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[The clinical significance of the oxytocin challenge test (author's transl)].

In order to test the function of fetoplacental unit 398 oxytocin challenge tests were performed on 280 patients who had exceeded the calculated date of delivery or where factors of risk were involved. 8% of the tests performed showed a positive result, 1% was suspect and 91% were negative. The figure of 20% of false-positive test results was relatively high compared to only 1.6% in the case of false-negative test results. In cases where the calculated date of delivery has been exceeded, pregnant women who showed a negative test result are kept under observation by us as out-patients, whilst patients whose oxytocin challenge test was positive are kept under close observation in hospital.

False Negative Reactions↗

Immunological aspects of the pathogenesis of pregnancy hypertension.

Changes involving the immune system may be instigators of, or consequent upon, disorders in other systems in the natural history of gestosis. The extent of the immune 'disorder' may not correlate with the severity of the disease as manifest in either eclampsia or fetal death. A number of variables, e.g. hormonal and genetic, could affect any immunological trigger mechanism or any secondary altered immune response. Thus attempts to find an immunological factor in gestosis that operates in all cases may prove unrewarding. Certain matings, immunogenetic constitutions, or certain feto-maternal immune relationships may predispose to a particular pathology and directly or indirectly potentiate other pathological processes. Others may either have no effect or conceivably have even a homeostatic effect protecting the maternal host from pathological change. The picture of the role of immunological factors in the pathogenesis of pregnancy hypertension is no more, as yet, than a few hesitant, unrelated lines. However, the lines are getting more numerous and stronger.

ABO Blood-Group System↗

Prevalence of elevated blood pressure in a village community with a high incidence of toxemia of pregnancy.

Blood pressure measurements were recorded in 95% of the men and 97% of the women aged 30 to 59 years in a small Israeli village populated by Jews of Kurdish origin and in which a high incidence of toxemia of pregnancy was previously observed. The prevalence of hypertension in the men, as well as in the women, was significantly higher in all age groups studied than in a sample of the general population. These findings support the hypothesis that toxemia of pregnancy is an expression of a preexisting hypertensive state rather than an etiological factor in the development of later hypertension in women.

Adult↗

[Diagnostic importance of ceruloplasmin and haptoglobin in nephropathy of pregnancy].

Serum ceruloplasmin and haptoglobin levels of 87 females-pregnant with toxicosis, with a past history of toxicosis with morbid manifestations and healthy pregnant ones were studied. Characteristic correlations are outlined--highly elevated ceruloplasmin level with normal haptoglobin level in the pregnant with toxicosis, moderate elevation of ceruloplasmin level with normal haptoglobin level--in the normally progressing pregnancy and slightly elevated ceruloplasmin level with elevated haptoglobin level--in patients with residual morbid manifestations after a past history of toxicosis. The establishment of such a combination in the last group, being characteristic for the chronic glomerulonephritis, provides grounds the latter to be used as a prognostic index in the evaluation of post-toxicosis kidney injuries--a tendency to chronification.

Ceruloplasmin↗