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Tibial torque generation in a flexed weight-bearing stance.

Internal and external torque generated about the long axis of the lower extremity was measured in 18 male subjects who were instructed to twist with maximal effort against a fixed footplate containing an instrumented torque cell. Mean torque values ranged from 30 to 71 newton meters (Nm) depending upon the test conditions. Torques recorded during the flexed single-leg stance were 19% to 49% higher than those measured while seated. Values at 45 degrees of knee flexion were 11% to 16% greater than those at 20 degrees. Torques generated while wearing a ski boot were 8% to 11% greater than those recorded in an athletic shoe. When movement of the pelvis and upper torso was allowed, torque values were 17% to 49% higher than those recorded when the hips and shoulders were restrained which allowed only lower leg musculature to act in an isolated fashion. There were no differences between internal versus external generated torques when the hips and torso were restrained. When the hips and shoulders were unrestrained, internal torque was 12% greater than external torque. There were no strong correlations between generated torque and body weight or height. These generated torque values suggest that if ski bindings are set to American Society for Testing and Materials (ASTM) standards for twist-release torque, then upper torso and pelvic movement in conjunction with tensed knee musculature (i.e., a "locked knee") may be necessary to accomplish binding release. Use of the lower leg musculature alone (i.e., ankle twist) may not generate sufficient torque for release.

Adult↗

The influence of regional insulation on the initial responses to cold immersion.

Twelve healthy male subjects performed three 10-min head-out immersions in water at 10 degrees C. The responses of the subjects to immersion were recorded under three conditions: a) Control condition (CC)--torso and limbs exposed; b) Torso protected/limbs exposed condition (TPC); and c) Limbs protected/torso exposed condition (LPC). Results showed that the LPC significantly reduced the heart rate (p less than 0.01), minute ventilation (p less than 0.05), and respiratory frequency (p less than 0.05) during the first minute of immersion compared to the CC. Subjects also found the LPC the most comfortable. The TPC significantly reduced minute ventilation (p less than 0.01) and respiratory frequency (p less than 0.01) on immersion compared to the CC, but did not significantly lower the heart rate response. A comparison of the LPC and TPC revealed no significant difference in minute ventilation and respiratory frequency recorded on immersion. The LPC however, produced significantly lower heart rates on immersion (p less than 0.05) than the TPC. It was concluded that the limbs may be more important than the torso for the initiation of cardiac response to cold water immersion.

Adult↗

Comparison of human impact response in restraint systems with and without a negative G strap.

A test program to assess the influence of a negative G strap on restraint dynamics and human impact response was conducted at AFAMRL. There were 131 experimental-level impact tests with volunteer subjects performed in eight different test conditions. Forward-facing (-Gx) impacts were carried out on a horizontal accelerator, while vertical (+Gz) impact tests were done on a vertical drop tower facility. In both axes, the experimental exposure was an approximate half-sine waveform with peak acceleration up to 10 G and velocity change up to 9.2 m X s-1. Subjects were restrained to the test vehicle using either the PCU-15/P torso harness and lap belt, which is used operationally in such aircraft as the A-20 and F-15, or a conventional double shoulder strap and lap belt configuration. In one half of the test conditions, fixed-length negative G straps were incorporated into these restraint systems. In the other test conditions, the unmodified restraint systems were evaluated. Adding the negative G strap to either restraint system had clearly beneficial effects. These included decreasing the tendency toward submarining in forward-facing impacts, providing better occupant-seat coupling during free falls, and improving vertical impact protection. Sufficient benefits appear to result from use of the negative G strap to warrant a recommendation for its incorporation into selected USAF restraint systems, such as the PCU-15/P torso harness and lap belt. Additional data analysis revealed that the conventional double shoulder strap and lap belt restraint provided better forward-facing and vertical impact protection than the PCU-15/P torso harness and lap belt configuration. Further research at AFAMRL is planned to identify restraint harness features which may improve the performance of current and future impact protection systems.

Acceleration↗

Labyrinth and cerebral-spinal fluid pressure changes in guinea pigs and monkeys during simulated zero G.

