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[New methods of type II tympanoplasty in erosion of the long incus process].

Reliable methods of reconstruction of the ossicular chain in the situation of an isolated errosion of the long process of the incus using a tympanoplasty type II have not been available until recently. Instead, the tympanoplasty type III has been generally performed with the interposition of an autologous incus. In this presentation, we are describing two methods for reconstruction of the ossicular chain between the in-situ residing incus and the stapes on the other side so that the direct connection eventually will result in a tympanoplasty type II. In the first case, we used ionomeric cement in a way that features two characteristics: the direct connection between the stapes and the long process of the incus could be achieved as well as an articulation that was created on the head of the stapes. Hence, a too stiff connection between the head of the stapes and the long process of the incus could be avoided. In addition, a new method for precise microapplication of cooled bone cement (IONOCAP LV) with a syringe will be presented. In the second method titanium-gold-angle prostheses have been crimped to the long process of the incus and positioned onto the head of the stapes in the way of an articulation. So far, comparison of the audiological results of those two methods of a tympanoplasty type II reveal in average better results than postoperative conductive hearing thresholds of the conventional tympanoplasty type III. If the achieved results can be reproduced on a larger number of patients, the expected audiological results are likely to resemble those of stapes surgery.

Auditory Threshold↗

[Epithelium-stroma interaction in cholesteatoma of the middle ear].

BACKGROUND: Local Infiltration and bony destruction are characteristic features of cholesteatomas. The aim of the study was assessment of cell ploidy, proliferation rates and expression of cell adhesion molecules to analyze the pathogenetic role of matrix (epithelium) in cholesteatoma. The cellbiologic parameters were compared to clinical findings. PATIENTS AND METHOD: Tissue samples from 48 patients with cholesteatomas were analyzed by: routine histology, quantitative DNA-cytometry with the DNA indices: 2cDeviation Index (2cDI) and 5c Exceeding Rate (5c ER), immunhistochemical analysis of proliferation rate (ki67-MIB1 and PCNA), cell adhesion molecules, cell-cell interaction: E-Cadherin, alpha 1 beta 6-Integrin, Inter-Cellular-Adhesion-Molecule (I-CAM), cell-matrix interaction: CD44v4/5, CD 44v6, alpha v-, beta 3-Integrinchains and vascular-Cell-Adhesion-Molecule (V-CAM). Clinical data included patient age, history of ear disease, pre-operative audiometry, intra-operative size and extension of the cholesteatoma, destruction of ossicles and petrous bone. For comparison healthy squamous epithelium was obtained from the external ear canal of 10 patients during stapes surgery. RESULTS: Ossicular destructions were found in 34 cases. Three patients had mesotympanic cholesteatomas, four patients had mesotympanic and epitympanic involvement. In 37 patients cholesteatomas extended into the mastoid and in four patients the perilabyrinth and the petrous apex were reached. DNA-cytometric examination of matrix showed normal diploid values and no aneuploid cells (DNA-content > 5c) in all patients. The proliferation rates of the matrix were increased in comparison to normal epithelium. Cell adhesion molecules for intercellular bindings were expressed in similar pattern in cholesteatomas and in normal epithelium. Cell adhesion molecules for cell matrix bindings showed new or increased expression in cholesteatomas. No significant correlation between proliferation and clinical findings could be established. CONCLUSION: The study confirms previous suggestions that the growth of cholesteatomas is not stimulated by the matrix. The increased proliferation of the matrix is a result of the inflammatory process in the cholesteatoma and is correlated to the size of the cholesteatoma. On a cellular or molecular level no correlation between bone destruction through the cholesteatoma and proliferation rate of the cholesteatomas could be established. These findings support suggestions that the perimatrix of the cholesteatomas is the main pathogenetic factor.

Adolescent↗

Carhart notch effect in otosclerotic ears measured by electric bone-conduction audiometry.

