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PubMed1988

Psychosocial issues for patients with AIDS-related cancers.

The social, psychological, and ethical challenge of AIDS, specifically AIDS-related cancers, is as complex as the biological and medical. Both the patient and his or her sexual partner experience a number of stresses to which they must adapt. AIDS also poses a challenge to professionals and to the social fabric of countries in which it occurs. One test of the worth of a society is the way in which it handles its fears, its sick, and its stigmatized individuals. The challenge to us all is to respond to this disease, to those endangered by it, to those overwhelmed by their fear, and to those who contract it with the clarity of thought, scientific excellence, high ethical standards, and human compassion that enables all of us to continue life with dignity and meaning.

Acquired Immunodeficiency Syndrome↗
PubMed1996

Molecular analysis of two functional homologues of the S3 allele of the Papaver rhoeas self-incompatibility gene isolated from different populations.

The S3 allele of the S gene has been cloned from Papaver rhoeas cv. Shirley. The sequence predicts a hydrophilic protein of 14.0 kDa, showing 55.8% identity with the previously cloned S1 allele, preceded by an 18 amino acid signal sequence. Expression of the S3 coding region in Escherichia coli produced a form of the protein, denoted S3e, which specifically inhibited S3 pollen in an in vitro bioassay. The recombinant protein was ca. 0.8 kDa larger than the native stigmatic form, indicating post-translational modifications in planta, as was previously suggested for the S1 protein. In contrast to other S proteins identified to date, S3 protein does not appear to be glycosylated. Of particular significance is the finding that despite exhibiting a high degree of sequence polymorphism, secondary structure predictions indicate that the S1 and S3 proteins may adopt a virtually identical conformation. Sequence analysis also indicates that the S1 and S3 proteins may adopt a virtually identical conformation. Sequence analysis also indicates that the P. rhoeas S alleles share some limited homology with the SLG and SRK genes from Brassica oleracea. Previously, cross-classification of different populations of P. rhoeas had revealed a number of functionally identical alleles. Probing of Western blots of stigma proteins from plants derived from a wild Spanish population which contained an allele functionally identical to the Shirley S3 allele with antiserum raised to S3e, revealed a protein (S3s) which was indistinguishable in pI and Mr from that in the Shirley population. A cDNA encoding S3s was isolated, nucleotide sequencing revealing a coding region with 99.4% homology with the Shirley-derived clone at the DNA level, and 100% homology at the amino acid level.

Alleles↗
PubMed1995

Expression level of the SLG gene is not correlated with the self-incompatibility phenotype in the class II S haplotypes of Brassica oleracea.

In Brassica, the S-locus glycoprotein (SLG) gene has been strongly implicated in the self-incompatibility reaction. Several alleles of this locus have been sequenced, and accordingly grouped as class I (corresponding to dominant S-alleles) and class II (recessive). We recently showed that a self-compatible (Sc) line of Brassica oleracea expressed a class II-like SLG (SLG-Sc) gene. Here, we report that the SLG-Sc glycoprotein is electrophoretically and immunochemically very similar to the recessive SLG-S15 glycoprotein, and is similarly expressed in stigmatic papillae. Moreover, by seed yield analysis, we observed that both alleles are associated with a self-compatibility response, in contrast with the other known recessive S haplotypes (S2 and S5). By genomic DNA blot analysis, we show the existence of molecular homologies between the Sc and S15 haplotypes, but demonstrate that they are not identical. On the other hand, we also report that the S2 haplotype expresses very low amounts of SLG glycoproteins, although it exhibits a self-incompatible phenotype. These results strongly question the precise role of the SLG gene in the molecular mechanisms that control the self-incompatibility reaction of Brassica.

Alleles↗
PubMed1984

Culture and mental disorder: the case of bebainan in Bali.

