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PubMed1980

Neuropsychological consequences of posttreatment drinking behavior in male alcoholics.

A prospective study was designed to determine the neuropsychological consequences of continued alcohol consumption after treatment for alcoholism. Performance on 24 commonly used clinical neuropsychological tests was examined in 56 male alcoholics approximately 7 months after completion of an inpatient alcoholism treatment program. Abstainers (n = 17) performed better than those who resumed alcohol consumption. Although there was a significant decrease in alcohol consumption, posttreatment drinking behavior still predicted cognitive performance, with increased frequency and quantity per occasion having more deleterious consequences even at consumption levels that are deemed by some to be socially acceptable. It is concluded that alcohol consumption by former alcoholics might serve to maintain cognitive performance at reduced levels, and that this possibility should be considered in determining appropriate treatment goals for alcoholic patients.

Adult↗

PubMed1989

Predicting microbial growth: the consequences of quantity of data.

Having developed a mathematical model of the growth responses in a laboratory medium of salmonellae (mixed inoculum of Salmonella thompson, S stanley and S. infantis) as affected by pH level, NaCl concentration and storage temperature, the consequences of systematic removal of data has been examined. Three-dimensional plots of fitted response surfaces for the whole data set and the data reduced by three strategies highlighted differences between models and illustrated the consequences of using insufficient data. The risk of an erroneous model was demonstrated.

Culture Media↗

PubMed1988

Antecedents and consequences of variations in girls' maturational timing.

The antecedents and consequences of variations in girls' physical development are reviewed. Girls' development is highlighted because research on antecedents addresses genetic and environmental influences on menarcheal age variations, and because findings on the behavioral consequences of tempo variations have been less consistent for girls than for boys. Implications for adolescent health care are considered, particularly for the early maturing girl.

Adolescent↗

PubMed1993

Development and consequences of group living in Sweden. A new mode of care for the demented elderly.

The process of developing a new mode of care for the demented elderly, group living (GL), is evaluated and the consequences discussed. The increasing proportion of very old persons in Sweden means a higher prevalence of dementia. The majority of patients in traditional institutional long term care show cognitive deterioration. An insufficient caring situation, both in quantity and quality has long been observed. This, and a better knowledge and understanding of dementing diseases, their symptoms and consequences, has been the impetus to develop an alternative care model, group living (GL), for well defined groups of demented elderly. The concept of GL discussed here means a setting strictly adapted to the abilities and psychosocial needs of moderately diseased Alzheimer and vascular demented patients. Security, integrity promoting therapy and activation are specially stressed. The importance of informing and educating different kinds of actors simultaneously to structural changes in social and physical patterns within the implementation of the new concept is illustrated.

Aged↗

PubMed1995

The validity of using health state indexes in measuring the consequences of traffic injury for public health.

This paper describes an assessment of the validity of using health state indexes as a means of describing the consequences of traffic injury for public health. Three issues are discussed: (1) Can questionnaire data be used as input for estimating health state values by means of health state indexes? (2) Can the validity of describing the consequences of traffic injury by means of different health state indexes (QALY-indexes) be assessed? (3) Can estimated health state values be used directly as a basis for decision making? It is concluded that questionnaire data can be used as input of health state value estimation. Four health state indexes are compared: The Quality of Well Being Scale, The McMaster Health Classification System, The Rosser and Kind Index and the EuroQol Instrument (transformed version). It is concluded that an assessment of the validity of these indexes is possible, and that the EuroQol Instrument appears to be the most valid of the four indexes that are compared. None of the four indexes give values that are consistent with public policy objectives, but objectives were not set with the benefit of knowing the relative utility loss associated with injuries at different levels of severity.

Accidents, Traffic↗

PubMed1994

Coping with long-term musculoskeletal pain and its consequences: is gender a factor?

We did a descriptive study of 121 patients (71 women and 50 men) to explore the role of gender in coping with long-term intractable pain of the neck, shoulder and back and to determine the consequences of pain. Questionnaires used to assess the dependent variables were the Coping Strategy Questionnaire (CSQ) and the Multidimensional Pain Inventory (MPI). Distinctions were found between men and women. In particular, the coping strategies used by women were those which in previous research had been found to be associated with dysfunction and poor outcome in terms of rehabilitation. Moreover, considering the consequences of pain on daily living, a more complex pattern of related factors was found in women rather than men. Given the high proportion of working women in Sweden with long-term musculoskeletal pain and considering recent observations in controlled studies showing that the benefits of cognitive behaviourally based treatments are confined to women, our findings suggest the need to tailor rehabilitative strategies differently for men and women and point to a research agenda which pays more attention to the distinctive challenges of women in the workplace when they are affected by chronic ailments.

Adaptation, Psychological↗

PubMed1996

A new concept in (adenoviral) oncogenesis: integration of foreign DNA and its consequences.