The Carhart notch is an elevation in the middle-frequency bone-conduction threshold of an ear with clinical otosclerosis. The study population consisted of 138 patients with clinical otosclerosis. Conventional air-conduction (AC) and bone-conduction (BC) and electric bone-conduction (EBC, with Audimax 500 audiometer) thresholds were measured 2 weeks before and 7 months after stapes surgery. The EBC thresholds were converted from mA values to dB SPL to compare the results obtained with the different methods. The mean differences in the BC thresholds before and after the operation were 3.2 dB (95% CI 1.9-4.6) at 1 kHz and 7.6 dB (95% CI 6.1-9.1) at 2 kHz. The mean differences in the EBC thresholds were 5.4 dB (95% CI 3.8-6.9) at 1 kHz and 5.3 dB (95% CI 3.4-7.1) at 2 kHz. Thus, both methods showed a distinct Carhart notch effect.

Audiometry, Pure-Tone↗

The anterior and superior malleal ligaments in otosclerosis: a histopathologic observation.

HYPOTHESIS: The aim of this study was to assess, in otosclerosis, whether the anterior and superior malleal ligaments show histologic changes that can lead to reduced malleal mobility and eventual fixation, and also to evaluate whether these changes are related to the degree of histologic otosclerosis. BACKGROUND: Fixation of the malleus seems to be one of the most controversial clinical entities in the acquired condition of otosclerosis. It has even been postulated that persistent conductive deafness, or progression of conductive deafness after initial improvement after stapedotomy, could be due to unsuspected malleus fixation. METHODS: Fifty eight temporal bones with known otosclerosis and 43 normal temporal bones were selected. In addition, 10 temporal bones of fetuses and children were also studied. Otosclerosis of the footplate and otic capsule was graded as none, mild, moderate, and severe. The histologic changes in the ligaments also were graded from none to severe. RESULTS: The median ages of patients in the otosclerotic and normal groups were 62 and 60 years, respectively. In the anterior malleal ligament of the otosclerotic bones, 10% mild (+), 60% moderate (++), and 30% severe (+++) degrees of hyalinization were observed. In the anterior malleal ligament of the nonotosclerotic bones, 14% showed no hyalinization, 24% had only a tinge of hyalinization (minimal), 51% had mild (+) hyalinization, and 11% had moderate (++) hyalinization. Superior ligament hyalinization appears to be related to the severity of anterior ligament hyalinization. The severity of otosclerosis in the footplate or the otic capsule did not appear to be related to the severity of hyalinization. CONCLUSION: From this study, it is apparent that otosclerotic bones have a significantly high incidence of hyalinization of the anterior malleal ligament. This seems to be related to the duration rather than the severity of otosclerosis. It is important to properly evaluate malleal mobility during all stapes surgery.

Adult↗

Impact of intrascalar blood on hearing.

OBJECTIVE/HYPOTHESIS: The objective of this controlled animal study was to evaluate the effects of intrascalar blood on hearing. MATERIAL AND METHODS: Eight guinea pigs underwent intrascalar administration of their own blood in one ear and control solution in the contralateral ear. Solutions were applied through cochleostomy to the scala tympani. Compound action potential (CAP) thresholds were determined before administration and at different intervals for 2 months thereafter. RESULTS: Immediate deterioration of thresholds was seen mainly in the high-frequency range, averaging 27 dB and 20 dB in the study and control groups, respectively. At day 3, threshold shifts recovered in the control group but remained in the low-frequency range in the study group. An extensive recovery was seen in both groups. However, permanent threshold shifts persisted. There was an enhanced shift of thresholds of up to 7 dB in the study group. CONCLUSIONS: Even small amounts of intrascalar blood seem to cause transient and permanent detrimental effects on cochlear function. In procedures involving opening of the otic capsule-like stapes surgery and cochlear implantation with hearing preservation-minimizing surgical blood admixture to intracochlear compartments seems therefore fundamental.

Animals↗

Speech discrimination in patients with Bell's palsy and a paralysed stapedius muscle.

