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At least 559 records · Page 31Linked to original sources
PubMed2005

Effects on instruments of the World Health Organization--recommended protocols for decontamination after possible exposure to transmissible spongiform encephalopathy-contaminated tissue.

It has been recommended by the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) that rigorous decontamination protocols be used on surgical instruments that have been exposed to tissue possibly contaminated with Creutzfeldt-Jakob disease (CJD). This study was designed to examine the effects of these protocols on various types of surgical instruments. The most important conclusions are: (1) autoclaving in 1N NaOH will cause darkening of some instruments; (2) soaking in 1N NaOH at room temperature damages carbon steel but not stainless steel or titanium; (3) soaking in chlorine bleach will badly corrode gold-plated instruments and will damage some, but not all, stainless-steel instruments, especially welded and soldered joints. Damage became apparent after the first exposure and therefore long tests are not necessary to establish which instruments will be damaged.

Animals↗
PubMed1993

Medicus and technicus.

Throughout history "medicus" and "technicus" worked closely in the design of surgical instruments. The early tools were relatively primitive in modern terms but most of them achieved the purpose for which they were designed. In recent centuries numerous surgical instruments were pioneered to execute a variety of tasks. As surgical and technical skills developed some instruments were modified while others were abandoned. Many instruments used in conventional open surgery have obviously stood the test of time, though they have been continuously adapted to the current requirements, the available surgical skills and preference. More recently instrument design and manufacture has been taken over by industry. There are a variety of reasons as to why this may have been an important and advantageous step but the main disadvantage lies in the reduction in the cooperation between "medicus" and "technicus".

Biomedical Engineering↗
PubMed1985

Posterior lumbar interbody fusion with specialized instruments.

Posterior lumbar interbody fusion (PLIF) has been performed in 100 individuals by use of specialized surgical instruments and allogeneic preserved bone grafts from 1979 to March 1982, after the advantages of performing PLIF in 342 individuals from 1965 to 1978 were noted. No deaths occurred, nor any infections or thrombophlebitis postoperation. Eleven (11%) reoperations were required: six for proven pseudarthrosis, three for gradual bone graft extrusion (of six extrusions total), one for bone graft fracture (with manifestations of nerve root compression), and one for hematoma. Operative results were excellent in 35%, good in 39%, fair in 17%, and poor in 9%. Specialized surgical instruments used for the operation included mortising chisels with cannulated reamers, right-angled curettes, and depth-limited impactors. PLIF is technically demanding; however, it establishes a mortise-graft interbody fusion to stabilize and restore the spinal architecture.

Adult↗
PubMed1998

Haemodynamic and metabolic changes induced by repeated episodes of hypoxia in pigs.

BACKGROUND: Repeated hypoxia and surgical trauma trigger a potent neuroendocrine response and their association is thought to play a pivotal role in the pathogenesis of multi-organ dysfunction. We investigated the cardiovascular and metabolic responses to repeated acute hypoxia in anaesthetised and surgically instrumented pigs. METHODS: Under ketamine-midazolam anaesthesia, 15 pigs were surgically instrumented for measurements of cardiac output, vascular pressures and organ blood flows. Lactate production and O2 uptake were determined in the brain, liver, kidney and intestine. Ten animals were subjected to two 12-min periods of ventilatory hypoxia (FIO2 = 7%) followed by re-oxygenation and 5 animals underwent 120-min normoxic ventilation (Control group). RESULTS: Both hypoxic challenges produced a comparable release of catecholamines that was associated with increased cardiac output and redistribution of blood flow away from the intestinal and renal areas towards the brain and the liver; O2 uptake was markedly reduced in the intestine (-56 +/- 10%, P < 0.05) and least affected in the brain and the kidney (-19 +/- 12% and -23 +/- 21%, respectively). During the second hypoxic test, lethal cardiovascular depression occurred in 5 animals; these non-survivors demonstrated impaired hyperdynamic response and incomplete recovery of intestinal O2 uptake during the first hypoxia/reoxygenation test. In the Control group, normoxic ventilation was not associated with significant haemodynamic and metabolic changes. CONCLUSION: Intraoperative hypoxia causes marked heterogeneity in organ blood flow and metabolism. The inability to develop a hyperdynamic cardiovascular response during a first hypoxic event, as well as a persistent intestinal O2 debt following re-oxygenation, predict the occurrence of death during the second hypoxic insult.

Anesthesia↗
PubMed2007

Removal of a pellet from the left orbital cavity by image-guided endoscopic navigation.

In the cranio-maxillofacial field, computer-aided surgery based on computed tomography data is becoming increasingly important. Complex surgical procedures can be performed utilizing preoperative imaging to provide real-time localization of surgical instruments in the surgical field. Image-data-based navigation plays an ever-increasing role in cases of minimal invasive surgery. The case is presented here of a 58-year-old male patient referred after a hunting accident with a pellet in the left orbit. After transferring the preoperatively acquired computed tomography data to a commercially available navigation system, the bullet was removed through the original wound canal using an intraoperatively calibrated high-resolution endoscope.

