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Discovery of Circularly Polarized Radio Emission from SS 433.

We report the discovery of circularly polarized radio emission from the radio-jet X-ray binary SS 433 with the Australia Telescope Compact Array. The flux density spectrum of the circular polarization, clearly detected at four frequencies between 1 and 9 GHz, is of the form V~nu-0.9+/-0.1. Multiple components in the source and a lack of very high spatial resolution do not allow a unique determination of the origin of the circular polarization or of the spectrum of fractional polarization. However, we argue that the emission is likely to arise in the inner regions of the binary, possibly via propagation-induced conversion of linear to circular polarization, and the fractional circular polarization of these regions may be as high as 10%. Observations such as these have the potential to help us investigate the composition, whether pairs or baryonic, of the ejecta from X-ray binaries.

Journal Article↗

Radio Pulsar Death Line Revisited: Is PSR J2144-3933 Anomalous?

We reinvestigate the radio pulsar "death lines" within the framework of two different types of the polar cap acceleration models, i.e., the vacuum gap model and the space-charge-limited flow model, with either curvature radiation or inverse Compton scattering photons as the source of pairs. General relativistic frame dragging is taken into account in both models. We find that the inverse Compton scattering-induced space-charge-limited flow model can sustain strong pair production in some long-period pulsars, which allows the newly detected 8.5 s pulsar PSR J2144-3933 to be radio loud without assuming special neutron star equations of state or ad hoc magnetic field configurations.

Journal Article↗

The Radio Supernebula in NGC 5253.

We present 1.3 cm and 2 cm subarcsecond resolution VLA images of the dwarf galaxy NGC 5253. Within the central starburst, we detect high-brightness [Tb&parl0;2 cm&parr0; approximately 100-12,000 K] radio continuum sources. These appear to be very dense, "compact" H ii regions. The dominant radio source is a nebula approximately 1-2 pc in size, requiring several thousand O stars within the volume to maintain its ionization. This nebula has no obvious optical counterpart. The number of ionizing photons we find for this cluster is nearly 2 orders of magnitude larger than indicated by Halpha fluxes, and the deduced stellar content accounts for a significant fraction of the total infrared luminosity of the galaxy. This cluster is a strong candidate for a globular cluster in the process of formation, perhaps the youngest globular cluster known.

Journal Article↗

The radio-opacity of surgical and radiological devices used in vivo: a test method for markers in surgical gauze.

Most radio-opaque markers used in surgical gauze contain barium sulphate, and a minimum percentage content of this is required to ensure an acceptable level of radio-opacity. When this minimum percentage is specified by Standards authorities, a suitable test method must be available to determine compliance. A new radiographic test method is presented which can be used to determine the barium sulphate content or equivalence to within 2% of compliance requirements. The method consists of immersing the marker in a solution of barium sulphate which is then radiographed. Compliance can be evaluated by inspection of the radiograph. The method was found to be virtually independent of x-ray energy, film-screen combination and thickness or shape of the test object. The method is also an appropriate test for any other material or object, such as vascular catheters used in radiology or small toys which pose an ingestion hazard.

Barium Sulfate↗

Changes in dielectric properties at 460 kHz of kidney and fat during heating: importance for radio-frequency thermal therapy.

We have developed a system to measure the changes due to heating to high temperatures in the dielectric properties of tissues in the radio-frequency range. A two-electrode arrangement was connected to a low-frequency impedance analyser and used to measure the dielectric properties of ex vivo porcine kidney and fat at 460 kHz. This frequency was selected as it is the most commonly used for radio-frequency thermal therapy of renal tumours. Tissue samples were heated to target temperatures between 48 and 78 degrees C in a hot water bath and changes in dielectric properties were measured during 30 min of heating and 15 min of cooling. Results suggest a time-temperature dependence of dielectric properties, with two separate components: one a reversible, temperature-dependent effect and the other a permanent effect due to structural events (e.g. protein coagulation, fat melting) that occur in tissues during heating. We calculated temperature coefficients of 1.3 +/- 0.1% degrees C(-1) for kidney permittivity and 1.6% degrees C(-1) for kidney conductivity, 0.9 +/- 0.1% degrees C(-1) for fat permittivity and 1.7 +/- 0.1% degrees C(-1) for fat conductivity. An Arrhenius model was employed to determine the first-order kinetic rates for the irreversible changes in dielectric properties. The following Arrhenius parameters were determined: an activation energy of 57 +/- 5 kcal mol(-1) and a frequency factor of (6 +/- 1) x 10(34) s(-1) for conductivity of kidney, an activation energy of 48 +/- 2 kcal mol(-1) and a frequency factor of 6 x 10(28) s(-1) for permittivity of kidney. A similar analysis led to an activation energy of 31 +/- 4 kcal mol(-1) and a frequency factor of (4.43 +/- 1) x 10(16) s(-1) for conductivity of fat, and an activation energy of 40 +/- 4 kcal mol(-1) and a frequency factor of 4 x 10(22) s(-1) for permittivity of fat. Structural events occurring during heating at different target temperatures as determined by histological analyses were correlated with the changes in the measured dielectric properties.

