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At least 559 records · Page 31Linked to original sources
PubMed2006

Randomized, single-blind, placebo-controlled multicenter trial to compare the efficacy and safety of metronidazole and satranidazole in patients with amebic liver abscess.

The aims of our randomized, single-blind trial involving 49 patients were to study the efficacy, side effects, and tolerance of metronidazole and satranidazole in patients of amebic liver abscess. Twenty-five patients received metronidazole (800 mg TID) and 24 received satranidazole (300 mg TID with placebo at mealtime). Patients recorded side effects and tolerability through a performa. The time taken for resolution of fever and pain and the fall in abscess size was not significant. However, tolerance of satranidazole as reported by the patients was significantly better than metronidazole (P < .005). The incidence of adverse effects was significantly lower in the group given satranidazole (P < .005). The incidence of nausea and metallic taste was significantly lower in the patients given satranidazole (P < .005). Thus, despite having a similar efficacy, satranidazole showed a far lower incidence of side effects and had a significantly better tolerance than Metronidazole.

Adult↗
PubMed2006

Pharmacoeconomic comparison of Helicobacter pylori eradication regimens.

BACKGROUND: Helicobacter pylori is the most important etiologic agent for development of peptic ulcer, chronic gastritis and gastric carcinomas. It is now well established that H. pylori eradication treatment is more cost-effective than acid suppressing therapies alone for the treatment of peptic ulcer disease. However, the comparative cost-effectiveness of various H. pylori eradication regimens is still not clear. OBJECTIVE: This study was designed to make a pharmacoeconomic comparison of different H. pylori eradication regimens in patients with peptic ulcer disease or chronic gastritis, using real-world cost and effectiveness data. SETTING: Istanbul University Hospital and Marmara University Hospital. METHOD: A total of 75 patients diagnosed as H. pylori (+) by endoscopy were randomized to receive one of the seven H. pylori treatment protocols. These protocols were as follows: (LAC) = 'lansoprazole 30 mg bid + amoxicillin 1 g bid + clarithromycin 500 mg bid' for 7 days and (OCM) = 'omeprazole 20 mg bid + clarithromycin 250 mg bid + metronidazole 500 mg bid'; (OAM) = 'omeprazole 40 mg qd + amoxicillin 500 mg tid + metronidazole 500 mg tid'; (MARB) = 'metronidazole 250 mg tid + amoxicillin 500 mg qid + ranitidine 300 mg hs + bismuth 300 mg qid'; (OAC) = omeprazole 20 mg bid + amoxicillin 1 g bid + clarithromycin 500 mg bid'; (OCA) = omeprazole 40 mg bid + clarithromycin 500 mg bid + amoxicillin 1 g bid'; (OAB) = 'omeprazole 20 mg bid + amoxicillin 500 mg tid + bismuth 300 mg qid' each for 14 days. Only direct costs were included in the analysis. Effectiveness was measured in terms of "successful eradication". The cost-effectiveness ratios of the regimens were calculated using these effectiveness and cost data. The perspective of the study was assumed as the Government's perspective. MAIN OUTCOME MEASURE: Cost-effectiveness ratios of eradication regimens. RESULTS: MARB and OCA regimens were found to be more cost-effective than the other treatment regimens. The eradication rates and cost-effectiveness ratios calculated for these protocols were 90% (158.7 euros) for MARB and 90% (195.8 euros) for OCA regimen. CONCLUSION: This study confirms the importance of using local pharmacoeconomic data. Analyses such as this give decision-makers the tools to choose a better treatment option which is both highly effective yet and has a low cost.

2-Pyridinylmethylsulfinylbenzimidazoles↗
PubMed1975

Defects of taste and smell in patients with hypothyroidism.

Taste and smell functions were measured in 18 unselected patients with untreated primary hypothyroidism, and in 15 of the 18 patients after treatment with thyroid hormones. Before treatment, 9 of the 18 patients (50 per cent) were aware of some alteration in their sense of taste, and 7 of the 18 patients (39 per cent) were aware of some alteration in their sense of smell. Distoritions of tase (dysgeusia) and smell (dysosmia) were frequent complaints among the untreated patients; dysgeusia was observed by 7 patients (39 per cent) and dysosmia by 3 patients (17 per cent). Median detection and recognition thresholds for four taste stimuli salt (sodium chloride), sweet (sucrose), sour (hydrochloric acid) and bitter (urea), and for two smell stimuli (pyridine and nitrobenzene), were determined in each patient before and after treatment with thyroid hormones. Before treatment, decreased taste acuity (hypogeusia) for at least one stimulus was observed in 14 of the patients (83 per cent); the most common abnormalities were in the detection and recognition of bitter stimuli. Median detection thresholds for both smell stimuli were also markedly elevated (hyposmia) before therapy. Treatment with throid hormones largely reversed both the taste and smell defects. In one patient, taste and smell abnormalities were completely corrected after 16 days of treatment with thyroxine. This study indicates that taste and smell defects are common clinical abnormalities in primary hypothyroidism, and suggests that these defects may contribute to the anorexia and lack of interest in eating which are frequently observed.

