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PubMed1989

Early and continued participation in a work-site health and fitness program.

This study examines social-environmental, physical-behavioral, and psychological factors influencing early and continued participation in physical activity. Data for the study were collected during the first six months of operation of a work-site Health and Fitness Center. The following sources were used to collect data (N = 403): 1) printouts of frequency of employee visits to the Health and Fitness Center; 2) a questionnaire; and 3) fitness files. Data measuring early (month one) and continued (month six) participation were obtained from printouts of frequency of employee visits. A questionnaire measured estimation of physical ability, attraction to physical activity, youth participation, social support, and convenience of the Health and Fitness Center. Fitness files were used to obtain measures of cardiovascular fitness, percent body fat, and recent participation. Linear discriminant analysis was conducted to determine the practical usefulness of the social-environmental, physical-behavioral, and psychological factors for classifying employees into categories of exercise adherers and nonadherers. A measure of exercise adherence was based on company policy of six visits each month. Results for early participation (month one) indicated that convenience, sex, youth participation, attitudinal commitment, and age discriminated (p less than .05) among adherers and nonadherers with 63% accuracy. At the end of six months, attitudinal commitment, sex, convenience, and estimation of physical ability discriminated (p less than .05) among adherers and non-adherers with 60% accuracy. In addition, when early participation in the health and fitness program served as the measure of recent participation for the six month analysis, recent participation and attitudinal commitment discriminated (p less than .05) between the two adherence categories with 75% accuracy. Adherers and nonadherers were classified with 66% and 85% accuracy, respectively.

Adult↗
PubMed2000

Physical fitness of adults with an intellectual disability: a 13-year follow-up study.

The purpose of this study was to describe the change in physical fitness of middle-aged adults with an intellectual disability over a period of 13 years. Participants were 32 adults who worked in a supported work environment in Montreal and had been participants in a physical fitness study in 1983. Using the Canadian Standardized Test of Fitness, the participants were evaluated for cardiovascular endurance, muscular strength, muscular endurance, flexibility, and body composition. A home visit prior to the testing session refamiliarized the participants with the test procedures. Two forms of analysis were used to describe the change in fitness over 13 years. First, a 2 x 2 (Group x Time) analysis of variance for each dependent variable assessed change over time. Second, effect sizes were calculated to measure the magnitude of change in fitness over the 13-year period in comparison to those without an intellectual disability. As expected, the physical fitness levels of the participants were low when compared to those without a disability and declined over the 13 years. In addition, the magnitude of change over the 13 years, as compared to those without a disability, was greater for male and female participants for body mass index and percentage of body fat and for female participants for cardiovascular endurance and sit-ups. It appears that adults with an intellectual disability may be particularly at risk for declining health associated with aging and low physical fitness.

Adipose Tissue↗
PubMed2003

Body fat, fitness and level of everyday physical activity in adolescents and young adults with meningomyelocele.

OBJECTIVE: Data on body fat and fitness in adolescents and young adults with meningomyelocele are scarce. The aim of this study was to assess body fat and fitness in this patient group. In addition, we explored whether the level of everyday physical activity is related to body fat and fitness. SUBJECTS AND METHODS: Body fat (skinfold thickness), fitness (VO2peak), and everyday physical activity (Activity Monitor, based on accelerometry) were measured in 14 patients with meningomyelocele (8 men, 6 women; age range 14-26 years). RESULTS: Peak VO2 was 20-30% lower than reference values and 4 patients were obese. Level of everyday activity was related to fitness (rs = 0.65, p = 0.01) but not to body fat. CONCLUSION: Young patients with meningomyelocele are at risk for developing obesity and have a distinctly subnormal fitness. Level of everyday physical activity is related to fitness in this patient group.

Adipose Tissue↗
PubMed2004

Relationships of insulin sensitivity with fatness and fitness and in older men and women.