Adaptation, Physiological↗

Radio-gas chromatography of chromium (III) hexafluoroacetylacetonate.

A method has been developed for the determination of trace levels of chromium by radio-gas chromatography. The technique involves conversion of radioactive 51Cr to a metal chelate compound, using C2H5I131 as an internal standard, and detection of radioactivity of 51Cr in the chelate by a flow system surrounding a Nal(TI) scintillation detector. The detection limit is found to be as low as 10(-12) g. From the observed radio-chromatogram it can be shown that the method is selective and free from interference.

Animals↗

Contribution of radio-electrocardiography in the rehabilitation of CVA patients.

Seventy-eight patients with cerebrovascular accidents (CVA) underwent radio-electrocardiographic evaluation (RECG) and blood pressure measurements, together with clinical observation during physical therapy and rehabilitation. Twenty-six out of 78 CVA patients had pathological RECG. Of the total, 20 (25.6%) patients had a history of ischemic heart disease prior to CVA, 11 of them manifested abnormalities on the radio-electrocardiography, suggesting myocardial ischemia, arrhythmia, or severe heart rate changes. Out of 58 patients without any cardiac history or complaints before CVA, 15 (25.9%) showed pathological tracings during active therapy. In 20 patients out of 26 with pathological RECG, marked improvement was seen in repeated telemetric evaluation after drug and/or physical therapy was changed. In 42 hypertensive patients, 12 (28,5%) were found to suffer from marked elevation of the diastolic blood pressure during active physical training. Since the energy cost of ambulation in hemiplegics is much higher than in people without motor disabilities, RECG helps us in the detection of cardiac disorders, assessement of myocardial performance, and prescription of optimal physical and/or drug therapy in CVA patients.

Aged↗

Generation and observation of radio frequency thermal lesion ablation for interventional magnetic resonance imaging.

RATIONALE AND OBJECTIVES: Recently, there has been increased interest in interventional magnetic resonance (MR) imaging and minimally invasive cancer therapy via radio frequency (RF) thermal ablation. In this work, we examined RF thermal lesion generation in phantoms and ex vivo bovine liver and correlated them with MR images under a variety of conditions, which begins our assessment of the role of MR imaging in this new method for cancer treatment. METHODS: Radio frequency lesions were created in gel phantoms and ex vivo bovine liver, using stationary (bovine liver) and variable speed (gel) moving electrodes to create lesions with shapes mimicking tumors. Ex vivo bovine liver lesions were made with the tissue held at room temperature (n = 4) and in a 37 degrees C saline bath (n = 3) using a 16-gauge electrode (tip temperature: 70 degrees C, 80 degrees C, and 90 degrees C; ablation time: 1-13 minutes). Electrical impedance and RF power were plotted during ablation. After ablation, RF-induced lesions were imaged with a 0.2-tesla (T) MR system using a variety of pulse sequences. RESULTS: Complex shaped lesions were created successfully in phantoms. Averaged maximum ex vivo lesion volume made at 90 degrees C ablation experiments holding the tissue temperature at 37 degrees C and at room temperature were 1.58 +/- 0.35 cm3 and 1.0 +/- 0.26 cm3 respectively (confidence interval: 90%). The aspect ratios and RF power of the lesions decreased as ablations proceeded. Impedance dropped during the first 2 minutes of the ablation. Ex vivo lesions appeared as regions of low-signal amplitude in T2-weighted MR images. CONCLUSIONS: Phantom ablation experience may be useful and applicable in thermotherapy planning. Lesions made in ex vivo bovine liver held at 37 degrees C via a saline bath are larger than those created at room temperature. Lesions shapes are ablation time dependent until thermal equilibrium is reached. Impedance reduction and lesion formation are related; 0.2-T MR systems can image RF energy-induced thermal lesions.