Endoscopes↗
PubMedDate not supplied

Pathophysiology and management of subretinal hemorrhage.

Subretinal hemorrhage can arise from the retinal and/or choroidal circulation. Significant subretinal hemorrhage occurs in several conditions, but most commonly is associated with age-related macular degeneration, presumed ocular histoplasmosis, high myopia, retinal arterial macroaneurysm, and trauma. Released toxins, outer retinal shear forces, and a diffusion barrier created by subretinal hemorrhage all contribute to photoreceptor damage and visual loss. The use of tissue plasminogen activator and improvements in surgical instrumentation have facilitated surgical drainage and have made it a useful option in the management of selected cases. Mechanisms of subretinal hemorrhage formation, underlying etiologies, diagnostic evaluation, and the histopathology of damage are summarized. Published surgical series are reviewed and surgical advances are summarized. The value of surgically removing subretinal hemorrhages to improve visual outcome remains unestablished, because definitive studies have not been performed. Guidelines for selecting candidates for surgical intervention are proposed.

Animals↗
PubMed1999

[Fixation of the prolapse vagina to the sacrotuberal ligament].

OBJECTIVE: To present personal experience in the fixation of the vaginal stump to the sacrotuberal ligament. METHOD: Description of the surgery including modified surgical instruments. RESULTS: 32 surgical procedures were performed during a 4-year period. Two relapses were recorded. DISCUSSION: Various surgical procedures including abdominal approach to the fixation are mentioned, complications and prevention of relapses are discussed. CONCLUSION: The method is appropriate for sexually active patients. It preserves the length, axis and volume of the vagina.

Aged↗
PubMed1998

Endoscopy and stereotaxy for aneurysms.

The combination of the endoscope and frameless stereotaxy improves surgical results by allowing the surgeon to look around structures and into tight spaces, monitor the success of aneurysm clipping, decrease the risk of perforator or cranial nerve injury, plan the surgical approach, and track surgical instruments in the surgical field. This article discusses the use of endoscopy and frameless stereotaxy in aneurysm surgery.

Adult↗
PubMed2002

Decontamination upgrading progresses.

Standards of decontamination of surgical instruments in the NHS in England have come under close scrutiny, and some significant improvements have been achieved. Action plans, developed to ensure the rate of improvement is maintained, are described in this article which is derived from the Department of Health/NHS Estate document 'A review of the decontamination of surgical instruments in the NHS in England'. The Institute of Healthcare Engineering and Estate Management is one of the organisations involved in the programme of work on decontamination.

Central Supply, Hospital↗
PubMed2006

The Spencer Wells forceps.

This is the first of a six-part biographical series tracing the lives of the people behind some of today's most commonly used surgical instruments. Surely the most recognisable 'name behind the instrument' must be that of Sir Thomas Spencer Wells (1818-1897), whose ratchet haemostatic forceps represented a simple but important advance in surgical instrument technology.

Hemostasis, Surgical↗
PubMed1995

Clinical evaluation of a system for precision enhancement in spine surgery.

Most techniques in segmental spinal fixation surgery rely on the identification of predefined targets with the help of anatomical landmarks and on intraoperative use of image intensifiers. However, because there is no direct link between the image information, the accessible spinal anatomy, and the action of surgical instruments several potential problems and possible complications are still involved. A novel system for spinal surgery has been designed allowing for the real-time, intraoperative localization of surgical instruments in medical images. In practice this was achieved by combining image-guided stereotaxis with advanced optoelectronic position sensing techniques. Modules were developed for image data processing, surgical planning and simulation, and various intraoperative procedures. A detailed validation of the system was performed indicating an overall accuracy to be better than the slice distance of the spinal image used. In an in-vitro setting 20 pilot holes for pedicle screws were prepared in human cadaveric lumbar spines. An analysis in 77 histological cuts showed an ideal location in 70 and only minor cortex engagement in seven sections. In vivo the system has been successfully applied in three posterior low lumbar stabilizations with overall 15 transpedicular screws. RELEVANCE--:This article focuses on the clinical evaluation of a computer-assisted surgery system and its application to the operating theatre for transpedicular fixation of the spine. The given approach effectively keeps the surgeon 'in the loop' and requires only minor modifications of the established surgical techniques and associated instruments. The results of this study indicate that advanced computer-assisted techniques may significantly improve the accuracy and safety of surgical interventions of the spine. The proposed technique may in future be adapted to other applications in orthopaedic surgery.

Journal Article↗
PubMed2001

Metalloproteinase inhibition prevents acute respiratory distress syndrome.

