinc values may in some way be related to pustulosis but not as causal factor.

Foot Dermatoses↗
PubMed1980

Treatment with an oral aromatic retinoid in linear porokeratosis.

Linear porokeratosis is a rare variant of porokeratosis of Mibelli and usually occurs in childhood. A 15-year-old boy is presented with typical clinical lesions of linear porokeratosis on the extensor surface of the right arm exhibiting the classical histopathologic criteria of the disease. Treatment with an oral aromatic retinoid resulted in a remission of the lesion.

Administration, Oral↗
PubMed1980

Disseminated porokeratosis Mibelli treated with RO 10-9359. A study of two cases with ultrastructural remarks.

2 patients with widespread porokeratosis Mibelli (PM) were treated orally with RO 10-9359. The dose was 75 mg/day for 10 days, then 50 mg/day for 3 weeks. The drug produced a good improvement of condition with no serious side effect. Ultrastructural examination of a healed lesion showed the presence of a fine granular substance in the intercellular space of the spinous layer, most likely produced by keratinocytes; ultrastructural cellular alterations of PM were still evident and the lesion recurred after suspension of treatment.

Aged↗
PubMed1988

Clinical picture and problems of keratoplasty in Richner-Hanhart syndrome (tyrosinemia type II).

The Richner-Hanhart syndrome seen in a middle-aged woman is described. The patient had the typical clinical manifestations of tyrosinemia II with a bilateral keratopathy, palmar and plantar hyperkeratosis. The patient was subjected to a specific diet and to perforating keratoplasty. Postoperative systemic therapy with steroids had a negative influence on the clinical manifestations; dendritic lesions which developed on the corneal graft disappeared after interruption of the systemic steroid therapy. This suggests that cortisone treatment after keratoplasty should be avoided in this special metabolic disorder.

Amino Acid Metabolism, Inborn Errors↗
PubMed1983

Skin maps in vitiligo.

Patterns of depigmentation in vitiligo are illustrated which appear to form maps of obscure local anatomical subdivisions of the human skin. These are distinctive but as yet poorly defined and do not generally correspond to known anatomical structures or boundaries.

Facial Dermatoses↗