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Flocculation of venereal disease research laboratory reagent by Helicobacter pylori.

Helicobacter pylori strains flocculated with Venereal Disease Research Laboratory (VDRL) reagent in a glass slide test. Other pathogenic bacterial and fungal strains were nonreactive. The specific VDRL reaction property of Helicobacter pylori indicates an affinity of the cells for lipoidal substances, and can be used as a diagnostic aid for species identification.

Bacteria↗

Problems of venereal disease in Nigeria. 1. Gonococcal resistance to antibiotics and treatment of gonorrhoea.

Venereal disease is becoming an increasingly serious problem in developing countries. The availability of antibiotics in chemists' shops has encouraged self-medication with sub-therapeutic doses and inadequate treatment regimens. At a health centre in Nigeria, a diagnosis of gonococcal urethritis was made in 159 out of 429 men presenting with urethritis. Neisseria gonorrhoeae was cultured in 141 cases and the sensitivity pattern to a number of antibiotics freely available at chemists was determined. The organisms were highly resistant to penicillin (84%), ampicillin (80%), tetracycline (68%), streptomycin (78%) and co-trimoxazole (83%). These were the cheapest of the drugs available, leaving only erythromycin and the more expensive drugs gentamicin and cefotaxime still effective for general use in treatment programmes.

Adult↗

Critical evaluation of the venereal disease control campaign in Poland 1970-76.

A comprehensive campaign to control venereal diseases was undertaken in Poland in 1970. During the eight-year period of the campaign a significant decrease in the morbidity rate of gonorrhoea and syphilis was achieved. The number of cases of primary and secondary syphilis decreased by 85% and the number of cases of gonorrhoea by 30%. This paper presents the main guidelines of the campaign and a critical evaluation of the various epidemiological methods applied, such as mass screening for syphilis and gonorrhoea, epidemiological treatment, contact-tracing, improvement of treatment methods, improvement of methods of health education, and training of physicians and laboratory staff in venereology.

Female↗

Issues in cerebrospinal fluid management. CSF Venereal Disease Research Laboratory testing.

Three policies for decreasing unnecessary cerebrospinal fluid (CSF) management Venereal Disease Research Laboratory (VDRL) tests were compared. The first policy attempted to educate physicians about the use of serologic tests for diagnosing neurosyphilis but allowed the CSF VDRL to be performed either as a screening test or as a retrospective test. The second policy required that the CSF VDRL be performed as a retrospective test without regard to the patient's serologic status. The third policy required that a patient be seropositive by either rapid plasma reagin (RPR) or fluorescent treponemal antibody absorbance (FTA-ABS) before a CSF VDRL could be performed. Before these policies were instituted, VDRL testing was performed on 18.2% of all CSF samples. The optional and required retrospective policies decreased the CSF VDRL rate to 13.0% and 8.5%, respectively, but the percentages of seropositive patients for whom these procedures were performed were only 7.3% and 12.9%. The third policy decreased the CSF VDRL test rate to 1.8% (P less than 0.001) with seropositivity improving to 90%. To assure serologic tests are obtained in the evaluation of neurosyphilis, requirement for seropositivity must be implemented with the use of retrospective CSF VDRL testing.

Antibodies, Bacterial↗

Social aspects of venereal disease aboard a U.S. navy destroyer.

This paper describes the social characteristics of venereal disease patients aboard a US Navy destroyer. The research team administered questionnaires to 247 crew members at the outset of the ship's 7 month-overseas deployment. When the ship returned to home port, the research staff gathered demographic and occupational information plus disciplinary records, job performance ratings, and complete dispensary visit information for the deployment period. The morbidity data indicated that 48% of the entire crew experienced at least one case of VD, and of these VD patients, 38% had multiple infections. A set of variables that best predicted VD incidence was determined by means of multiple regression analysis. These variables included disciplinary record, pay grade, division or type of job ("blue-collar" versus "white-collar"), and education. Other variables that correlated with VD incidence were age, length of service, marital status, performance ratings, and verbal aptitude scores.

Adolescent↗

Human cervical cancer as a venereal disease.

The operation of venereal factors in human cervical cancer is suggested by demographic and epidemiological data. Recent evidence supporting the genital herpesvirus hypothesis is consistent with this notion. A controlled epidemiological investigation has been undertaken on the role of the male coital partner in cervical carcinogenesis. An answer is sought to the question, "Is the risk of developing cervical cancer increased among the wives of men who at some other time were married to other women who developed cervical cancer?" With one-quarter of the study completed, a total of 14 marital clusters have been identified in which 2 or more wives of the same men developed cervical carcinoma. The expected number of such clusters is estimated to be 4.

Circumcision, Male↗

Medical treatment of sexually transmitted diseases in developing countries. Part II: Other venereal diseases.

Although gonorrhoea and syphilis are the better known of the sexually transmitted diseases, attention has been drawn to the other sexually transmitted diseases caused by bacteria, viruses, fungi and parasites. Although statistics are not available in most developing countries, herpes genitalis has been suggested as commoner than syphilis as a cause of genital ulceration while non-specific urethritis is commoner than gonorrhoea as a cause of urethritis. The incidence, clinical features and diagnostic procedures of syphilis, herpes genitalis, non-gonococcal urethritis, lymphogranuloma venereum and trichomoniasis have been briefly discussed. The management of these conditions in developing countries have been outlined.

Anti-Bacterial Agents↗