The contraction of the stapedius muscle results in a frequency dependant attenuation of sound through the middle ear. Idiopathic facial nerve paralysis (Bell's palsy) usually results in a paralysis of the stapedius muscle. This prospective study included 119 patients presenting with Bell's palsy over an 18-month period. After applying exclusion criteria, 80 patients with normal pure-tone audiograms underwent speech audiometry. This was performed on presentation and after recovery of the facial nerve palsy. Fifty-six patients (70%) with an absent stapedius reflex showed marked 'roll-over' from means of 98-49% on their speech audiogram. This resolved completely with recovery of the facial nerve palsy and return of the stapedial reflex. To determine whether this effect was due primarily to the paralysis of the stapedius muscle or to an associated polyneuropathy, a second study on six normal patients was done. These patients had both ears (12 in total) tested with speech filtered to simulate a paralysed stapedius muscle. This resulted in a mean 'roll-over' from 90.9 to 59.9%. The magnitude of this roll-over (31%) was only two-thirds of that seen in Bell's palsy patients (49%) with the difference between these means statistically significant (P < 0.05). This suggests that Bell's palsy, usually considered a mononeuropathy, involves certain of the auditory fibres of the eighth nerve and is a polyneuropathy. Stapedius function is important in speech discrimination at higher levels of sound intensity such as speech in noise and severing the stapedius tendon in stapes surgery may affect speech discrimination after successful surgery.

Adult↗

Assessing otolith function by the subjective visual vertical.

The effects of peripheral vestibular diseases on the subjective visual vertical (SVV) are resumed and provide the basis for some insights into the otolith pathophysiology. With a normal range of 0 +/- 2 deg (when measured in an upright body position), the SVV was shifted by 11 +/- 6 deg toward the ipsilateral ear in 40 patients following an acute unilateral vestibular deafferentiation (UVD), but in the opposite direction in 9 of 52 patients after stapes surgery. These opposite effects suggest a push-pull mechanism of the pairs of otolith organs with respect to the SVV. The dissociation between the SVV and the perception of body position indicates influences by unconscious reflexive mechanisms such as ocular cyclotorsion on the SVV. In chronic UVD patients, lateral shifts of the subjects during constant angular velocity rotation into various eccentric positions (+/- 16 cm) revealed a shift of the "center of graviception" close to the remaining intact contralateral inner ear. To date, this seems to be the most consistent test for clinical identification of a chronic compensated unilateral loss of otolith function. The findings regarding asymmetries in otolithic sensitivity to medially and laterally directed roll-tilts remain controversial, probably mainly because of influences of extravestibular cues.

Afferent Pathways↗

Malleus grip prosthesis.

The malleus grip prosthesis is designed for ears with conductive hearing loss caused by pathologic conditions of the stapes in association with pathologic conditions of the malleus or incus. The malleus grip procedure was performed on 220 ears, and follow-up studies are available on 203. Mild to profound sensorineural hearing losses occurred in 16 (8.37%). The remaining 187, on the first postoperative test, had an average air-bone gap of 14 dB, and subsequent examinations on 100 of them showed no significant change with the passage of time. The procedure is technically more difficult than stapes surgery for otosclerosis, and success is highly dependent upon selection of appropriate cases and meticulous implantation of the prosthesis.

Deafness↗

Histological and morphological observations of the paravestibular canaliculus.

The paravestibular canaliculus was studied by light microscopy in serial sections of the temporal bones from otosclerotic patients who underwent fenestration or stapes surgery. In all examined 23 specimens (13 cases), the endolymphatic duct and sac were observed to be normally developed with no pathological findings. The paravestibular canaliculus was found in 14 of the specimens (60.9%). Its course was traced from the proximal to the distal area in 12 specimens, and it appeared to merge into the distal portion of the endolymphatic sac in 7 of them. Twelve of the paravestibular canaliculi contained one vein, and 3 contained several veins. No artery was found. The paravestibular canaliculus was observed to originate from small vascular channels around the vestibule in the otic capsule, lateral to and near the internal aperture of the vestibular aqueduct.

Adult↗

[Congenital auditory ossicle malformation without external ear abnormality].

