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Results for “Personality Development”

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PubMed1986

A study of disturbed and non disturbed adolescents: the Toronto Adolescent Longitudinal Study. I.

The Toronto Adolescent Longitudinal Study was undertaken to examine personality development in a non-clinical sample of children from ages 10 through 19. Fifty-nine boys and girls, selected to represent the full range of behavior presentation in regular classrooms, have participated throughout the complete study. Each year the students and at least one parent participated in a full day evaluation during which a comprehensive battery of measures was administered to assess their psychosocial characteristics. Some exemplary results are presented regarding the personality functioning and associated characteristics of the group at age 13. Our results lead us to conclude that adolescence should not be considered as a homogeneous developmental stage. Young adolescents can be differentiated along a dimension of competence in personality functioning which is associated with differences in their clinical presentation, self concept and behavior patterns.

Adolescent↗
PubMed1981

[Diagnostic approach to psychogenic processes--an attempt to differentiate psychodynamic patterns (author's transl)].

An attempt is made to define "emotional reactions", a disease concept in child and adolescent neuropsychiatry which encompasses all processes of psychogenic origin. Emotional reaction, which is defined as psychophysical perturbation of short duration induced by trauma or some other event, is distinguished from neurotic reaction, one of the forms of an unconscious psychodynamic process, and from abnormal personality development, which encompasses all factors affecting psychological development, i.e. deprivation, stimulation, as well as abnormal field and environmental conditions. The differentiation between these 3 processes, which are based on entirely different psychodynamic patterns, has diagnostic and, of still greater importance, therapeutic implications.

Adolescent↗
PubMed2003

Stability and change in adult personality over 6 years: findings from the Victoria Longitudinal Study.

Data from the Victoria Longitudinal Study were used to examine the 6-year longitudinal stability of personality in older adults. Personality was measured with the NEO Personality Inventory. The longitudinal sample consisted of 223 adults initially ranging from 55 to 85 years of age. Longitudinal confirmatory factor analyses were used to examine the stability of individual differences in change over time, and the stability of the longitudinal factor structure. The results indicated both substantial stability at the level of individual differences in change, as well as significant individual differences in change that were related to age and gender. Finally, the factor structure of personality was invariant over time but did not approximate simple structure for the five dimensions of personality. Our study of 6-year personality development provided both (a). a confirmation of early significant stability findings and (b). unique evidence for significant individual differences in late adulthood.

Aged↗
PubMed2006

Gene silencing in the development of personalized cancer treatment: the targets, the agents and the delivery systems.

The advent of sophisticated experimental tools that can probe the molecular pathology of cancer has revealed a number of genes and gene families that could prove attractive targets for cancer therapy. Thus, gene silencing strategies have been envisioned to treat cancer by targeting the cancer cell's capacity to: (I) resist conventional treatment methods (chemotherapy and radiotherapy), (II) promote angiogenesis, and (III) metastasize and/or to survive microenvironments that normally would promote cell apoptosis/necrosis. The realization of such strategies is limited by the lack of pharmaceutically-viable technologies that enable the safe and effective delivery of gene-targeting agents to neoplastic cells following systemic administration. There are many reasons for this, including an incomplete understanding of how cancer cells respond when genes are silenced. Further the pharmacokinetic and pharmacodynamic attributes of gene therapy products are not well understood. This review will discuss gene therapy strategies that have been developed based on gene inhibition by the use of antisense oligonucleotides, ribozymes and RNA interference (RNAi). In this context, several particularly promising targets will be described, with a focus on strategies that have progressed to the stage where clinical trials have been initiated. The review highlights product development strategies that emphasize non-viral systemic formulations and the potential for delivery systems to become an enabling technology for development of effective gene therapy products.

Animals↗
PubMed2004

[Evaluation of personal empowerment: development of a scale of psychologic indices of power (MIPPA)].