Animals↗

Monitoring of radio frequency tissue ablation in an interventional magnetic resonance environment. Preliminary ex vivo and in vivo results.

RATIONALE AND OBJECTIVES: The authors evaluate the feasibility of monitoring radio frequency (RF) ablation in an interventional, open-configuration, 0.5-tesla magnetic resonance (MR) environment. METHODS: Ex vivo and in vivo RF coagulation necrosis were induced in porcine paraspinal muscle tissue using a 300 kHz monopolar RF generator applying 5 to 20 W over 3 to 9 minutes. Images were acquired simultaneous to RF application, after RF application, and in an intermittent mode (60 seconds of RF followed by 15 seconds of MR imaging). Temperature changes were monitored based on amplitude (ex vivo) and phase alterations (in vivo) of a T1-weighted graded refocused echo (GRE) sequence enabling an update every 2.5 seconds. A standardized color-coded subtraction technique enhanced signal changes. Additionally, T2- and T1-weighted spin echo (SE) images were acquired with and without intravenous contrast. Macroscopic coagulation size was compared with lesion size seen on MR images. RESULTS: Although lesion diameters were related directly to applied RF power, the application mode had no significant impact on coagulation size (P > 0.05). As could be expected, MR imaging during RF ablation resulted in major image distortion. Radio frequency effects were seen on images acquired in the continuous and intermittent modes. Coagulation size seen on GRE images correlated well with macroscopy both ex vivo (r = 0.89) and in vivo (r = 0.92). Poorer correlation was found with postinterventional SE sequences (r = 0.78-0.84). CONCLUSIONS: Magnetic resonance monitoring of RF effects is feasible both ex vivo as well as in vivo using temperature-sensitive sequences in an open-configuration MR environment.

Animals↗

Total and segmental colonic transit time with radio-opaque markers in adolescents with functional constipation.

BACKGROUND: In most instances, constipation is considered idiopathic or functional. The total and segmental colonic transit time, traced by radio- opaque markers, makes possible the identification of the colon segment that has the motility alteration that causes constipation. METHODS: A study was performed of 13 adolescents, aged 12 to 18, with functional chronic constipation and 13 without constipation. In all of them the total and segmental colonic transit times were measured with radio-opaque markers. The adolescents ingested 20 markers each on three successive days, and on the fourth day a plain abdominal radiograph was performed. RESULTS: In the nonconstipated adolescents the total colonic transit time (mean +/- SD) was 30.2 +/- 13.1 hours, in the right colon 5.7 +/- 3.9 hours, in the left colon 7.9 +/- 7.8 hours, and in the rectosigmoid 15.5 +/- 10.6 hours. In the constipated adolescents, the total colonic transit time was 58.3 +/- 17.4 hours, in the right colon 15.9 +/- 12.4 hours, in the left colon 14.7 +/- 13.4 hours, and in the rectosigmoid 17.2 +/- 16.2 hours. There was a statistically significant difference (p < 0.05) in the total colonic transit time, and in both the right and left colon transit times between constipated and nonconstipated adolescents. CONCLUSIONS: The measurement of total and segmental colonic transit times is a simple method that allows one to distinguish constipation due to colonic dysfunction (right colon and left colon) from constipation due to distal obstruction (rectosigmoid).

Adolescent↗

Tumor localization and systemic absorption of intravesical instillation of radio-iodinated iododeoxyuridine in patients with bladder cancer.

PURPOSE: We evaluated tumor uptake and systemic distribution of intravesically instilled iododeoxyuridine (IUdR) in patients with superficial bladder cancer. MATERIALS AND METHODS: We performed 24 intravesical instillation studies in 11 patients with a mean age of 71 years. Radio-iodinated IUdR was administered through a Foley catheter. Gamma camera imaging was done after instillation and after 5 to 7 bladder irrigations. Tumor uptake was estimated by region of interest analysis. Bladder biopsy samples and surgical tumor specimens were tested for acid insoluble (deoxyribonucleic acid incorporated) radioactivity. Blood samples were obtained and analyzed for systemic absorption. RESULTS: Imaging was positive in all patients with bladder cancer. Average tumor uptake plus or minus standard deviation was 0.185+/-0.120% of the instilled dose. Preferential uptake of IUdR in the tumor was observed in all 6 patients undergoing tissue analysis. The tumor-to-normal bladder ratio ranged from 3.2 to 74,000 (median 202). Systemic absorption of IUdR was minimal. Blood sample analysis performed after intravesical instillation in all 11 cases revealed an average uptake of 3.2x10(-5)% instilled dose per ml. (range 0.69x10(-5) to 6.7x10(-5)) in the systemic circulation. Instillation within 24 hours after transurethral bladder tumor resection in 5 cases resulted in a higher but not dangerous average systemic uptake of 7.3x10(-4)% instilled dose per ml. (range 1.3x10(-5) to 2.6x10(-3)). Instillation 1 to 4 weeks after transurethral surgery in 8 cases resulted in no increased systemic absorption with an average blood level of 3.4+/-1.8x10(-5)% instilled dose per ml. There was no detectable distribution of radioactivity into other organs, including the thyroid. We noted no evidence of systemic toxicity in the study. CONCLUSIONS: Intravesical instillation of radio-iodinated IUdR achieves selective localization in the bladder tumor with minimal uptake by the normal bladder and minimal systemic absorption. The use of intravesical IUdR therapy for bladder cancer appears to be promising and requires further study.