This study was undertaken to explore the hypothesis that shifts of body fluids from the legs and torso toward the head contribute to the motion sickness experienced by astronauts and cosmonauts. The shifts in body fluids observed during zero-G exposure were simulated by elevating guinea pigs' and monkeys' torsos and hindquarters. Cerebral-spinal fluid pressure was recorded from a transducer located in a brain ventricle; labyrinth fluid pressure was recorded from a pipette cemented in a hole in a semicircular canal. An anticipated divergence in cerebral-spinal fluid pressure and labyrinth fluid pressure during torso elevation was not observed. The results of this study do not support a fluid shift mechanism of zero-G-induced motion sickness. However, a more complete test of the fluid shift mechanism would be obtained if endolymph and perilymph pressure changes were determined separately; we have been unable to perform this test to date.

Animals↗

Effects of head and body restraint on experimental motion-induced sickness in squirrel monkeys.

Each of 16 Bolivian-phenotype squirrel monkeys of mixed sex had a machine bolt mounted on the skull with acrylic cement; 13 were provided with temporary plaster body casts allowing free movement. With eyes open, all were rotated in the horizontal plane at 30 rpm every other day until vomiting occurred or for a maximum duration of 120 min/spin. Latencies for motion-sickness signs were recorded under three experimental conditions: free movement, torso fixed to an aluminum frame and both torso and head restrained by bolting to the frame. Subsequently, 10 monkeys from this sample were rotated while blindfolded with head and torso immobilized. Results partially confirmed human and animal findings reported by others: reduced mobility was accompanied by a reduction in the incidence and an increase in the latency of motion sickness. The importance of optokinetic input for the generation of motion sickness in this species was clear.

Animals↗

Empirical model of intracranial pressure and head motion resulting from a vibrating seated rhesus.

A series of experiments was designed to measure the head X and Z accelerations and the intracranial pressure in the unrestrained head of a rhesus monkey. The subject was exposed to a continuum of vibration frequencies from 2 to 35 Hz and peak acceleration amplitudes of 5, 10, 20, and 40 m/s2. The resulting data was used to build a frequency response model relating the head accelerations and pressures to the torso acceleration. The head-to-torso relationships, based upon a single subject, were both repeatable and invariant for torso acceleration amplitudes of 10, 20, and 40 m/s2. At frequencies above the 10Hz, the model strongly suggested the presence of linear system, and the inherent advantages of superposition. The model demonstrates the validity of the experimental method, involving a slow sweep through a range of frequencies, and of the analysis procedures used. More importantly, it promises to be a useful approach to the study of human response to vibration.

Animals↗

Model study of influence of extracardial factors on the inverse localization of preexcitation sites.

Inverse solution techniques are expected to help in noninvasive localization of ventricular preexcitation sites. The influence of selected extracardial factors on the accuracy of the inverse localization of the initial activation sites was studied on a model. Each of 8 simulated activation sequences was initiated in a different single starting point at the atrioventricular ring. Corresponding ecg potentials on the surface of a realistic model of inhomogeneous torso were used for the inverse localization procedure. A multiple dipole (MD) model of the cardiac generator composed of 39 segmental dipoles was used in the inverse computations. As it was shown in a previous study, the method was able to localize the 8 starting points even if a simplified torso model and a limited number of leads was used. In this study, influence of another two factors was evaluated: inaccuracy of location of the MD generator and presence of noise in surface potentials. Several shifts and rotations of the heart generator relative to its exact position were modeled. When the mean deviation of starting points was about 1 cm the mean localization error varied from 0.5 cm up to 1.0 cm for complete model data--198 surface potentials and a torso model including lungs and ventricular cavities. When a noise with uniform and Gaussian distribution was added to the surface potentials, the use of averaged body surface potentials significantly improved accuracy and stability of the inverse solution. For root mean square value of noise sigma = 14 microV the mean error of localization was 0.9 cm. For higher noise (sigma = 30 microV) the results were substantially deteriorated. The influence of a noise was studied on complete model data. (Tab. 3, Fig. 5. Ref. 6.)

Body Surface Potential Mapping↗

Correlations between the spread of ventricular activation and map patterns of measured and difference maps.

Three kinds of torso surface isopotential maps (measured, simulated, and difference maps) were delineated at every 1.5 (or 3) msec. during the QRS duration from the 85 unipolar lead ECG's led from the surface of a cylindrical torso model filled with perfusate and containing a canine heart undergoing Langendorff's perfusion. These three maps were compared as to the propagation process of ventricular activation obtained from the same heart and close correlations were found between the spread of ventricular activation and the map patterns of measured and difference maps. The difference map mainly reflected the proximity potential at each instant of ventricular activation in QRS duration and, when used in combination with the measured map, it was useful to estimate the spread of ventricular activation, especially around the stage of epicardial breakthrough of the activation front. It was confirmed that the interpretation of the difference map expressed in the present paper would not be misleading even if applied to a difference map obtained in a human torso model experiment.

