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At least 559 records · Page 31Linked to original sources
PubMed1992

Parent, family interaction, and child predictors of outcome among sons at psychiatric risk.

This study was a longitudinal investigation of 95 families who previously had experienced the psychiatric hospitalization of a parent. Promising and/or proven parent, family interaction, and child predictors of 3-year outcome for the male offspring (beginning ages, 4, 7, and 10) were evaluated comparatively with correlations and multiple regressions. Among parent variables, chronicity of parent disorder and the degree of recovery between acute phases of disorder were broadly predictive of six diverse outcome indices. Variables that reflected diagnostic classifications were notably less successful. Time 1 child IQ was the best preditor of outcome, independent of all others; family interaction quality and degree of recovery were also prominent.

Child↗
PubMed1990

Free proximal trisomy 21 in the mother and malformation syndrome in the son.

We report on a new case of duplication of the proximal part of the long arm of chromosome 21. The proposita presents normal mental development, no trisomy 21 manifestations; on the contrary, she had a few monosomy 21-like stigmata. She gave birth to a severely malformed infant with a pattern of malformations suggesting a partial 21-monosomy syndrome, but with a 46,XY normal karyotype in his peripheral blood lymphocytes. The findings are explained in the following way: the infant probably had originally a 47,XY,+21q- karyotype like his mother. Post zygotic nondisjunctional events produced a prevalent 46,XY,21q- line responsible for the severe malformations and the normal 46,XY line found in his blood lymphocytes.

Abnormalities, Multiple↗
PubMedDate not supplied

Progressive systemic sclerosis in a family: case report of a mother and son and review of the literature.

Progressive systemic sclerosis (PSS) developed in a 6-year-old boy and in his 38-year-old mother 9 years later. Both parent and child had Raynaud's phenomenon, integumental sclerosis, and pulmonary involvement, but they differed in other aspects of their disease. Previous descriptions of the familial occurrence of PSS are reviewed and compared to the present case reports. Environmental and genetic factors of possible etiologic significance are discussed.

Adolescent↗
PubMed2001

Three sons of fortune: early embryogenesis, evolution and ecology of nematodes.

Comparative analysis of nematode development has revealed considerable variations in how the fates of embryonic cells are specified. Such early variations seem enigmatic as they do not influence the resultant structure or performance of the emerging animal. Three different nematode species are used to consider why alternative ways to reach the same goal may have been established during evolution and why early steps of embryogenesis are particularly variable. A scenario is sketched with a shift from late to early cell specification, along with an increase in maternal contribution and developmental tempo and a decrease in regulative potential expressing different developmental strategies. Future studies of larger numbers of species are needed to assess the extent of such variations and to understand more fully the underlying mechanisms, rules and driving forces.

Animals↗
PubMed2006

Family conflict in dementia: prodigal sons and black sheep.

OBJECTIVE: To describe family conflict in cases of dementia referred to the Guardianship Tribunal of New South Wales, Australia. METHOD: The file notes of 50 cases of family and systems conflict in cases of dementia presented to the Guardianship Tribunal were examined. Demographics, MMSE score, and type and severity of dementia were recorded. The documents and evidence presented to the Tribunal were coded and subjected to thematic analysis to identify the themes of the conflict, the protagonists and the position of the person with dementia with respect to the conflict. RESULTS: Family conflict was most commonly seen in mild to moderate dementia. Conflict occurred most frequently between siblings (with a group of siblings allied against a 'black sheep' member) and involved other systems such as service providers in 25% of cases. The person with dementia was usually involved in the conflict or in alliance with one or other of the family members in conflict, especially when paranoid ideation was fuelled by family members. Common themes included accusations of neglect, exploitation, lack of communication or sequestration of the person with dementia. No family had received family therapy prior to the application; conciliation during the hearing was successful in 30% of cases. Legal transactions such as Powers of Attorney were frequently made and frequently revoked by persons with dementia involved in family conflict. CONCLUSION: Dementia may be a great family divider, particularly when there are cracks in family solidarity. The understanding of family conflict in dementia has ramifications for both clinical and medico-legal practice. These findings may encourage family-centered interventions which address family dynamics and interpersonal conflict. They may also assist in capacity assessments of persons with dementia who change legal documents because of family conflict.

Aged↗