PURPOSE: Increased body fatness, especially abdominal obesity, and low levels of fitness are associated with decreased insulin sensitivity. Men and women differ in obesity, body fat distribution, and fitness levels. This cross-sectional study evaluated sex differences in the relationships of insulin sensitivity with fatness and fitness and obesity. METHODS: Subjects were nonsmoking, nondiabetic, sedentary men (n = 50) and women (n = 61) aged 55-75 years with mild hypertension. Study measures were insulin sensitivity (QUICKI: 1/[log(fasting insulin) + log(fasting glucose)]), lipids and lipoproteins, total body fatness using dual energy x-ray absorptiometry (DXA), anthropometrics, abdominal obesity using magnetic resonance imaging (MRI), and aerobic fitness assessed as Vo(2) peak during treadmill testing. RESULTS: Women had a higher percentage of body fat and more abdominal subcutaneous and less visceral fat than men. Among women, QUICKI correlated negatively with body mass index (BMI), percent body fat, abdominal total fat, subcutaneous fat, and visceral fat but not with lipids. Among men, QUICKI correlated negatively with total and abdominal fatness and triglycerides. QUICKI correlated with fitness in men only. Using stepwise regression, among women, decreased total abdominal fat accounted for 33%, and postmenopausal hormone therapy accounted for an additional 5% of the variance in QUICKI. Among men, only a higher level of fitness independently correlated with insulin sensitivity, accounting for 21% of the variance (p < 0.01). CONCLUSIONS: Abdominal obesity among women and fitness among men were the strongest determinants of insulin sensitivity in this older cohort. This raises the question whether there are sex differences in the lifestyle changes that would be most effective in improving insulin sensitivity.

Abdomen↗
PubMed2001

Familial aggregation of 7-year changes in musculoskeletal fitness.

The purpose of this study was to determine the degree of familial resemblance in baseline and 7-year changes in musculoskeletal fitness. Data from the 1981 Canada Fitness Survey and the Campbell's Survey 7-year follow-up were used. The sample consisted of 1264 people (635 males and 629 females) between the ages of 7 and 69 years for whom measurements of musculoskeletal fitness were available at baseline. A subsample of 834 people had measurements at both baseline and 7-year follow-up. Sit-and-reach trunk flexibility, number of push-ups without time limit, number of sit-ups in 60 seconds, and hand-grip strength were used as indicators of musculoskeletal fitness. The data were adjusted for the effects of age and body mass index (and baseline level of the variable for changes) by using regression procedures, and they were standardized to zero mean and unit variance within each of the four sex-by-generation groups (fathers, mothers, sons, and daughters). Familial correlation models were fitted to the data by using the computer software SEGPATH. The results indicate significant familial resemblance for all indicators of musculoskeletal fitness for baseline measures and 7-year changes. The heritabilities, or the percentages of the total variance attributable to heredity, were 64% for trunk flexibility, 37% for push-ups, 59% for sit-ups, and 48% for grip strength. Similarly, heritabilities for the change scores were 48% for trunk flexibility, 52% for push-ups, 41% for sit-ups, and 32% for grip strength. The results suggest that familial, and perhaps genetic, factors are important in explaining the variance in musculoskeletal fitness not only cross-sectionally but also for changes over time.

Adolescent↗
PubMed2004

Prevalence, attributes, and outcomes of fitness and frailty in community-dwelling older adults: report from the Canadian study of health and aging.

BACKGROUND: Frailty and fitness are important attributes of older persons, but population samples of their prevalence, attributes, and outcomes are limited. METHODS: The authors report data from the community-dwelling sample (n = 9008) of the Canadian Study of Health and Aging, a representative, 5-year prospective cohort study. Fitness and frailty were determined by self-reported exercise and function level and testing of cognition. RESULTS: Among the community-dwelling elderly population, 171 per 1000 were very fit and 12 per 1000 were very frail. Frailty increased with age, so that by age 85 years and older, 44 per 1000 were very frail. The risk for adverse health outcomes increased markedly with frailty: Compared with older adults who exercise, those who were moderately or severely frail had a relative risk for institutionalization of 8.6 (95% confidence interval, 4.9 to 15.2) and for death of 7.3 (95% confidence interval, 4.7 to 11.4). These risks persist after adjustments for age, sex, comorbid conditions, and poor self-rated health. At all ages, men reported higher levels of exercise and less frailty compared with women. Decreased fitness and increased frailty were also associated with poor self-ratings of health (42% in the most frail vs 7% in the most fit), more comorbid illnesses (6 vs 3), and more social isolation (34% vs 29%). CONCLUSIONS: Fitness and frailty form a continuum and predict survival. Exercise influences survival, even in old age. Relative fitness and frailty can be determined quickly in a clinical setting, are potentially useful markers of the risk for adverse health outcomes, and add value to traditional medical assessments that focus on diagnoses.

