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At least 559 records · Page 31Linked to original sources
PubMed1991

[The significance of immunogenetic body characteristics in the formation and development of bronchial asthma].

The antigenic composition of tissues was shown to be of importance in the formation of bronchial asthma on the basis of the clinicoimmunological data with regard to histocompatibility antigens in 235 patients suffering from bronchial asthma and preasthma. Well-defined correlations were established between the development of bronchial asthma with carriership of antigens A2, B13, B21 and B35, between the disease pattern and nature of its course and antigens B7, B12, B27, B35, B40 together with their combinations. Possible variants of the relationship between the body traits and certain mechanisms by which bronchial asthma develops are under discussion.

Aging↗
PubMed1991

Immunogenetics of the human major histocompatibility complex.

The biologic significance of the human major histocompatibility complex (MHC), also referred to as HLA, is well known through its influence on transplant immunity and its association with many diseases. This article attempts to summarize recent progress in the field of HLA polymorphisms. Topics discussed include the genetic basis of HLA, methods to determine HLA polymorphisms, and definitions of HLA Class I and II polymorphisms.

Genes, MHC Class I↗
PubMed1991

The role of the immunogenetics laboratory in marrow transplantation.

Allogeneic marrow transplants from genotypically HLA-identical siblings have become lifesaving therapy for patients with various congenital and acquired diseases of the immune and hematopoietic systems. Unfortunately, less than 30% of patients in the United States have an HLA-identical sibling; therefore, many are denied the opportunity for potentially curative treatment for otherwise fatal conditions. The results of marrow transplantation from haploidentical family members who were partially compatible for nonshared haplotypes with the patients demonstrated the relevance of HLA compatibility for engraftment and graft-vs-host disease. These results have provided the rationale for using HLA-identical unrelated volunteers as marrow donors. The recent development of a national registry of volunteer bone marrow donors (the National Marrow Donor Program in the United States) has made it possible to access a centralized file of more than 260,000 HLA-typed volunteers. Marrow transplants from an unrelated donor have become feasible. However, our preliminary clinical experience clearly demonstrated an increase in the incidence and severity of graft-vs-host disease. It is likely that standard HLA typing techniques are not adequate to provide data for sufficient donor and recipient matching. It is possible that currently available molecular technology could be applied to HLA typing and donor matching to improve on clinical results.

Bone Marrow Transplantation↗
PubMed1990

[Immunogenetic characteristics of the gene fund of Kakhetian swine and dynamics of population parameters in several generations].

Some peculiarities of gene fund and dynamics of populational characters of the oldest in Europe Kakhetian (Georgian) pigs were investigated during 18 years (10 generations). Genetic peculiarity of the aboriginal species populations in conditions of intensive pressure of natural selection and relatively weak artificial selection was determined with the help of codominant alleles of the blood groups E system. Considerable qualitative and quantitative differences were detected between Kakhetian pigs and all subspecies of European boars and domestic pigs of cultured breeds studied. Kakhetian pigs are strongly similar to wild boar, as concerns their morpho-physiological and behavioral characteristics. However, the assumption that they originated from Romanian (Caucasian) wild boar by direct domestication, without hybridization, is wrong, since they have alleles which are never found in European wild boars. The results of comparative study of Kakhetian and other domesticated and wild pig forms characteristics makes it possible to suppose that the presence in Kakhetian pigs gene fund of some alleles of East Asian origin is due to a certain participation of the Large White and Mangalica breeds in their phylogenesis. The two latter breeds, in their turn, obtained these alleles as a result of two waves of pig importation in Europe from the South-East Asia (on the eve of a.d. and about 150-200 years ago). This is indirectly confirmed by historical and zootechnical data.

Alleles↗
PubMed1990

[Immunogenetic approaches to the study of leukemia in humans].

One hundred and ten families having one child suffering from acute leukemia were included in HLA studies. These families were found to have unequal distribution of the parent HLA-haplotypes among the sibs. Three groups of families were conditionally distinguished. The first group showed the predominance of one parental, the second group of one maternal, and the third group of one maternal and one paternal HLA haplotypes. This suggests that impairment of the evolutionally derived principle of equal participation of both gamete types of each parent in the zygote formation is deleterious for the progeny.

Acute Disease↗