This is an investigation of bebainan, a disorder which Balinese believe to be caused by sorcery. Most attacks are brief, lasting 1/4-1 hour. The most common symptoms are sudden feelings of confusion, crying, screaming and shouting, followed by inability of the sufferer to control his or her actions. Most sufferers are aware of their behavior during an attack, and remember the occurrence afterwards. The investigator interviewed all the members (296 persons) in the compound of the descendants of the former royal family of Klungkung, among whom 27 people had suffered bebainan attacks. The victims, mostly females, offspring of endogamous marriges, experienced their first attack between the ages of 16 and 30. Analysis of the psychological and social pressures acting on these women suggests that bebainan attacks provide sufferers with an opportunity to release feelings of frustration and anger without risk of widespread disapprobation or stigmatization. However, bebainan is not instrumental in altering access to resources within the restricted environment of the royal compound, nor does it empower the victim within this environment in any but the most transitory ways. Bebainan cannot be regarded as a form of psychosis, even of the reactive or atypical type, it is neither an organic mental disorder, nor a form of neurosis. Instead bebainan can be considered a form of dissociation which is only understandable in the local context of Balinese culture.

Ethnicity↗
PubMed1983

Contact glasses for use with high power lasers. Two new contact glasses for microsurgery at the iris, in the pupillary and the retropupillary space.

Two new contact glasses, one for irradiation of the iris and the other for irradiation of pathological structures within the pupillary and retropupillary regions are described. First order geometric considerations using the Young-Weierstrass imaging theorem indicate nearly aberration-free, stigmatic focussing, even for large numerical apertures. For surgical tasks utilizing high-power lasers, excellent focussing of strongly convergent ray-bundles which lead to small focus diameter and large diameters while passing through the pre-focal optical media are seen to be essential. Thus the efficiency of the laser-surgical treatment, its reliability, as well as security and harmlessness within the pre-focal media are increased.

Humans↗
PubMed1996

Modification of reproductive development in Arabidopsis thaliana under spaceflight conditions.

Reproductive development in Arabidopsis thaliana (L.) Heynh. cv. Columbia plants was investigated under spaceflight conditions on shuttle mission STS-51. Plants launched just prior to initiation of the reproductive phase developed flowers and siliques during the 10-d flight. Approximately 500 flowers were produced in total by the 12 plants in both the ground control and spaceflight material, and there was no significant difference in the number of flowers in each size class. The flower buds and siliques of the spaceflight plants were not morphologically different from the ground controls. Pollen viability tests immediately post-flight using fluorescein diacetate indicated that about 35% of the pollen was viable in the spaceflight material. Light-microscopy observations on this material showed that the female gametophytes also had developed normally to maturity. However, siliques from the spaceflight plants contained empty, shrunken ovules, and no evidence of pollen transfer to stigmatic papillae was found by light microscopy immediately post-flight or by scanning electron microscopy on fixed material. Short stamen length and indehiscent anthers were observed in the spaceflight material, and a film-like substance inside the anther that connected to the tapetum appeared to restrict the release of pollen from the anthers. These observations indicate that given appropriate growing conditions, early reproductive development in A. thaliana can occur normally under spaceflight conditions. On STS-51, reproductive development aborted due to obstacles in pollination or fertilization.

Arabidopsis↗
PubMed1994

Otoplasty: shaping the antihelix.

In completing a satisfactory repair of the prominent ear, the shape of the antihelical fold is often the key to the aesthetic outcome. Correction involves not just creating a fold in the antihelix but also establishing a smooth sweep or antihelical curve anterior to posterior as well. The essential components described include accurate scoring of the antihelical fold followed by placement of mattress fixation sutures, with emphasis on obliquely placed sutures to control the final curve and shape of the antihelix. Sutures placed obliquely can solve the problem of persistent upper-pole prominence as in a telephone deformity, or overfolding which can stigmatize otoplasty.

Ear, External↗
PubMed1992

Mental illness topics in popular periodicals.

Recent emphases on educating the general public about mental illness have included the encouragement of the publication of plainly written, lay-oriented information about mental disorders and their treatment in popular periodicals. To examine the extent to which coverage of mental health topics in popular magazines is being accomplished, the present study looked at the numbers and types of articles related to mental health indexed in the Readers' Guide to Periodical Literature and changes in indexed articles between 1965 and 1988. The number of articles and number of headings related to mental illness and treatment have increased significantly since 1965, particularly those describing specific disorders. In addition, many of the changes in headings used by the Readers' Guide are consistent with changes in the field (e.g., the introduction of new diagnostic categories) and with desired changes in terminology (e.g., using less stigmatizing terms). These general findings are encouraging for mental health education advocates, although more detailed analysis of the content of articles is needed to be sure that the increased periodical information available to the public is accurate and up-to-date.