Aged↗
PubMed1980

Intellectual differences of adult men related to age and physical fitness before and after an exercise program.

Fluid and crystalized intelligence differences among high-fit, young; high-fit, old; low-fit, young, and low-fit, old groups were investigated before and after an exercise program. The high-fit group had higher fluid intelligence than the low-fit group. Likewise, the young group scored higher than the old group. The four groups scored higher at the posttest on two of the fluid intelligence subtests of the Cattell Culture. Fair Intelligence Test. No differences were observed on crystallized intelligence. It is uncertain how biological factors and psychological changes, either individually or in combination, produce differences in cognitive functioning due to physical fitness.

Adult↗
PubMed2026

Synonymous mutations in essential genes infrequently produce fitness effects in human cell lines.

The assumption that synonymous mutations are fitness-neutral is central to many foundational results in the fields of genetics, genomics, evolutionary biology, and medicine. However, recent results suggest synonymous mutations have pervasive and strong fitness effects. These vigorously debated studies in non-human model systems have even suggested that the proportion of synonymous mutations and their fitness effect sizes are similar to non-synonymous mutations. To probe the fitness effect of synonymous mutations, we utilized recent advances in base editing to test 8558 potential synonymous mutations in 128 highly essential genes in human cell lines. Importantly, our library design excluded splice-proximal sites, ensuring a direct test of codon-level synonymous effects independent of splicing disruption. We find that synonymous mutations rarely have fitness effects on growth, occurring around 37.9-fold (95% CI: 22.16-81.48-fold) less frequently than missense mutations. In this experimental context, these findings demonstrate that synonymous mutations impact cellular fitness far less frequently than missense mutations. These results deviate from earlier reports of widespread synonymous fitness effects in yeast, yet they align with recent prime editing data observed in other human cell lines.

Humans↗
PubMed1989

Surrogate measures of physical activity and physical fitness. Evidence for sedentary traits of resting tachycardia, obesity, and low vital capacity.

Studies on physical activity, physical fitness, and health have been hampered because of invalid, unreliable, or impractical measures of physical activity. This report examines the validity of sedentary traits (resting tachycardia, obesity, and low vital capacity) as predictors of physical fitness as assessed by a maximal treadmill exercise test. Study participants were women (n = 3,943) and men (n = 15,627) with at least one visit to the Cooper Clinic in Dallas, Texas. Association of the sedentary traits with physical fitness was examined by multiple regression analyses. Sedentary traits were associated with physical fitness in all age and sex groups, accounting for 12-40% of the variance in treadmill time. When smoking, a simple physical activity index, and sedentary traits were included in a model to predict physical fitness, R2 values ranged from 0.20 to 0.53 in women and 0.45 to 0.61 in men and were significant at p less than 0.0001. These models account for approximately twice as much variance in physical fitness as has been reported previously. The addition of sedentary traits measurements to a simple physical activity index provides a valid estimate of physical fitness in epidemiologic studies.

Adult↗
PubMed1999

Physical fitness and clustering of risk factors associated with the metabolic syndrome.

