Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “CERVIX EROSION”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 577 records · Page 32Linked to original sources
PubMed2003

Prevention of carcinoma cervix: role of Pap smear screening.

This study was undertaken to evaluate the prevalence of Cervical precancerous and Cancer pick up by single pap smear test. A prospective study of pap smear test of three years duration 2000-2002 in Obstetrics and Gynecology department, NMCTH, Kathmandu. A total 800 cases were included Maximum number of patients are in the age group of active reproductive period (21-40 yr) with higher rate of an abnormal smear in Brahmin ethnic group. The main complaints are of lower abdominal pain and white discharge per vaginum. The main cervical pathology is cervicitis, cervical erosion and cervical hypertrophied with bleeding on touch. 4.8% of the patients had abnormal smear including three patients with invasive cervical squamous cell carcinoma detected on pap smear test. This study shows that routine pap smear screening in patients attending gynecological OPD is the good method of detecting precancerous cervical intraepithelial neoplasia (CIN) lesion and early cervical cancer, which would go undiagnosed otherwise with worst morbidity and mortality. We should try to cover 100% screening if possible in an institution at least to begin with.

Adolescent↗
PubMed1995

[Human papillomavirus type 16-gene functions relevant to molecular human carcinogenesis].

Human papillomavirus type 16 is a strong ethiologic agent of tumor development in human mucous epithelia such as uterine cervix. The virus two early genes, E6 and E7, have been characterized to be oncogenes that transform various cells and cell lines in vitro. Extensive analyses of E6 and E7 proteins revealed that these two oncoproteins interacted with cellular tumor suppressors, p53 and pRb, respectively. Thus, oncogenic potentials of the E6/E7-genes could be explained in part by the consequence of crosstalk of E6/E7-proteins and the cell cycle regulators. Furthermore, telomerase activation that protects telomere erosion appeared to by necessary for HPV16-oncogenesis and was demonstrated in HPV16-immortalized human epithelial cell lines. This line of evidence now enabled us to describe, but not fully, a scheme of an earlier process of human carcinogenesis induced by this virus type.

Cell Cycle↗
PubMed2005

Gingival lesions as a first symptom of pemphigus vulgaris in pregnancy.

The erosive gingival lesions associated with vesiculobullous diseases can be an important early clinical manifestation of serious diseases such as pemphigus vulgaris (PV). PV is a vesiculobullous disease of the skin and mucosa which tends to be chronic and which normally affects people of 40-60 years of age. Its incidence varies from 0.5 to 3.2 cases per 100,000 per year. Mucosal lesions are located mainly in the oral and pharyngeal mucosa, although conjunctiva, larynx, nasal mucosa, vulva, vagina, cervix, and ano-rectal mucosa may also be involved. It is a serious mucocutaneous disease of an autoimmune nature, whose appearance during pregnancy is extremely rare.

Adult↗
PubMed1990

Risk factors related to biological behaviour of precancerous lesions of the uterine cervix.

In a study of factors related to cervical carcinogenesis, a cohort of 1,107 cervical dysplasia along with 1,077 controls matched for age and parity were followed up prospectively. During the follow up 75 dysplasia cases progressed to carcinoma in situ. The overall rate of progression of dysplasia to malignancy was observed to be 15.7% at the end of 108 months of follow-up. The analysis of progression rates in relation to various factors revealed significantly higher progression rates for initially higher grade of dysplastic lesions, and early age at consummation of marriage (ACM). The other factors, such as religion, literacy status of the patient, number of pregnancies, presence of cervical erosion, history of fetal loss and positivity to HSV-II antibodies, did not reveal statistical significance. The case-control comparison for detection of HPV 16/18 by in situ hybridisation revealed the presence of HPV 16/18 sequences in 67.3% of the dysplasia subjects progressed to carcinoma in situ while 27.3% of precancerous cases regressed to normalcy. The difference was found to be statistically significant (P less than 0.001).

Adult↗
PubMed2005

Abdominal sacrocolpopexy for vault prolapse without burial of mesh: a case series.

