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PubMed1999

Toward the development of antibacterial vaccines: report of a symposium and workshop. Organizing Committee.

On 26 and 27 October 1998, the Department of Medicine at the University of California, San Francisco (UCSF), hosted a symposium and workshop on bacterial vaccines. The symposium featured invited speakers who are internationally recognized authorities in their fields and who discussed selected topics related to specific pathogens or specific principles of bacterial vaccine development. The workshop, held on the day following the symposium, brought together the invited speakers and members of the organizing committee, who came from UCSF and the University of California, Berkeley, to discuss 4 specific topics and to define priorities for future vaccine development. Considerable knowledge has been gained from successful and unsuccessful vaccine development efforts, and large gains in knowledge relevant to vaccine development have resulted from studies of basic immunology and microbial pathogenesis. This report summarizes the presentations at the symposium and the discussions of the workshop sessions.

Bacterial Vaccines↗
PubMed2003

Detection of noroviruses in water--summary of an international workshop.

Noroviruses (NVs) are the most common cause of acute nonbacterial gastroenteritis worldwide. An international workshop of 36 people from 5 countries was held on 20-22 March 2002, in Voorhees, New Jersey, to identify barriers to the development of methods for detection of NVs in water and to develop a multiyear research agenda to coordinate efforts to advance the development of methods for detection of NVs. The workshop focused on 3 areas: (1) collection, concentration, and processing of samples; (2) molecular methods for detection and confirmation of NVs; and (3) the detection of infectious NVs through cell culture, infectivity surrogates, and human volunteers. Twelve research projects were developed by the workshop participants.

Animals↗
PubMed1982

Analysis of the NIH workshop monoclonal antibodies to human melanoma antigens.

Reagents exchanged at the 2nd workshop on monoclonal antibodies (MoAb) to human melanoma antigens were analyzed using both serological and immunochemical assays. The analysis by laboratories participating in the workshop of our MoAb 225.28S, 345.134S, 376.96S, 465.12S, and 763.24TS reaffirms our own analysis of these reagents in that (1) they all react with the majority of melanoma cell lines tested and (2) the reactivity of MoAb 225.28S and 763.24TS is much more restricted than that of MoAb 345.134S 376.96S, and 465.12S. Our serological analysis revealed that the majority of workshop reagents reacted with cultured melanoma cells. Immunochemical analysis of these monoclonal antibodies allowed for their division into three groups according to the molecular weights of the antigens recognized in immunoprecipitation experiments, greater than 100 kd, 80-100 kd, and DR antigens. Further analysis of the first two groups of monoclonal antibodies by immunodepletion and antibody binding inhibition assays revealed that MoAb 9.2.27, 225.28S, and 763.24TS recognize distinct determinants with a heterogeneous distribution on subpopulations of a high molecular weight melanoma associated antigen. MoAb 376.96S and 705.F6 recognize either the same or spatially close determinant(s).

Antibodies, Monoclonal↗
PubMed1996

Report of workshop 5: early high-dose chemotherapy.

Workshop 5, entitled 'Early High-Dose Chemotherapy for Hodgkin's Lymphoma', was conducted at the Third International Symposium on Hodgkin's Lymphoma in Köln, Germany, on September 23, 1995. The objective of the workshop was to determine whether one could identify, at diagnosis, a high-risk group of Hodgkin's disease patients who could be subjected to high-dose therapy with acceptable toxicity as part of their initial therapy. D. Hasenclever of Leipzig, Germany, presented a preliminary analysis of a multivariate model which involved over 4000 patients with advanced Hodgkin's disease. Unfortunately, the model did not permit the definition of a significant group of patients with less than a 50% progression free survival at 5 years. A. Carella from Genoa, Italy, and S. J. Proctor from Newcastle-upon-Tyne, U.K., presented their ongoing randomized trials of early high-dose therapy while N. Schmitz from Kiel, Germany, presented the results of a matched pair analysis of patients receiving high-dose chemotherapy compared to patients receiving conventional chemotherapy. A. H. Goldstone from London, United Kingdom, and J. O. Armitage from Omaha, U.S.A., presented important long-term toxicity data. C. Gisselbrecht from Paris, France, presented the data on second neoplasms. D. L. Longo from Frederick, U.S.A., focused on the results of using either conventional or high-dose therapy as salvage therapy. In summary the workshop defined both the enthusiasm for improving the treatment results of patients with advanced Hodgkin's disease by using high-dose therapy and the problems associated with conducting those type of studies.