PURPOSE: The purposes of this study were to 1) assess the prevalence of clustering of metabolic markers of the MS in a defined population and 2) determine the association between CRF and such clustering in a large group of adult men (N = 15,537) and women (N = 3,899). METHODS: Metabolic markers of the MS included systolic blood pressure (BP) > or = 140 mm Hg, serum triglycerides > or = 150 mg x dL(-1), fasting blood glucose > or = 110 mg x dL(-1), and elevated central adiposity (waist circumference > 100 cm). Cardiorespiratory fitness was defined as total time on a maximal treadmill exercise test. The cohort was grouped by the number of metabolic abnormalities and level of CRF. Associations between CRF and the number of metabolic abnormalities were assessed using proportional odds logit models. RESULTS: Among men, the age-adjusted cumulative odds ratio for abnormal markers of the MS was 3.0 (95% C.I. 2.7-3.4; P < 0.001) for the least-fit men when compared with moderately-fit ones, and 10.1 (95% C.I. 9.1-11.2; P < 0.001) when compared with the most-fit men. Among women, the age-adjusted cumulative odds ratio was 2.7 (95% C.I. 2.1-3.5; P < 0.001) for the least-fit women when compared with moderately-fit ones, and 4.9 (95% C.I. 3.8-6.3; P < 0.001) when compared with the most-fit women. CONCLUSIONS: These cross-sectional results suggest that low CRF is associated with an increased clustering of the metabolic abnormalities associated with the MS in both adult men and women and support the need for future prospective analyses.

Adult↗
PubMed2000

Familial risk ratios for high and low physical fitness levels in the Canadian population.

PURPOSE: To estimate the familial risk of being physically fit or unfit in Canada. METHODS: The sample consisted of 11,680 participants from 4144 nuclear families of the 1981 Canada Fitness Survey. Indicators of physical fitness included estimated physical working capacity at a heart rate of 150 beats x min(-1) derived from a step test (PWC150), hand grip strength, sit-ups, and trunk flexibility. Probands were defined as reference individuals who were physically fit (95th, 85th, and 75th percentiles) or physically unfit (25th, 15th, and 5th percentiles) for each fitness indicator, respectively. RESULTS: Standardized risk ratios, adjusted for age and sex (SRR), for spouses and first-degree relatives of probands exceeding the 95th percentile are 1.63 and 1.81 for PWC150, 2.38 and 3.16 for grip strength, 2.63 and 3.98 for sit-ups, and 2.59 and 3.56 for trunk flexibility, respectively, whereas the SRR for spouses and first-degree relatives of probands below the 5th percentile are 1.54 and 1.34 for PWC150, 1.83 and 1.85 for grip strength, 1.13 and 1.53 for sit-ups, and 1.42 and 1.84 for trunk flexibility, respectively. The familial risks tend to be greatest at the extremes (95th and 5th percentiles) and the risks for first-degree relatives of physically fit probands are generally greater than those for spouses for grip strength, sit-ups and trunk flexibility, whereas those for PWC150 show no clear pattern. CONCLUSION: There is significant familial risk for being physically fit or unfit in the Canadian population. The pattern of SRR suggests that the familial risk for indicators of strength and flexibility may be due, in part, to genetic factors, whereas the shared family environment is largely contributing to the familial risk for PWC150.

Adolescent↗
PubMed2001

Tracking of physical fitness during adolescence: a panel study in boys.

PURPOSE: To investigate the tracking in physical fitness (PF) viewed as a whole, a multidimensional trait of the subject, and to establish the stability of each factor of PF in adolescence from the perspective of a panel study using the structural equation modeling approach. METHODS: From a sample of 454 boys followed from 12 to 18 yr of age of the Leuven Growth Study, we considered only three consecutive measurement occasions with a mean age of 12.76, 14.69, and 17.73 yr. Physical fitness was evaluated by means of a battery composed of the following tests: plate tapping, sit and reach, vertical jump, arm pull, leg lifts, bent arm hang, and shuttle run. Structural equation models were fitted to the data, namely autoregressive models with latent variables. These models were used to quantify the tracking of PF as a whole and also of the individual marker variables of fitness. RESULTS: Stability estimates of PF as a whole are rather high, beta21 = 0.86 and beta32 = 0.68, with an explained variance of 74% and 73%, respectively. Tracking coefficients represented by disattenuated autocorrelations among the fitness factor gave high results: r1,2 = 0.86; r1,3 = 0.78; and r2,3 = 0.85. CONCLUSIONS: Physical fitness as a whole is highly stable in adolescent years and very predictable from early years. The same is observed for each factor of fitness. Moreover, autoregressive models within the context of structural equation modeling are better suited than simple Pearson or Spearman autocorrelations to study the tracking problem of PF.