In 29 ears of 24 patients with auditory ossicle malformation, but without external ear abnormalities, who were operated on at our clinic in the 10 years between June 1993 and June 2002, we studied the condition of ossicles, preoperative examination, surgical procedures, and postoperative hearing improvement. Our study did not include patients with cholesteatoma or those with only fixed stapes but without ossicular deformity. Samples were 12 ears of 11 men and 17 ears of 13 women. We clinically distinguished 3 major categories: (i) discontinuity between the incus and stapes with mobile stapes, (ii) congenital fixation of the stapes with ossicular deformity, and (iii) congenital fixation of the malleus and deformity of the incus with mobile stapes. We classified each category into minor abnormalities based on the condition of the long process of the incus, the superstructure of the stapes, and the stapes footplate. We conducted auditory ossicle reconstruction by mobilization of the malleus and incus in 2 ears, by type III tympanoplasty in 5 ears, by type IV tympanoplasty in 13 ears, and by stapes surgery in 8 ears. Improvement in hearing after the operation was observed in 25 of the 29 ears treated. In the classification of the auditory ossicle malformation without external ear abnormalities, we should evaluate discontinuity or fixation of the ossicles and their deformity. This requires that varied ossicular reconstruction be prepared for surgery, but the possibility of hearing improvement is high, so intensive treatment is needed in many cases of auditory ossicle malformation.

Adolescent↗

Can a Persistent Stapedial Artery be Safely and Effectively Removed? A Case Report with Therapeutic Implications.

In the past, a persistent stapedial artery was frequently cited as a reason to discontinue stapes surgery, however, several authors have had success operating on the oval window despite the presence of a persistent artery. We present a case of a patient with conductive hearing loss and tinnitus successfully treated with removal of a persistent stapedial artery that was filling the obturator foramen. This experience, in conjunction with a review of the literature and a discussion with several neurotologic colleagues, leads us to suggest that a stapedial artery can be safely removed allowing unhindered access to the oval window.

Journal Article↗

Tinnitus in childhood.

All of 1,420 children seen for clarification of a hearing disorder or to follow up for known difficulty in hearing were questioned as to whether they experienced tinnitus. The interview was carried out after a hearing test was conducted, which was based on play audiometry or normal pure-tone threshold audiometry, depending on the age of the child. When being interviewed, 102 children reported that tinnitus had appeared or was still present. Seventy-five children (73.5%) demonstrated difficulty in hearing in one or both ears, whereas 27 children (26.5%) had normal hearing in both ears. The most frequently obtained information (29.4%) was the progression of an existing hearing loss. Meningitis is an important cause of hearing loss and of tinnitus and could be identified in 20% of our patients. We also considered as a cause of tinnitus skull or brain trauma, acute hearing loss, and stapes surgery. However, the mechanisms of tinnitus development were not immediately clear in a large proportion of the children studied: Problems included central sensory perception (14.7%) and emotional factors (11.8%). No additional information that might lead to an understanding of the hearing loss was available for 14.7% of the patients studied. Tinnitus is a frequent symptom in childhood and, because children seldom complain about their tinnitus, such hearing problems that they report must always be taken seriously. The diagnosis should exclude metabolic disturbances, possible damage to the sensory level of the central nervous system, and circulatory disturbances. In addition, the physician should always consider emotional problems and disturbances of perception.

Adolescent↗

[Carhart's effect; a study of postoperative outcome of 47 surgically treated cases of otosclerosis].

The Carhart Effect can explain a bone conduction improvement after stape surgery in otosclerosis, because of the mechanical factors in transmission of sound vibrations. The authors have studied 47 cases of total stapedectomy for otosclerosis to point out this bone conduction improvement. A correlation between the bone conduction improvement and others parameters has been searched: a statistic correlation between pre-operative bone curve and the 1000 Hz bone conduction improvement has been found.

Audiometry↗

[Sound transmission loss within the middle ear].

