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At least 577 records · Page 32Linked to original sources
PubMed1989

Does the act of migration provoke psychiatric breakdown? A study of Greek Cypriot immigrants.

This article describes a community psychiatric survey of a random sample (n = 291) of Greek Cypriot immigrants living in London. Over three quarters of the immigrants were first generation. Information from the subject and from hospital case records were used to date previous episodes of psychiatric disorder. Datable episodes had occurred in 52 subjects. There was no evidence that the risk of breakdown was increased in the immediate aftermath of immigration. For 34 subjects who experienced their first illness after migration, the mean interval was 15 years. In only 9% did breakdown occur within 2 years of migration. The age-specific incidence of psychiatric disorder was the same as that seen in a native British sample. Although there were differences in the age of onset of first- and second-generation subjects, this was in the opposite direction to that expected if immigration appreciably provoked breakdown.

Acculturation↗
PubMed2006

The impact of genotype on endocrine complications in thalassaemia major.

BACKGROUND: The clinical severity in thalassaemia major (TM) depends on the underlying mutations of the beta-globin gene and the degree of iron overload. OBJECTIVE: The aim of the study was to investigate the impact of genotype on the development of endocrine complications in TM in our center. SUBJECTS AND METHODS: 126 (62 males, 64 females) thalassaemic patients of Greek Cypriot origin with a mean age of 31.2 (17-68) yr were included in the study. All patients, who were on the standard treatment protocol, were subsequently divided into two groups according to their genotype, group A (92): TM with no mitigating factor and group B (34): TM carrying one or more mitigating factors in the beta- and/or alpha-globin genes. Iron overload calculation was based on the amount of red cell consumption and the mean ferritin level over a 12-year period. Statistical analysis was performed with the SPSS program. RESULTS: Patients in group A, who were consuming larger amounts of blood on transfusions, were more likely to develop hypogonadism (P = 0.001) compared with patients in group B, despite their similar mean ferritin levels. The incidence of other endocrinopathies (short stature, hypothyroidism, and diabetes mellitus) was similar in the two groups. The prevalence of hypothyroidism in splenectomized patients was significantly higher (P = 0.005), whereas the presence of hypogonadism, impaired glucose homeostasis and insulin resistance, although more frequent, was not statistically significant. The clinical severity of TM had no impact on bone mineral density (BMD) in both men and women. BMD was only influenced by gonadal function. CONCLUSIONS: This study demonstrates that the underlying genetic defect in TM is a contributing factor for gonadal dysfunction, because the patients with the more severe defects have a greater rate of iron loading through higher red cell consumption.

Adolescent↗
PubMed1972

Incidence of -thalassaemia trait among Cypriots in London.

The incidence of beta-thalassaemia trait among Cypriots in London is about 14%, and the birth rate of children with thalassaemia major is 0.6%. The high incidence of the beta-thalassaemia gene among Cypriots suggests the desirability of screening Cypriot school-leavers for thalassaemia trait and following up any incidentally discovered cases with family studies and genetic counselling.

Cyprus↗
PubMed1988

Beta thalassaemia mutations in Turkish Cypriots.

Using oligonucleotide hybridisation or restriction endonuclease analysis, we have characterised the molecular defect in 94 patients with thalassaemia major and four with thalassaemia intermedia of Turkish Cypriot descent. We found that four mutations, namely beta+ IVS-1 nt 110, beta zero IVS-1 nt, beta+ IVS-1 nt 6, and beta+ IVS-2 nt 745 were prevalent, accounting for 69.9%, 11.7%, 8.7%, and 5.6% respectively of the beta thalassaemia chromosomes. This information may help in the organisation of a large scale prevention programme based on fetal diagnosis of beta thalassaemia by DNA analysis in the Turkish population.

Cyprus↗
PubMed1987

Hyperbaric oxygen for a thalassaemic leg ulcer.

A thalassaemic ulcer in a male Greek Cypriot patient, resistant to standard medical treatment, was treated using hyperbaric oxygen in a recompression chamber. The patient breathed 100% oxygen by face mask whilst the chamber was compressed with air to a pressure of 2.5 atmospheres absolute. The ulcer became fully epithelialised within three weeks of starting treatment.

Adult↗
PubMed1997

Setting heat stress limits for acclimatised soldiers exercising in heat.

Heat illness is a recognised risk of military training. The Combat Fitness Test (CFT) has been identified as an activity that has been associated with heat casualties. The aim of this study was to establish whether a heat stress limit could be set for acclimatised soldiers performing the CFT by measuring the group mean rises in core temperature whilst performing the CFT at various environmental temperatures. The study showed that CFTs should not be undertaken when the start or expected end Wet Bulb Globe Test (WBGT) is greater than 25 degrees C if the group mean rise in core temperature is not to exceed 0.6 degree C (95% CI 0.2 degree C to 1 degree C).

Acclimatization↗
PubMed1991

Controversy in the management of cholangitis secondary to hydatid daughter cysts.

A 36 year old Cypriot woman, resident in the U.K. since the age of three years, presented with pyrexia, jaundice and upper abdominal pain. On ultrasound examination the biliary tree was dilated, contained sludge and a cystic lesion was present in the liver. An endoscopic cholangiogram showed multiple filling defects in the bile duct which were not felt to be removable endoscopically and a nasobiliary drain was therefore inserted. On resolution of the cholangitis with drainage and antibiotics a laparotomy was performed. The right lobe of the liver was largely replaced by a multiloculated cyst and the bile duct contained multiple hydatid daughter cysts. A right hepatectomy was performed with t-tube drainage of the evacuated bile duct. She made an uneventful recovery and has had no problems on subsequent follow up. Histology confirmed an intrabiliary rupture of a hydatid liver cyst. Cholangitis secondary to daughter cysts is a rare but recognised complication of hydatid liver cysts. Management of hydatid liver cysts by formal resection is controversial but may be preferable in this situation.

Adult↗
PubMedDate not supplied

A4T mutation in the SOD1 gene causing familial amyotrophic lateral sclerosis.

We report the clinical and laboratory findings in the largest kindred so far recorded with familial amyotrophic lateral sclerosis due to an A4T mutation in the SOD1 gene. The age of onset ranged from 32 to 60 years, with a mean of 46 years. Weakness in the legs was the most frequent early symptom and there was a predominance of lower motor neuron signs. The mean time from onset of symptoms to death was 14 months. One man with onset at the age of 37 has shown a slowly developing form and is currently alive 76 months after diagnosis (October 2002), although severely affected. The A4T mutation, with one exception, was of similar severity to the A4V mutation.

Adult↗
PubMed2006

Prosodic shaping of consonant gemination in Cypriot Greek.

This paper presents an experimental investigation of durational variation in lexical and post-lexical geminate alveolar laterals, under different stress conditions, in Cypriot Greek. Lexical geminates are found to be longer than post-lexicals, and both geminates and non-geminates are longer in word-initial position. The durational distinction is robust in all conditions, but particularly for word-initial lexical geminates. Post-lexical geminates and word-initial lexical geminates are significantly longer when pre-stress. Word-initial geminates are longer when preceded by a word-final nasal (the condition for post-lexical gemination), thus creating a kind of 'supergeminate' consonant and indicating that word-final nasals are not deleted, as has previously been thought to be the case. Implications for the phonological analysis of Cypriot Greek geminates and the role of prosodic and phonotactic restrictions are considered.

Adult↗