Antineoplastic Agents↗
PubMed1989

Dissemination of fibreoptic airway endoscopy skills by means of a workshop utilizing models.

A questionnaire was mailed to 182 attendees of four practical workshops on fibreoptic endoscopy. After the workshops, 35% of the attendees were able to introduce fibreoptic intubation into their clinical practice or improve their success rate. This suggests that a new psychomotor skill can be disseminated effectively to clinicians by a practical workshop that utilizes inanimate models, and is based on sound educational principles.

Adult↗
PubMed2000

Improving residents' breastfeeding assessment skills: a problem-based workshop.

BACKGROUND: It is well documented that residents have limited knowledge about common breastfeeding problems. OBJECTIVES: The purpose of this study was to assess whether a problem-based, interactive breastfeeding workshop would improve resident skill level. METHODS: Two groups of second- and third-year family medicine residents were assigned to an intervention or control group; both groups participated in pre-and post-intervention Objective Structured Clinical Examinations (OSCEs) and completed written questionnaires. The intervention consisted of a 4.5 hour interactive workshop with didactic presentations and opportunities to work with a lactation consultant and standardized patients trained to role-play selected breastfeeding problems. RESULTS: There were no baseline differences in knowledge or performance scores on the OSCEs between the intervention and control groups. OSCE scores after intervention were significantly better in the intervention group for the content areas assessing position and latch and the evaluation of sore nipples (P < 0.001 and P = 0.05, respectively). There was a trend towards improvement in assessment of the problem of low milk supply (P = 0.31). All residents in the intervention group correctly diagnosed the cause of both the sore nipples and low milk supply at the follow-up OSCE, with P values of <0.001 and 0.068, respectively. The intervention group felt significantly more confident in their breastfeeding problem-solving (P < 0.001). CONCLUSIONS: An interactive, problem-based workshop to teach residents the basics of breastfeeding problem solving can be implemented in residency and improve clinical diagnostic skills and residents' comfort with breastfeeding.

Adult↗
PubMed2006

The CITRA research-practice consensus-workshop model: exploring a new method of research translation in aging.

PURPOSE: On the basis of the experience of an extensive community-based research partnership in New York City, we developed an innovative process for bridging the gap between aging-related research and practice, using a consensus-workshop model. DESIGN AND METHODS: We adapted the traditional scientific consensus-workshop model to include translation of the research into nontechnical language and the involvement of practitioners in the process. We then applied the model to the specific issue of falls prevention among community-dwelling older adults. RESULTS: The dialogue and interaction among researchers and practitioners provided new insights beyond a traditional research review. Practitioners offered astute guidance for future research based on their day-to-day field experience. IMPLICATIONS: The recommendations that emerged from the workshop demonstrated the value of close interaction between the aging-related research and practice communities. The consensus-conference model has significant potential to establish a bridge between the worlds of research and practice in a variety of settings.

Accidental Falls↗
PubMed2006

Introduction to the 5th Amino Acid Assessment Workshop.