Absorption↗

The investigation of renovascular hypertension in children: the accuracy of radio-isotopes in detecting renovascular disease.

Renovascular disease is an important cause of hypertension in children because it is potentially treatable by surgical or angioplasty techniques. The aim of this study was to assess the accuracy of radio-isotopes (DMSA, DTPA and MAG3) combined with the angiotensin converting enzyme inhibitor, captopril, in detecting children with renovascular hypertension. We retrospectively reviewed the ultrasound and pre- and post-captopril radionuclide studies (either DMSA and/or DPTA and/or MAG3) of children with sustained hypertension investigated at our institution. Renal angiography was used as the 'reference technique'. Thirty-nine children, over a period of 10 years, were evaluated: 17 (44%) children had renovascular disease that involved the proximal three divisions of the renal arteries, some of which were amenable to treatment. The overall sensitivity, specificity, positive predictive value and negative predictive value for detecting such renovascular disease, as assessed by changes between pre- and post-captopril radio-isotope studies, were disappointing at 59%, 68%, 59% and 68%, respectively. When considering only abnormalities in post-captopril studies, these indices were 82%, 41%, 52% and 75%, respectively. Three children with potentially treatable renovascular disease were not identified on the captopril studies. We conclude that renal angiography should remain the 'reference technique' in identifying children suspected of renovascular hypertension.

Adolescent↗

Radio-guided surgery of differentiated thyroid cancer using (131)I or 99mTc-Sestamibi.

The classical therapeutic approach to patients with differentiated thyroid cancer (DTC) is based on total or near-total thyroidectomy, followed by (131)I treatment and thyroid-stimulating hormone suppressive therapy. This approach allows complete cure in many patients, especially when the tumour is diagnosed at an early stage; it also allows long-term survival in patients with locoregional recurrences or distant metastases if they can be treated with (131)I. In contrast, when metastatic DTC deposits lose their ability to trap (131)I (non-functioning metastases), a worse prognosis is expected. Nevertheless, in patients with locoregional non-functioning recurrences, an early diagnosis and prompt surgical extirpation can lead to a favourable prognosis. In these cases, radical surgery is needed. This can be achieved with radio-guided surgery using a hand-held gamma probe and a tumour-seeking radiotracer to detect, intraoperatively, the smallest metastatic lesions. In this paper, we discuss the two principal techniques proposed in the literature for radio-guided surgery of non-functioning DTC metastatic recurrences, the first using high doses of (131)I and the second using low doses of 99mTc-Sestamibi.

Clinical Trials as Topic↗

Instability of the distal radio-ulnar joint: stabilization by a Gore-Tex ligament.

Diagnosis and treatment of problems caused by instability of the distal radio-ulnar joint are complex. In this retrospective study, the results of a uniform procedure by using a Gore-Tex ligament for stabilization of the distal radio-ulnar joint are presented. In eight patients, nine wrists were operated on. The mean age of the patients was 35 years. The dominant side was involved in six patients. The mean follow-up was 3.4 years. Three of nine wrist problems were of spontaneous onset. In these wrists, the final results were excellent. The other six wrists were operated on for problems after trauma: four patients after soft-tissue injury, one patient after distal radius fracture, and one patient after forearm fracture. Among these cases, one result was excellent, four were good, and another one was fair.

Adolescent↗

Salvage radical prostatectomy for radio-recurrent prostate cancer: is this a viable option?