OBJECTIVES: To audit the clinical outcome of abdominal vault suspension (sacrocolpopexy, hysteropexy or cervicopexy) using non-absorbable mesh, without burial by closure of the peritoneum. DESIGN: A case series. SETTING: Urogynaecology units of four hospitals. POPULATION: One hundred and twenty-eight women having open or laparoscopic sacrocolpopexy (121), hysteropexy (6) or cervicopexy (1) using non-absorbable mesh for vault prolapse. METHODS: Patients had suspension of the vault, uterus or cervix from the sacral promontory using a monofilament polypropylene mesh. The pelvic peritoneum was not closed over the mesh. Patients were followed up every six months. MAIN OUTCOME MEASURES: Incidence of bowel complications as a consequence of the mesh; cure rate of prolapse and incidence of other post-operative complications; rate of re-operation for prolapse or incontinence. RESULT: After a median follow up of 19 months (1.5-62), there were no bowel complications as a result of non-burial of mesh. Three patients had asymptomatic vaginal mesh erosion, which required minor surgical intervention. Ninety percent of patients had good resolution of their prolapse symptoms while 10% of patients required further surgery. CONCLUSION: Leaving the mesh uncovered by the pelvic peritoneum was not associated with complications. It appears safe to perform vault suspension without closing the peritoneum.

Adult↗
PubMedDate not supplied

The prevalence of Chlamydia trachomatis infection in pregnant women.

PURPOSE: The aim of our study was to estimate the prevalence of Chlamydia trachomatis infection, the risk factors, the impact of the infection on the course of pregnancy and the condition of neonates born from pregnancies complicated by Chlamydia trachomatis infection. MATERIALS AND METHODS: 558 pregnant women aged 18-42 yrs, between the 4th and 40th week of pregnancy recruited from the Department of Obstetrics and Gynaecology, Medical Academy Lublin, and 10 men, partners of Chlamydia trachomatis infected patients were included in the study. All patients were examined using an immunoenzymatic method (MEIA). The ligase chain reaction (LCR) method was used only in cases of Chlamydia trachomatis detection with the use of MEIA method, in male partners of infected women and in patients with a cervical erosion and with a mucopurulent cervicitis. There were 64 women and 10 men who were examined using the LCR method. RESULTS: Positive results of MEIA test were found in 10 women (1.8% of studied population). Among men, the infection by Chlamydia trachomatis was present in 9 cases (90%). There were no infections with Chlamydia trachomatis in the group of neonates born from infected mothers. CONCLUSIONS: The prevalence of Chlamydia trachomatis infection was 1.8% in the studied group. The factors favourable for an infection are: young, unmarried patients, residents of towns or cities and changes in the cervix such as cervicitis or ectopy. In the cases of pathological pregnancy we should take into account Chlamydia trachomatis infections as a cause of abdominal pain or premature uterine contractions. The test towards Chlamydia trachomatis infection should be performed in pregnant patients to decrease the rate of pregnancy complications.

Adult↗
PubMed1995

False positive cervical smears: a cytometric and histological study.

The evidence of exfoliative cytology of the cervix uteri depends on various factors. The rate of false positive cervical smears is on average 8.8%. We have reviewed 170 false positive routinely Papanicolaou-stained cervical smears and the corresponding histological specimens. The aim was to look for non-neoplasic changes explaining the cytological over-interpretation. In addition, nuclear Feulgen-DNA measurements of the smears were made to look for changes in DNA pattern. In 50% of all cases, a cause was found for the false positive cytological diagnosis by means of histological reexamination: non-neoplastic nuclear and cellular polymorphia, severe purulent-erosive inflammation, a higher reclassification or a positive presurgical biopsy. In 51.9% of these cases, there were signs of an infection with human papilloma virus (HPV). In cases without histological explanation of the cytological findings, DNA measurements were made on the suspicious cells. By means of single cell algorithm (5c/9c exceeding events), a general rate of 62.7% of aneuploid specimens was detected. The number of aneuploid single cells ranged between 5 and 63 per slide. Of these cases, 23.1% showed signs of HPV infection. As a result of the study, the number of real 'false positive' cytological diagnoses decreased from 170 to 97 as a result of histological reexamination and DNA measurement. In doubtful cases, DNA measurement of suspicious smears should be made.

Carcinoma↗
PubMed2003

Cervical cytology in an urban population in Lagos, Nigeria.