Adolescent↗
PubMed2001

Seven-year stability of physical activity and musculoskeletal fitness in the Canadian population.

BACKGROUND: Knowledge of population patterns of physical activity levels and musculoskeletal fitness are important in the selection of appropriate target groups for public health interventions. PURPOSE: To examine the stability of physical activity levels and musculoskeletal fitness in the Canadian population. METHODS: The sample included 951 male and 958 female subjects, aged 11-69 yr, for whom the appropriate measurements were available in the 1981 Canada Fitness Survey and its 7-yr follow-up, the Campbell's Survey. Participants were divided into 2-yr age groups in childhood (11-18 yr) and 10-yr age groups in adulthood (19-69 yr). Measures of physical activity were estimated activity energy expenditure (AEE) and time spent on activity, whereas indicators of musculoskeletal fitness consisted of sit-ups, push-ups, grip strength, and sit-and-reach (trunk flexibility). RESULTS: 7-yr inter-age correlations ranged from -0.08 to 0.39 for AEE, -0.10 to 0.33 for time on activity, 0.42 to 0.80 for sit-ups, -0.07 to 0.73 for push-ups, 0.44 to 0.82 for grip strength, and 0.47 to 0.85 for sit-and-reach. In general, significant tracking correlations for physical activity levels were limited to adulthood, whereas significant tracking of musculoskeletal fitness was observed at all ages for all indicators except push-ups. Male subjects exhibited greater stability in push-ups than female subjects. The average percentage of participants remaining in the lower and upper quintiles of the distribution over 7 yr was greater for musculoskeletal fitness (36-68%) than for physical activity level (30-34%). CONCLUSION: Physical activity level is not a very stable characteristic in the Canadian population; however, indicators of musculoskeletal fitness are moderately stable over 7 yr.

Adolescent↗
PubMedDate not supplied

Association of physical fitness and transient myocardial ischemia in patients with coronary artery disease.

PURPOSE: To examine the relationship between physical fitness and transient myocardial ischemia (TMI) in the laboratory and during daily life, in a sample of coronary patients with a recent positive exercise test. METHODS: 47 patients with coronary disease (CAD) participated in laboratory mental and exercise stress testing and 48-hour outpatient Holter monitoring after being withdrawn from ant-ischemic medications. During laboratory testing, left ventricular performance was assessed by radionuclide ventriculography. Physical fitness was assessed by measurement of oxygen consumption during symptom-limited exercise treadmill testing. RESULTS: Higher physical fitness subjects were less likely to exhibit wall-motion abnormalities in response to mental stress (P < .05), and to exercise stress (P < .05) testing. They also had smaller decreases in left ventricular ejection fraction (LVEF) in response to mental stress than less fit subjects (P .056), and exhibited a mean increase in LVEF during exercise, compared to the less fit subjects who exhibited a decrease in LVEF (P < .02). Moreover, higher fit subjects exhibited fewer episodes of TMI (P < .04), for a shorter duration (P < .04), and less total ischemic burden (P < .04) during Holter monitoring. CONCLUSION: These findings suggest that within a population of CAD patients, higher levels of physical fitness are associated with less TMI assessed in the laboratory and during routine activities of daily living.

Adult↗
PubMed1988

Factors associated with enrollment in an employee fitness center.

Employee fitness programs may be evaluated by comparing program participants with nonparticipants on program outcome variables. This study was designed to identify how participants in an employee fitness program may selectively differ from nonparticipants. Joiners were more likely to have engaged in prior fitness activity, to consider fitness a high priority, and to have more positive attitudes about keeping fit. Traditional factors such as demographic or health status variables were not different between joiners and nonjoiners. Although the fitness center was not systematically selecting the more fit employee, participants were different from nonparticipants in terms of attitudinal and behavioral factors which reflect a health promotion orientation.

