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At least 559 records · Page 31Linked to original sources
PubMed1995

Thymomas and thymic carcinomas. A retrospective investigation with histological reclassification.

The morphological heterogeneity of thymomas has caused much confusion respecting their classification. Recently Kirchner & Müller-Hermelink (4) proposed a histological subclassification which has been claimed to represent an independent prognostic factor: medullary and mixed thymomas are benign; organoid and cortical type as well as well-differentiated thymic carcinomas are low-grade malignant tumors, which have the capacity to recur and spread, even if they are clinically benign. High-grade malignant thymomas are always malignant. We present the clinicopathological data on 10 clinically benign and 14 clinically malignant thymomas. Having reclassified the thymomas, we found four low-grade malignant examples among the clinically benign thymomas. It is important to identify this group of patients as they are at risk of tumor recurrence. However, further investigation is needed to support the validity of this subclassification system.

Aged↗
PubMed1995

[Role of the COTOREP (Technical Commission for Professional Orientation and Reclassification) in occupational allergies].

A study done by a regional commission for handicapped workers career guidance (COTOREP) from the medical files of the years 1990 to 1994 show that requests concerning occupation-related allergies are less frequent than for other occupational pathologies such as osteoarticular, mental or sensorial diseases. Nevertheless, the patients are young and have a good standard of education. In addition they have often already lost their job as a result of their allergy. So, the help of the commission is both essential and urgent. The allergies in question are principally due to flour, cement, hairdressing preparations, and metals. Two thirds of the requesters, by way of aids or appropriate professional training, have found a new employment. Most of the others are on the way to find a job suited to their situation.

Adult↗
PubMed1977

A reclassification of the genus Aplodontopus (Acari: Sarcoptiformes) with a description of Aplodontopus micronyx sp. n. from the thirteen-lined ground squirrel, Spermophilus tridecemlineatus, in Indiana, USA.

The genus Aplodontopus is transferred from the family Glycyphagidae to the family Chortoglyphidae and a new species Aplodontopus micronyx is described. The new species is from the tail-hair follicles of Spermophilus tridecemlineatus in Indiana, USA; deutonymphs and a female are described.

Animals↗
PubMed1997

Reclassification after delivery of diabetes in pregnancy.

Gestational diabetes mellitus (GDM) constitutes a risk factor for the development of non insulin-dependent diabetes mellitus (NIDDM). The search for parameters to provide discrimination between a high risk and a low risk for future development of NIDDM is today the aim of many investigations. The absence or presence of several factors such as glycemia during pregnancy and post partum, the need for insulin treatment, disorders of the pancreatic insulin secretion, the number of pregnancies, maternal obesity, the early diagnosis of GDM, the family history of diabetes mellitus, the race and immune disorders give rise to a very high relative risk (RR) of developing NIDDM. To know the degree of risk will allow a future appropriate clinical intervention to reduce the incidence of NIDDM and its economic cost.

Adult↗
PubMed1998

Prescription to over-the-counter drug reclassification.

Self-care is becoming increasingly popular among health care consumers. The availability of over-the-counter medications makes it possible for consumers to treat numerous ailments without the supervision of a health care professional. Many of the medications now available without a prescription were previously classified as prescription-only products. The U.S. Food and Drug Administration has procedures in place that allow prescription products to be reclassified as over-the-counter medications if certain criteria are met. Reclassified products have had clinical and economic effects on the U.S. health care system and have led to concerns among health care professionals. Patient education and counseling are particularly important to promote safe and effective use of over-the-counter products.

Humans↗
PubMed1998

Reclassification of Skrjabinodon anolis (Chitwood, 1934) Inglis, 1968 as Spauligodon anolis (Chitwood, 1934) n. comb. (Nematoda: Pharyngodonidae) from Anolis lizards of the Caribbean.

Parathelandros anolis Chitwood, 1934, Pharyngodon anolis (Chitwood, 1934) sensu Acholonu (1976), and Spauligodon caymanensis Bursey and Goldberg, 1995 have been reexamined from Anolis lizards (Polychrotidae) of the Caribbean. Study of the male caudal structures and of the egg demonstrate that these names represent a single species. The specimens are assigned to Spauligodon anolis (Chitwood, 1934) n. comb. Spauligodon caymanensis is considered a junior subjective synonym of S. anolis.

Animals↗
PubMed1987

Impact of selection on components of variance and heritabilities of Canadian Holstein conformation traits.

Sire and error variance components and heritabilities were estimated for 26 conformation traits using linear type classifications of 175,693 daughters of 6681 Holstein sires in 21,869 herd-round-classifier subclasses. Estimates from first classifications during first lactations were contrasted with estimates from the same 175,693 females' most recent classification, which included reclassifications. Only cows that have their final classification raised a full category receive an official reclassification record; thus, heritability estimates from data that include these reclassification records may be biased. A total of 9420 (5.4%) of the first lactation, first classifications were replaced by reclassifications for the second analysis, which is current practice for official sire evaluations for Holsteins in Canada. Records, expressed as Snell's scores, were preadjusted for age within parity and stage of lactation at classification. Sire and error components of variance were estimated by Henderson's new method. When reclassifications replaced first classifications in the analysis, estimates of sire and error variances increased 7.2 and 11.1% respectively, as compared with the first lactation, first classification estimates. Heritabilities ranged from .07 for rear heel to .38 for stature and decreased by an average of 2.5% when first lactation, first classifications were replaced by reclassifications. Results indicate that the inclusion of reclassifications tends to bias heritabilities downward.