Eight hundred and eighty-four consecutive women had cervical smears in a clinic in Lagos, Nigeria between September 1998 and 31 August 1999. Mean age was 36.6 - 11.6 years (range 16-81 years); 93.7% were first-time screening. Three hundred and twenty-five (36.5%) smears were normal, inflammatory smears 52.7%, mild dyskaryosis 2.4%, moderate dyskaryosis 1.5%, severe dyskaryosis 0.3% and probable malignancy (malignant cells) 0.8%. Abnormal smears were higher in symptomatic cases compared with asymptomatic cases (chi2=15.3, P< 0.01); 6.1% and 2.1% of symptomatic cases had dyskaryosis and carcinoma, respectively, compared with 3.4% and 0.1% for asymptomatic cases. In postcoital bleeding 9.3% and 1.9% had dyskaryosis and carcinoma, respectively. Fifty-six of 62 cases of cervical erosion had abnormal smears. In postmenopausal bleeding 13.0% and 4.3% had dyskaryosis and carcinoma, respectively. Prevalence of abnormal cervical smears is high in women who have genital tract disease. In places with no national screening programmes every effort should be made to screen such women.

Adolescent↗
PubMed2003

Brief communication: Study of noncarious cervical tooth lesions in samples of prehistoric, historic, and modern populations from the South of France.

Noncarious tooth lesions (NCTL) are frequent findings in contemporary dental practices. Unlike other dental and periodontal diseases, NCTL have not been studied in an anthropological context. The purpose of the present study was to compare the prevalence of NCTL in three archaeological samples from the Copper Age and Middle Ages and in subjects examined in three dental practices. Both archaeological samples and dental-practice subjects were from southern France. In the archaeological sample group, no NCTL were detected in 3,927 teeth from 259 individuals. In the dental-practice group, prevalence rates were in agreement with current epidemiological data. Our data also suggest that prevalence of NCTL increases with age and is higher in females. Premolars were the most affected tooth type. Occurrence of NCTL has long been attributed to toothbrushing and to erosion by intrinsic and extrinsic acids. More recently, occlusal stress associated with tooth flexure has been implicated. The reasons underlying the total absence of NCTL in archaeological samples are discussed. The most likely explanations involve differences in lifestyle, diet, and dental condition.

Adolescent↗
PubMed2003

[A comparative study utilizing different methods for establishing an experimental periodontitis model in rats].

OBJECTIVE: To evaluate the experimental periodontitis in rats induced by ligature plus high sugar water with and without infection of periodontopathic bacteria. METHODS: Forty SD rats (5 weeks of age) were randomly divided into a control group (N) and three experimental groups (P1, P2 and P3). All experimental groups were given silk ligatures around the cervix of the second maxillary molars and were provided with drinking water containing 10% glucose. Group P2 was inoculated with P. gingivalis, three times; group P3 was inoculated with P. gingivalis and F. nucleatum, three times. At weeks 0, 2 and 4, microbiological and histological examinations were made; alveolar bone loss was stereoscopically measured as the distance from the cement-enamel junction to the alveolar crest. RESULTS: Microbiological examination indicated that the bacteria inoculated in groups P2 and P3 were successfully colonized and both of P. gingivalis and F. nucleatum were predominant among the bacterial colonies of the examined sites. At week 2, histological examination showed gingival erosion and alveolar bone loss in all experimental groups and periodontal pockets in groups P2 and P3. The most serious lesions were observed in group P3. At week 4, the periodontal destruction in all experimental groups became more severe. CONCLUSION: Ligature, high sugar water combined with mixed infection of periodontopathic bacteria can successfully induce experimental periodontitis in rats.

Animals↗
PubMed1997

Uterosacral ligament fixation for vaginal vault suspension in uterine and vaginal vault prolapse.