Action Potentials↗

Are 1974-1975 automotive belt systems hazardous to children?

The 1974 and early-1975 model automobiles are equipped with belt interlock systems that require front outboard seat occupants who weigh more than 21.5 kg (47.3 lb) to wear threepoint lap and diagonal upper-torso belts (or wear the lap belt and position upper-torso belt behind them), assuming that the interlock has not been circumvented. Recent legislation has eliminated the interlock requirement, but new models are still likely to be fitted with three-point restraints for the front outboard seating positions. These restraint systems were designed and tested for adult use. Thus, based on the different structure of a younger child and the fact that there is a wide variation of belt orientation, child size, and seating environments, there is legitimate concern that the upper diagonal belt might contribute to injury of the child under certain impact conditions.

Adolescent↗

Injuries among 4- to 9-year-old restrained motor vehicle occupants by seat location and crash impact site.

Four-to-9-year-old children are a special group with respect to motor vehicle occupant restraints. Having outgrown child safety seats, they are often placed in adult seat belts. This study was undertaken to examine patterns of injury among restrained 4- to 9-year-old by seat location and crash impact site. The data were obtained from an ongoing hospital-based monitoring system. Seventy percent of the sample sustained a head or face injury. Upper-torso and extremity injuries were infrequent. Lower torso injuries occurred primarily in frontal impacts in both the back and front seats. Frontal impacts resulted in a greater proportion of serious injuries than rear impacts. The most serious injuries, however, occurred to children seated on the side of impact in lateral collisions. Questions must be raised regarding the appropriateness of the present restraint system for young children. Recommendations, given current seat belt systems, are provided. However, technological improvements in vehicle design and belt systems are needed to improve protection, particularly in lateral impacts.

Accidents, Traffic↗

Hypertonic saline infusion for pulmonary injury due to ischemia-reperfusion.

HYPOTHESIS: Inhibition of neutrophil-endothelial cell interactions by hypertonic saline (HTS) may confer protection against organ injury in states of immunologic disarray. This study tested the hypothesis that infusion of HTS modulates the development of end-organ injury in a model of lower-torso ischemia-reperfusion injury. DESIGN: Ischemia-reperfusion injury was induced in 30 male Sprague-Dawley rats by infrarenal aortic cross-clamp for 30 minutes, followed by reperfusion for 2 hours. At 0 and 60 minutes of reperfusion, intravenous HTS (7.5% sodium chloride, 4 mL/kg) was administered to 6 rats each, and another 12 received either 4 or 30 mL/kg of isotonic sodium chloride solution. Six rats received HTS, 4 mL/kg, before ischemia. At 2 hours, we assessed liver function, pulmonary injury, neutrophil infiltration (myeloperoxidase activity), endothelial permeability (bronchoalveolar lavage and wet-dry weight ratios), and proinflammatory cytokine levels (tumor necrosis factor alpha and interleukin 6). RESULTS: Infusion with HTS before or after ischemia significantly reduced end-organ injury. Histopathologic pulmonary injury scores were markedly attenuated in the HTS group (5.82 +/- 1.3) and the HTS pretreated group (4.91 +/- 1.6) compared with the isotonic sodium chloride solution groups (8.54 +/- 1.1) (P =.04). Pulmonary neutrophil sequestration (2.07 +/- 0.23) and increased endothelial permeability (4.68 +/- 0.44) were manifest in animals resuscitated with isotonic sodium chloride solution compared with HTS treatment (1.54 +/- 0.19 [P =.04] and 2.06 +/- 0.26 [P =.02]) and pretreatment (1.18 +/- 0.12 [P =.04] and 1.25 +/- 0.07 [P =.002]). In addition, a significant reduction in serum tumor necrosis factor alpha (P =.04) and interleukin 6 (P =.048) levels was observed, whereas HTS resuscitation attenuated the upsurge in aspartate transaminase (P =.03) and alanine transaminase levels (P =.047). CONCLUSIONS: Resuscitation with HTS attenuates the pulmonary edema and tissue injury due to lower-torso ischemia-reperfusion and maintains a more benign immunologic profile.

