SEARCH · Search PubMed
Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
Tumoral Calcinosis is a rare clinical entity characterized by the presence of calcified, periarticular masses, as seen on radiographs. A severe case in a patient with chronic renal failure is presented and the complex etiology of this disease is discussed.
We report 2 exceptional cases of solitary nodular calcinosis of the skin, the first to be observed in Greece, with the clinical appearance of cutaneous horn and milium respectively. The latter clinical form has not been described in the literature. Histopathological examination of the first case shows the presence of numerous calcified concretions in the papillary dermis, directly beneath the epidermis, which is intensely hyperkeratotic and papillomatous. The calcified concretions are also seen in the lymphatic capillaries, the intraepidermal sweat ducts and horny layer; at a site they perforate the epidermis and penetrate in a sweat pore. The stroma presents an angiomatous appearance. Histopathological examination of the second case shows the presence of two well demarcated calcified masses in the upper dermis, the larger one being subepidermal, the other one being situated a little further from the epidermis. The smaller mass contains numerous hair shafts and is partially surrounded by a true epithelial wall, similar to that of an epidermal cyst.
In this article, the CT, three-dimensional CT, and MR findings are reviewed in a 59-year-old woman with tumoral calcinosis involving the temporomandibular joint.
Diffuse pulmonary calcinosis has been observed in hyperparathyroidism, chronic renal disease, vitamin D intoxication, but has never been reported in the absence of any underlying disease. We report the case of a young man in whom diffuse pulmonary calcifications was found without any underlying disease and whose clinical and histological features suggest a variant or an incomplete form ('forme fruste') of alveolar microlithiasis.
Tumoral calcinosis is a distinct clinicopathological entity characterized by periarticular soft-tissue calcium deposits. It is a rare condition in Tunisia (8 cases during 23 years). Six patients were aged 14 years or younger. There was male predominance (SR: 7/1). Lesions were located about the hip in five patients and the elbow in three patients. Multiple localisations occurred in two patients. Histologically, all cases exhibited active phase of the disease. In our patients lesions were only surgically excised.
Intervertebral disc calcification in children is a rare, primary and benign disease which often disappears after a single painful crisis, especially in cervical involvement. In adults, thoracic and lumbar discs are mainly involved; calcification is less expressive and is often detected during a casual radiograph. Intervertebral disc calcification is primary or secondary to chondrocalcinosis, apatite deposition disease, ochronosis and hemodialysis spondylarthropathy. Except CPPD deposits in chondrocalcinosis, calcium complex accounting for most discal calcinosis is hydroxy-apatite. Iatrogenic intervertebral disc calcification was recently described in patients treated with a discal injection of a long-acting corticosteroid.
Clinical observations of 11 new cases of tumoral calcinosis are reported. The condition is characterized by calcified masses of varying size in the region of major joints. Surgical excision is recommended in selected cases determined by the size of the lesion, the deformity present and functional complaints. In this series surgical excision was done in 6 patients, and the diagnosis was confirmed histopathologically. After a complete excision of the tumor, no recurrences were seen in 5 cases with a mean follow-up time of 25 months. Incomplete excision led to multiple recurrences in one patient.
The authors report an unusual case of diffuse bronchial calcinosis of established histology, found during a routine bronchoscopy in a pulmonary tuberculous patient aged 46. The lesions consisted in several small pale bulgings on the wall of the main bronchi on both sides. This finding led to the diagnosis of rough primary hyperparathyroidism.
The typical symmetric lesions in a patient with tumor calcinosis avidly accumulated bone-seeking compounds. Thus, bone scanning is very helpful in the diagnosis of this rare disease, especially if the calcareous masses are not situated periarticularly.
A case report on tumoral calcinosis (Teutschländer disease), a comparatively rare clinical entity, is presented. The localization of these painful, mostly periarticular soft tissue calcifications as well as their aetiology in connection with chronic renal failure, longstanding hemodialysis or secondary hyperparathyroidism are stressed. The surgical approach as the primary therapeutic option is compared with the more traditional conservative management.