OBJECTIVE: The purpose of this study was to determine the simplicity, safety, anatomic, and functional success of using the uterosacral ligaments for correction of significant complex uterine and vaginal vault prolapse by the vaginal route. STUDY DESIGN: Fifty women with uterine or vaginal vault prolapse with descent of the cervix or the vaginal vault to the introitus or greater were treated between 1993 and 1996 by the same surgeon with bilateral uterosacral ligament fixation to the vaginal cuff by the vaginal route. Included were patients with significant enterocele, cystourethrocele, rectocele, and stress urinary incontinence who had concomitant repair of coexisting pelvic support defects. An etiology of vaginal vault prolapse is discussed. RESULTS: Uterosacral ligaments were identified and used for successful vaginal vault suspension by the vaginal route in all 50 consecutive patients without subsequent failure or significant complications with a maximum follow-up of 4 years. One patient had recurrent stress urinary incontinence and two had asymptomatic cystoceles. Three patients had erosion of monofilament sutures at the vaginal apex. CONCLUSIONS: In these 50 patients with significant complex uterine or vaginal vault prolapse, uterosacral ligaments could always be identified and safely used for vaginal vault suspension by the vaginal route with no persistence or recurrence of vaginal vault prolapse 6 to 48 months after surgery. Excessive tension by the surgeon on tagged uterosacral ligaments at the time of hysterectomy may be an etiologic factor in vaginal vault prolapse.

Adult↗
PubMed2006

[Transvaginal cervico-isthmic cerclage using polypropylene tape: surgical procedure and pregnancy outcome: Fernandez's procedure].

OBJECTIVE: To assess the efficacy of performing transvaginal cervico-isthmic cerclage using synthetic tape in prevention of preterm labor in high-risk women. PATIENTS AND METHODS: A retrospective analysis of 24 transvaginal cerclages using polypropylene tape performed in women presenting with high risk of preterm delivery: prior histories of pregnancy losses in the second trimester, prior failure of Mac Donald's cerclage and/or absent portio vaginalis of the cervix. Cerclage was performed between 12 and 16 weeks of gestation. A polypropylene tape was placed at the cervicoisthmic junction by vaginal route. RESULTS: The median age of the patients in this series was 32.1 years (range 22-39 years). No intra-operative complication occurred. The median operating time was 34.9 minutes (+/-5.1) (range 30-45 min). Cesarean delivery was systematically performed in all patients since the cerclage was considered to be definitive. Mean gestational age and birth weight at delivery were respectively 37.1 weeks (+/-1.8) and 2850 g (+/-745). Preterm birth rate was 19% (4/21). Birth at less than 32 weeks occurred in only one patient (4%). In one case, the tape has been removed later because symptomatic vaginal erosion was noted. One neonatal death occurred following amniotic fluid infection at 34 weeks. At the present time, 3 women are at 22, 26 and 26 weeks of gestation with no preterm labor. CONCLUSION: Transvaginal cerclage using polypropylene tape may be considered as an effective and minimally invasive alternative to transabdominal cervico-isthmic cerclage in women presenting with high risk of preterm delivery.

Adult↗
PubMed1993

[Clinical and experimental studies on sanpin therapy for chronic cervical diseases].

Chronic cervical diseases belong to the category of precancerous diseases whose treatment is important in preventing cervical cancer. 135 cases were treated with Sanpin preparations therapy after exclusion of heart, liver, kidney and cancerous diseases. After the treatment of 2-3 months, 133 cases were cured. Two cases have not finished their treatment courses and so have been excluded from the study. Among them, 110 have been followed up for 1 to 11 years. All of the patients with pretreatmental hypertrophic cervices had normal sizes after the treatment. The cure rate of cervical erosion was 83.81% and the cure rate of cervical neoplasms was 91.84%. The basic studies of toxicology, pharmacology, pharmacochemistry and genetic toxicology of the Sanpin pills and rods have been done. Results showed that this therapy was safe so long as its indications and contraindications were handled correctly and the drug was given routinely. This therapy is simple, economical, safe and effective. After short training, it can be applied in county and township hospitals.

Administration, Topical↗
PubMed1975

[Colposcopic and cytological studies in pretumorous and malignant changes in the cervix uteri].

814 patients with various pathological changes in the uterine neck were subjected to the complex investigation, taking into consideration the fact that all specialists should be equally competent in their fields. Diagnostic errors were analysed in each method of investigation in relation to a histological conclusion in every series of patients. The diagnosis of preinvasive cancer proved to be most difficult. The number of errors was less in microcarcinoma. The organization of large colpocytological centres in big cities is advocated.

Biopsy↗
PubMed2005

Noncorrelating Pap tests and cervical biopsies: histological predictors of subsequent correlation.