Health Education↗
PubMed1993

Cognitive representations of bodily parts and products: implications for health behavior.

This study investigated the unexplored hypothesis that people may have cognitive representations of the body's parts and products (body schema) and that these may be relevant to illness behavior. Factor and MANOVA analyses revealed that body parts are viewed as differing in the Stigma attached to them and in the extent to which they are seen as Important, Vulnerable, Sexual, and Private, with these five dimensions found to be independent of age and health history. Seeking help for dysfunction varied across body parts, with subjects reluctant to seek help for highly stigmatized and private parts but likely to seek help for parts viewed as important and vulnerable. Significant gender and ethnic differences in representations of body parts also emerged.

Adolescent↗
PubMed1980

Community differences in conceptions of deviant behavior: an exploratory study of attitudes toward alcohol-related help sources.

This exploratory study examined the conceptions shared by members of geographically and socioeconomically defined communities toward help sources for alcohol problems. The larger hypothesis was that the social-psychological factors underlying the initial identification of deviance affects expectancies of and reactions to treatment facilities. Low socioeconomic status (SES) respondents were aware of fewer help sources or acquisition strategies than higher SES communities, and were more oriented toward community-based nonprofessional help sources. Low SES attitudes toward help sources were also less complex, and showed a substantial pattern of disfranchisement from traditional help sources. In contrast, higher SES respondents had a more comprehensive and positive conception of help sources, particularly higher status professional agencies, and felt familiar local help sources to be stigmatizing. Attitude factors found to be salient to these differences were respondents' familiarity and expected social embarrassment, and the extent to which a help source dealt with serious problems and exerted control over clients.

Adolescent↗
PubMed1989

Impact of a television film on attitudes toward mental illness.

The possible impact of a prime time television film portraying a mentally ill killer was investigated. Groups of college students were shown the film with and without a film trailer reminding viewers that violence is not characteristic of mentally ill persons. A third group viewed a film not about mental illness. Postfilm responses to the Community Attitudes toward the Mentally Ill scale indicated that those who saw the target film expressed significantly less favorable attitudes toward mental illness and community care of mentally ill persons than did those who saw the control film, regardless of whether of not they received the trailer along with the target film. Results support concerns that media depictions add to mental illness stigma and also suggest that corrective information alone may be sufficient to counteract the stigmatizing impact of such audience-involving mass media portrayals.

Attitude↗
PubMed1992

Bereavement support groups: who joins; who does not; and why.

Compared widowed spouses who joined (n = 40) bereavement support groups (BSGs) during the first 13 months of bereavement with those who declined to join (n = 96). Controlling for gender, age, and socioeconomic status, no differences were found for perceived levels of social support, but joiners, compared with nonjoiners, reported experiencing more stressful events and scored significantly higher on measures of depression, anger, anxiety, and subjective stress. Nonjoiners and, to a lesser extent, joiners viewed those attending groups as less self-sufficient (e.g., need help, lonely), suggesting a mildly stigmatizing image of BSGs. A dialectical model is proposed in which BSG utilization rates are seen as the product of an avoidance-avoidance conflict involving the choice between suffering emotional distress on one's own or the perceived stigma of joining a BSG. Implications for future research on participation in self-help and mutual support groups are discussed.

Adult↗
PubMed1992

Neuropsychiatric rehabilitation for persistent mental illness.

The benefits of new knowledge on the psychobiology and neuropsychology of serious mental illnesses have been slow to impact on psychiatric rehabilitation technology. A literature review reveals that, at least in the case of schizophrenia, enough is known about neurobiological deficits and their impact on neurocognitive functioning to justify a more informed approach to psychiatric rehabilitation. Essential elements for a program of research are presented and preliminary data are reported examining the prevalence of executive deficits, correlations between neuropsychological deficits and social adjustment, and the nature of socially stigmatizing neuromotor deficits and their reliable assessment. In addition, early experience with the remediation of executive deficits is described and suggestions are made for future developments in this area. The authors conclude that barriers to the integration of knowledge from biological psychiatry and psychiatric rehabilitation have been largely related to academic "cultural" isolation, and that active cross fertilization of ideas is clearly justified by the present state of knowledge.