This article presents the results of a series of studies devoted to creating an empowerment scale. The scale has been constructed from a dedicated conceptual framework and several empirical studies carried out over the last 5 years, designed to evaluate its conceptual articulation, linguistic properties, and psychometric qualities. Results show a scale composed of three factors that are conceptually distinct and consistent with the literature on the subject.

Adolescent↗
PubMed2003

Group psychotherapy reduces illness intrusiveness in systemic lupus erythematosus.

OBJECTIVE: We investigated whether brief supportive-expressive group psychotherapy might reduce illness-induced interference with valued activities and interests (i.e., illness intrusiveness) among women with systemic lupus erythematosus (SLE) in relation to 3 life domains: (1) relationships and personal development (family relationships, other social relationships, self-expression), (2) intimacy (relationship with spouse, sex life), and/or (3) instrumental life (work, finances, active recreation). METHODS: Women with SLE recruited from 9 rheumatology centers were randomly assigned to receive either usual care (n = 66) or a 12 week brief supportive-expressive group psychotherapy followed by 3 monthly booster sessions (n = 58). Standard instruments assessed disease activity and damage, illness intrusiveness, and psychological distress at 4 measurement occasions: (1) pretreatment, (2) posttreatment, (3) 6 month followup, and (4) 12 month followup. RESULTS: Analysis of covariance, controlling for disease activity and household income, indicated that women who received brief supportive-expressive group psychotherapy experienced significant reductions in illness intrusiveness for 2 of 3 domains: (1) relationships and personal development and (2) intimacy. Benefits were evident at 6 and 12 month followups. CONCLUSION: Brief supportive-expressive group psychotherapy facilitates adaptation to SLE by assisting women in reducing illness-induced disruptions into important domains of life experience.

Adaptation, Psychological↗
PubMedDate not supplied

[Multidrug resistance determinants in acute myeloid leukemia developed in persons exposed to ionizing radiation due to the Chernobyl accident].

The results of multidrug resistance determinants expression analysis on leukemic cells of 56 acute myeloid leukemia (AML) patients by immunophenotyping are presented. Of these, there were 21 persons exposed to ionizing radiation due to the Chemobyl accident with radiation-associated AML and 35 patients with spontaneous leukemia. The aim of this study was to determine if transport proteins (P-glycoprotein, LRP, and MDR1), apoptosis-related proteins (Fas, Bcl-2, Bax, p53, and Bcl-X(L)), and topoisomerase IIalpha expression in AML patients with the history of radiation exposure differed from those in spontaneous AML cases. Leukemic cells in patients with radiation-associated diseases compared to spontaneous AML more often overexpressed antiapoptotic oncoprotein Bcl-2 (12/21 vs. 6/35, p < 0.005) and less often demonstrated expression of Fas receptor (12/21 vs. 30/35, p < 0.05). Moreover, leukemic cells were simultaneously Fas negative and Bcl-2 positive in 4 out of 21 patients exposed to ionizing radiation but none of spontaneous cases had similar phenotype (p < 0.05). Leukemic cells in patients with radiation-associated AML compared to spontaneous cases more often were P-glycoprotein positive (12/20 vs 9/31, p < 0.05). P-glycoprotein overexpression significantly correlated with resistant disease in patients with radiation-associated AML (r = 0.47, p < 0.05), but was not a prognostic variable for the treatment outcome in terms of overall survival. Defects in pathways of drug-induced apoptosis and function of pump, that actively effluxes drugs could contribute significantly to developing drug resistance in radiation-associated AML.

ATP Binding Cassette Transporter, Subfamily B, Mem↗
PubMed1994

Recent history of European psychiatry--ideas, developments, and personalities: the annual Eliot Slater Lecture.

Erik Strömgren had planned to revise and expand his Slater lecture to a more systematic and comprehensive paper for publication. Shortly before his death, he asked for the editorial opinion of one of us (IIG), but unfortunately he did not get the opportunity to complete his lecture manuscript. We find, however, that although kaleidoscopic and impressionistic, the manuscript, as it is, contains historic and autobiographical information of high value, which deserves a posthumous publication, for availability to a broader audience. His wife, Dr. Lizzie Sand Strömgren, has kindly released the manuscript, which here appears essentially as delivered at the Slater lecture in 1986, except for a few minor textual adaptions and the addition of a list of references (by A.B.).