The effect of vitamin K2 on calcium (Ca) and inorganic phosphorus (P) levels in the aorta and kidney obtained from experimental calcinosis induced by vitamin D2(2.5 x 10(5) I.U./ kg b.w.) of male rats was investigated. A high dose of vitamin K2 (100 mg/kg b.w.) inhibited the increase in the aortic Ca and P or in the renal Ca and P induced by vitamin D2, and a low dose of vitamin K2 (10 mg/kg b.w.) showed the same tendency, but the degree of the efficacy was small. It may be suggested that a high dose of vitamin K2 suppressed experimental calcification of soft tissues induced by vitamin D2. Therefore, a pharmacological dose of vitamin K2 might have a usefulness for the prevention and treatment of arteriosclerosis with calcification.
We describe two boys affected by Down syndrome (DS), who showed milia-like idiopathic calcinosis cutis (MICC). The clinical diagnosis was confirmed by histological examination. All reported cases are reviewed and compared. Syringeal structures play a significant part in the pathogenesis of this dermatosis. MICC appears to be a poorly recognized condition which, rarely, is associated with DS.
Tumoral calcinosis is an uncommon ectopic calcification syndrome characterized clinically by the presence of irregular, painless, periarticular soft tissue calcifying masses, and pathologically by fibrous-walled cystic spaces containing structureless calcific debris and associated with a variable inflammatory reaction. The pathogenesis remains obscure but the condition probably represents a disordered tissue reparative process. Of the previous literature reports, almost all have been in patients of African origin. We report a case in a white English woman.
Diaphysitis is uncommon in children. We describe a case of diaphyseal inflammation in several bones with high levels of phosphorus in an 8-year-old boy who later developed subcutaneous masses of tumoral calcinosis. This report serves as a review of this puzzling problem in clinical diagnosis.
Soft tissue calcification are common in chronic hemodialysis patients and often affect the periarticular tissues, where they occasionally form tumoral masses. In a retrospective study of 254 hemodialysis patients we identified three such cases. Affected sites were the wrist, shoulder, and chest wall. None of the patients had secondary hyperparathyroidism. A discussion is provided of the roentgenographic and clinical features of tumoral calcinosis, of current pathogenic hypotheses, and of available treatments.
Eighteen years after an uneventful renal transplantation, the chest radiograph of an asymptomatic 50 year old man showed diffuse bilateral infiltrations, predominately at the right apex. Computed tomography (CT) scan demonstrated a diffuse alveolar pattern, the alveoli being filled with a very dense material, with some tracheal calcifications. Bronchoalveolar lavage fluid analysis was normal, but bronchial and transbronchial biopsies revealed calcium deposits in the bronchial mucosa and in the alveolar septa. The diagnosis of diffuse pulmonary calcinosis was established, despite normal blood calcium, phosphorus and magnesium levels, based upon computed tomography scan and pathological findings at fibreoptic bronchoscopy, without the need for an open lung biopsy.
Three patients with extensive, symptomatic tumoral calcinosis (TC) were studied after renal transplantation. Changes in TC-related symptoms, radiological appearances, calcium, phosphate and intact parathyroid hormone concentrations were recorded. All patients noted an immediate reduction in pain and in 2 patients the TC rapidly resolved. Their TC was not palpable by 6 months and radiographs showed near complete resolution at 12 months. Both developed hypercalcemia and in one patient this was associated with polyuria and renal impairment. Bisphosphonates reduced the hypercalcemia but increasing the corticosteroids had no effect. The third patient remained dialysis dependent due to technical problems and rejection but continued on immunosuppression to preserve residual graft function. His TC improved symptomatically but grew radiologically. These cases demonstrate that rapid resolution of TC may occur after successful renal transplantation and that bisphosphonates can ameliorate the associated hypercalcemia. Early symptomatic benefit may occur without graft function and is probably due to the anti-inflammatory action of corticosteroids.
We describe a tumoral calcinosis (TC) patient with a calcified mass around the hip joint. Once diagnosed, she was followed up with vinpocetine [14-ethoxycarbonyl-(3alpha,16alpha-ethyl)/14,15-eburnamenine] treatment, which was reported to be effective in eliminating TC in a previous study. We think that vinpocetine contributed, at least in part, to the process of TC elimination. Although there are many reports about the surgical excision of calcified masses in TC, local recurrences are not uncommon. Our success with conservative treatment has encouraged us to refrain from surgical procedures in patients with TC.