Adult↗
PubMed1985

Cautopyreiophagia. Cause of life-threatening hyperkalemia in a patient undergoing hemodialysis.

A male patient undergoing hemodialysis in whom the cause of severe hyperkalemia (more than 8 mmol/liter) was found to be an unusual pica is described. His pica consisted of ingestion of burnt match heads (cautopyreiophagia). The potassium content of his daily consumption of burnt matches added 80 mmol to his 45 mmol dietary potassium intake. Hypogeusia and hypozincemia were documented. Oral zinc supplementation (zinc sulfate 220 mg per day for 10 weeks) normalized his plasma zinc level and taste acuity. He abandoned his pica and his plasma potassium level dropped significantly to 5.5 to 6 mmol/liter. It is suggested that inquiry about pica should be part of the dietary history in patients with renal failure.

Adult↗
PubMed1986

Safety profiles of the angiotensin converting enzyme inhibitors captopril and enalapril.

The safety profiles of the angiotensin converting enzyme inhibitors, captopril and enalapril, are the focus of this review. Adverse effects are reviewed as those associated with sulfhydryl compounds and as those considered class-specific adverse effects of angiotensin converting enzyme inhibitors. Specifically discussed are the incidences of the adverse effects of rash, taste disturbance, neutropenia, and proteinuria, which are characteristic of compounds containing sulfhydryl moieties, such as captopril. It is concluded from the review of these safety data that enalapril is well tolerated, has few class-specific adverse effects, and may offer a potential advantage over captopril by having fewer sulfhydryl-related adverse effects.

Angiotensin-Converting Enzyme Inhibitors↗
PubMed1992

Cisplatin-induced conditioned taste aversion: attenuation by dexamethasone but not zacopride or GR38032F.

The 5-HT3 receptor antagonists zacopride and GR38032F are highly effective inhibitors of emesis induced by ionizing radiation and chemotherapeutic drugs such as cisplatin. The present study evaluated zacopride and GR38032F for efficacy in inhibiting the formation of the conditioned taste aversion (CTA) induced by cisplatin or lithium chloride in rats. The glucocorticoid dexamethasone, which has been reported to be effective against both the emetic and CTA-inducing effects of cisplatin, was included as a reference compound. When administered alone by i.p. injection, zacopride (0.1-10 mg/kg), GR38032F (10 mg/kg) and cisplatin (0.32-1.8 mg/kg) induced a CTA to an 0.1% saccharin solution; lower doses of each compound were ineffective. When administered as a pretreatment, neither zacopride (0.001-0.1 mg/kg) nor GR38032F (0.01-10 mg/kg) attenuated the CTA induced by cisplatin (0.32 and 0.56 mg/kg) or lithium chloride (10 mg/kg). In contrast, dexamethasone (0.32 and 1.0 mg/kg) attenuated the CTA induced by 0.32 but not 0.56 mg/kg of cisplatin. In an attempt to evaluate higher doses of zacopride against cisplatin without the potentially confounding factor that these doses by themselves induce a CTA, rats were injected with zacopride on three separate days prior to the aversion conditioning session. This pre-exposure treatment blocked the formation of the zacopride-induced CTA, but did not improve the efficacy of zacopride in attenuating the cisplatin-induced CTA. These results suggest that neither the cisplatin- nor the lithium-induced CTA in rats are due to effects that are sensitive to 5-HT3 receptor blockade.

Analysis of Variance↗
PubMed1990

Veterans Administration Cooperative Studies Project No. 147: association of metallic taste with metal ceramic alloys.

We examined patients to find out whether they noticed the prevalence of metallic taste and set out to determine the association of metallic taste with demographic, medical, and dental factors. Data were collected as part of a Veterans Administration Cooperative Study investigating the suitability of alternative metal ceramic alloys as substitutes for alloys that contain gold. Crowns and fixed partial dentures were made from control and alternative alloys for accepted volunteer patients. A month after placement of the restorations and at regularly scheduled recall appointments, the patients were asked if they tasted a metallic flavor. Of the 2023 times the question was asked, 101 positive responses were given by 68 patients (46 reported metallic flavor once, and 22 reported it more than once). Results indicated that youth, sensitivity to heat and cold, bruxism, grinding, and an increasing number of restorative units were significantly related to metallic taste. For any given visit, about 5% of the patients reported tasting a metallic flavor regardless of the type of alloy that was used in the restoration. Metallic taste does not appear to be a problem with alternative alloys.