BACKGROUND: The acute respiratory distress syndrome (ARDS) occurs in patients with clearly identifiable risk factors, and its treatment remains merely supportive. We postulated that patients at risk for ARDS can be protected against lung injury by a prophylactic treatment strategy that targets neutrophil-derived proteases. We hypothesized that a chemically modified tetracycline 3 (COL-3), a potent inhibitor of neutrophil matrix metalloproteinases (MMPs) and neutrophil elastase (NE) with minimal toxicity, would prevent ARDS in our porcine endotoxin-induced ARDS model. METHODS: Yorkshire pigs were anesthetized, intubated, surgically instrumented for hemodynamic monitoring, and randomized into three groups: (1) control (n = 4), surgical instrumentation only; (2) lipopolysaccharide (LPS) (n = 4), infusion of Escherichia coli lipopolysaccharide at 100 microg/kg; and (3) COL-3 + LPS (n = 5), ingestion of COL-3 (100 mg/kg) 12 h before LPS infusion. All animals were monitored for 6 h following LPS or sham LPS infusion. Serial bronchoalveolar lavage (BAL) samples were analyzed for MMP concentration by gelatin zymography. Lung tissue was fixed for morphometric assessment at necropsy. RESULTS: LPS infusion was marked by significant (P < 0.05) physiological deterioration as compared with the control group, including increased plateau airway pressure (P(plat)) (control = 15.7 +/- 0.4 mm Hg, LPS = 23.0 +/- 1.5 mm Hg) and a decrement in arterial oxygen partial pressure (P(a)O(2)) (LPS = 66 +/- 15 mm Hg, Control = 263 +/- 25 mm Hg) 6 h following LPS or sham LPS infusion, respectively. Pretreatment with COL-3 reduced the above pathophysiological changes 6 h following LPS infusion (P(plat) = 18.5 +/- 1.7 mm Hg, P(a)O(2) = 199 +/- 35 mm Hg; P = NS vs control). MMP-9 and MMP-2 concentration in BAL fluid was significantly increased between 2 and 4 h post-LPS infusion; COL-3 reduced the increase in MMP-9 and MMP-2 concentration at all time periods. Morphometrically LPS caused a significant sequestration of neutrophils and monocytes into pulmonary tissue. Pretreatment with COL-3 ameliorated this response. The wet/dry lung weight ratio was significantly greater (P < 0.05) in the LPS group (10.1 +/- 1.0 ratio) than in either the control (6.4 +/- 0.5 ratio) or LPS+COL-3 (7.4 +/- 0.6 ratio) group. CONCLUSIONS: A single prophylactic treatment with COL-3 prevented lung injury in our model of endotoxin-induced ARDS. The proposed mechanism of COL-3 is a synergistic inhibition of the terminal neutrophil effectors MMPs and NE. Similar to the universal practice of prophylaxis against gastric stress ulceration and deep venous thromboses in trauma patients, chemically modified tetracyclines may likewise be administered to prevent acute lung injury in critically injured patients at risk of developing ARDS.

Animals↗
PubMed1989

Inhibition of tumor-cell attachment to extracellular matrix as a method for preventing tumor recurrence in a surgical wound.

Studies with four different transplantable murine tumors demonstrated that surgical instruments contaminated by contact with a tumor mass could produce tumors in a surgical wound. Eighty-seven per cent of mice with wounds made by invisibly contaminated scissors developed tumors. Irrigation with water did not prevent tumor growth. Before spilled tumor cells can invade and grow into a recurrence in the wound site, they must first attach to underlying extracellular matrix. We have devised a simple in vitro assay to identify inhibitors of tumor-cell attachment to develop therapeutic compounds that can prevent tumor-cell reimplantation. Various test compounds, including proteases (trypsin and Dispase), known modulators of matrix metabolism (proline analogues, cycloheximide, heparin, cortisone, cortexolone, and heparin-steroid combinations), large molecular weight polymers (agarose, dextran, polyethylene oxide), and synthetic fibronectin peptides were tested for their ability to inhibit mouse melanoma (B16-F10) cell attachment to gelatinized dishes. Most of these compounds had little or no effect on tumor-cell adhesion when cells were plated in serum-containing medium. However we identified three compounds that inhibited tumor-cell attachment in a reversible fashion: (1) a specific inhibitor of collagen deposition (L-azetidine-2-carboxylic acid); (2) a bacterial neutral protease (Dispase); and (3) synthetic fibronectin peptides that contained the arginine-glycine-asparate (RGD) sequence that is responsible for cell binding. Dispase and the RGD-containing peptides also inhibited cell implantation and prevented tumor formation in a surgical wound. We propose that inhibitors of attachment might be used either alone or with other biologic modifiers to prohibit implantation of free tumor cells at the time of surgery and thus, to prevent local tumor recurrence.

Animals↗
PubMed1987

Microbial contamination associated with routine aseptic practice.

We have studied the rate of fortuitous contamination associated with routine aseptic technique under operational conditions. Stainless steel strips, as simulators of surgical instruments, were contained in sterilized surgical packs and assayed by nursing personnel during surgical and other invasive procedures at three different hospitals. The rates of contamination observed for the 36 investigators ranged from 0% to 11.3%, with an overall rate of 2.7%. Assays conducted in a clean room environment, under conditions approaching industrial sterility standards, showed a contamination rate of 0.16%. We concluded that aseptic practices, as routinely performed without any noticeable breaks or transgressions, do not guarantee sterility. The concept of surgical sterility implies low level, but measurable, microbial contamination.

Antisepsis↗