Adult↗
PubMed2002

Fitness self-perception and Vo2max in firefighters.

Firefighters work at maximal levels of exertion. Fitness for such duty requires adequate aerobic capacity (maximum oxygen consumption [Vo2max]). Aerobic fitness can both improve a worker's ability to perform and offer resistance to cardiopulmonary conditions. Inactive firefighters have a 90% greater risk of myocardial infarction than those who are aerobically fit. Participants (101 firefighters) completed a questionnaire that asked them to rank their fitness level from 0 to 7; e.g., Level 0 was low fitness: "I avoid walking or exertion, e.g., always use elevator, drive whenever possible." The level of activity rating increased to Level 7: "I run over 10 miles per week or spend 3 hours per week in comparable physical activity." Each participant then completed two measures of Vo2max: a 5-minute step test and a submaximal treadmill test. There was no association between the firefighters' self-perception of their level of fitness and their aerobic capacity as measured by either step test or submaximal treadmill. Because of the critical job demands of firefighting and the negative consequences of inadequate fitness and aerobic capacity, periodic aerobic capacity testing with individualized exercise prescriptions and work--community support may be advisable for all active-duty firefighters.

Adult↗
PubMed2006

Comparing cochlear implant users' speech performance with processor fittings based on conventionally determined T and C levels or on compound action potential thresholds and live-voice speech in a prospective balanced crossover study.

OBJECTIVE: The objective of the present study is to improve the efficiency of the fitting procedure of cochlear implant processors by making use of measurements of the electrically evoked compound actio potential (ECAP) and live-voice speech. DESIGN: In a randomised prospective cross-over design we compare speech performance of eighteen adult subjects when following the conventional fitting procedure to a procedure in which we use the profile of the ECAP threshold levels across the full electrode array measured intra-operatively. The overall level of the profile is shifted (by an equal amount of current units per electrode) until we find the threshold for live speech (new T levels) and the loudness comfort level (new C levels). Each fitting procedure is tested for 6 wk. Speech performance is measured in quiet and in noise every other week. RESULTS: The results show little difference between the scores (Dutch CVC words) for the conventional fitting procedure and the ECAP based fitting, although the T and C levels may differ markedly. CONCLUSION: The new fitting procedure is much faster and easier in the initial phase. Further improvement of performance may be obtained in a later stage of the fitting procedure by changing some individual electrodes on the basis of subjective responses.

Action Potentials↗
PubMed2004

Relationship between physical fitness and lifestyle behaviour in healthy young men.

BACKGROUND: There is substantial knowledge about the inverse association of physical fitness and CVD risk factors and CVD mortality. However, physical fitness per se might be influenced by lifestyle conditions such as physical training, smoking and drinking habits. HYPOTHESIS: We evaluated the relationship between physical fitness, physical activity, endurance training, smoking and drinking habits and blood pressure, lipids and leukocytes as surrogate cardiovascular risk markers in a large-scale cross-sectional study of healthy young men. STUDY DESIGN AND METHODS: A total of 6748 healthy young men were selected during their primary flight medical examination for military flying duties. Physical fitness was assessed by achieved physical working capacity at a heart rate of 170 beats per min (PWC170) during cycle ergometry. Parameters such as physical activity, endurance sports, smoking of cigarettes and drinking of alcoholic beverages were assessed by means of standardized questionnaires. Systolic and diastolic blood pressures were measured manually. Fasting cholesterol and triglycerides as well as white blood counts were obtained. RESULTS: Physical activity itself was not related to significant differences in the tested variables, whereas good physical fitness showed a significant association with improved blood pressure and blood lipids (P<0.001) with no detectable threshold. This effect was independent of endurance training, smoking and drinking. Whereas drinking was associated with elevated systolic blood pressure, smoking was associated with markedly increased triglycerides as well as with elevated leukocytes. CONCLUSION: Physical fitness is associated with improved blood pressure and blood lipids. This effect is independent of participating mainly in endurance or nonendurance sports, of physical activity per se, and it does not depend on smoking and drinking habits. Smoking itself revealed relevant higher inflammation independent of fitness.

Adult↗