Lack of correlation between dysplastic cervicovaginal Papanicolaou (Pap) tests and subsequent cervical biopsies raises the concern that a significant squamous intraepithelial lesion (SIL) may go unconfirmed. Additional tissue sections of cervical biopsies may detect SILs after noncorrelation on initial sections. Complete step sectioning of paraffin blocks was undertaken on 111 noncorrelating biopsy specimens from 95 patients and selected slides were reviewed for the presence of SIL. The initial negative biopsy slides were evaluated for four histological features: chronic cervicitis, acute cervicitis, mucosal erosion, and squamous atypia. Twenty-seven biopsies (24.3%) demonstrated the presence of a SIL in deeper levels. The presence of squamous atypia was significantly associated with the presence of dysplasia deeper in the block (P < 0.002). Acute and chronic cervicitis was seen roughly equally. Additional tissue levels are a productive way of confirming SILs, and squamous atypia allows a refined selection of negative cervical biopsies most likely to reveal an SIL on review of deeper levels.

Acute Disease↗
PubMedDate not supplied

Alternative rubber dam isolation technique for the restoration of Class V cervical lesions.

This article describes an expedited, atraumatic technique of restoring cervical abrasion-erosion, abfraction or carious lesions using an alternative placement sequence of the dental rubber dam for adequate field isolation. As shown by this technique, the rubber dam retainer is modified and positioned on the tooth with subsequent placement of the dental dam material over theretainer and tooth. This technique saves time and provides good retraction of the gingival tissue and isolation of the cavity preparation from contamination (saliva, hemorrhage) that can potentially cause post-operative symptoms and possible restoration replacement.

Dental Caries↗
PubMed2005

[A comparison of human papillomavirus detection and ThinPrep cytology test for women in Guangdong province].

OBJECTIVE: To evaluate the etiological significance of human papillomavirus (HPV) in cervical cancer and the clinical utility of HPV detection in cervical cancer screening. METHODS: Hybrid capture II test was used to detect 13 high-risk HPV genotypes from cervical scrapes of 2636 women. Cervical cytology was also evaluated in 454 of them by ThinPrep Pap smear. RESULTS: Among 2636 women, 699 (26.5%) were found to be high-risk HPV positive. The highest infection rate (59.4%) was found in the age group of < or = 20 years and the lowest infection rate in the age group of 41 approximately 50 years (21.0%). Significant differences in HPV infection rate were found between different cities in Guangdong province, such as those between Xinhui and Guangzhou, Xinhui and Shenzhen, Xinhui and Dongguan (P < 0.01). Fifteen out of 16 women (93.8%) with cervical carcinoma were infected with high-risk HPV versus 24 out of 125 women (19.2%) attending routine cervical cancer screening (P < 0.001). The HPV infection rate was 30.8% (142 out of 461) in women with cervical erosion, which was significantly lower than that in patients with cervical carcinoma (P < 0.001). HPV DNA were detected in 100% (2/2) of squamous cell carcinoma (SCC), 100% (12/12) high grade squamous intraepithelial lesion (HSIL), 88.9% (16/18) of low grade squamous intraepithelial lesion (LSIL) and 37.8% (28/74) of atypical squamous cells (ASC). CONCLUSION: High-risk HPV genotypes are the major causes of cervical cancers and HPV detection is a reliable adjuvant tool for cervical cancer screening.

Carcinoma, Squamous Cell↗
PubMed1988

Historical and clinical factors associated with Chlamydia trachomatis genitourinary infection in female adolescents.

Five hundred sixty-eight adolescent female patients receiving routine gynecologic care at urban clinics were screened by culture for Chlamydia trachomatis infection at both the urethra and endocervix. Culture results for 562 were available from either or both sites. Positive cultures were obtained from 139 (25%). Urethral infection was not associated with either urinary tract symptoms or sterile pyuria, but urethral or endocervical infection was associated with cervical friability (P = less than 0.0001), endocervical mucopus (P = 0.0001), cervical erythema (P = 0.0002), and cervical ectopy or erosion (P = 0.01). Increased chlamydial infection rates were associated with older age (P = 0.01), history of more frequent intercourse (P = 0.01), and history of more than one lifetime partner (P = 0.023), with a marginal association for being black (P = 0.05). Method of contraception, reason for attending clinic, age at menarche, age at first intercourse, years sexually active, number of sexual partners in preceding 6 months, parity, and prior history of sexually transmitted disease were not associated with having chlamydial genitourinary infection.

Adolescent↗