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At least 559 records · Page 31Linked to original sources
PubMed1979

Activity and effective serum level of repository sulphones (DADDS) in lepromatous leprosy.

35 cases of lepromatous leprosy were studied to evaluate the effective blood level and long depot action of acedapsone (DADDS). It was revealed that serum level of this drug is maintained well above the minimum inhibitory concentration upto 60 days following single intramuscular injection. No significant untoward effects of the drug were encountered except one case of Erythema Nodosum Leprosum and six patients with mild reactional symptoms in the form of fever and arthralgia.

Acedapsone↗
PubMed1982

[Implantable repository adrenaline tablets for long-term studies on rats].

Implantable coated Eudragit matrix tablets containing adrenaline in various concentrations should overcome the problem of additional handling stress during long term infusions. The efficiency of those tablets was tested in vitro, as well as in vivo using labeled adrenaline. Both in vitro and in vivo testing yielded satisfactorily output rates up to 20 h whereby the liver and serum content of 14C-fragments served as an additional prove for the postulated mode of action. Good correlation has been found between the mentioned out-put rates and adrenaline serum levels (measured according to Da Prada).

Animals↗