Animals↗

Effects of laparotomy, cage type, gestation period and spaceflight on abdominal muscles of pregnant rodents.

We studied the effects of four variables on the histological properties of three body wall muscles-rectus abdominis (RA), transversus abdominis (TA), and external oblique (EO)-from pregnant rats. The variables examined were (1) gestation period; (2) cage design; (3) the effect of a midline laparotomy, performed to determine fetus numbers; and (4) exposure to a nine-day spaceflight. We measured fiber cross-sectional area (CSA), metabolic enzyme levels (succinate dehydrogenase, glycerophosphate dehydrogenase), and myosin heavy chain (MHC) immunoreactivity in samples from each muscle. A major effect of spaceflight was an increase of 42-171% in fibers double-labeled for MHC in all three muscles. Based on fiber CSA, the TA and RA muscles showed signs of stretching with increased gestation; i.e., the CSA decreased 11-12% over a nine-day period. The EO, a torso rotator, hypertrophied by 9% in rats group-housed in cages with a complex 3-D structure, compared to controls housed singly in standard flat-bottom cages. The TA and EO, whose contractions would pull on the suture line, showed signs of atrophy in laparotomized animals, exhibiting a 12% decrease in muscle fiber CSA. Exposure to weightlessness is known to induce atrophy in most skeletal muscles. Surprisingly, the EO actually hypertrophied 11% in our flight animals; however, this can be explained by the fact that those rats actively rotated their torsos seven times more often than ground controls. The flight rats also had twice as many contractions as controls. However, they were still able to give birth on time postflight.

Abdominal Muscles↗

Effects of spaceflight and cage design on abdominal muscles of male rodents.

We examined the effects of a 16-day spaceflight mission on the size of muscle fibers in the rectus abdominis, external oblique and transversus abdominis muscles of adult male Fisher rats. The rats were individually housed in orbit, in contrast to the one previous spaceflight investigation of the same muscles, where the rats were group-housed pregnant females. The cross-sectional area of the muscle fibers was used as a measure of muscle atrophy or hypertrophy. The transversus, which is presumed to be the primary expiratory muscle and consequently works against internal hydrostatic pressures that are not likely to change much between 1 G and weightlessness, did not change in size. However, both the rectus abdominis (a spinal flexor) and the external oblique (a rotator of the torso), which resist gravity in the 1 G environment, showed significant signs of atrophy after extended exposure to microgravity. The atrophy of the external oblique was diametrically opposite to hypertrophy of the same muscle observed in group-housed rodents previously exposed to spaceflight. Although the two missions differed in several factors, such as the gender of the rats and mission duration, we believe that housing of the animals was the key factor that accounted for the different responses of the external oblique. Previous research has shown that group-housed rats in spaceflight exhibited seven times more rotations of their torsos than matched ground controls. Thus unloading of the musculoskeletal system may not be achieved in weightlessness when animals have the freedom to interact with each other.

Abdominal Muscles↗

Influence of staging celiotomy in localized presentations of Hodgkin's disease.

Staging celiotomy was performed in 139 previously untreated patients with lymphogram negative Stage I and II Hodgkin's disease. Sixteen additional patients received definitive radiotherapy for symptomatic relief of upper torso disease prior to abdominal exploration. The overall incidence of positive abdominal findings for these two groups was 34.5% and 31.2%, respectively. Further analysis of the 139 previously untreated cases revealed notable differences in incidence of positive abdominal findings for stage, presentation, and specific histology. Stage I patients with upper cervical or inguinal presentations or a lymphocytic predominance classification had negative celiotomies, as contrasted with a 43% incidence of positive abdominal findings in patients with supraclavicular presentations. In Stage II disease, the incidence of positive findings was related to the status of the mediastinum. For mediastinal presentations, the incidence was 33.3%, as compared to 48% for nonmediastinal presentations. To date, the number of relapses in celiotomy Stage I and II patients has been low regardless of whether or not prophylactic irradiation was administered to the major lymph-node-bearing regions of the upper and lower torso. Of 9 patients with progression, extranodal spread occurred as the first evidence of new disease in 4 patients. The implication of this finding is considered in a discussion on the influence of staging celiotomy in the management of Stage I and II patients with Hodgkin's disease.

Abdominal Neoplasms↗

Mechanical implications of chimpanzee positional behavior.