The role of salvage prostatectomy for radio-recurrent prostate cancer remains unclear. Recurrent prostate cancer after radiation therapy is in many cases biologically aggressive. It is unclear whether the biologic aggressiveness of radio-recurrent prostate cancer is due to time-dependent cancer clonal evolution (potentially induced by radiation damage), or is due to an innately aggressive tumor secondary to overexpression or mutation of apoptotic inhibitors that render these tumors resistant to radiation. Recent studies examined the role of DNA ploidy, p53 and bcl-2 expression, proliferative indices and glutathione S-transferase-pi in predicting response to radiation therapy or salvage prostatectomy. Because of the potential for significant morbidity after salvage prostatectomy, preoperative parameters that aid in the identification of the patients who are most likely to benefit from surgery are needed.

Biomarkers, Tumor↗

The radiographic evolution of radio frequency ablated renal tumors.

PURPOSE: Radio frequency ablation (RFA) of renal tumors is a relatively new technology. Few groups are familiar with the posttreatment appearance of these lesions and how they differ from cryoablated renal masses. We describe the evolution of the appearance of these lesions on followup contrast enhanced (CE) computerized tomography (CT). METHODS AND MATERIALS: A total of 64 consecutive renal tumors treated with RFA from April 2000 to September 2003 for which posttreatment CE-CT was done were included in this study. CE-CT was reviewed at 6 weeks, 3 months, 6 months and every 6 months thereafter to determine the characteristic features and evolution of these lesions. RESULTS: Renal tumors were treated with CT guided percutaneous (34), laparoscopic (28) or open (2) RFA. At a median followup of 13.7 months (range 6 weeks to 29 months) 62 RFA lesions demonstrated an absence of contrast enhancement on CE-CT. Treated endophytic tumors developed a low density, nonenhancing, wedge-shaped defect with fat infiltration seen between the ablated tissue and normal parenchyma. Treated exophytic tumors retained a configuration similar to that of the original with a lack of contrast enhancement and minimal shrinkage. Percutaneous treated lesions developed a peritumor scar or halo that demarcated ablated and nonablated tissue (perirenal fat). Persistent tumor was marked by contrast enhancement within the ablation borders of the original mass in 1 case, whereas tumor recurred after initial successful ablation with an enhancing nodule in 1. CONCLUSIONS: The radiographic features and evolution of radio frequency ablated renal tumors are unique. Successfully treated tumors demonstrated no contrast enhancement, minimal shrinkage and occasional retraction from normal parenchyma by fat infiltration.

Adenocarcinoma, Clear Cell↗

Defining the complications of cryoablation and radio frequency ablation of small renal tumors: a multi-institutional review.

PURPOSE: Ablative treatments (cryoablation or radio frequency ablation) for renal cell carcinoma aim to decrease morbidity by treating renal tumors in situ, eliminating the need for extirpation. These technologies have potential for complications previously unassociated with renal tumor treatment. We identified complications associated with percutaneous and laparoscopic ablative treatment of renal tumors. MATERIALS AND METHODS: Groups at medical centers with reported experience with ablation of renal tumors were invited to participate in this study. Each group submitted retrospective data regarding overall ablative treatment experience and associated complications. For each incident the nature of the complication, its associated morbidity, the necessity and nature of any subsequent interventions, and the final patient outcome were evaluated. Complications were divided into minor and major categories. Data were collected from groups at 4 institutions with a combined experience of 271 cases. Of these cases 139 were cryoablation and 133 were radio frequency ablation. There were 181 procedures performed percutaneously and 90 performed laparoscopically. RESULTS: A total of 30 complications occurred (11.1%) with 5 major (1.8%) and 25 minor (9.2%) complications, and 1 death (0.4%). Overall 26 of the 30 complications (86.7%) were directly attributable to the ablation procedure. The most common complication was pain or paraesthesia at the probe insertion site. CONCLUSIONS: Ablation technologies appear to have a low complication profile when used to treat small renal tumors. The majority of complications are minor and require observation only. Further study and followup are necessary to determine long-term oncological efficacy.

Adult↗

Measurement of the solar gravitational deflection of radio waves using geodetic very-long-baseline interferometry data, 1979-1999.

We used very-long-baseline interferometry (VLBI) to measure the deflection by the Sun of radio waves emanating from distant compact radio sources. This bending is characterized in the parametrized post-Newtonian formalism by gamma, which is unity in general relativity. Using a large geodetic VLBI data set, we obtained gamma=0.9998(3)+/-0.0004(5) (estimated standard error). We found no systematic biases from our analysis of subgroups of data.

Journal Article↗