A new concept for viral oncogenesis is presented which is based on experimental work on the chromosomal integration of adenovirus DNA into mammalian genomes. The mechanism of adenovirus DNA integration is akin to non-sequence-specific insertional recombination in which patch homologies between the recombination partners are frequently observed. This reaction has been imitated in a cell-free system by using nuclear extracts from hamster cells and partly purified fractions derived from them. As a consequence of foreign DNA insertion into the mammalian genome, the foreign DNA is extensively de novo methylated in specific patterns, presumably as part of a mammalian host cell defense mechanism against inserted foreign DNA which can be permanently silenced in this way. A further corollary of foreign (adenovirus or bacteriophage lambda) DNA integration is seen in extensive changes in cellular DNA methylation patterns at sites far remote from the locus of insertional recombination. Repetitive cellular, retrotransposon-like sequences are particularly, but not exclusively, prone to these increases in DNA methylation. It is conceivable that these changes in DNA methylation are a reflection of a profound overall reorganization process in the affected genomes. Could these alterations significantly contribute to the transformation events during viral or other types of oncogenesis? These sequelae of foreign DNA integration into established mammalian genomes will have to be critically considered when interpreting results obtained with transgenic, knock-out, and knock-in animals and when devising schemes for human somatic gene therapy. The interpretation of de novo methylation as a cellular defense mechanism has prompted investigations on the fate of food-ingested foreign DNA. The gastrointestinal (GI) tract provides a large surface for the entry of foreign DNA into any organism. As a tracer molecule, bacteriophage M13 DNA has been fed to mice. Fragments of this DNA can be found in small amounts (about 1% of the administered DNA) in all parts of the intestinal tract and in the feces. Furthermore, M13 DNA can be traced in the columnar epithelia of the intestine, in Peyer's plaque leukocytes, in peripheral white blood cells, in spleen, and liver. Authentic M13 DNA has been recloned from total spleen DNA. If integrated, this DNA might elicit some of the described consequences of foreign DNA insertion into the mammalian genome. Food-ingested DNA will likely infiltrate the organism more frequently than viral DNA.

Adenoviridae↗

PubMed1996

Amygdala kindling in the rat: anxiogenic-like consequences.

Patients with complex partial seizures of temporal lobe origin may experience behavioural disorders like depressive, anxiety-related or schizophrenic-like symptoms between seizures, i.e. interictally. The neural mechanisms underlying these enduring interictal disorders remain to be investigated. The aim of the present study was to examine the behavioural consequences of kindling of the basolateral nuclei of the amygdala, an animal model of limbic complex partial seizures. Animals having experienced 15 stage 5 seizures were compared to non-kindled controls in different behavioural tests performed at least seven days after the last seizure. Kindled animals showed a significant reduction of exploration of open arms in the elevated plus-maze test. In the social interactions test, they showed a decrease of non-social behaviour and an increase of immobility. No modifications were observed in kindled animals when tested in the open field, the sucrose preference or the forced swimming test. The reduction of open arm exploration in the elevated plus-maze was reversed by a pretreatment with chlordiazepoxide (2 mg/kg i.p.), a benzodiazepine anxiolytic. Finally, a similar reduction of open arm exploration was observed when animals were kindled only until a stage 3 seizure occurred. These data, along with previous studies, suggest that kindling of the amygdala has anxiogenic consequences and provide an animal model to study the neuroplasticity phenomena underlying enduring interictal disorders in humans.

Amygdala↗

PubMed1988

The etiopathogenesis of premenstrual syndrome as a consequence of altered blood rheology: a new hypothesis.

The multisystem symptoms of premenstrual syndrome (PMS), the variable nature of their occurrence and their relatively rapid disappearance with the onset of bleeding are highly suggestive of a systemic factor as the causal agent of the disorder. Reports of increased blood viscosity and enhanced red blood cell (RBC) hydration provide a basis for proposing that PMS is the consequence of an aberration of the change in blood viscosity which occurs in the third week of the normal menstrual cycle. The seriousness of the viscosity-impaired capillary blood flow will be greatest in organs and capillary beds with the smallest capillaries. Such an assumption implies that those women who suffer from PMS will be individuals whose capillaries are smaller in size than non-sufferers. The frequency of occurrence of fluid retention as a symptom suggests that the specific etiologic agent could be a reduction in RBC deformability as a consequence of impaired linoleic acid metabolism or high levels of noradrenaline or hypothyroidism or combinations of the three factors. If poorly deformable RBCs are involved then the use of agents such as evening primrose oil or fish oil to improve RBC deformability could ameliorate the symptoms of PMS. It is speculated that similar changes in RBC deformability should occur at other times of hormonal change. Health problems occurring during pregnancy, or after parturition, or after cessation of ovarian function might be caused by or exacerbated by reduced RBC deformability.

