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PubMed1989

[Experience in the treatment of patients with chromomycosis].

Three cases of chromomycosis, a disease rare in this country, are described. The authors analyze the difficulties associated with the diagnosis of this disease and review the methods of its treatment. All the patients reported in this paper have been administered polychemotherapy including intrafocal injections of amphotericin B (an antimycotic drug), iodine preparations, vitamin D2, and nizoral. This therapy has been effective in all the cases. The employed mode of administration of amphotericin B (injections round the infection focus) helps create a high concentration of the drug in the involved skin sites, resolve the nearby foci, and rules out the general reactions. Combined therapy cuts down the length of treatment.

Adult↗
PubMed1987

[Chromomycosis].

A case of chromomycosis with an evolution of 25 years, in a caucasoid man, aged 57, living in Mozambique, is reported. Fonsecae pedrosoi, the most frequently responsible agent of chromomycosis in Mozambique's cases, was isolated. Prognosis seemed poor since good results from therapy were unexpected, considering the long course of disease, the extensive and fibrotic lesions, and the unsuccessful treatment with 5-fluorocytosine and ketoconazole. The patient was treated with associated amphotericin B-5-fluorocytosine, and topical heat. Clinical improvement and mycologic negative studies were obtained.

Amphotericin B↗
PubMed1986

[Treatment of chromomycosis with liquid nitrogen].

Five patients with chromomycosis have been treated by liquid nitrogen application. The evolution of disease has been of one to twenty five years, with 4 patients with verrucous patches and one patient with sarcoid-like lesion. In all cultures grows-up Fonseca pedrosi. The authors believe that this method of treatment has advantage to be more economic, to avoid hospitalization and surgical acts with anesthesia, and also could be realized at ambulatory level. The efficacy of this method has been proved by the follow-up the patients during a period between two to four years, without any recurrency.

Adult↗
PubMed1987

Chromomycosis in a horse.

A 6-year-old Quarter Horse gelding was examined because it had a sharply circumscribed, firm, brown-black, roughly spherical dermal nodule at the right tuber ischii. After it was excised, the lesion did not recur. Microscopically, the dermis of the excised specimen had multiple pyogranulomas, many of which contained thick-walled, dark brown fungal elements, some with internal septation compatible with chromomycotic fungi. Chromomycosis is a rare skin disease in the horse. It may be included in the differential diagnoses of nodular and/or pigmented skin lesions that include melanoma, pyogranuloma, mycetoma, squamous cell carcinoma, habronemiasis, and onchocerciasis.

Animals↗
PubMed1985

Cutaneous chromomycosis in renal transplant recipients. Successful management in two cases.

Cutaneous chromomycosis occurred in two renal transplant recipients from the south central United States. Both patients have been managed successfully with surgical excision of isolated lesions, and the condition of one of these has been improved but not cured with low-dose ketoconazole therapy. Even in the immunocompromised host, localized cutaneous chromomycosis may not require more aggressive systemic antifungal chemotherapy.

Abscess↗