Amino acids (AAs) may be consumed at intakes above those that could be obtained from the normal diet, to promote health status in certain specific situations (e.g., sports training, aging). In this context, the relevant AAs may be used at high intake levels, which may in turn trigger adverse effects. There is little information on the adverse effects or pathophysiological consequences of excessive intakes of individual amino acids or mixtures. Hence, a series of workshops (named AAAW) are being organized to bring together experts in the fields of amino acid metabolism and nutritional effects, cell and molecular biology, toxicology, and regulatory issues and policy, with the aim of establishing a paradigm for the characterization of risks associated with specific intakes of amino acids by humans. The first 3 workshops covered general aspects concerning AAs (functions, risk characterization, differences in subpopulations, definition of surrogate markers, etc.). The fourth AAAW focused on branched-chain AAs. The articles in this supplement issue of the journal summarize the fifth workshop in the series, which focused on sulfur amino acids.

Amino Acids↗
PubMed1994

New avenues of translational research in leukemia and lymphoma: outgrowth of a Leukemia Society of America-National Cancer Institute workshop.

The workshop was organized on the premise that truly innovative approaches are needed if we are to significantly change the clinical outcomes for leukemias and lymphomas. Several new concepts and pioneering approaches surfaced during the workshop discussions, as summarized above. The design and implementation of translational clinical trials that emphasize these innovative strategies were encouraged as a way to test the concepts put forward at the workshop. Representatives of the Leukemia Society of America and the National Cancer Institute plan to continue their dialogue to develop recommendations regarding the priorities for linked clinical-laboratory investigations on the hematopoietic malignancies and the optimal ways in which to foster such translational research. To this end, the explosion in basic science discoveries during the last two decades and especially during the last 5 years is producing a critical mass of knowledge. This knowledge, in turn, allows us to view leukemia from new perspectives that span molecular pathogenesis, epidemiology, early detection of minimal disease, and the selective targeting of critical leukemogenic mechanisms for therapeutic and ultimately preventive purposes. As in previous decades, during which leukemia has served as the testing ground for precedent-setting concepts of curative therapy (dose-intensity, non-cross-resistance-inducing combinations and aggressive therapy in the minimal residual disease state), leukemia should again serve as a clinical beacon for the identification and exploitation of new molecular targets for therapy. Any impact on curability and duration and quality of survival will be achieved only by building on the cumulative knowledge accrued at multiple levels--molecular and cellular levels as well as in the intact patient--and augmenting the momentum of the bidirectional exchange of information between the laboratory and the clinic that has characterized leukemia research from its incipience. The challenge is formidable and worthy of our most creative and concerted efforts.

Animals↗
PubMed2001

Informed Consent in Early Psychosis Research: National Institute of Mental Health workshop, November 15, 2000.

Recent research on the early detection and treatment of schizophrenia has generated significant scientific interest along with considerable controversy and debate. Because our ability to alleviate fully the symptoms and deficits of established schizophrenia is limited, the prospect of interrupting disease progression early is compelling. At the same time, in the absence of an infallible marker of disease risk, there are serious questions about the safety, feasibility, and ethics of intervention research on "at-risk" or putatively prodromal individuals. A workshop, Informed Consent in Early Psychosis Research, was convened by the National Institute of Mental Health (NIMH) on November 15, 2000, to review the results of recent research on early detection and intervention in schizophrenia. Beginning with the assumptions that (1) treatment of asymptomatic individuals with antipsychotic medication is not appropriate in research or clinical care, and (2) neither data nor clinical consensus defines optimal intervention for symptomatic at-risk individuals, workshop participants-including clinical researchers, mental health consumers and family members, bioethicists, community health care providers, and NIMH staff-systematically reviewed available data on the potential risks and benefits of alternate approaches to the management of prodromal states. Ethical issues involved in early detection and intervention studies were discussed. Workshop participants summarized information presented during the meeting into informed consent "bullets" that must be communicated to, and understood and appreciated by, potential research participants.

Adolescent↗
PubMed1999

Antipsychotics: Past and Future: National Institute of Mental Health Division of Services and Intervention Research Workshop, July 14, 1998.