Blood Pressure↗

PubMed1988

Contingency management in methadone maintenance: effects of reinforcing and aversive consequences on illicit polydrug use.

Treatment outcomes were compared for an intervention emphasizing reinforcement for abstinence from illicit drug use and an alternative intervention which combined the same reinforcement contingencies with aversive consequences for unauthorized drug use. Sixteen polydrug abusing methadone maintenance patients were randomly assigned to one of two treatment groups. Both groups received the opportunity to take methadone doses away from the clinic (take-home dose) as reinforcement for submitting urines testing negative for illicit substances. A regular weekly take-home dose of methadone could be earned for every 2 weeks of verified abstinence from unauthorized drugs, up to a maximum of three take-home doses per week. The combined intervention group had an additional contingency which involved a reduction in methadone dose as an aversive consequence for submitting urine samples testing positive for illicit substances. Specifically, 10% of the patient's daily methadone dose was lost for each week in which two of three urines tested positive for illicit drugs. An examination of the urinalysis results indicated no between group differences. Overall, 8% of the 12-week baseline urinalysis results tested negative for illicit substances while 42% tested negative for unauthorized substances during the 20 weeks of treatment intervention. At the end of the intervention period, nine subjects remained in treatment with three patients in each group receiving at least once weekly take-home privileges. Of the seven subjects no longer in treatment, five were in the combined intervention group.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1990

The prevalence and self-reported consequences of cocaine use: an exploratory and descriptive analysis.

In this study, prevalence rates for cocaine use were estimated by sex and race, as well as for selected social role and lifestyle characteristics, including educational level, martial status, living arrangements, job type and employment status. Prevalence rates were based on an estimation procedure that made the age-race-sex distributions balanced to that of the nation as a whole. Data were gathered from a multi-site probability sample of adults interviewed in 1981-1984 as part of the National Institute of Mental Health Epidemiologic Catchment Area Program (ECA) (n = 14,333). In addition to prevalence of use, rates of self-reported consequences of cocaine use were generated, by level of cocaine use. Striking differences in prevalence were found by education and marital status, which remained after controlling for age of respondent. Respondents who were employed full-time had a higher prevalence of cocaine use than those who were not. Individuals residing in households at the time of interview had a 6.4% lifetime prevalence of cocaine use, vs. hospitalized respondents (22%) and incarcerated respondents (40%). Cocaine use consequence rates varied greatly across survey sites, with self-reported tolerance (28%-51%) and withdrawal sickness (8%-33%) figuring prominently among sustained daily users.

Adult↗

PubMed1988

Follow-up study of psychological consequences of caesarean childbirth.

This study was the follow-up part of a survey of psychosocial consequences of caesarean delivery (J. Psychosom. Obstet. Gynecol., 6 (1987) 197-209). Two groups of primiparous mothers were compared, one group of 103 mothers delivered by caesarean section and one control group of 103 mothers delivered by vaginal delivery. Semi-structured questionnaires were mailed at 2 months and 1 year after birth to explore the mothers' physiological and psychological condition and mother-infant adaptation. At 2 months, 92 mothers in the caesarean section group and 84 mothers in the control group returned a completed questionnaire. At one year there were, respectively, 79 and 71 in each group. The data indicated that the most obvious long-term psychological ill-effects of caesarean delivery appeared to be on mothers. They more often reported psychosomatic symptoms during first year than controls. At 2 months the concerns of caesarean mothers seemed more self-oriented than in the control group. They also felt less confident about their abilities to care for their babies. At 1 year these differences disappeared. Signs of disturbance in mother-infant interaction were not linked to the mode of delivery either at 2 months or at 1 year. The influence of the mode of anaesthesia for surgical delivery was also examined. The positive consequences of epidural analgesia which were observed are discussed taking into account the role of confounding variables.

Adaptation, Psychological↗

PubMed1993

Consequences of cerebellar lesions at early and later ages: clinical relevance of animal experiments.

Animal experiments demonstrated that reactions of the brain after early lesions differ from those after lesions at adult age. Detailed knowledge on the neuroanatomical and neurophysiological consequences of brain lesions was obtained in humans and will be gained from lesion experiments in animals. Prerequisites for extrapolating animal data to the clinical situation are discussed: knowledge on the maturational stage at which the lesion occurs and the behavioral expression of the damaged neural system. The extensive remodelling after early unilateral cerebellar hemispherectomy and its consequences for behavioural development in the rat are presented and discussed.

Aging↗

PubMed1990

The spectrum of diseases of small coronary arteries and their physiologic consequences.