Mechanical hypotheses concerning the function of chimpanzee anatomical specializations are examined in light of recent positional behavior data. Arm-hanging was the only common chimpanzee positional behavior that required full abduction of the humerus, and vertical climbing was the only distinctive chimpanzee positional behavior that required forceful retraction of the humerus and flexion of the elbow. Some elements of the chimpanzee anatomy, including an abductible humerus, a broad thorax, a cone-shaped torso, and a long, narrow scapula, are hypothesized to be a coadapted functional complex that reduces muscle action and structural fatigue during arm-hanging. Large muscles that retract the humerus (latissimus dorsi and probably sternocostal pectoralis major and posterior deltoid) and flex the elbow (biceps brachii, probably brachialis and brachioradialis) are argued to be adaptations to vertical climbing alone. A large ulnar excursion of the manus and long, curved metacarpals and phalanges are interpreted as adaptations to gripping vertical weight-bearing structures during vertical climbing and arm-hanging. A short torso, an iliac origin of the latissimus dorsi, and large muscles for arm-raising (caudal serratus, teres minor, cranial trapezius, and probably anterior deltoid and clavicular pectoralis major) are interpreted as adaptations to both climbing and unimanual suspension.

Adaptation, Physiological↗

Topical lidocaine gel relieves postherpetic neuralgia.

Postherpetic neuralgia (PHN) following herpes zoster is a common and disabling neuropathic pain syndrome. In a double-blind, three-session study, 5% lidocaine gel or vehicle was applied simultaneously to both the area of pain and to the contralateral mirror-image unaffected skin. In the local session, lidocaine gel was applied to the painful skin area. In the remote session, lidocaine gel was applied to mirror-image skin. In the placebo session, vehicle was applied bilaterally. For cranial PHN, gel was applied without occlusion for 8 hours. For limb or torso PHN, gel was applied under occlusion for 24 hours. The 16 subjects with cranial PHN reported pain relief significantly favoring local drug application at 30 minutes, 2, 4, and 8 hours. The 23 subjects with torso or limb PHN reported significantly lower pain intensity with local drug application at 8 hours and both pain relief and reduced pain intensity at 24 hours. Remote lidocaine application to mirror-image skin was no different from placebo. No systemic adverse effects were reported and blood levels did not exceed 0.6 microgram/ml. Topical application of 5% lidocaine gel relieves PHN pain by a direct drug action on painful skin.

Administration, Cutaneous↗

Current densities induced in swine and rat models by power-frequency electric fields.

Measurements have been made of vector current densities induced by vertical, uniform, 60-Hz electric fields in the torsos of homogeneous models of swine and rats. The observed data were a strong function of the five grounding configurations invested: all four feet grounded, only front feet grounded, only rear feet grounded, left front and right rear feet grounded, and right front and left rear feet grounded. In the first configuration and with an exposure field strength of 10 kV/m, average total current densities induced in the torsos of pigs and rats were 34 nA/cm2 and 20 nA/cm2, respectively. The corresponding value for human exposure is about 250 nA/cm2, 7.3 and 12.5 times larger than for swine and rats, respectively. Current densities measured at 60 Hz can be linearly extrapolated to frequencies in a range extending from at least 1 Hz to 1 MHz. Human and animal current-density data can provide an improved rationale for extrapolating biological data across species. In addition, these data can be used to validate the predictions of numerical models.

Animals↗

Trunk muscle cocontraction: the effects of moment direction and moment magnitude.

This study investigated the cocontraction of eight trunk muscles during the application of asymmetric loads to the torso. External moments of 10, 20, 30, 40, and 50 Nm were applied to the torso via a harness system. The direction of the applied moment was varied by 30 degrees increments to the subjects' right side between the sagittally symmetric orientations front and rear. Electromyographic (EMG) data from the left and right latissimus dorsi, erector spinae, external oblique, and rectus abdominus were collected from 10 subjects. The normalized EMG data were tested using multivariate and univariate analyses of variance procedures. These analyses showed significant interactions between the moment magnitude and the moment direction for seven of the eight muscles. Most of the interactions could be characterized as due to changes in muscle recruitment with changes in the direction of the external moment. Analysis of the relative activation levels, which were computed for each combination of moment magnitude and direction, indicated large changes in muscle recruitment due to asymmetry, but only small adjustments in the relative activation levels due to increased moment magnitude.

Adult↗