A workshop on "Antipsychotics: Past and Future" was convened by the National Institute of Mental Health (NIMH), Division of Services and Intervention Research (DSIR), on July 14, 1998, to review the results of recent antipsychotic drug research, discuss current standards of treatment, and identify areas needing further study. There has been a proliferation of new antipsychotic medications and a rapid increase in their clinical utilization. The new atypicals are beginning to supplant the older typical neuroleptic antipsychotics, and the scientific and ethical issues raised by this transition prompted the workshop. Given the apparent, albeit not fully defined, advantages of atypical drugs, particularly their safety profiles, the question is whether more comparisons with typical antipsychotics are warranted and whether clinical trial designs warrant (or would be justified in) the inclusion of typical drugs as standard active comparators. Workshop participants--including clinical researchers, patient advocates, bioethicists, and NIMH staff--discussed the conclusions drawn from current data, ethical issues for subjects in clinical trials, funding for ongoing studies using typical agents, and appropriate comparators for trials using atypical agents.

Antipsychotic Agents↗
PubMed2002

Teaching consultation skills in higher specialist training: experience of a workshop for specialist registrars in rheumatology.

OBJECTIVES: To design, implement and evaluate an initial communication skills workshop for higher specialist trainees in rheumatology, and to determine their prior experience of and attitude towards such training. METHODS: The setting for this study was a rheumatology specialist registrar study day in the West Midlands region of the UK. The workshop was jointly facilitated by a hospital specialist and a general practitioner educationist, providing both the credibility of subject expertise and experience of teaching consultation skills to groups of doctors. Simple, structured observations of pre-recorded consultations and simulations, based on scenarios from within the specialist field, were used. RESULTS: There was strong agreement amongst the trainees that the workshop was enjoyable and useful, that prior training and experience in this area was inadequate, and that it is feasible and important to develop the communication skills of hospital specialists. CONCLUSIONS: Undergraduate teaching in communication skills has been inadequate in the past and it receives little or no attention in most specialist training. There is a compelling argument for the inclusion of communication skills teaching in higher medical training within rheumatology. More work is required to research the optimum methods of delivering teaching in this area in a postgraduate setting, and to assess the impact of communication skills teaching on clinical practice.

Communication↗
PubMed2004

Overview of the wisdom stakeholder workshop on restoration management.

A Workshop to extend the Involvement of Stakeholders in Decisions On restoration Management (WISDOM) was held at New College, Oxford from 15 to 17 September 2003. The aim was to promote awareness and interest in the wider application of stakeholder involvement in the formulation of strategies for the management of contaminated agricultural land and produce following a nuclear accident. The workshop, through 25 plenary papers and a set of two facilitated discussion sessions, provided valuable feedback on a wide range of issues including technical and social factors affecting countermeasure selection, acceptability of intervention levels, the challenges of rural waste disposal and crisis management. The workshop achieved its aim and the findings will be disseminated widely. Stakeholder groups are already active in the UK, Finland, Belgium, France and Greece; there was commitment from participants to establish further, similar groups in other member states within the European Union.

Decision Support Systems, Management↗
PubMed1990

Report of a workshop on genetic linkage studies in schizophrenia.

A workshop on genetic linkage studies in schizophrenia was held at Columbia University's Arden House Conference Center in October 1989. This report summarizes the contents of invited talks by Drs. Arno Motulsky and T. Conrad Gilliam and the discussions at the five workshop sessions. Topics of the workshop sessions were (1) diagnostic boundaries and hierarchies in schizophrenia, (2) genetic models and linkage parameters, (3) selection and ascertainment of pedigrees, (4) future extensions of molecular genetics strategies, and (5) possibilities for future collaboration.

Genetic Linkage↗
PubMed2005

Workshop proceedings: managing conflict of interest in science. A little consensus and a lot of controversy.

