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A temporal and spatial scaling hypothesis for the behavioral effects of psychostimulants.

A variety of psychoactive substances (amphetamine, nicotine, scopolamine, apomorphine, lisuride, and MDMA) were tested to examine whether a proposed scaling hypothesis is appropriate for the description of the amount and the structure of rat locomotor paths recorded in the Behavioral Pattern Monitor (BPM). The analytical approach was based on the assumption that the scaling behavior of a few collective variables may characterize sufficiently changes in the animal's behavior induced by different drugs. The temporal scaling exponent alpha, describing the ratio of fast to slow responses in the BPM, sensitively reflected the different stimulant properties of the substances. The spatial scaling exponent d, which relates the average path length to the resolution used to measure consecutive responses, was found to discriminate substances that had been separated previously via qualitative descriptions. Several behavioral response categories emerged from comparisons of the locations of different drugs on a two-dimensional d-a plane. Scopolamine, MDMA, lisuride, and high doses of apomorphine increased a while decreasing d, whereas amphetamine, nicotine, and caffeine produced an increased a with no change or an increase in d. Stereotypies could be identified on the opposite ends of the spatial scaling exponent scale and were interpreted as reflecting two kinds of perseveration. These results suggest that scaling approaches can be used to assess quantitatively the state of the animal based on its locomotor behavior and that the exponents can serve as collective variables providing a macroscopic description based on the microscopic elements of behavior.

Animals↗

Responses of human-reared monkeys to strange simian calls.

The responses of 16 young (10-12 month and 19-20 month) hand-reared rhesus monkeys to rhesus vocalizations heard for the first time were recorded. The vocal stimuli were: (1) a "clear call" of a noncolony adult; (2) a "bark" of a noncolony adult; (3) a "bark" of a noncolony juvenile; and (4) a "bark" of a colony juvenile. Behavior was video-tape recorded for 5-min periods preceding and following the calls and scored according to standard categories. The characteristic response to the stimuli was a sharp reduction in overt behavior. Reaction to the adult sounds was greater than to the juvenile sounds.

Age Factors↗

Differential reinforcement of other behavior and noncontingent reinforcement as control procedures during the modification of a preschooler's compliance.

Differential reinforcement of other behavior (DRO) and noncontingent reinforcement were compared as control procedures during the modification of a 3-yr-old preschooler's compliance. The recorded reinforcer was teacher proximity (within 3 ft (0.9) of the subject for at least 5 sec) which was often accompanied by positive verbal comments that varied in content across experimental conditions. The verabal content during contingent reinforcement might have been: "Thank you for picking up the blocks"; during non-contingent reinforcement: "You're wearing a pretty dress"; and during DRO: "I don't blame you for not picking up because it isn't any fun". Contingent reinforcement increased compliance in all manipulation conditions. Noncontingent reinforcement decreased compliance during two reversal conditions. However, the behavior was variable and did not decrease to the low levels reached during the two DRO reversals.

Behavior Therapy↗

Ethanol consumption and place-preference conditioning in the alcohol-preferring C57BL/6 mouse: relationship with motor activity patterns.

Ethanol place-preference conditioning (PC) was conducted in drug-naive and ethanol pre-exposed female and male C57BL/6J (C57) mice to assess whether environmental cues can develop positive incentive value for ethanol-preferring animals when associated with administration of ethanol. After 12 days episodic access to free-choice ethanol and/or water self-administration, mice received eight ethanol injections (1.75 g/kg/i.p.) 5 min before placement in their nonpreferred PC chamber and eight saline injections paired with their preferred chamber. Control mice received eight saline injections (20 ml/kg) in both their preferred and nonpreferred chambers. Mice of both sexes developed strong ethanol PC. Correlational analysis indicated that the strength of ethanol PC for mice with a prior ethanol drinking experience was inversely related to the amount of ethanol consumed regardless of gender. Furthermore, depending on gender and previous ethanol drinking experience, ethanol PC was differentially related to initial baseline motor activity, the initial motor response to ethanol, or rapid change in the motor response to ethanol. Thus, a complicated relationship between neural systems that mediate ethanol reward and motor activity may exist as suggested by current addiction theory.

Alcohol Drinking↗

Mother-infant attachment: the importance of the mother's visual field.

The purpose of this study was to answer 2 questions: (1) how important to 2-year-old children is fact-to-face contact with the mother, and (2) do attachment behaviors, such as looking at, talking to, and being close to mothers, interact in a compensatory fashion? 24 male and female children, 18 to 30 months, were observed with their mothers for 15 minutes in 3 conditions: (1) mother facing tethered toys, (2) mother facing away from toys, and (3) mother behind a partition and not visible from toys. Observations were made by time-lapse photography techniques. Results indicated that the potential for face-to-face contact was important: children spent 94% of their time in mother's visual field when she faced the toys and 50% of their time in her visual field when she either faced away or was behind the partition. Overall, they established face-to-face contact about 12% of the time. Some compensation was observed: talking and physical proximity increased as visual contact decreased.

Child, Preschool↗

Behavioral airsickness management program for student pilots.

The management of recurrent airsickness in student pilots has traditionally involved positive reinforcement of motivation and limited use of medication. The Behavioral Airsickness Management (BAM) program seeks to establish an effective behavioral and cognitive intervention format for managing airsickness symptoms. There were 37 student pilots experiencing recurrent airsickness who were exposed to an assessment and rehabilitation program designed to develop diaphragmatic breathing skills while rapidly reducing physiological tension via cue-evoked relaxation strategies. Cognitive modification techniques were also included in the treatment protocol. Of the 37 students, 35 were returned to their flying training program with no recurrences of the airsickness problems. Cross-validation evidence is offered, as well as hypotheses for the program's success.

Adult↗

Border symbolism.

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Association↗

Spatial performance correlates with long-term potentiation of the dentate gyrus but not of the CA1 region in rats with fimbria-fornix lesions.

Although hippocampal long-term potentiation (LTP) is generally assumed to be a cellular mechanism of learning and memory, there has not been definitive evidence for this hypothesis. In the present study, therefore, we addressed the possible relationship between spatial learning ability and LTP by using rats with bilateral fimbria-fornix lesions. The animals were tested for spatial performance in spontaneous alternation behaviors with further in vivo investigation of LTP. The behavioral parameters of spatial memory showed a significant correlation with LTP in the dentate gyrus, but we found no evidence for a linkage with LTP in the CA1 region. Thus, LTP in the dentate gyrus may be important for spatial cognitive ability.

Animals↗

Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility.

This study used a novel delayed nonmatching-to-position task to compare visuospatial learning and memory in young and aged beagle dogs (Canis familiaris). The task used 3, rather than 2, spatial locations, which markedly increased difficulty. There were striking age differences in acquisition. Most of the aged canines did not learn the task, and those that did showed impaired learning when compared with the young canines. The aged canines also showed reduced maximal working memory capacity compared with the young canines. Analysis of the response patterns of individual canines indicated that the deficits were related to the use of ineffective strategies and inflexibility in strategy modification.

Aging↗