Europe↗
PubMed1984

Adolescent abuse and the development of personal sense of control.

The link between adolescent abuse, the adolescent's psychological functioning, and locus of control orientation is explored. Maltreated adolescents experience such problems as low self-esteem, antisocial behavior, and suicidal tendencies. It is argued that the adolescent's locus of control orientation, deriving from his/her experiences in the home, may determine the extent to which the adolescent exhibits problematic behavior and personal maladjustment. Although locus of control in abused adolescents has not been investigated, studies show that individuals who experience the same types of problems evidenced by abused adolescents are more likely to have perceptions of external control. The nature of the relationship between locus of control and abuse may depend upon the duration of the abuse (i.e., long- versus short-term abuse). For example, adolescents who have experienced abusive behavior throughout childhood are expected to be more externally oriented than those adolescents who have been abused for a shorter time. Thus, long-term abused adolescents will be more likely to have perceptions of external control than nonabused adolescents, with short-term abused adolescents falling in the middle. The distinction between short- and long-term abuse in the context of locus of control may be important to consider when designing treatment programs for abused adolescents.

Achievement↗
PubMed2001

Development of personal neutron dosemeters at the PTB and first measurements in the space station MIR.

A passive neutron dosemeter with thermoluminescence and etched-track detectors was used in the space station MIR in 1995 and 1997 and during some shuttle flights to MIR. High neutron doses of about 200 microSv d-1 were measured with track detectors, while the contribution of protons to the track density was estimated to be small. An active personal dosemeter based on silicon diodes providing a direct readout, improved sensitivity and spectrometric properties is proposed for additional monitoring. Firstly, measurements with a prototype were performed in the stray radiation fields of the CERN-EU Reference Radiation Facility. When mounted on a phantom at different positions, both the passive and the active dosemeter provide the directional distribution of neutrons via an unfolding procedure. This can be helpful for a better understanding of the complex radiation field in space and for comparisons with calculations.

Calibration↗
PubMed2002

Obstetrical complications, parenting practices and risk of criminal behaviour among persons who develop major mental disorders.

OBJECTIVE: The present study examined whether socio-economic status (SES) of the family of origin, inadequate parenting, and pre and perinatal factors are antecedents of criminality among men and women who develop a major mental disorder. METHOD: The sample included the 82 men and 79 women from the 1953 Stockholm birth cohort who developed a major mental disorder by age 30. Information was extracted from obstetric files, health, social and work records and official criminal records. RESULTS: Among males, neonatal complications increased the risk of offending two-fold, the risk of violent offending 2.5 times, and the risk of early start offending 3 times. Neither pregnancy or birth complications, inadequate parenting, or SES of the family of origin increased the risk for offending. Among females, none of the factors that were examined were associated with offending. CONCLUSION: Complications in the neonatal period are associated with offending among men who develop major mental disorders.

Adult↗
PubMed2006

Development of personality disorder symptoms and the risk for partner violence.

In a community sample (N = 543) followed over 20 years, the authors studied associations among childhood family violence exposure, personality disorder (PD) symptoms, and adult partner violence. PD symptoms (DSM-III-R Clusters A, B, and C) in early adulthood partially mediated the effect of earlier childhood risks on the odds of perpetrating partner violence. The authors tested whether stability of PD symptoms from adolescence to the early 20s differs for individuals who later perpetrated partner violence. Cluster A ("Odd/Eccentric") symptoms declined less with age among partner violent versus nonviolent men and women. Cluster B ("Dramatic/Erratic") symptoms were more stable through late adolescence in partner violent men, compared with nonviolent men and violent women. Cluster C ("Anxious") symptoms were most stable among partner violent men.

Adolescent↗