There is no doubt that participants in the Conflict of Interest (COI) Workshop at the Society of Toxicology (SOT) 2005 Annual Meeting (New Orleans, 6-10 March 2005) engaged in a vigorous and useful exchange of diverse ideas and viewpoints. While there was consensus on the value and interest of this Workshop, there was less consensus and more controversy over many of the issues discussed during the Workshop, which included the distinction between bias and conflict, the success or failure of policies of disclosure, whether waivers should or should not be granted to conflicted individuals in order to seat a "balanced" committee with appropriate expertise, whether conflicted individuals retain the ability to recognize their own conflict, and more. The discussion left no doubt, however, that conflict of interest will remain an important and controversial issue in the scientific community for some time to come.

Bias↗
PubMed2005

In silico methods for evaluating human allergenicity to novel proteins: International Bioinformatics Workshop Meeting Report, 23-24 February 2005.

The ILSI Health and Environmental Sciences Institute (HESI) hosted an expert workshop 22-24 February 2005 in Mallorca, Spain, to review the state-of-the-science for conducting a sequence homology/bioinformatics evaluation in the context of a comprehensive allergenicity assessment for novel proteins, to obtain consensus on the value and role of bioinformatics in evaluating novel proteins, and to discuss the utility and methods of allergen-specific IgE testing in the diagnosis of food allergy. The workshop participants included over forty international experts from academia, industry, and government. The workshop was hosted by the HESI Protein Allergenicity Technical committee, which has established a long-term program whose mission is to advance the scientific understanding of the relevant parameters for characterizing the allergenic potential of novel proteins.

Allergens↗
PubMed2003

Nonhuman primate models of menopause workshop.

The Nonhuman Primate Models of Menopause Workshop was held on the National Institutes of Health campus in January 2001. The purpose of this workshop, sponsored by the National Institute on Aging, was to review what is known about the female reproductive aging process in various species of monkeys (particularly rhesus, baboons, cynomolgus, and chimpanzees), including hormone profiles during the menopausal transition, occurrence of hot flashes, extent of age-related and menopause-associated changes in hormone levels on metabolism, bone loss, and impaired cardiovascular and cognitive function. Many aspects of the female reproductive aging process appear to be concordant between humans and these monkey species, but several important features may be species-specific. Those features that appear to parallel human menopause and aging include general similarity of hormone profiles across the menopausal transition, progression to cycle termination through irregular cycles, declining fertility with age, age-related gains in weight and percentage body fat content (with tendencies toward insulin resistance and glucose intolerance), increased low-density lipoprotein cholesterol and decreased high-density lipoprotein cholesterol, declines in serum dehydroepiandrosterone, similarities in temperature-regulation systems, protective responses to estrogen replacement following ovariectomy in terms of bone metabolism, lipid profiles, and cognitive changes. Important differences include relatively short postmenopausal life span, timing in menopause-related changes in hormone secretion, and seasonal menstrual cycles. In addition, the question of whether ovariectomy in young adults is an appropriate model for the consequences of natural or surgical menopause in middle-aged and older adults is unresolved, and the numbers of older female animals available for research on menopause are very limited. The use of animal models is seen by workshop participants to be crucial for a mechanistic understanding of the human menopausal process and its connections to postmenopausal health problems; however, extensive in-depth and broad-based research is required to determine if nonhuman primates are appropriate models of human menopause.

Aging↗
PubMed1988

A workshop on ethnic and cultural awareness for second-year students.

In 1984, 50 percent of the first-year students at the University of Southern California School of Medicine felt unprepared to handle the cultural barriers between themselves and their patients during their clinical rotations. Therefore, in 1985 a group of students developed a four-hour workshop designed to teach fellow students about ethnic and cultural issues in patient care. Since then the workshop, which uses videotaped vignettes, discussions, and role-playing exercises, has become a required part of the Introduction to Clinical Medicine course for all second-year students. Evaluation of the program in 1985 compared pretest and posttest questionnaires. The participants showed improvement in understanding several specific issues discussed during the workshop, but overall no significant differences were found. In 1986 and 1987, evaluations were based upon the students' attitudes about content, format effectiveness, and subject matter. They consistently responded favorably in all these areas.

Attitude of Health Personnel↗