Adult↗
PubMed1978

An early behavioral description of a person with Turner's syndrome.

A person with Turner's syndrome was described by Dr. Charles Pears in the Philosophical Transactions of the Royal Society, London, in 1805. The description included behavioral traits of mild temperament, absence of heterosexual interests, and concern about social stigmatization. These traits are the object of current behavior genetic studies of persons with Turner's syndrome.

England↗
PubMed1983

Barriers to working with impaired trainees: a resident's viewpoint.

Psychiatric trainees and educators alike know that significant impairment may occur during training. Although psychiatry programs can do much to identify, treat, and prevent trainee impairment, barriers that may hinder programs from adequately addressing the problems of the impaired trainee continue to exist. These barriers include stigmatization and rejection of the impaired trainee, lack of focus on primary prevention, problematic supervisor-resident relationships, and trainee resistance to intervention. An atmosphere of candor and support, impairment-related seminars, and informed and alert supervisors can be helpful in easing the stress of training and reducing trainee impairment.

Humans↗
PubMed1993

The ethics of HIV testing by physicians.

This essay argues that informed consent remains desirable for both moral and practical reasons in regard to HIV testing by physicians. At the very least, respect for consent preserves patient control over treatment and affords the opportunity for education about the nature of HIV-related disorders. Nevertheless, there do appear to be circumstances under which involuntary testing may occur especially when health care workers may have become occupationally exposed to risk of HIV infection. To eliminate conflicts between health workers and their patients, however, it is desirable to work to eliminate the stigmatizing and discriminatory effects of HIV infection that can induce persons to resist testing.

AIDS Serodiagnosis↗
PubMed1988

Neuropeptides in interscapular and perirenal brown adipose tissue in the rat: a plurality of innervation.

The occurrence of neuropeptides in rat brown adipose tissue has been investigated. Immunohistochemical studies on interscapular and perirenal brown fat have demonstrated unequivocally the presence of substance-P (SP)-like, neuropeptide-Y (NPY)-like and calcitonin gene related-peptide (CGRP)-like immunoreactive elements (putative nerves) in adventitial distribution on inter- and intralobular supply arteries and in accompanying nerve bundles. At a more peripheral level, some NPY-like immunoreactive elements and a greater number of CGRP-like immunoreactive elements were observed in the parenchymal field. Somatostatin, bombesin, neurotensin, enkephalin, and vasoactive-intestinal-polypeptide immunoreactivities were not detected. No differences in neuropeptide distribution were noted between interscapular and perirenal brown fat. There is a degree of coincident distribution of SP, NPY and CGRP with that of noradrenergic nervous elements as visualized by condensation histochemistry. Since after 6-hydroxydopamine treatment not all the nerve terminals in rat brown adipose tissue are stigmatized (earlier report), the present results have been discussed in the light of a possible pluralism in innervation of brown adipose tissue.

Adipose Tissue, Brown↗
PubMedDate not supplied

Perceptions of body size and obesity: a selected review of the literature.

In this article, the literature on body image and related obesity perceptions is discussed. Research findings which span a 20 year period are summarized. Initially, Cheryl Rittenbaugh's concept of obesity as 'a culture bound syndrome' serves as a rationale for understanding sociocultural dimensions of body size perceptions. In this regard, the premise that perceptions of obesity and overweight have cultural determinants is substantiated in the reviewed literature. Societal preferences for body build and size and attitudes about weight are examined as a framework for understanding the impact that social perceptions have on individuals who are either overweight or obese. As a result of negative attitudes toward fatness, stigmatization of overweight people has been consistently documented. In related studies, investigators have centered on self-perceptions of obese and overweight individuals. According to the data, the existence of body image disturbance among extremely overweight individuals is a common phenomenon. However, evidence is also presented that suggests that normal weight individuals (especially women) may also have difficulty in accurately assessing their body size. The final focus of this paper is the relationship between body image and weight change behavior. As indicated in the discussion, this area of research has received the least amount of attention in the literature, and the present findings are contradictory. The paper concludes with recommendations for future research directions.

Body Image↗