OBJECTIVE: To assess the amount of sound transmission loss in order to deeply understand the mechanism of middle ear sound transmission for ossicular reconstruction and for guidance of crimping between prosthesis and stapes on sound transmission in stapes surgery. METHODS: In order to get a correcting magnetic field 2 temporal bone models was used first. Temporal bone models was developed using 17 human temporal bones from fresh cadavers. To measure the sound transmission properties in the middle ear, 15 temporal bone models were detected by scanning laser Doppler interferometry with acoustical stimulation and electromechanical stimulation. An algorithm was developed to simulate acoustical stimulation with electromechanical stimulation. A sound transmission loss within the incudostapedial joint was detected by electromechanical stimulation in 10 temporal bone models. RESULTS: The average transmission loss within the incudostapedial joint remained 3 dB over the frequencies detected. CONCLUSIONS: There was a sound transmission loss within the incudostapedial joint, which was a physiological and protection way.

Acoustic Stimulation↗

[Changes in area of mucous membrane in otosclerosis].

In 98 samples of middle-ear mucosa, taken from patients during otosclerotic stapes surgery, considerable pathological changes in the organization of the capillaries were found (endothelial hydrops, proliferation of the intima and adventitia, total obliteration of small vessels). They caused pathological reactions of the mesenchymal elements of the submucosa: fibrocytes undergo lysis, collagen fibres show fibolysis and hyalinosis. Free and cellular bound calcium deposits are located in these lytic areas. Even the epithelial stratum reveals uncommon inclusions such as glycogen and acid mucopolysaccharides. The basement membranes of the capillaries as well as of the epithelium show enlargements and solution of their ultrastructure. The changes of the connective tissue and of the epithelium are secondary to the capillary obstructions.

Capillaries↗

Sodium hyaluronate application to the open inner ear: an ultrastructural investigation.

The effect of 1 percent sodium hyaluronate on the open inner ear was tested in a series of guinea pigs. By removing the stapes footplate from its original position in the oval window, direct access to the vestibule from the inner ear was achieved. The oval window niche was filled with either 1 percent sodium hyaluronate or 0.9 percent NaCl. The animals were examined with regard to both the cochlear and the vestibular partitions of the inner ear. No marked differences could be seen between the test group and the controls. Thus the organ of Corti as well as the vestibular end organs presented with normal anatomy throughout. Neither did the behavior of the animals in any way indicate any signs of inner ear disturbance. It is concluded that 1 percent sodium hyaluronate does not seem to harm the inner ear sensory structures even in the case of direct access to the vestibule as can be foreseen if the compound is used during stapes surgery.

Animals↗

Circulatory changes during a hypotensive technique of anesthesia.

The blood circulation and the oxygen consumption of the tissues during general hypotensive anesthesia for stapes surgery is quantitatively studied on 40 patients. The rate of oxygen consumption of the whole body and of the tissue of an upper extremity is determined together with the rate of blood flow in that extremity. A series of other parameters such as the PaCO2 and the acid-base balance of arterial and venous blood, the blood pressure, the pulse frequency and the temperature are also measured. Most measurements are performed before premedication, after premedication and after surgery. The state of the patient in the immediate postoperative period is completely comparable with the peroperative anesthetic state. Some of the parameters mentioned above are measured also on a series of 8 normal persons at awake and at asleep state. The numerical results show clearly that the used type of general anesthesia "Protected Sleep" obeys the demands necessary for performing microsurgery of the ear in a successful way. (Acta anaesth. belg., 1980, 31, 15-27).

Acid-Base Equilibrium↗

Hearing aids and otosclerosis.

The purpose of this article on the use of hearing aids in patients with otosclerosis is to emphasize that all otosclerosis patients cannot be assumed to be good users of hearing aid amplification. Patients with losses of 60 dB or less and with purely conductive lesions may be able to use aids well. Individuals with mixed-type impairments due to otosclerosis may have significant problems utilizing amplification. These cases demonstrate the use of hearing aid amplification in patients with mixed-type hearing impairment due to otosclerosis. This is a very different group of patients from the group with a pure conductive lesion, in which there is little problem in fitting a hearing aid, provided that the instrument has sufficient power and gain to override the loss. A special subgroup of patients who have far-advanced otosclerosis and have successful stapes surgery to correct the conductive component of their hearing loss present a unique problem. They may initially suffer from severe recruitment requiring patience, special training and compression-type hearing aids.

Aged↗