Adult↗
PubMed1993

Intraoral galvanic corrosion: literature review and case report.

This article reviewed the dental history of a patient with symptomatic electro-chemical reactions after the occlusal relationship of an existing complete gold crown and silver amalgam restoration was changed. A literature review of oral galvanism is presented with diagnostic techniques and treatment options.

Composite Resins↗
PubMed1984

Serum zinc and copper in oral/oropharyngeal carcinoma. A study of seventy-five patients.

Seventy-five patients with oral/oropharyngeal carcinoma were studied to assess the relationship between serum zinc and copper levels, radiation-induced taste loss, and tumor status. There were no significant differences between pretreatment and posttreatment serum mineral levels in cancer patients and in 21 healthy persons who served as controls. Of 30 patients who did not experience spontaneous postradiation taste recovery and were supplemented with zinc sulfate daily for at least 1 month, 11 reported improvement in taste. Serum zinc levels rose markedly in the patients with taste improvement.

Carcinoma, Squamous Cell↗
PubMed1989

Oral discomfort at menopause.

The relationship between oral discomfort and menopause was assessed in 149 women who were divided into three groups determined by response to a questionnaire. The groups consisted of 50 premenopausal women (30 to 43 years old), 47 menopausal women not receiving medical treatment for symptoms of menopause (37 to 66 years old), and 52 menopausal women attending a menopause clinic before and during treatment for menopausal symptoms (30 to 63 years old). The last group had a general medical assessment, including psychological and oral examinations with oral smears and cultures, and the following blood tests: full blood examination, follicle-stimulating hormone, oestradiol, folate, vitamin B12, iron, and total iron binding capacity. Of this last group, 33% reported oral discomfort but had no obvious organic abnormalities that could account for this symptom. The prevalence of oral discomfort was found to be significantly higher in perimenopausal and postmenopausal women (43%) than in premenopausal women (6%). The results also showed an association between oral discomfort and psychological symptoms in menopausal women. Approximately two thirds of the menopausal women with oral discomfort, but without oral clinical signs, found that this symptom was relieved after hormone replacement therapy. The results indicated that oral discomfort is a common symptom of menopause, that it often occurs without overt clinical signs, and that it frequently resolves during appropriate hormone replacement therapy.

Adult↗
PubMed1986

D-penicillamine: chemistry and clinical use in rheumatic disease.

The discovery of D-penicillamine and its uses in medicine are reviewed. Chemical-physical properties are discussed, and the molecular structure of D-penicillamine and several of its reaction products are illustrated. Examples of its three main types of biochemical reactions--sulfhydryl-disulfide exchange, thiazolidine formation, and metal chelation are included. Trials of D-penicillamine in RA patients are reviewed critically. The administration of the drug is discussed in detail, including dosages, clinical and laboratory responses, patterns of adverse side effects or toxicity, drug-induced autoimmune diseases, indications and contraindications, and the monitoring and management of patients.

Arthritis, Rheumatoid↗
PubMedDate not supplied

Caffeine: preferential consumption by rats.

The present experiment explored the effect of forced daily consumption of large amounts of caffeine (analogous to that of heavy coffee drinkers) upon the subsequent intake of caffeine in a free-choice situation. It was found that forced caffeine consumption is directly related to subsequent free-choice intake and that a flavor associated with the forced caffeine is not preferred.

Animals↗
PubMed1995

Stimulus control of addictive behavior: persistence in the presence and absence of a drug.

Rats were exposed daily to a food schedule-induced polydipsia condition, in which water and 0.16 mg/ml cocaine solution were available concurrently, with the cocaine solution indicated by a discriminative stimulus (SD) light. The cocaine solution was preferred, and the preference was maintained when the SD was gradually eliminated by fading its intensity. For a second group, if cocaine concentration was the stimulus gradually eliminated, preference for the resulting solution (water) indicated by the SD was stably maintained. For two additional groups, if either the light SD or the cocaine stimulus was removed abruptly rather than gradually, few animals retained preferences. These studies reveal the importance of establishing strong stimulus control for the initiation and persistence of drug abuse behavior.

Animals↗