Animals↗
PubMed1998

The value of the coefficient of variation in assessing repeat variation in ECG measurements.

AIMS: The coefficient of variation is a popular measure for describing the amount of repeat variability present in ECG measurements from recording to recording. However, it can be misleading. The aim of the present study was to assess repeat variation (reclassification) in computer measured ECG criteria, i.e. positive to negative or vice versa, and compare this with the coefficient of variability. METHODS AND RESULTS: Two ECGs were obtained from each of 295 patients, one day apart, and separately from a further 364 patients, several minutes apart. All patients were considered to be in a stable condition. Estimates of the coefficients of variation were obtained for a number of ECG parameters used in the diagnosis of left ventricular hypertrophy. Corresponding reclassification rates of relevant ECG criteria were also calculated. Large coefficients of variation were observed in voltage parameters, e.g. R in V5 (20% for day-to-day recordings and 6% for minute-to-minute recordings) while the corresponding reclassification rates were 8% and 0% respectively. The repeat variation in the diagnosis of left ventricular hypertrophy was up to 5% for day-to-day recordings and up to 3% for minute-to-minute recordings based on several different criteria. CONCLUSION: A large coefficient of variation in a particular variable does not necessarily correspond to a high reclassification rate. A better measure of the impact of ECG variability for a particular measurement is obtained from its reclassification rate. In turn, this may have a minimal effect on the overall diagnosis of a particular abnormality.

Adult↗
PubMed2005

Over-the-counter availability of nicotine replacement therapy and smoking cessation.

In 1996, the FDA approved over-the-counter (OTC) availability of nicotine gum and two brands of nicotine skin patches. Little is known about how this reclassification has influenced the effectiveness and use of nicotine replacement therapy (NRT) and whether it has been a public health benefit. Data for the present study came from a prospective cohort study of 1,639 adult smokers surveyed by telephone in 1993, as part of the National Cancer Institute's Community Intervention Trial for Smoking Cessation (COMMIT), and resurveyed in 2001. NRT-assisted quit rates, NRT use rates, and the characteristics of NRT users were calculated before and after the 1996 OTC reclassification. Also calculated was the percentage of NRT users who quit by year. Results are presented for patch and gum separately and combined. OTC NRT use rates were lower for Hispanics and higher for those with no desire to quit at baseline. The quit rate decreased for patch-assisted quit attempts after OTC reclassification (22.5% to 18.5%, p = .05), but it did not change for gum-assisted quit attempts (11.9% to 10.5%, p = .54). NRT use rates increased for both patch and gum by about 60% following reclassification. A greater percentage of gum users had quit in the post-OTC period than in the pre-OTC period (9.7% vs. 14.6%, p = .05). Long-term quit rates in patch users were similar in both periods. Insurance coverage of NRT and concurrent attendance in a stop smoking clinic decreased for both patch- and gum-assisted attempts in the post-OTC period. The results suggest that OTC reclassification may have contributed to the increased use of NRT, compared with the pre-OTC period, whereas the efficacy for quitting decreased slightly for those using nicotine patch and remained about the same for those using the gum.

Adult↗
PubMed2025

Clinical and genetic variant re-analysis among pediatric probands undergoing genetic testing for arrhythmia syndromes.

BACKGROUND: Despite increases in genetic testing, longitudinal data regarding changes in diagnostic yield and variant reclassification for inherited arrhythmia syndromes are limited. OBJECTIVE: Determine longitudinal changes in diagnostic yield and variant classification. METHODS: Single-center retrospective study of probands <18 years undergoing genetic testing for suspected inherited cardiac conditions associated with arrhythmias, 2007 to 2018. Variants were classified as diagnostic (pathogenic/likely pathogenic), non-diagnostic (benign/likely benign [B/LB]), or variants of uncertain significance (VUS). Variant reclassification was performed in October 2023 using VarSome and American College of Medical Genetics criteria. We evaluated results by era (early 2007-2013 vs. later 2014-2018, coinciding with Sanger and next-generation sequencing, respectively) and by likelihood of disease based on clinical evaluation. RESULTS: Of 306 probands, initial testing was 23.2% diagnostic, 55.6% non-diagnostic (33.7% no variant, 21.9% B/LB), and 21.2% VUS. When comparing eras, diagnostic yield decreased (34.1%-15.3%), VUS increased (9.3%-29.9%), and non-diagnostic remained similar (55% to 57%). Variants for 22.7% (46/203) of probands with &#x2265;1 variant changed: 9.9% of diagnostic variants (7/71) downgraded to VUS or non-diagnostic, and 60.0% of VUS changed (23.1% upgraded, 36.9% downgraded). B/LB variants did not change. Probands with higher disease likelihood had 6-times the odds of diagnostic results compared to lower disease likelihood, regardless of era (odds ratio 6.3, 95% confidence interval 3.2-12.4, P < .0001). CONCLUSION: Variant reclassification led to changes in 23% of probands, both downgrading and upgrading status, even among probands initially thought to be pathogenic. When comparing later to earlier eras, VUS variants increased while diagnostic yield decreased. Findings support the need for variant re-interpretation and periodic reclassification over time.

Humans↗