There is a wide spectrum of abnormalities in the structure of small coronary arteries, with regard both to the portion of the arterial wall involved and to the histologic nature of the disease. A fuller understanding of this spectrum permits more useful interpretation of the pathophysiologic basis for the functional consequences of small coronary artery disease. In this review based on personal observations during examination of more than 1,000 human hearts postmortem there is initially a description of the wide variety of structural abnormalities, then a discussion of the functional consequences of these abnormalities and finally a section of general comments to weave together the structural and functional discussion in the context of clinical evaluation of patients who have small coronary artery disease. Future studies should apply fractal analysis and quantitative topology, methods that lend themselves particularly well to an investigation of the progressively smaller branching of the human coronary tree.

Coronary Circulation↗

PubMed1996

Long-term opioid therapy: assessment of consequences and risks.

Medical practice with respect to the use of opioids for the treatment of pain has been heavily influenced by societal perceptions of problems of addiction and by laws governing the use of opioids. To effectively use opioids for the treatment of chronic pain, physicians must recognize pervasive, but clinically often irrelevant societal and legal influences on prescribing, while at the same time respecting opioid properties which may lead to unwanted consequences in the course of opioid therapy. This paper reviews history and legislation that has shaped medical prescribing of opioids, examines the potential risks and consequences of long-term opioid therapy and assesses three models of long-term opioid therapy.

Analgesics, Opioid↗

PubMed1992

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity.

Expression of oncogenic ras in PC12 cells causes neuronal differentiation and sustained protein tyrosine phosphorylation and activity of extracellular signal-regulated kinases (ERKs), p42erk2 and p44erk1. Oncogenic N-ras-induced neuronal differentiation is inhibited by compounds that block ERK protein tyrosine phosphorylation or ERK activity, indicating that ERKs are not only activated by p21ras but serve as the primary downstream effectors of p21ras. Treatment of PC12 cells with nerve growth factor or fibroblast growth factor results in neuronal differentiation and in a sustained elevation of p21ras activity, of ERK activity, and of ERK tyrosine phosphorylation. Epidermal growth factor, which does not cause neuronal differentiation, stimulates only transient (< 1 hr) activation of p21ras and ERKs. These data indicate that transient activation of p21ras and, consequently, ERKs is not sufficient for induction of neuronal differentiation. Prolonged ERK activity is required: a consequence of sustained activation of p21ras by the growth factor receptor protein tyrosine kinase.

Animals↗

PubMed2005

Childhood adversity and poor mothering: consequences of polydrug abuse use as a moderator.

Drug abuse consequences have been typically examined as a direct or main effect on various later outcomes. Drug abuse may also serve as a consequence that alters (moderates) critical developmental trajectories. This study examined the relationship between childhood adversity factors (parent alcohol and drug-related problems, childhood maltreatment) and future parenting practices through an analysis of the moderating effects of polydrug problems. Data from a community sample of mothers was divided into two groups based on the median split level of polydrug problems (alcohol, marijuana, cocaine) that they reported (low, N=123; high, N=114). Confirmatory factor models (CFAs) were developed for the two groups and compared with multiple group analyses (MGAs). Results revealed that mothers who had parents with alcohol or drug-related problems were more likely to become poor parents, if they themselves used drugs and had problems related to drug use.

Alcoholism↗

PubMedDate not supplied

Neurophysiologic consequences of neonatal ethanol exposure in the rat.

Many of the neurotoxic and neurobehavioral consequences of neonatal ethanol exposure in the rat have been characterized. However, in few studies has adult neurophysiologic function been assessed in rats exposed to ethanol during this key developmental period. In the current study, the effects of neonatal ethanol exposure on adult electroencephalographic (EEG) activity and auditory event-related potentials (ERPs) were examined in the rat. Male Sprague-Dawley rats were exposed to ethanol at 6.0 g/kg/day between postnatal days 4 through 9 by using an artificial-rearing procedure. Two control groups were used: a suckle control (SC) group and a gastrostomized control (GC) group. After reaching adulthood (i.e., at 3.5-4 months old), recording electrodes were implanted into the brain of each rat, so that EEG activity and auditory ERPs from the cortex and hippocampus could be assessed. Rats exposed to ethanol during the neonatal period were hyperactive as adults. Assessment of the EEG activity revealed that ethanol exposure increased peak frequency in the frontal cortical and parietal cortical 16-32 Hz frequency bands. Assessment of ERPs revealed that parietal cortical N1 amplitude was reduced in ethanol-exposed rats. Furthermore, parietal cortical N1 latency was increased in the GC group. These findings demonstrate that enhanced motor activity in rats exposed to ethanol during neonatal development occurs in combination with EEG indices of enhanced cortical and hippocampal arousal. Furthermore, a deficiency in cortical N1 amplitude indicates adult rats may have attention deficits. Overall, these results indicate that neonatal ethanol exposure has enduring neurobehavioral consequences, which persist into adulthood. This neurobehavioral profile in the rat is consistent with clinical observations of attention deficits and hyperactivity in children exposed to ethanol during prenatal development.

Age Factors↗